Click here to switch to the map view.

The map label for this gene is 73539325

Identifier: 73539325

GI number: 73539325

Start: 2299313

End: 2300326

Strand: Direct

Name: 73539325

Synonym: Reut_B5503

Alternate gene names: NA

Gene position: 2299313-2300326 (Clockwise)

Preceding gene: 73539324

Following gene: 73539327

Centisome position: 84.34

GC content: 65.48

Gene sequence:

>1014_bases
ATGATCGACATCCATTCGCACTTTCTCCCGCTCATCAGCCGCCAGGAAGCACAGGCCGTCGATGCGGAGCGCGCACCATG
GCTCGCCGTGGATCCGTCCGGCGAAACCGGGCAGATCATGCTGGCCGACCAGCCGTTCCGGCCCGTGTACCGCGCGCTGT
GGGATGCCGATTTCCGCATCGCCGAACTCGACGCACAGGGCATTGCCACGCAGCTCGTCTGCGCAACGCCGGTGATGTTC
GGCTATGGCTGGGACGCAGCGAAGGCCGCCGACTGGGCCGCGCAGATGAACGACAAGGCGCTCGCGTTCTGCGCGGGGCA
CCCTGACCGGCTCAAGGCGCTTGCGCAAGTGCCGCTGCAGGACACGCGCCTTGCGTGCGCCGAGGCTTCGCGCGCCGTGG
CCAACGGTTGTGTTGGTGTGCAGATCGGCAACCATGTCGGGGACAAGGACCTCGATCATCCAGACCTTGTCGACTTCCTG
ACGTACTGTGCGGAGAACGACATCCCCGTGCTGGTGCATCCGTGGGACATGATGGGTGGCGGCAAGCGCATGAAGCAATG
GATGCTGCCGTGGCTGGTCAGCATGGCTGCGGAGACGCAGCTCGGCATGATGTCGCTGATCCTGTCAGGCGCGCTTGAAC
GCATCCCGGAGTCGCTGCGCATCTGCTTTGCGCATGGCGGCGGCAGTTTCGCCTTCCTGTTGGGCCGCGCCGACAACGCG
TGGAAGCATCGCGACATCGTGCGCAAGGATTGCCCCCGCCTGCCATCCGAATACGCGCACCGCTTGCATGTGGACAGCAT
CGTCTTCGACGAAGGCGCGCTGCGGCTGCTCGTCGACGTGATGGGCGTCGAGCGCGTGATGCTCGGCTCCGACTATCCGT
TTCCGCTCGGCGAGCAGGAAGTCGGCGGGCTCGTGCGCGGTGTGTCGTTCCTGGACGGGGCGCAGAAGCGGAAGATTCTC
GCGGACAACGCGAGCCGGTTCTTCAGGCTCGACGCGGAGAGCAACGCTGTCTGA

Upstream 100 bases:

>100_bases
ACGCCAGCTCCGAGGATGCCCGCCGTTGCCCGGGCTGCGGCGAAATCCACCCCGGCCGCGATTTCCAGGCTTGGCACCGC
ACGCTCGCCAGGCACTCTTC

Downstream 100 bases:

>100_bases
CCTCGGCCGGTCGGTCAACAAGCCGGCATCAGCCGTTCAGCATCTTGCAGCGCGCCGCCAAACAATCGCGGAACGCCGCG
GCGCTCGGTGACAGCGAGCG

Product: aminocarboxymuconate-semialdehyde decarboxylase

Products: 2-aminomuconate semialdehyde; CO2

Alternate protein names: Amidohydrolase; 2-Amino-3-Carboxylmuconate-6-Semialdehyde Decarboxylase; Amidohydrolase/Decarboxylase; 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase; 2-Amino-3-Carboxymuconate-6- Semialdehyde Decarboxylase; Tryptophan 2 3-Dioxygenase; Decarboxylase; Amidohydrolase Family; 2-Amino-3-Carboxymuconate 6-Semialdehyde Decarboxylase; Amidase; Metal-Dependent Hydrolase; Barh Protein; 5-Carboxy-2-Hydroxymuconate-6-Semialdehyde Decarboxylase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MIDIHSHFLPLISRQEAQAVDAERAPWLAVDPSGETGQIMLADQPFRPVYRALWDADFRIAELDAQGIATQLVCATPVMF
GYGWDAAKAADWAAQMNDKALAFCAGHPDRLKALAQVPLQDTRLACAEASRAVANGCVGVQIGNHVGDKDLDHPDLVDFL
TYCAENDIPVLVHPWDMMGGGKRMKQWMLPWLVSMAAETQLGMMSLILSGALERIPESLRICFAHGGGSFAFLLGRADNA
WKHRDIVRKDCPRLPSEYAHRLHVDSIVFDEGALRLLVDVMGVERVMLGSDYPFPLGEQEVGGLVRGVSFLDGAQKRKIL
ADNASRFFRLDAESNAV

