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The map label for this gene is ilvD

Identifier: 71892355

GI number: 71892355

Start: 732181

End: 734031

Strand: Reverse

Name: ilvD

Synonym: BPEN_611

Alternate gene names: 71892355

Gene position: 734031-732181 (Counterclockwise)

Preceding gene: 71892356

Following gene: 71892354

Centisome position: 92.72

GC content: 36.95

Gene sequence:

>1851_bases
ATGCCTAAATATCGCTCTATTACTACTACGCATGGTCGTAATATGACTGGTGCTCGAGCATTGTGGCGTGCTACAGGTAT
GACCACTGAAGATTTTGATAAAATGATTATTGCTGTGGTTAATTCATTTACCCAATTTGTTCCTGGGCACATACATTTAC
GAAACGTAGGAGCATTAGTGTCCGAACAAATTAATATTACTGGAGGAGTTGCAAAAGAATTTAATACCATTGCAATAGAC
GATGGAATTGCTATGGGTCATAGCGGCATGCTATATTCTTTGCCATCTAGAGATCTTATTGCTGATTCTGTGGAATATAT
GATTAATGCCCACTGCGTTGATGCTATGGTATGTATTTCTAATTGTGATAAAATAACACCTGGAATGTTAATGGCGGCAT
TACGCTTAAATATTCCAGCTATCTTTGTATCAGGTGGACCAATGGAATCTGGTGCAATAACTTTGTCTAATCAAAACGTT
AAGTTAAATTTAATTGACGCAATCACTTGTTCTGTAGATCCTAATATTTCTGATGTTGATCAACAACGCATTGAATCAGC
AGCGTGTCCTACATGCGGGTCTTGTTCAGGGATGTTTACGGCGAACTCTATGAATTGTTTAACAGAAGCATTGGGATTAG
CACAACCGGGTAATGGATCGTTGTTGGCTACTCATTCTGATCGTAAAAAATTATTTTTAAATGCCGGTAAATATATTGTT
CATTTAGCTAAATCTTATTATGAAGAGAATAATTATTCTGTTCTACCGCGCAATATAGCTAACAAGTCTTCTTTTGAAAA
TGCAATGATGTTAGACATTGCAATGGGTGGCTCTACTAATACTGTATTGCACTTACTTGCGGCTGCTCAAGAAGGAGAGA
TAGATTTTACTATGGCAGATATTGATAAATTATCTCGAAAAGTACCGCATTTATGTAAAGTAGCTCCAAATACTCAACGA
TATCACATGGAAGATTTTCATCGAGCTGGAGGAGTAATGGGTGTGCTTGGTGAATTACATCGTTGTGGTTTATTACATGA
AGACACACGTAATATATTGAATAAATCTTTATTAGAAACGTTACTAAATTATGACATTTTTTCATGTGATAATTTTGAAT
CAAAAAACATGTATGCTGCAGCACCAGCAGGAATACGTAGCACACAAGCTTTTATTCAAAAAAACAGATGGACTTCGTTA
GATACGGATCGTCGCTCTGGATGTATTCGTTCACGTGAACATGCTTATAGCCAAGACGGAGGTTTAGCAGTATTGTACGG
CAATCTAGCTGTAGATGGATGTCTTGTAAAAACAGCTGGAGTTCATATAAACCTTCAAAAATTTAGTGGACCAGCTAAGG
TGTATGAGAGTCAAGAAGAATCTGTTCAAGCAATTTTAACAGGAAATATACATTCTGGCGATGTTATTGTAATTCGATAT
GAAGGACCAAAAGGTGGACCAGGTATGCAAGAAATGTTATATCCGACATCTTTTCTTAAATCCATGGGGTTAGATTTATG
TTGCGCTTTGATTACAGATGGTAGATTTTCAGGAGGAACATCAGGACTATCTATTGGTCATATATCTCCGGAAGCAGCTA
ATAAAGGATTAATTGGACTAGTACACGATGGGGACATAATTAATATCGATATTAGCATGCGTAGTATTACCTTAGAAGTT
TCTGAGCATATACTAAAAATACGACATGCAGCAGAAATTGCCCGAGGAAATAAAGCGTGGACCCCAACCAACAGAAATAG
AAACATATCTATTTCTTTAAAGGCATACGCCCACTTAGTAACAAGCGCAGACAAAGGCGCGGTTCGTGATAAATCTAAAT
TGTTAGGATAA

Upstream 100 bases:

