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The map label for this gene is zwf [H]

Identifier: 73539151

GI number: 73539151

Start: 2094000

End: 2095448

Strand: Reverse

Name: zwf [H]

Synonym: Reut_B5329

Alternate gene names: 73539151

Gene position: 2095448-2094000 (Counterclockwise)

Preceding gene: 73539153

Following gene: 73539150

Centisome position: 76.86

GC content: 65.98

Gene sequence:

>1449_bases
ATGCCTGATTTCGACATGGTGCTGTTCGGCGGCACCGGCGACCTGGCCCGGCGCAAGCTGTTGCCGTCGCTTTATGAAGC
CCACCATGCCGGGCTGCTGCACCCGCGTGCGCGCATTCTCGCGACGGGCAGCCAGCCACTGAGCCAGGAAGACTACATTG
CGTCGCTGGAGCAGGGCGTACGGCCGGGCCTGGCGCATGCGCCGCCCGAGTCATGGGCCGCGTTCCTGGCCCGCATCTGC
TACGTGCAGGCCGACGCACGCGTGCCCGCGCACTTCGATGCACTCGCCGAAAAGGTGCTGTCGCGCCGCCCCGAAGTGGT
GGTGTGCTACCTTGCAACGGCGCCACATCTTTTCGTGCCGATCTGCGAGCAACTGGCGCGTACCGGGCTGAACACGCCGA
ATGTCCGGATCGTGCTGGAAAAGCCGCTGGGGCACGATCTCGAATCGTCCGAAGCGATCAACGCCGCAGTCGCGAAATTC
TTTGCCGAGGACCAGATCTACCGCATCGATCATTACCTCGGCAAGGAGTCGGTGCAGAACCTGATGGCAATCCGCTTCGG
CAACGCGCTGTTCGAGCCGCTGTGGCGGCGAGAGTGGGTGCAGGATGTGCAGATCACGATCGCCGAGGAACTCGGCGTCG
AGACGCGCGGGGACTTCTACGATCGCACGGGCGCCTTGCGCGACATGGTGCAGAACCACCTGCTGCAGCTGCTGTGCATG
GTGGCCATGGAGCCCCCGAGCAGCCTGTCGGAAGACGCGATCCGCGACGAGAAGATCAAGATCCTCAAGGCGCTCAAGCC
GATTACGCCGCAGGCCGTGGCCGAGAAGACCGTGCGCGGCCAGTATCGCGCCGGCGCCATCGGGGGCAAGCCGGTGCCGG
GCTACCTCGACGAGAAAGGCATTGCCGCCGACAGCCGGACCGAGACCTTTGTCGCGATCAAGGCGGAGATCGCCAACTGG
CGCTGGGAAGGCGTGCCGTTCTACCTGCGCACGGGCAAGCGCATGCAGTCGCGCGTGGCCGAGATCGTGGTGCATTTCCG
CGATGTGCCGCATGCCATCTTTCCGCGGCCGCTGACGCTGTCGCCGCAGAACCGGCTCGTGATCCAGCTGCAGCCCGAGG
AAAGCATCCGCTTGTACTTCCTGGTCAAGCAGCCTGGCGACACGCTGGAACTGACGCCCACCTCGCTCGACCTGGACTTC
GCCAACTCGTTCAAGGTGCGCCGCGCGGGCGCCTATGAACGGCTGCTGCTCGACGTGATCCGCGGCAGGCTGGGCCTGTT
CGTGCGGCGTGACGAGCAGGTGCAGGCGTGGCGCTGGGTCGAGCCGATTCTCGACACATGGGAAGAAAGCAACGTGCCGC
CCAAGCCGTATACCGCGGGCACGTGGGGTCCGGCGGCGTCGTCGGCGCTGATGTCGCGCGACGACTCGCTGTGGCACGAG
GAAGCCTGA

Upstream 100 bases:

>100_bases
GGCCGCTGCGGGACACTCATTGCATGCGGCCGCATCGGGCAGGTGCCGCGCATGCGCGCGTTCTGACCGCCATCCTCATG
CCTAGGAGCCCACGGTGAGC

Downstream 100 bases:

>100_bases
CTGGAGATACCGCCATGCGCGAATTCGAGCATGCAAACGCGATGGACCAGGCCGAGGCGCTGGCCATTTCCATCGGCAAT
GCACTGGACCAGGCGATCCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MPDFDMVLFGGTGDLARRKLLPSLYEAHHAGLLHPRARILATGSQPLSQEDYIASLEQGVRPGLAHAPPESWAAFLARIC
YVQADARVPAHFDALAEKVLSRRPEVVVCYLATAPHLFVPICEQLARTGLNTPNVRIVLEKPLGHDLESSEAINAAVAKF
FAEDQIYRIDHYLGKESVQNLMAIRFGNALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGALRDMVQNHLLQLLCM
VAMEPPSSLSEDAIRDEKIKILKALKPITPQAVAEKTVRGQYRAGAIGGKPVPGYLDEKGIAADSRTETFVAIKAEIANW
RWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTLSPQNRLVIQLQPEESIRLYFLVKQPGDTLELTPTSLDLDF
ANSFKVRRAGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVEPILDTWEESNVPPKPYTAGTWGPAASSALMSRDDSLWHE
EA

Sequences:

>Translated_482_residues
MPDFDMVLFGGTGDLARRKLLPSLYEAHHAGLLHPRARILATGSQPLSQEDYIASLEQGVRPGLAHAPPESWAAFLARIC
YVQADARVPAHFDALAEKVLSRRPEVVVCYLATAPHLFVPICEQLARTGLNTPNVRIVLEKPLGHDLESSEAINAAVAKF
FAEDQIYRIDHYLGKESVQNLMAIRFGNALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGALRDMVQNHLLQLLCM
VAMEPPSSLSEDAIRDEKIKILKALKPITPQAVAEKTVRGQYRAGAIGGKPVPGYLDEKGIAADSRTETFVAIKAEIANW
RWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTLSPQNRLVIQLQPEESIRLYFLVKQPGDTLELTPTSLDLDF
ANSFKVRRAGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVEPILDTWEESNVPPKPYTAGTWGPAASSALMSRDDSLWHE
EA
>Mature_481_residues
PDFDMVLFGGTGDLARRKLLPSLYEAHHAGLLHPRARILATGSQPLSQEDYIASLEQGVRPGLAHAPPESWAAFLARICY
VQADARVPAHFDALAEKVLSRRPEVVVCYLATAPHLFVPICEQLARTGLNTPNVRIVLEKPLGHDLESSEAINAAVAKFF
AEDQIYRIDHYLGKESVQNLMAIRFGNALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGALRDMVQNHLLQLLCMV
AMEPPSSLSEDAIRDEKIKILKALKPITPQAVAEKTVRGQYRAGAIGGKPVPGYLDEKGIAADSRTETFVAIKAEIANWR
WEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTLSPQNRLVIQLQPEESIRLYFLVKQPGDTLELTPTSLDLDFA
NSFKVRRAGAYERLLLDVIRGRLGLFVRRDEQVQAWRWVEPILDTWEESNVPPKPYTAGTWGPAASSALMSRDDSLWHEE
A

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=480, Percent_Identity=37.9166666666667, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI108773793, Length=480, Percent_Identity=37.9166666666667, Blast_Score=314, Evalue=9e-86,
Organism=Homo sapiens, GI52145310, Length=498, Percent_Identity=26.9076305220884, Blast_Score=156, Evalue=5e-38,
Organism=Escherichia coli, GI1788158, Length=480, Percent_Identity=47.5, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17538218, Length=479, Percent_Identity=36.9519832985386, Blast_Score=315, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6324088, Length=479, Percent_Identity=34.6555323590814, Blast_Score=282, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24643352, Length=468, Percent_Identity=36.7521367521368, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24643350, Length=468, Percent_Identity=36.7521367521368, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=29.4117647058824, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54235; Mature: 54104

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFDMVLFGGTGDLARRKLLPSLYEAHHAGLLHPRARILATGSQPLSQEDYIASLEQGV
CCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCHHHHHHHHHHCC
RPGLAHAPPESWAAFLARICYVQADARVPAHFDALAEKVLSRRPEVVVCYLATAPHLFVP
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
ICEQLARTGLNTPNVRIVLEKPLGHDLESSEAINAAVAKFFAEDQIYRIDHYLGKESVQN
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHH
LMAIRFGNALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGALRDMVQNHLLQLLCM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VAMEPPSSLSEDAIRDEKIKILKALKPITPQAVAEKTVRGQYRAGAIGGKPVPGYLDEKG
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
IAADSRTETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTL
CCCCCCCCEEEEEEEECCCCEECCCCEEECCCHHHHHHHHHHHHHHHCCCHHHCCCCCEE
SPQNRLVIQLQPEESIRLYFLVKQPGDTLELTPTSLDLDFANSFKVRRAGAYERLLLDVI
CCCCCEEEEECCCCCEEEEEEEECCCCEEEECCCEECCCCCCCCCCHHCCHHHHHHHHHH
RGRLGLFVRRDEQVQAWRWVEPILDTWEESNVPPKPYTAGTWGPAASSALMSRDDSLWHE
HHHHCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHCC
EA
CC
>Mature Secondary Structure 
PDFDMVLFGGTGDLARRKLLPSLYEAHHAGLLHPRARILATGSQPLSQEDYIASLEQGV
CCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCHHHHHHHHHHCC
RPGLAHAPPESWAAFLARICYVQADARVPAHFDALAEKVLSRRPEVVVCYLATAPHLFVP
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
ICEQLARTGLNTPNVRIVLEKPLGHDLESSEAINAAVAKFFAEDQIYRIDHYLGKESVQN
HHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHH
LMAIRFGNALFEPLWRREWVQDVQITIAEELGVETRGDFYDRTGALRDMVQNHLLQLLCM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VAMEPPSSLSEDAIRDEKIKILKALKPITPQAVAEKTVRGQYRAGAIGGKPVPGYLDEKG
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
IAADSRTETFVAIKAEIANWRWEGVPFYLRTGKRMQSRVAEIVVHFRDVPHAIFPRPLTL
CCCCCCCCEEEEEEEECCCCEECCCCEEECCCHHHHHHHHHHHHHHHCCCHHHCCCCCEE
SPQNRLVIQLQPEESIRLYFLVKQPGDTLELTPTSLDLDFANSFKVRRAGAYERLLLDVI
CCCCCEEEEECCCCCEEEEEEEECCCCEEEECCCEECCCCCCCCCCHHCCHHHHHHHHHH
RGRLGLFVRRDEQVQAWRWVEPILDTWEESNVPPKPYTAGTWGPAASSALMSRDDSLWHE
HHHHCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHCC
EA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]