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The map label for this gene is yxbG [H]

Identifier: 73538381

GI number: 73538381

Start: 1231706

End: 1232461

Strand: Direct

Name: yxbG [H]

Synonym: Reut_B4554

Alternate gene names: 73538381

Gene position: 1231706-1232461 (Clockwise)

Preceding gene: 73538380

Following gene: 73538382

Centisome position: 45.18

GC content: 66.93

Gene sequence:

>756_bases
ATGGAAATTCGCAATAACGTCTTCATTGTCACCGGCGGCGCGTCGGGACTTGGCGAGGCCACGGCCCGAATGCTGGCCGC
CGCCGGAGGCAAGGTGGTCATTGCCGACATCAATCCGGCCGGCGAAGCCGTGGCCGAGGAGATCTGCGCACGCTTCGTGC
GCTGCGATGTCGTAAGCGAGGCCGACGGCACGGCGGTCGTCAACGCTACTGCAGCACTGGGCCGCGTGGCCGGGCTGGTC
AACTGCGCGGGCGTCGCGCCGGCCTGCAAGACCGTAGGCAAAGATGGTCCCCACCCGCTCGACGTGTTCGAGCGCACGGT
CCGCATCAACCTGATCGGCACGTTCAACATGGTGAGGCTGGCCGCTGCACAGATGGTGAACAACACACCGGATGCCGACG
GCGAACGCGGCGTGATCGTCAACACGGCGTCGGTAGCGGCGTTCGAAGGACAGATCGGACAGGCTGCGTACGCGGCCTCC
AAGGGCGGCGTGGCCGCGATGACACTGGCCGTCGCGCGCGACCTCTCTCGCGACGGCGTGCGCTGCGTGACCATCGCCCC
GGGCTTGTTCGAGACGCCGATGCTGCTCGGCCTGCCGGAAACCGTGCGCGATGCGCTCGGCAAGATGGTGCCCTTTCCGT
CTCGCCTGGGGCGGCCCCCGGAGTATGCGAAGCTGGCCGCGGCGATCATCGGGAATCCGATGATCAATGGCGAGGTGATC
CGGCTGGATGGGGCGATTCGGATGCAGCCGAAGTAA

Upstream 100 bases:

>100_bases
TCGAAATGTCGGCCGGGTTCCAGGCGCTGGCGCACCATACCGCCGAACACGAAGCCGCACTCGATGGCTTCCTGGCATGC
ATCAAAGGCTGAGGAACGCC

Downstream 100 bases:

>100_bases
TTCAGCGCGGCGCACTTCACCCAAGGCGCAAGGGCCGGCACATCATGCCGGCCTTTTGCTTTGCACGGCCGGACAATCCC
TGATTGTTTAATCCGACCGT

Product: Short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MEIRNNVFIVTGGASGLGEATARMLAAAGGKVVIADINPAGEAVAEEICARFVRCDVVSEADGTAVVNATAALGRVAGLV
NCAGVAPACKTVGKDGPHPLDVFERTVRINLIGTFNMVRLAAAQMVNNTPDADGERGVIVNTASVAAFEGQIGQAAYAAS
KGGVAAMTLAVARDLSRDGVRCVTIAPGLFETPMLLGLPETVRDALGKMVPFPSRLGRPPEYAKLAAAIIGNPMINGEVI
RLDGAIRMQPK

Sequences:

>Translated_251_residues
MEIRNNVFIVTGGASGLGEATARMLAAAGGKVVIADINPAGEAVAEEICARFVRCDVVSEADGTAVVNATAALGRVAGLV
NCAGVAPACKTVGKDGPHPLDVFERTVRINLIGTFNMVRLAAAQMVNNTPDADGERGVIVNTASVAAFEGQIGQAAYAAS
KGGVAAMTLAVARDLSRDGVRCVTIAPGLFETPMLLGLPETVRDALGKMVPFPSRLGRPPEYAKLAAAIIGNPMINGEVI
RLDGAIRMQPK
>Mature_251_residues
MEIRNNVFIVTGGASGLGEATARMLAAAGGKVVIADINPAGEAVAEEICARFVRCDVVSEADGTAVVNATAALGRVAGLV
NCAGVAPACKTVGKDGPHPLDVFERTVRINLIGTFNMVRLAAAQMVNNTPDADGERGVIVNTASVAAFEGQIGQAAYAAS
KGGVAAMTLAVARDLSRDGVRCVTIAPGLFETPMLLGLPETVRDALGKMVPFPSRLGRPPEYAKLAAAIIGNPMINGEVI
RLDGAIRMQPK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=256, Percent_Identity=56.25, Blast_Score=259, Evalue=1e-69,
Organism=Homo sapiens, GI83715985, Length=257, Percent_Identity=54.4747081712062, Blast_Score=239, Evalue=1e-63,
Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=30.2583025830258, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=29.9212598425197, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI59889578, Length=209, Percent_Identity=32.0574162679426, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4504505, Length=214, Percent_Identity=28.9719626168224, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082100, Length=234, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=27.9527559055118, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=27.5193798449612, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789057, Length=227, Percent_Identity=28.6343612334802, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786812, Length=198, Percent_Identity=30.8080808080808, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789208, Length=201, Percent_Identity=29.8507462686567, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=49.1869918699187, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI25147288, Length=248, Percent_Identity=28.6290322580645, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=30.3149606299213, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=27.5193798449612, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=213, Percent_Identity=28.6384976525822, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=225, Percent_Identity=28.4444444444444, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=238, Percent_Identity=28.9915966386555, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=210, Percent_Identity=31.9047619047619, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=258, Percent_Identity=27.5193798449612, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=232, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320089, Length=239, Percent_Identity=26.7782426778243, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=56.6929133858268, Blast_Score=266, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=30.8300395256917, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357041, Length=238, Percent_Identity=31.9327731092437, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571526, Length=237, Percent_Identity=30.8016877637131, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=31.3432835820896, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24644339, Length=240, Percent_Identity=29.1666666666667, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 25763; Mature: 25763

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRNNVFIVTGGASGLGEATARMLAAAGGKVVIADINPAGEAVAEEICARFVRCDVVSE
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
ADGTAVVNATAALGRVAGLVNCAGVAPACKTVGKDGPHPLDVFERTVRINLIGTFNMVRL
CCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHCEEEEEEEEEHHHHHHH
AAAQMVNNTPDADGERGVIVNTASVAAFEGQIGQAAYAASKGGVAAMTLAVARDLSRDGV
HHHHHHCCCCCCCCCCEEEEEECCEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCC
RCVTIAPGLFETPMLLGLPETVRDALGKMVPFPSRLGRPPEYAKLAAAIIGNPMINGEVI
EEEEECCCCHHCCHHCCCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEE
RLDGAIRMQPK
EECCEEEECCC
>Mature Secondary Structure
MEIRNNVFIVTGGASGLGEATARMLAAAGGKVVIADINPAGEAVAEEICARFVRCDVVSE
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
ADGTAVVNATAALGRVAGLVNCAGVAPACKTVGKDGPHPLDVFERTVRINLIGTFNMVRL
CCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHCEEEEEEEEEHHHHHHH
AAAQMVNNTPDADGERGVIVNTASVAAFEGQIGQAAYAASKGGVAAMTLAVARDLSRDGV
HHHHHHCCCCCCCCCCEEEEEECCEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCC
RCVTIAPGLFETPMLLGLPETVRDALGKMVPFPSRLGRPPEYAKLAAAIIGNPMINGEVI
EEEEECCCCHHCCHHCCCCHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHCCCCCCCEEE
RLDGAIRMQPK
EECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]