Sequences:

>Translated_337_residues
MIDIHSHFLPLISRQEAQAVDAERAPWLAVDPSGETGQIMLADQPFRPVYRALWDADFRIAELDAQGIATQLVCATPVMF
GYGWDAAKAADWAAQMNDKALAFCAGHPDRLKALAQVPLQDTRLACAEASRAVANGCVGVQIGNHVGDKDLDHPDLVDFL
TYCAENDIPVLVHPWDMMGGGKRMKQWMLPWLVSMAAETQLGMMSLILSGALERIPESLRICFAHGGGSFAFLLGRADNA
WKHRDIVRKDCPRLPSEYAHRLHVDSIVFDEGALRLLVDVMGVERVMLGSDYPFPLGEQEVGGLVRGVSFLDGAQKRKIL
ADNASRFFRLDAESNAV
>Mature_337_residues
MIDIHSHFLPLISRQEAQAVDAERAPWLAVDPSGETGQIMLADQPFRPVYRALWDADFRIAELDAQGIATQLVCATPVMF
GYGWDAAKAADWAAQMNDKALAFCAGHPDRLKALAQVPLQDTRLACAEASRAVANGCVGVQIGNHVGDKDLDHPDLVDFL
TYCAENDIPVLVHPWDMMGGGKRMKQWMLPWLVSMAAETQLGMMSLILSGALERIPESLRICFAHGGGSFAFLLGRADNA
WKHRDIVRKDCPRLPSEYAHRLHVDSIVFDEGALRLLVDVMGVERVMLGSDYPFPLGEQEVGGLVRGVSFLDGAQKRKIL
ADNASRFFRLDAESNAV

Specific function: Unknown

COG id: COG2159

COG function: function code R; Predicted metal-dependent hydrolase of the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI109715856, Length=337, Percent_Identity=36.2017804154303, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71995651, Length=334, Percent_Identity=34.4311377245509, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71995655, Length=383, Percent_Identity=30.2872062663185, Blast_Score=174, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.45

Molecular weight: Translated: 37065; Mature: 37065

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIHSHFLPLISRQEAQAVDAERAPWLAVDPSGETGQIMLADQPFRPVYRALWDADFRI
CCCCHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCEE
AELDAQGIATQLVCATPVMFGYGWDAAKAADWAAQMNDKALAFCAGHPDRLKALAQVPLQ
EEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCH
DTRLACAEASRAVANGCVGVQIGNHVGDKDLDHPDLVDFLTYCAENDIPVLVHPWDMMGG
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHCCC
GKRMKQWMLPWLVSMAAETQLGMMSLILSGALERIPESLRICFAHGGGSFAFLLGRADNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEECCCCEEEEEECCCCC
WKHRDIVRKDCPRLPSEYAHRLHVDSIVFDEGALRLLVDVMGVERVMLGSDYPFPLGEQE
HHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
VGGLVRGVSFLDGAQKRKILADNASRFFRLDAESNAV
HHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCC
>Mature Secondary Structure
MIDIHSHFLPLISRQEAQAVDAERAPWLAVDPSGETGQIMLADQPFRPVYRALWDADFRI
CCCCHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCHHHHHHHHCCCCEE
AELDAQGIATQLVCATPVMFGYGWDAAKAADWAAQMNDKALAFCAGHPDRLKALAQVPLQ
EEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCH
DTRLACAEASRAVANGCVGVQIGNHVGDKDLDHPDLVDFLTYCAENDIPVLVHPWDMMGG
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECHHHCCC
GKRMKQWMLPWLVSMAAETQLGMMSLILSGALERIPESLRICFAHGGGSFAFLLGRADNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEEEECCCCEEEEEECCCCC
WKHRDIVRKDCPRLPSEYAHRLHVDSIVFDEGALRLLVDVMGVERVMLGSDYPFPLGEQE
HHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
VGGLVRGVSFLDGAQKRKILADNASRFFRLDAESNAV
HHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate

Specific reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA