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The map label for this gene is 73539324

Identifier: 73539324

GI number: 73539324

Start: 2298747

End: 2299316

Strand: Direct

Name: 73539324

Synonym: Reut_B5502

Alternate gene names: NA

Gene position: 2298747-2299316 (Clockwise)

Preceding gene: 73539323

Following gene: 73539325

Centisome position: 84.32

GC content: 65.26

Gene sequence:

>570_bases
ATGTTCGACCTGAAATACGGCCGGCCGCTGAACTTCAAGCGCTGGCTCGACGACCACGCCGACAAGCTGAAGCCGCCGGT
TGGCAACCAGCAGATCTGGCAGGACAGCGACATGATGGTCACCGTGGTCGGCGGCCCCAACGAACGCAGCGACTTCCACG
ACGACCCGATCGAAGAGCTGTTCTACCAGTTCAAGGGCAACGCCTACCTGCTGCTGTGGGAAGACGGCCGCTACGAGCGT
GTCGACCTGCGCGAGGGCGACATGCTCCTGTTGCCGCCGCACACGCTGCATTCGCCACAGCGCCCCGAGGCGGACAGCCG
CTGCCTGGTGGTCGAACGCAAACGGCCGCAGGGCCAGAACGATGCGTTCCAGTGGAGCTGTGCCAGCTGCGGCACTATCG
TGCAGCGCCATGAAGTGACGCTGCAGAGCATCGTGGCCGACCTGCCGCCGCTGTACGAGAAGTTCTACGCCAGCTCCGAG
GATGCCCGCCGTTGCCCGGGCTGCGGCGAAATCCACCCCGGCCGCGATTTCCAGGCTTGGCACCGCACGCTCGCCAGGCA
CTCTTCATGA

Upstream 100 bases:

>100_bases
ACACGGACGACAGTAGCGGTGCACCAGCTTCCGCATCCGCACCTGCTTATCGAGATCAAGGGCACGGCGTACAAGCCGCT
GGCCAGAAAGGAGGCATGAT

Downstream 100 bases:

>100_bases
TCGACATCCATTCGCACTTTCTCCCGCTCATCAGCCGCCAGGAAGCACAGGCCGTCGATGCGGAGCGCGCACCATGGCTC
GCCGTGGATCCGTCCGGCGA

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MFDLKYGRPLNFKRWLDDHADKLKPPVGNQQIWQDSDMMVTVVGGPNERSDFHDDPIEELFYQFKGNAYLLLWEDGRYER
VDLREGDMLLLPPHTLHSPQRPEADSRCLVVERKRPQGQNDAFQWSCASCGTIVQRHEVTLQSIVADLPPLYEKFYASSE
DARRCPGCGEIHPGRDFQAWHRTLARHSS

Sequences:

>Translated_189_residues
MFDLKYGRPLNFKRWLDDHADKLKPPVGNQQIWQDSDMMVTVVGGPNERSDFHDDPIEELFYQFKGNAYLLLWEDGRYER
VDLREGDMLLLPPHTLHSPQRPEADSRCLVVERKRPQGQNDAFQWSCASCGTIVQRHEVTLQSIVADLPPLYEKFYASSE
DARRCPGCGEIHPGRDFQAWHRTLARHSS
>Mature_189_residues
MFDLKYGRPLNFKRWLDDHADKLKPPVGNQQIWQDSDMMVTVVGGPNERSDFHDDPIEELFYQFKGNAYLLLWEDGRYER
VDLREGDMLLLPPHTLHSPQRPEADSRCLVVERKRPQGQNDAFQWSCASCGTIVQRHEVTLQSIVADLPPLYEKFYASSE
DARRCPGCGEIHPGRDFQAWHRTLARHSS

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family

Homologues:

Organism=Homo sapiens, GI188497625, Length=153, Percent_Identity=31.3725490196078, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562218, Length=166, Percent_Identity=35.5421686746988, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6322485, Length=171, Percent_Identity=33.9181286549708, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 3HAO_CUPPJ (Q46PT7)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_299691.1
- ProteinModelPortal:   Q46PT7
- SMR:   Q46PT7
- GeneID:   3614547
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B5502
- NMPDR:   fig|264198.3.peg.6202
- HOGENOM:   HBG341987
- OMA:   LKPPVNN
- ProtClustDB:   PRK13264
- BioCyc:   REUT264198:REUT_B5502-MONOMER
- HAMAP:   MF_00825
- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- TIGRFAMs:   TIGR03037

Pfam domain/function: PF06052 3-HAO; SSF51182 RmlC_like_cupin

EC number: =1.13.11.6

Molecular weight: Translated: 21938; Mature: 21938

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: BINDING 49-49 BINDING 59-59 BINDING 101-101 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLKYGRPLNFKRWLDDHADKLKPPVGNQQIWQDSDMMVTVVGGPNERSDFHDDPIEEL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHH
FYQFKGNAYLLLWEDGRYERVDLREGDMLLLPPHTLHSPQRPEADSRCLVVERKRPQGQN
HHHHCCCEEEEEEECCCEEEEECCCCCEEEECCHHCCCCCCCCCCCEEEEEECCCCCCCC
DAFQWSCASCGTIVQRHEVTLQSIVADLPPLYEKFYASSEDARRCPGCGEIHPGRDFQAW
CCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHCCCCCCCCCCCCCHHHH
HRTLARHSS
HHHHHHCCC
>Mature Secondary Structure
MFDLKYGRPLNFKRWLDDHADKLKPPVGNQQIWQDSDMMVTVVGGPNERSDFHDDPIEEL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCCCCHHHHH
FYQFKGNAYLLLWEDGRYERVDLREGDMLLLPPHTLHSPQRPEADSRCLVVERKRPQGQN
HHHHCCCEEEEEEECCCEEEEECCCCCEEEECCHHCCCCCCCCCCCEEEEEECCCCCCCC
DAFQWSCASCGTIVQRHEVTLQSIVADLPPLYEKFYASSEDARRCPGCGEIHPGRDFQAW
CCEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHCCCCCCCCCCCCCHHHH
HRTLARHSS
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA