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The map label for this gene is czcC [H]

Identifier: 73537336

GI number: 73537336

Start: 38172

End: 39641

Strand: Direct

Name: czcC [H]

Synonym: Reut_B3501

Alternate gene names: 73537336

Gene position: 38172-39641 (Clockwise)

Preceding gene: 73537335

Following gene: 73537337

Centisome position: 1.4

GC content: 67.55

Gene sequence:

>1470_bases
ATGACGAAATATCGTCAGTTCGGTGCACCAATCGGCGGGCACGGTCGTTTACCTTTGACTGTTGTCGAACCCGAGCCAGA
TCGAACCGTGCCTTTTCCTGTTTCAAGCGCTACTGCTGCCGCCATCCTGGCGGTCGTGGCCGGCCTGACGGCCCCGTTGG
CCCACGGGGCGAGCCAGCCGCTGCCGCCCGATGGGCCCTGCCTGCCGCCGCCCCCGAAGGCCACCCTGACCCTGGCGCAG
GCGCGTCAGGATGCTCTGCGCTGCAACCGCGACATCATTGCCGCGCGCCGCGGCGAGGAAGCGAGCCAGGCGGATATCCA
GATCGCGTCGCAGCGCCCGAATCCCGTGTTGAGCGTTGGTGTGCAGAACATCAATCCGCACGCCGGCGTCGGCTCCGGCA
ACCTGCGCAGCAAGACCGTGGATTCCACGTTCCGCATCGACCAGCTGATCGAAACCGCGAACAAGGGCAACCTGCGCAAG
GACGCCGCGCAGAAGGCGAGCGTGGCGGCCGGCGAGGCCGTGCAGGCCGTGGTGGCCCAGCAGACCGGCGCCGTCGAGCA
GGCGTTCTACGATGCCGTGGTAAGCCAGGAGCGCGTCCAGGTGCTGAGCGAGACCGTAGCGCTCTATACCCGCACGCAGC
AGGCTAACGAGACTCGCCTGAAGGCCGGCGACGTGTCGCGCGCCGACGTGACCAAGCTCCAGCTCGACAACCTGCGTGCG
CAGAACGACATGCGCCAGGCCATGGCCGACCATATGCGCGACAAGGCGCAACTGGCCCAGGCCATGGGGGTGCCGGGCAC
GCTGGCCGACAACCGCCTAGTGGCGGACTGGCCGTCGCTCGACGAGCCGACCCCGCCGGTCGATCTCGAAATTGCGCAGC
GCCGCCCCGACGTGACCGCGGCCGAGGCCCGTCTGGCTGCCGCCGCCTCGGCGCGTGACCTTGCCCGTGCCGGCCGCGTG
CCCGATGTGACCGTGGGTGCGCAATACGAGCACTACCCGATTTCCGAAACTAATACGAACGGCAGCGGCAACAGCTACGG
CGTCTTTGTCTCGATTCCGCTGTTCGTGCGCCACAGCAATGGCGGCGAAGCGCGCCGCGCCGAGGTCGACTATTACGCCG
CGCTCGACGATCGCAACCGCGTGCTGCTCGAGGCGCAGAATGAGGTCGAACGCTTGCGCAACCAGCTCGAAGCCGCACGC
CTGTCGCTGAGGCAGATGCGCGAATCCGTCGTGCCCGCCGCCGAATCGGTAGCAGGAAGCGCCGAATTTGCCTATACGAA
GGGCGCAACCGGCGTGCTCGACTTGCTCGATGCACGCCGCGCGCTGCGTCAGACCCGGCTGGACGCCACCAATGCCCAGG
GCGACTACGCCAAGGCCCTGTCGGCTTACCGCACGGCGTTGCAGTCCACCACCACTCCCGTCAGCTCCATCCCGAATTCC
CAGGTCCGTACCGATGCGCCGCGTCCCTAA

Upstream 100 bases:

>100_bases
AGGATGAAAGCGCTTTGTAATCCGATTCGGTTTGAATGCGGGCGGGAGATCGTGCGAAGGTCCCGTAGATAGCGGATAAC
ACGCGACGGGAACGCGCCAG

Downstream 100 bases:

>100_bases
TCTGCTGTCCGAAGTGTTTCGAGTTTCTCCCGCCGGCCTGCCTGCGCGCGTGGCCGCCTTGTCCCTGTGCGCGCTGGCGC
TTGCCGCTTGCGGCAAGGAA

Product: Outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTKYRQFGAPIGGHGRLPLTVVEPEPDRTVPFPVSSATAAAILAVVAGLTAPLAHGASQPLPPDGPCLPPPPKATLTLAQ
ARQDALRCNRDIIAARRGEEASQADIQIASQRPNPVLSVGVQNINPHAGVGSGNLRSKTVDSTFRIDQLIETANKGNLRK
DAAQKASVAAGEAVQAVVAQQTGAVEQAFYDAVVSQERVQVLSETVALYTRTQQANETRLKAGDVSRADVTKLQLDNLRA
QNDMRQAMADHMRDKAQLAQAMGVPGTLADNRLVADWPSLDEPTPPVDLEIAQRRPDVTAAEARLAAAASARDLARAGRV
PDVTVGAQYEHYPISETNTNGSGNSYGVFVSIPLFVRHSNGGEARRAEVDYYAALDDRNRVLLEAQNEVERLRNQLEAAR
LSLRQMRESVVPAAESVAGSAEFAYTKGATGVLDLLDARRALRQTRLDATNAQGDYAKALSAYRTALQSTTTPVSSIPNS
QVRTDAPRP

Sequences:

>Translated_489_residues
MTKYRQFGAPIGGHGRLPLTVVEPEPDRTVPFPVSSATAAAILAVVAGLTAPLAHGASQPLPPDGPCLPPPPKATLTLAQ
ARQDALRCNRDIIAARRGEEASQADIQIASQRPNPVLSVGVQNINPHAGVGSGNLRSKTVDSTFRIDQLIETANKGNLRK
DAAQKASVAAGEAVQAVVAQQTGAVEQAFYDAVVSQERVQVLSETVALYTRTQQANETRLKAGDVSRADVTKLQLDNLRA
QNDMRQAMADHMRDKAQLAQAMGVPGTLADNRLVADWPSLDEPTPPVDLEIAQRRPDVTAAEARLAAAASARDLARAGRV
PDVTVGAQYEHYPISETNTNGSGNSYGVFVSIPLFVRHSNGGEARRAEVDYYAALDDRNRVLLEAQNEVERLRNQLEAAR
LSLRQMRESVVPAAESVAGSAEFAYTKGATGVLDLLDARRALRQTRLDATNAQGDYAKALSAYRTALQSTTTPVSSIPNS
QVRTDAPRP
>Mature_488_residues
TKYRQFGAPIGGHGRLPLTVVEPEPDRTVPFPVSSATAAAILAVVAGLTAPLAHGASQPLPPDGPCLPPPPKATLTLAQA
RQDALRCNRDIIAARRGEEASQADIQIASQRPNPVLSVGVQNINPHAGVGSGNLRSKTVDSTFRIDQLIETANKGNLRKD
AAQKASVAAGEAVQAVVAQQTGAVEQAFYDAVVSQERVQVLSETVALYTRTQQANETRLKAGDVSRADVTKLQLDNLRAQ
NDMRQAMADHMRDKAQLAQAMGVPGTLADNRLVADWPSLDEPTPPVDLEIAQRRPDVTAAEARLAAAASARDLARAGRVP
DVTVGAQYEHYPISETNTNGSGNSYGVFVSIPLFVRHSNGGEARRAEVDYYAALDDRNRVLLEAQNEVERLRNQLEAARL
SLRQMRESVVPAAESVAGSAEFAYTKGATGVLDLLDARRALRQTRLDATNAQGDYAKALSAYRTALQSTTTPVSSIPNSQ
VRTDAPRP

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52259; Mature: 52128

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYRQFGAPIGGHGRLPLTVVEPEPDRTVPFPVSSATAAAILAVVAGLTAPLAHGASQP
CCCCHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
LPPDGPCLPPPPKATLTLAQARQDALRCNRDIIAARRGEEASQADIQIASQRPNPVLSVG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEECCCCCCEEEEE
VQNINPHAGVGSGNLRSKTVDSTFRIDQLIETANKGNLRKDAAQKASVAAGEAVQAVVAQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QTGAVEQAFYDAVVSQERVQVLSETVALYTRTQQANETRLKAGDVSRADVTKLQLDNLRA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHH
QNDMRQAMADHMRDKAQLAQAMGVPGTLADNRLVADWPSLDEPTPPVDLEIAQRRPDVTA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCHH
AEARLAAAASARDLARAGRVPDVTVGAQYEHYPISETNTNGSGNSYGVFVSIPLFVRHSN
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEECC
GGEARRAEVDYYAALDDRNRVLLEAQNEVERLRNQLEAARLSLRQMRESVVPAAESVAGS
CCCCEEEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
AEFAYTKGATGVLDLLDARRALRQTRLDATNAQGDYAKALSAYRTALQSTTTPVSSIPNS
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCC
QVRTDAPRP
CCCCCCCCC
>Mature Secondary Structure 
TKYRQFGAPIGGHGRLPLTVVEPEPDRTVPFPVSSATAAAILAVVAGLTAPLAHGASQP
CCCHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
LPPDGPCLPPPPKATLTLAQARQDALRCNRDIIAARRGEEASQADIQIASQRPNPVLSVG
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEECCCCCCEEEEE
VQNINPHAGVGSGNLRSKTVDSTFRIDQLIETANKGNLRKDAAQKASVAAGEAVQAVVAQ
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QTGAVEQAFYDAVVSQERVQVLSETVALYTRTQQANETRLKAGDVSRADVTKLQLDNLRA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHHHH
QNDMRQAMADHMRDKAQLAQAMGVPGTLADNRLVADWPSLDEPTPPVDLEIAQRRPDVTA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCHH
AEARLAAAASARDLARAGRVPDVTVGAQYEHYPISETNTNGSGNSYGVFVSIPLFVRHSN
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEECC
GGEARRAEVDYYAALDDRNRVLLEAQNEVERLRNQLEAARLSLRQMRESVVPAAESVAGS
CCCCEEEEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
AEFAYTKGATGVLDLLDARRALRQTRLDATNAQGDYAKALSAYRTALQSTTTPVSSIPNS
CCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHCCCC
QVRTDAPRP
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]