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The map label for this gene is zitB [H]

Identifier: 73539952

GI number: 73539952

Start: 270724

End: 271740

Strand: Reverse

Name: zitB [H]

Synonym: Reut_A0246

Alternate gene names: 73539952

Gene position: 271740-270724 (Counterclockwise)

Preceding gene: 73539953

Following gene: 73539947

Centisome position: 7.14

GC content: 66.37

Gene sequence:

>1017_bases
ATGCACACCGAGAATCTTTCCTCCTGGACCCACAGCCACGTCTTCGACAGCGGCAACCATGCGGCCGAGCGCGGCACGCG
GCTGGTGATGGCGATCACCGCCGCGACCATGGTGGTAGAGATCGCCGCGGGCTGGTGGTTCAACTCGATGGCGCTGCTGG
CGGATGGGTGGCACATGAGTTCGCACGCGTTGGCCATCGGCATGACGGCATTTGCCTACGCCGCCGCGCGCCGCTACGCG
AGCGATGCGCGCTTTGCGTTCGGCACCTGGAAGATCGAGGTGCTGGCGGGTTTCGCCAGCGCCATATTCCTGCTTGGCGT
GGCCGCGCTGATGGCGATCGGCTCCGTGGAGCGTTTGTTCAGCCCGCAAGCGATCCACTACCGTGAAGCCATGGCGGTTA
CGGCGCTCGGGCTGCTGGTGAATCTTGGCTGCGCGCTGATTCTCGGCGGCGCGCATCACCACCACGACGGTCACGACCAT
CACGGGCATCACCACGGGCATGCGCACGATCACCATGATCACGGCCACCACCACGACATCAACCTGCGCTCGGCCTACCT
GCACGTGCTCGCGGACGCGGCAACGTCAGTGCTCGCCATCGTCGCACTGGCTGGTGGATGGTGGCTCGGCTGGAGCTGGC
TGGACCCAGTGATGGGACTGGTGGGCGCGGCACTGGTCGGCCGCTGGGCACTAGGCCTGCTGCGCCAGAGCGGCACCGTG
CTGCTGGACAGAGAGATGGATCATCCCGTGGTCGAAGAGGTACGCGAAGTGCTCGCCGCCTTCGAGGACGCCGGCGATGC
GCGTGACGCCACGCGCGTGACTGACCTGCATGTCTGGCGCGTCGGCAAGCAGCAGTTCGCCTCCATCGTCTGCCTGGTCA
CGCACGACGCCACGCTGACGCCGCAGTCTGTGCGCGAGGCGTTGTCCGTGCACGAGGAACTCGTGCACGTGACGGTGGAG
ATCAGTGTTTGCCGCGACCAGCACTGGCACGCGGCGTCCGCAACGCAGCAAGTCTGA

Upstream 100 bases:

>100_bases
TCGCCCGGCTCATTTCCCTTCCGTGCAGCATGGACGGATGCGATACCGACATCGCCCTCTGCTACGCTTTTCGTCTCGCT
TCCTTCGGTCTTCTAACGCC

Downstream 100 bases:

>100_bases
TCGACACTACGGGAGCAATACGATTGCCCCGGTCGTCGCCCGGGACTCTGCGGCGGCATGCGCTTTGGCAACGTCCTGCA
GCGCGAAACGCGCGCCGATC

Product: cation efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MHTENLSSWTHSHVFDSGNHAAERGTRLVMAITAATMVVEIAAGWWFNSMALLADGWHMSSHALAIGMTAFAYAAARRYA
SDARFAFGTWKIEVLAGFASAIFLLGVAALMAIGSVERLFSPQAIHYREAMAVTALGLLVNLGCALILGGAHHHHDGHDH
HGHHHGHAHDHHDHGHHHDINLRSAYLHVLADAATSVLAIVALAGGWWLGWSWLDPVMGLVGAALVGRWALGLLRQSGTV
LLDREMDHPVVEEVREVLAAFEDAGDARDATRVTDLHVWRVGKQQFASIVCLVTHDATLTPQSVREALSVHEELVHVTVE
ISVCRDQHWHAASATQQV

Sequences:

>Translated_338_residues
MHTENLSSWTHSHVFDSGNHAAERGTRLVMAITAATMVVEIAAGWWFNSMALLADGWHMSSHALAIGMTAFAYAAARRYA
SDARFAFGTWKIEVLAGFASAIFLLGVAALMAIGSVERLFSPQAIHYREAMAVTALGLLVNLGCALILGGAHHHHDGHDH
HGHHHGHAHDHHDHGHHHDINLRSAYLHVLADAATSVLAIVALAGGWWLGWSWLDPVMGLVGAALVGRWALGLLRQSGTV
LLDREMDHPVVEEVREVLAAFEDAGDARDATRVTDLHVWRVGKQQFASIVCLVTHDATLTPQSVREALSVHEELVHVTVE
ISVCRDQHWHAASATQQV
>Mature_338_residues
MHTENLSSWTHSHVFDSGNHAAERGTRLVMAITAATMVVEIAAGWWFNSMALLADGWHMSSHALAIGMTAFAYAAARRYA
SDARFAFGTWKIEVLAGFASAIFLLGVAALMAIGSVERLFSPQAIHYREAMAVTALGLLVNLGCALILGGAHHHHDGHDH
HGHHHGHAHDHHDHGHHHDINLRSAYLHVLADAATSVLAIVALAGGWWLGWSWLDPVMGLVGAALVGRWALGLLRQSGTV
LLDREMDHPVVEEVREVLAAFEDAGDARDATRVTDLHVWRVGKQQFASIVCLVTHDATLTPQSVREALSVHEELVHVTVE
ISVCRDQHWHAASATQQV

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=331, Percent_Identity=23.8670694864048, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI40255009, Length=331, Percent_Identity=23.8670694864048, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI20070323, Length=257, Percent_Identity=29.1828793774319, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786966, Length=293, Percent_Identity=28.3276450511945, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32564488, Length=227, Percent_Identity=35.6828193832599, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17555794, Length=304, Percent_Identity=26.9736842105263, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555796, Length=303, Percent_Identity=27.3927392739274, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193210990, Length=318, Percent_Identity=26.4150943396226, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=340, Percent_Identity=22.9411764705882, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320411, Length=202, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24656728, Length=335, Percent_Identity=27.4626865671642, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656724, Length=335, Percent_Identity=27.4626865671642, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656720, Length=335, Percent_Identity=27.4626865671642, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656715, Length=335, Percent_Identity=27.4626865671642, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357035, Length=335, Percent_Identity=27.4626865671642, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24645863, Length=139, Percent_Identity=30.9352517985612, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36800; Mature: 36800

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTENLSSWTHSHVFDSGNHAAERGTRLVMAITAATMVVEIAAGWWFNSMALLADGWHMS
CCCCCCCHHHHHHHCCCCCHHHHHCCEEHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
SHALAIGMTAFAYAAARRYASDARFAFGTWKIEVLAGFASAIFLLGVAALMAIGSVERLF
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPQAIHYREAMAVTALGLLVNLGCALILGGAHHHHDGHDHHGHHHGHAHDHHDHGHHHDI
CCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NLRSAYLHVLADAATSVLAIVALAGGWWLGWSWLDPVMGLVGAALVGRWALGLLRQSGTV
CHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LLDREMDHPVVEEVREVLAAFEDAGDARDATRVTDLHVWRVGKQQFASIVCLVTHDATLT
EEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEECCCHHHHHHEEEEEECCCCCC
PQSVREALSVHEELVHVTVEISVCRDQHWHAASATQQV
HHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MHTENLSSWTHSHVFDSGNHAAERGTRLVMAITAATMVVEIAAGWWFNSMALLADGWHMS
CCCCCCCHHHHHHHCCCCCHHHHHCCEEHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
SHALAIGMTAFAYAAARRYASDARFAFGTWKIEVLAGFASAIFLLGVAALMAIGSVERLF
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPQAIHYREAMAVTALGLLVNLGCALILGGAHHHHDGHDHHGHHHGHAHDHHDHGHHHDI
CCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
NLRSAYLHVLADAATSVLAIVALAGGWWLGWSWLDPVMGLVGAALVGRWALGLLRQSGTV
CHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LLDREMDHPVVEEVREVLAAFEDAGDARDATRVTDLHVWRVGKQQFASIVCLVTHDATLT
EEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEECCCHHHHHHEEEEEECCCCCC
PQSVREALSVHEELVHVTVEISVCRDQHWHAASATQQV
HHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]