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The map label for this gene is adk [H]

Identifier: 71893526

GI number: 71893526

Start: 201244

End: 201882

Strand: Reverse

Name: adk [H]

Synonym: MHJ_0170

Alternate gene names: 71893526

Gene position: 201882-201244 (Counterclockwise)

Preceding gene: 71893527

Following gene: 71893525

Centisome position: 22.5

GC content: 28.95

Gene sequence:

>639_bases
ATGAAAAGCAATAAAAAAATTCTTTTTATAGGAGCTCCTGGCTCAGGTAAAGGAACTATTTCAAAAATTTTAGTTGAAAA
ATACAAGTTAGTTCATATTTCTACAGGTGATCTTTTTCGAAAAAAAATTAGTGAAGATTCCCAATTTGCAGCACAAATTC
AAAATTATTTAAGTTCAGGAAGTTATGTCCCTGATGAAATAACAAATAAATTAGTTGCTGATTTTATCAAAAAAATCCCT
AAAAATCAAGGTTATATTCTTGATGGTTATCCTCGAACGCTTCAACAGTTGGAATTTATGATCAAAAATGGCATCAATCT
AGATTGTGTTTTTTATCTAAAAATAAAAAATGAGACGATAATTTCGCGTCTTTCTCAGCGACTTTTTTGTCAAAAATGTC
AAAAATCTTATAATTTATTGCTTGCAAAACCGAAAAACGAACTAAAATGTGACCTTGATAGCACCGATTTAATTACCAGA
AATGATGATCGTCCCGAAATTATCACACATCGAATTGAAAAATTCAATAATTCAGTGATTCCAATTGTTGAATTTTTCAA
AAAAAGTGGTATAATATATTATCTAGATGCCGAGCAAACCCTTGAAGAAACAGTTATAGAAATTGAAAAATGGCTATAA

Upstream 100 bases:

>100_bases
ACAAGTTCGAAAAAATTCTCCTTCTATTGATTCAAATCAGGATCTTTTATGGTAAAATTTAATTTTTAACATTTTTGATT
AAAAGAAGGCAAACTTAAAA

Downstream 100 bases:

>100_bases
TTAAAAATGAATTTGAAATAAGCCAGTTGAAAATTGCTGGCAAAATCTTGGCAGAAGTTAAGGCAAAAATTTATGACTTT
GTAAGACCAGGAATCTCTTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSQFAAQIQNYLSSGSYVPDEITNKLVADFIKKIP
KNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETIISRLSQRLFCQKCQKSYNLLLAKPKNELKCDLDSTDLITR
NDDRPEIITHRIEKFNNSVIPIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL

Sequences:

>Translated_212_residues
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSQFAAQIQNYLSSGSYVPDEITNKLVADFIKKIP
KNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETIISRLSQRLFCQKCQKSYNLLLAKPKNELKCDLDSTDLITR
NDDRPEIITHRIEKFNNSVIPIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL
>Mature_212_residues
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSQFAAQIQNYLSSGSYVPDEITNKLVADFIKKIP
KNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETIISRLSQRLFCQKCQKSYNLLLAKPKNELKCDLDSTDLITR
NDDRPEIITHRIEKFNNSVIPIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=199, Percent_Identity=30.6532663316583, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI4502013, Length=199, Percent_Identity=30.6532663316583, Blast_Score=123, Evalue=9e-29,
Organism=Homo sapiens, GI19923437, Length=195, Percent_Identity=29.7435897435897, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=28.7179487179487, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=28.7179487179487, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=28.7179487179487, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=28.7179487179487, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502011, Length=203, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28144897, Length=211, Percent_Identity=27.0142180094787, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI28144899, Length=211, Percent_Identity=27.0142180094787, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI7706497, Length=210, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI22749187, Length=145, Percent_Identity=28.9655172413793, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=31.6037735849057, Blast_Score=130, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=32.5358851674641, Blast_Score=136, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17537943, Length=209, Percent_Identity=31.1004784688995, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=31.5270935960591, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=208, Percent_Identity=28.8461538461538, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=208, Percent_Identity=27.4038461538462, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=199, Percent_Identity=31.6582914572864, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=29.7979797979798, Blast_Score=101, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=23.9234449760766, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=32.994923857868, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=32.994923857868, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI22026816, Length=196, Percent_Identity=32.1428571428571, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221459597, Length=210, Percent_Identity=27.6190476190476, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356893, Length=210, Percent_Identity=27.6190476190476, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24663208, Length=204, Percent_Identity=25.4901960784314, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647141, Length=204, Percent_Identity=25.4901960784314, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24450; Mature: 24450

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSQFAAQIQNYLSSG
CCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHCCCHHHHHHHHHHHHCC
SYVPDEITNKLVADFIKKIPKNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETI
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCHHH
ISRLSQRLFCQKCQKSYNLLLAKPKNELKCDLDSTDLITRNDDRPEIITHRIEKFNNSVI
HHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCCCCCEECCCCCHHHHHHHHHHHCCCCH
PIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL
HHHHHHHHCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSNKKILFIGAPGSGKGTISKILVEKYKLVHISTGDLFRKKISEDSQFAAQIQNYLSSG
CCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEECCHHHHHHHHCCCHHHHHHHHHHHHCC
SYVPDEITNKLVADFIKKIPKNQGYILDGYPRTLQQLEFMIKNGINLDCVFYLKIKNETI
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCCEEEEEEEEECCHHH
ISRLSQRLFCQKCQKSYNLLLAKPKNELKCDLDSTDLITRNDDRPEIITHRIEKFNNSVI
HHHHHHHHHHHHHHHHCCEEEECCCCCCEECCCCCCCEECCCCCHHHHHHHHHHHCCCCH
PIVEFFKKSGIIYYLDAEQTLEETVIEIEKWL
HHHHHHHHCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA