Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 71892354

GI number: 71892354

Start: 730628

End: 732172

Strand: Reverse

Name: ilvA [H]

Synonym: BPEN_610

Alternate gene names: 71892354

Gene position: 732172-730628 (Counterclockwise)

Preceding gene: 71892355

Following gene: 71892353

Centisome position: 92.49

GC content: 35.99

Gene sequence:

>1545_bases
ATGAAAAAAATTTATTCTTTTTCTCATGCACCATGTCCTGCAGAATATCTACGTGCTGCTTTGCGCTCTCACGTGTATGA
AGTAGCTCAAATAACTCCATTACAAATTATGAACAAATTGTCAGAACGTCTTGAAAATACAATATTAGTTAAACGAGAAG
ATAGACAGCCGGTACATAGCTTTAAACTACGTGGAGCTTATGCTATGATCTCAAGTCTTAACGAAACACAAAAATCTTCT
GGAGTTATTACTGCTTCAGCAGGTAATCACGCTCAGGGGGTAGCTTTTTCTGCTACTCGTCTAGGTATTACATCTTTGAT
TGTGATGCCTATAAATACCGCTGATATAAAAATAGATGCGGTACGTGATTTTGGAGGAAAACCGTTATTATGTGGAGCTA
ATTTTGATGAGGCTAAGATTAAAGCTATGTATTTAGCTGATAAACATCAATTAACTTTTATTCCTCCATTTGATCATCCA
ACGGTAATTGCGGGACAAGGAACATTAGCGATGGAATTATTACAGCAAGATGCTCATTTAGATCGCATTTTTGTTCCAGT
AGGAGGGGGTGGTTTAGCGGCAGGTGTTTCTGTATTAATTAAACATCTTATGCCGCAAATAAAAGTTATAGGAGTTGAAT
CAGCAGAATCGGCTTCTTTATGTGCTGCCTTATCGGCTGGTATGCCAGTGTGGTTGCATAAAGTAGGTGTATTTGCTGAA
GGAGTAGCTGTACGATGTGTTGGCAACGAAACATTTCGTTTATGCCAAGAATATCTAGACGATGTAATTACAGTGGATAA
TGATGCGATTTGTGCTGCAATAAAAGATTTATTCGAAGACGTACGTGCTATTGCTGAACCCTCAGGTGCGTTAGCATTAG
CTGGAATGAAGAAGTATATTCAAAGATATGCAATTCGAGGTGAAAGATTAGCTCATGTTCTTTCAGGTGCCAATATAAAT
TTTCATGAATTACGTTATATTTCAGAACGTTGTGAACTAGGAGAGCAGCGAGAAGCGTTAATGGCGATTACTATTCCAGA
AAAAAAAGGTAGTTTTTTAGAATTCTATAAAATATTAGGAAACAGATCAGTAACAGAATTTAATTATCGATTCAATGGAT
CTAAAAACGTTTGTATTTTTATTGGTATACGTTTGAAGCACGGACGTTCCGAAAGAAACACAATAGTTCAAGAAATACTT
GCTAATGGTTTTCACGTTGTAGATTTATCTGACGACGAAATGGCTAAATTGCATGTTAGATACATGGTAGGAGCACGTTT
ATTCCAGCCTTTACAGGAGCGAATTTTTAGTTTTGAGTTTCCAGAAGCTCCAGGAGCATTATTGAAATTTCTTCATACTT
TAGGTGCTAATTGGAACATCTCTTTATTTCATTATCGAAATCATGGTACTGATTACGGACGTGTTCTAGCCGGGTTTGAA
CTATCTAATCAAAAAGAATCAGAATTTAAAGAATATTTATCTAAATTAGGATACGAATGGCACGATGTTACAACTAATCC
AGTGTTTGAAGTATTTTTAAATTAA

Upstream 100 bases:

>100_bases
GAAACATATCTATTTCTTTAAAGGCATACGCCCACTTAGTAACAAGCGCAGACAAAGGCGCGGTTCGTGATAAATCTAAA
TTGTTAGGATAACATCCTAA

Downstream 100 bases:

>100_bases
TAAAACATTGTGATGGAAAATTATTAAATTATTTTTCACATTATTTAAAAGAGATATTTTATGGCTAATTATTTTAATAC
ATTAACTTTCATAGAAAAAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKKIYSFSHAPCPAEYLRAALRSHVYEVAQITPLQIMNKLSERLENTILVKREDRQPVHSFKLRGAYAMISSLNETQKSS
GVITASAGNHAQGVAFSATRLGITSLIVMPINTADIKIDAVRDFGGKPLLCGANFDEAKIKAMYLADKHQLTFIPPFDHP
TVIAGQGTLAMELLQQDAHLDRIFVPVGGGGLAAGVSVLIKHLMPQIKVIGVESAESASLCAALSAGMPVWLHKVGVFAE
GVAVRCVGNETFRLCQEYLDDVITVDNDAICAAIKDLFEDVRAIAEPSGALALAGMKKYIQRYAIRGERLAHVLSGANIN
FHELRYISERCELGEQREALMAITIPEKKGSFLEFYKILGNRSVTEFNYRFNGSKNVCIFIGIRLKHGRSERNTIVQEIL
ANGFHVVDLSDDEMAKLHVRYMVGARLFQPLQERIFSFEFPEAPGALLKFLHTLGANWNISLFHYRNHGTDYGRVLAGFE
LSNQKESEFKEYLSKLGYEWHDVTTNPVFEVFLN

Sequences:

>Translated_514_residues
MKKIYSFSHAPCPAEYLRAALRSHVYEVAQITPLQIMNKLSERLENTILVKREDRQPVHSFKLRGAYAMISSLNETQKSS
GVITASAGNHAQGVAFSATRLGITSLIVMPINTADIKIDAVRDFGGKPLLCGANFDEAKIKAMYLADKHQLTFIPPFDHP
TVIAGQGTLAMELLQQDAHLDRIFVPVGGGGLAAGVSVLIKHLMPQIKVIGVESAESASLCAALSAGMPVWLHKVGVFAE
GVAVRCVGNETFRLCQEYLDDVITVDNDAICAAIKDLFEDVRAIAEPSGALALAGMKKYIQRYAIRGERLAHVLSGANIN
FHELRYISERCELGEQREALMAITIPEKKGSFLEFYKILGNRSVTEFNYRFNGSKNVCIFIGIRLKHGRSERNTIVQEIL
ANGFHVVDLSDDEMAKLHVRYMVGARLFQPLQERIFSFEFPEAPGALLKFLHTLGANWNISLFHYRNHGTDYGRVLAGFE
LSNQKESEFKEYLSKLGYEWHDVTTNPVFEVFLN
>Mature_514_residues
MKKIYSFSHAPCPAEYLRAALRSHVYEVAQITPLQIMNKLSERLENTILVKREDRQPVHSFKLRGAYAMISSLNETQKSS
GVITASAGNHAQGVAFSATRLGITSLIVMPINTADIKIDAVRDFGGKPLLCGANFDEAKIKAMYLADKHQLTFIPPFDHP
TVIAGQGTLAMELLQQDAHLDRIFVPVGGGGLAAGVSVLIKHLMPQIKVIGVESAESASLCAALSAGMPVWLHKVGVFAE
GVAVRCVGNETFRLCQEYLDDVITVDNDAICAAIKDLFEDVRAIAEPSGALALAGMKKYIQRYAIRGERLAHVLSGANIN
FHELRYISERCELGEQREALMAITIPEKKGSFLEFYKILGNRSVTEFNYRFNGSKNVCIFIGIRLKHGRSERNTIVQEIL
ANGFHVVDLSDDEMAKLHVRYMVGARLFQPLQERIFSFEFPEAPGALLKFLHTLGANWNISLFHYRNHGTDYGRVLAGFE
LSNQKESEFKEYLSKLGYEWHDVTTNPVFEVFLN

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=300, Percent_Identity=30.6666666666667, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI33469958, Length=314, Percent_Identity=27.3885350318471, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI19923959, Length=310, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790207, Length=513, Percent_Identity=72.5146198830409, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1789505, Length=291, Percent_Identity=36.426116838488, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=326, Percent_Identity=33.4355828220859, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=328, Percent_Identity=33.2317073170732, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=251, Percent_Identity=31.8725099601594, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=48.0544747081712, Blast_Score=461, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=33.4405144694534, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=27.112676056338, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355833, Length=273, Percent_Identity=34.0659340659341, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24645328, Length=212, Percent_Identity=31.6037735849057, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 57180; Mature: 57180

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIYSFSHAPCPAEYLRAALRSHVYEVAQITPLQIMNKLSERLENTILVKREDRQPVHS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCHHH
FKLRGAYAMISSLNETQKSSGVITASAGNHAQGVAFSATRLGITSLIVMPINTADIKIDA
HHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHHHHCEEEEEEEECCCCCEEEEE
VRDFGGKPLLCGANFDEAKIKAMYLADKHQLTFIPPFDHPTVIAGQGTLAMELLQQDAHL
ECCCCCCEEEECCCCCHHHEEEEEEECCCCEEEECCCCCCEEEECCCHHHHHHHHHCCCC
DRIFVPVGGGGLAAGVSVLIKHLMPQIKVIGVESAESASLCAALSAGMPVWLHKVGVFAE
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCC
GVAVRCVGNETFRLCQEYLDDVITVDNDAICAAIKDLFEDVRAIAEPSGALALAGMKKYI
CEEEEEECCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHH
QRYAIRGERLAHVLSGANINFHELRYISERCELGEQREALMAITIPEKKGSFLEFYKILG
HHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHC
NRSVTEFNYRFNGSKNVCIFIGIRLKHGRSERNTIVQEILANGFHVVDLSDDEMAKLHVR
CCCEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
YMVGARLFQPLQERIFSFEFPEAPGALLKFLHTLGANWNISLFHYRNHGTDYGRVLAGFE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEECCC
LSNQKESEFKEYLSKLGYEWHDVTTNPVFEVFLN
CCCCCHHHHHHHHHHCCCEEECCCCCCEEEEEEC
>Mature Secondary Structure
MKKIYSFSHAPCPAEYLRAALRSHVYEVAQITPLQIMNKLSERLENTILVKREDRQPVHS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEEECCCCCHHH
FKLRGAYAMISSLNETQKSSGVITASAGNHAQGVAFSATRLGITSLIVMPINTADIKIDA
HHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEHHHHCEEEEEEEECCCCCEEEEE
VRDFGGKPLLCGANFDEAKIKAMYLADKHQLTFIPPFDHPTVIAGQGTLAMELLQQDAHL
ECCCCCCEEEECCCCCHHHEEEEEEECCCCEEEECCCCCCEEEECCCHHHHHHHHHCCCC
DRIFVPVGGGGLAAGVSVLIKHLMPQIKVIGVESAESASLCAALSAGMPVWLHKVGVFAE
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCC
GVAVRCVGNETFRLCQEYLDDVITVDNDAICAAIKDLFEDVRAIAEPSGALALAGMKKYI
CEEEEEECCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHH
QRYAIRGERLAHVLSGANINFHELRYISERCELGEQREALMAITIPEKKGSFLEFYKILG
HHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHC
NRSVTEFNYRFNGSKNVCIFIGIRLKHGRSERNTIVQEILANGFHVVDLSDDEMAKLHVR
CCCEEEEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHH
YMVGARLFQPLQERIFSFEFPEAPGALLKFLHTLGANWNISLFHYRNHGTDYGRVLAGFE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHEEECCC
LSNQKESEFKEYLSKLGYEWHDVTTNPVFEVFLN
CCCCCHHHHHHHHHHCCCEEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3315862; 3550695; 1379743; 9278503; 3003115; 2473940; 9562556 [H]