>100_bases
ATGGAATTGGTTAGATCCAGTGCATTAGCAATACTACATTGATGCAATGTTAATTCTTAAGATAATCAATATTCAATAAT
ATAGAATACTGGAGTTAAAT

Downstream 100 bases:

>100_bases
CATCCTAAATGAAAAAAATTTATTCTTTTTCTCATGCACCATGTCCTGCAGAATATCTACGTGCTGCTTTGCGCTCTCAC
GTGTATGAAGTAGCTCAAAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 616; Mature: 615

Protein sequence:

>616_residues
MPKYRSITTTHGRNMTGARALWRATGMTTEDFDKMIIAVVNSFTQFVPGHIHLRNVGALVSEQINITGGVAKEFNTIAID
DGIAMGHSGMLYSLPSRDLIADSVEYMINAHCVDAMVCISNCDKITPGMLMAALRLNIPAIFVSGGPMESGAITLSNQNV
KLNLIDAITCSVDPNISDVDQQRIESAACPTCGSCSGMFTANSMNCLTEALGLAQPGNGSLLATHSDRKKLFLNAGKYIV
HLAKSYYEENNYSVLPRNIANKSSFENAMMLDIAMGGSTNTVLHLLAAAQEGEIDFTMADIDKLSRKVPHLCKVAPNTQR
YHMEDFHRAGGVMGVLGELHRCGLLHEDTRNILNKSLLETLLNYDIFSCDNFESKNMYAAAPAGIRSTQAFIQKNRWTSL
DTDRRSGCIRSREHAYSQDGGLAVLYGNLAVDGCLVKTAGVHINLQKFSGPAKVYESQEESVQAILTGNIHSGDVIVIRY
EGPKGGPGMQEMLYPTSFLKSMGLDLCCALITDGRFSGGTSGLSIGHISPEAANKGLIGLVHDGDIINIDISMRSITLEV
SEHILKIRHAAEIARGNKAWTPTNRNRNISISLKAYAHLVTSADKGAVRDKSKLLG

Sequences:

>Translated_616_residues
MPKYRSITTTHGRNMTGARALWRATGMTTEDFDKMIIAVVNSFTQFVPGHIHLRNVGALVSEQINITGGVAKEFNTIAID
DGIAMGHSGMLYSLPSRDLIADSVEYMINAHCVDAMVCISNCDKITPGMLMAALRLNIPAIFVSGGPMESGAITLSNQNV
KLNLIDAITCSVDPNISDVDQQRIESAACPTCGSCSGMFTANSMNCLTEALGLAQPGNGSLLATHSDRKKLFLNAGKYIV
HLAKSYYEENNYSVLPRNIANKSSFENAMMLDIAMGGSTNTVLHLLAAAQEGEIDFTMADIDKLSRKVPHLCKVAPNTQR
YHMEDFHRAGGVMGVLGELHRCGLLHEDTRNILNKSLLETLLNYDIFSCDNFESKNMYAAAPAGIRSTQAFIQKNRWTSL
DTDRRSGCIRSREHAYSQDGGLAVLYGNLAVDGCLVKTAGVHINLQKFSGPAKVYESQEESVQAILTGNIHSGDVIVIRY
EGPKGGPGMQEMLYPTSFLKSMGLDLCCALITDGRFSGGTSGLSIGHISPEAANKGLIGLVHDGDIINIDISMRSITLEV
SEHILKIRHAAEIARGNKAWTPTNRNRNISISLKAYAHLVTSADKGAVRDKSKLLG
>Mature_615_residues
PKYRSITTTHGRNMTGARALWRATGMTTEDFDKMIIAVVNSFTQFVPGHIHLRNVGALVSEQINITGGVAKEFNTIAIDD
GIAMGHSGMLYSLPSRDLIADSVEYMINAHCVDAMVCISNCDKITPGMLMAALRLNIPAIFVSGGPMESGAITLSNQNVK
LNLIDAITCSVDPNISDVDQQRIESAACPTCGSCSGMFTANSMNCLTEALGLAQPGNGSLLATHSDRKKLFLNAGKYIVH
LAKSYYEENNYSVLPRNIANKSSFENAMMLDIAMGGSTNTVLHLLAAAQEGEIDFTMADIDKLSRKVPHLCKVAPNTQRY
HMEDFHRAGGVMGVLGELHRCGLLHEDTRNILNKSLLETLLNYDIFSCDNFESKNMYAAAPAGIRSTQAFIQKNRWTSLD
TDRRSGCIRSREHAYSQDGGLAVLYGNLAVDGCLVKTAGVHINLQKFSGPAKVYESQEESVQAILTGNIHSGDVIVIRYE
GPKGGPGMQEMLYPTSFLKSMGLDLCCALITDGRFSGGTSGLSIGHISPEAANKGLIGLVHDGDIINIDISMRSITLEVS
EHILKIRHAAEIARGNKAWTPTNRNRNISISLKAYAHLVTSADKGAVRDKSKLLG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=73.8636363636364, Blast_Score=967, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=544, Percent_Identity=30.1470588235294, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=500, Percent_Identity=29.6, Blast_Score=162, Evalue=8e-41,
Organism=Escherichia coli, GI1786464, Length=530, Percent_Identity=28.3018867924528, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322476, Length=618, Percent_Identity=35.1132686084142, Blast_Score=317, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BLOPB (Q491Z0)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278089.1
- STRING:   Q491Z0
- GeneID:   3563084
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_611
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   ERISHTV
- ProtClustDB:   PRK12448
- BioCyc:   CBLO291272:BPEN_611-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 66674; Mature: 66543

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSITTTHGRNMTGARALWRATGMTTEDFDKMIIAVVNSFTQFVPGHIHLRNVGALV
CCCCCCEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHH
SEQINITGGVAKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSVEYMINAHCVDAMVCIS
HCCEEECCCCCCCCCEEEEECCEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPAIFVSGGPMESGAITLSNQNVKLNLIDAITCSVDPNISDVD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEEEEECCCCCCHHH
QQRIESAACPTCGSCSGMFTANSMNCLTEALGLAQPGNGSLLATHSDRKKLFLNAGKYIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCHHHH
HLAKSYYEENNYSVLPRNIANKSSFENAMMLDIAMGGSTNTVLHLLAAAQEGEIDFTMAD
HHHHHHHCCCCCEECCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDKLSRKVPHLCKVAPNTQRYHMEDFHRAGGVMGVLGELHRCGLLHEDTRNILNKSLLET
HHHHHHHCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLNYDIFSCDNFESKNMYAAAPAGIRSTQAFIQKNRWTSLDTDRRSGCIRSREHAYSQDG
HHCCCEECCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHHHCCCCCC
GLAVLYGNLAVDGCLVKTAGVHINLQKFSGPAKVYESQEESVQAILTGNIHSGDVIVIRY
CEEEEECCEEECCEEEEECCEEEEEEECCCHHHHHCCHHHCEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLDLCCALITDGRFSGGTSGLSIGHISPEAANKGLIGL
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEECCCHHHCCCCEEEE
VHDGDIINIDISMRSITLEVSEHILKIRHAAEIARGNKAWTPTNRNRNISISLKAYAHLV
EECCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHEEEHH
TSADKGAVRDKSKLLG
HCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSITTTHGRNMTGARALWRATGMTTEDFDKMIIAVVNSFTQFVPGHIHLRNVGALV
CCCCCEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHH
SEQINITGGVAKEFNTIAIDDGIAMGHSGMLYSLPSRDLIADSVEYMINAHCVDAMVCIS
HCCEEECCCCCCCCCEEEEECCEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPAIFVSGGPMESGAITLSNQNVKLNLIDAITCSVDPNISDVD
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCEEEEEEEEEEEECCCCCCHHH
QQRIESAACPTCGSCSGMFTANSMNCLTEALGLAQPGNGSLLATHSDRKKLFLNAGKYIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCHHHH
HLAKSYYEENNYSVLPRNIANKSSFENAMMLDIAMGGSTNTVLHLLAAAQEGEIDFTMAD
HHHHHHHCCCCCEECCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEHHH
IDKLSRKVPHLCKVAPNTQRYHMEDFHRAGGVMGVLGELHRCGLLHEDTRNILNKSLLET
HHHHHHHCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LLNYDIFSCDNFESKNMYAAAPAGIRSTQAFIQKNRWTSLDTDRRSGCIRSREHAYSQDG
HHCCCEECCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCHHHHCCHHHHHHCCCCCC
GLAVLYGNLAVDGCLVKTAGVHINLQKFSGPAKVYESQEESVQAILTGNIHSGDVIVIRY
CEEEEECCEEECCEEEEECCEEEEEEECCCHHHHHCCHHHCEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSFLKSMGLDLCCALITDGRFSGGTSGLSIGHISPEAANKGLIGL
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCEEEECCCHHHCCCCEEEE
VHDGDIINIDISMRSITLEVSEHILKIRHAAEIARGNKAWTPTNRNRNISISLKAYAHLV
EECCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHEEEHH
TSADKGAVRDKSKLLG
HCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA