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The map label for this gene is vipA [H]

Identifier: 73539197

GI number: 73539197

Start: 2156721

End: 2157998

Strand: Reverse

Name: vipA [H]

Synonym: Reut_B5375

Alternate gene names: 73539197

Gene position: 2157998-2156721 (Counterclockwise)

Preceding gene: 73539198

Following gene: 73539196

Centisome position: 79.16

GC content: 58.92

Gene sequence:

>1278_bases
ATGGACCTCAGCAACGCAAAGATCGCCATCATCGGACTGGGCTATGTCGGCCTGCCGCTTGCAGTGGAGTTCGGCAAGCA
ACGCCAAGTCGTAGGCTTCGACATCAATGCCGTACGCATTGACGAATTGCGCAGCGGACAGGACTCGACGCTCGAGGTAA
GCCATGATGACCTGCGCGGCGCACGCTCCCTGAAGTTCTCCTGCGATCCGGCGGATCTGAAAGACTGCCAGGTATTTATT
GTCACGGTGCCAACCCCGGTGGACCGGGCGAAGCGCCCGGACCTCACGCCGCTGATTCGCGCCAGTGAGACGGTGGGCCG
GGTCATGGGACAGGACGCTGTGGTCATCTATGAGTCGACGGTGTATCCCGGCGCTACAGAAGAAGTCTGTGTACCGCTTC
TCGAACAGCACAGCGGCTTGAAGTTCAATGTGGATTTCTATTGCGGTTACAGTCCCGAACGTATCAATCCGGGAGACAAG
GAACACCGGCTGCCGGACATCCGCAAGGTCACCAGTGGCAGCACGCCCGAGGTCAGCGTGGCTATCGACGAGCTGTACCG
CAGAATCATTGTGGCAGGTACGCATCGCGCCAGCAGCATTCGTGTAGCGGAGGCCGCAAAGGTTATCGAGAATACCCAGC
GCGACGTAAATATCGCGCTGATGAATGAACTCAGCCTGCTTTTCCACAGGCTGGGCATTGACACGCTGGAGGTGTTGAAG
GCAGCGGGCACGAAATGGAACTTCCTGCCTTTCCGGCCGGGGCTGGTGGGAGGACATTGCATAGGTGTAGATCCCTACTA
TCTCACCCATAAGGCGCAGGAAGTGGGCTATCACCCGCAGGTCATCCTGGCGGGCCGTCGTATCAACGACCGAATGGCCA
TCCATGTCGCGGATGAGCTGGTGAAACTGATGCTGCGCCGGGGCATTTCCGTGCTGGGCAGCCGCATTCTCATGCTTGGT
CTCACATTCAAGGAAAACTGCCCCGACGTTCGAAATACGAAGGCAGTCGATATCGTGACCACACTGCGCGGCTACAACGC
CTCGATTGACGTCTACGACCCCTGGATCGATGTGGAGGAAGCCGAAGCGGAGTATGGGCTCGCATGCCTGCGTGAACTTC
CGCGCCATGATCAATACGACGCCATCGTACTGGCCGTGCCCCATCATCAGTTCGTCACGATGGGGGTGCGGGCGATCAGG
GCCTTTGGCAAATCGCACGCCGTGCTGTTCGACGTAAAGGGCATCTTGCCGAGGAGCGATGTCGACGCCCGCCTCTAG

Upstream 100 bases:

>100_bases
CACGAAGCCCTGCGCACAGGGCGCCGCATGCCCACGATAATTCTTTAAAAGTCCCACATCCATGCCGCCGCCAGGCCCAC
TCACCACGGAGATTTTGGTC

Downstream 100 bases:

>100_bases
AAGCGCACCGCCACGAAGAGCTCACATGGAATCCATCACCTACGCGAATCTGAGGACCAGTCTGGTTGCCAATCCGTGCA
CGTGGCTGGTCACAGGAGTG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MDLSNAKIAIIGLGYVGLPLAVEFGKQRQVVGFDINAVRIDELRSGQDSTLEVSHDDLRGARSLKFSCDPADLKDCQVFI
VTVPTPVDRAKRPDLTPLIRASETVGRVMGQDAVVIYESTVYPGATEEVCVPLLEQHSGLKFNVDFYCGYSPERINPGDK
EHRLPDIRKVTSGSTPEVSVAIDELYRRIIVAGTHRASSIRVAEAAKVIENTQRDVNIALMNELSLLFHRLGIDTLEVLK
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQEVGYHPQVILAGRRINDRMAIHVADELVKLMLRRGISVLGSRILMLG
LTFKENCPDVRNTKAVDIVTTLRGYNASIDVYDPWIDVEEAEAEYGLACLRELPRHDQYDAIVLAVPHHQFVTMGVRAIR
AFGKSHAVLFDVKGILPRSDVDARL

Sequences:

>Translated_425_residues
MDLSNAKIAIIGLGYVGLPLAVEFGKQRQVVGFDINAVRIDELRSGQDSTLEVSHDDLRGARSLKFSCDPADLKDCQVFI
VTVPTPVDRAKRPDLTPLIRASETVGRVMGQDAVVIYESTVYPGATEEVCVPLLEQHSGLKFNVDFYCGYSPERINPGDK
EHRLPDIRKVTSGSTPEVSVAIDELYRRIIVAGTHRASSIRVAEAAKVIENTQRDVNIALMNELSLLFHRLGIDTLEVLK
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQEVGYHPQVILAGRRINDRMAIHVADELVKLMLRRGISVLGSRILMLG
LTFKENCPDVRNTKAVDIVTTLRGYNASIDVYDPWIDVEEAEAEYGLACLRELPRHDQYDAIVLAVPHHQFVTMGVRAIR
AFGKSHAVLFDVKGILPRSDVDARL
>Mature_425_residues
MDLSNAKIAIIGLGYVGLPLAVEFGKQRQVVGFDINAVRIDELRSGQDSTLEVSHDDLRGARSLKFSCDPADLKDCQVFI
VTVPTPVDRAKRPDLTPLIRASETVGRVMGQDAVVIYESTVYPGATEEVCVPLLEQHSGLKFNVDFYCGYSPERINPGDK
EHRLPDIRKVTSGSTPEVSVAIDELYRRIIVAGTHRASSIRVAEAAKVIENTQRDVNIALMNELSLLFHRLGIDTLEVLK
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQEVGYHPQVILAGRRINDRMAIHVADELVKLMLRRGISVLGSRILMLG
LTFKENCPDVRNTKAVDIVTTLRGYNASIDVYDPWIDVEEAEAEYGLACLRELPRHDQYDAIVLAVPHHQFVTMGVRAIR
AFGKSHAVLFDVKGILPRSDVDARL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=437, Percent_Identity=32.2654462242563, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17560350, Length=456, Percent_Identity=25.8771929824561, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136908, Length=453, Percent_Identity=24.9448123620309, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47097; Mature: 47097

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSNAKIAIIGLGYVGLPLAVEFGKQRQVVGFDINAVRIDELRSGQDSTLEVSHDDLRG
CCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECCEEEEHHHCCCCCCEEEECCHHCCC
ARSLKFSCDPADLKDCQVFIVTVPTPVDRAKRPDLTPLIRASETVGRVMGQDAVVIYEST
CCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECC
VYPGATEEVCVPLLEQHSGLKFNVDFYCGYSPERINPGDKEHRLPDIRKVTSGSTPEVSV
CCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHCCCCCHHHHCCCCCCEEEE
AIDELYRRIIVAGTHRASSIRVAEAAKVIENTQRDVNIALMNELSLLFHRLGIDTLEVLK
EHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHH
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQEVGYHPQVILAGRRINDRMAIHVADEL
HCCCCCCEECCCCCCCCCEEECCCCHHEECCHHHCCCCCEEEEECCCCCCEEEEEEHHHH
VKLMLRRGISVLGSRILMLGLTFKENCPDVRNTKAVDIVTTLRGYNASIDVYDPWIDVEE
HHHHHHCCHHHHCCEEEEEEEEHHCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCH
AEAEYGLACLRELPRHDQYDAIVLAVPHHQFVTMGVRAIRAFGKSHAVLFDVKGILPRSD
HHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
VDARL
CCCCC
>Mature Secondary Structure
MDLSNAKIAIIGLGYVGLPLAVEFGKQRQVVGFDINAVRIDELRSGQDSTLEVSHDDLRG
CCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECCEEEEHHHCCCCCCEEEECCHHCCC
ARSLKFSCDPADLKDCQVFIVTVPTPVDRAKRPDLTPLIRASETVGRVMGQDAVVIYEST
CCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECC
VYPGATEEVCVPLLEQHSGLKFNVDFYCGYSPERINPGDKEHRLPDIRKVTSGSTPEVSV
CCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHCCCCCHHHHCCCCCCEEEE
AIDELYRRIIVAGTHRASSIRVAEAAKVIENTQRDVNIALMNELSLLFHRLGIDTLEVLK
EHHHHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHH
AAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQEVGYHPQVILAGRRINDRMAIHVADEL
HCCCCCCEECCCCCCCCCEEECCCCHHEECCHHHCCCCCEEEEECCCCCCEEEEEEHHHH
VKLMLRRGISVLGSRILMLGLTFKENCPDVRNTKAVDIVTTLRGYNASIDVYDPWIDVEE
HHHHHHCCHHHHCCEEEEEEEEHHCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCH
AEAEYGLACLRELPRHDQYDAIVLAVPHHQFVTMGVRAIRAFGKSHAVLFDVKGILPRSD
HHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
VDARL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]