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The map label for this gene is ilvC

Identifier: 71892353

GI number: 71892353

Start: 729092

End: 730567

Strand: Reverse

Name: ilvC

Synonym: BPEN_609

Alternate gene names: 71892353

Gene position: 730567-729092 (Counterclockwise)

Preceding gene: 71892354

Following gene: 71892352

Centisome position: 92.28

GC content: 31.71

Gene sequence:

>1476_bases
ATGGCTAATTATTTTAATACATTAACTTTCATAGAAAAATTAAAACATTTGGGAAAATGTCGATTTATGAGTAACAATGA
ATTTTCTAATGGAATTCAGGCATTATTATCTAAAAAAGTAGCTATAATAGGCTGTGGATCTCAAGGTTTGAATCAAGGTT
TAAATATGAGAGATTCGGGGGTAAATATTACATACGCTTTACGTCGTGAATCTATTCTTAATAAACAAGAATCTTGGGCA
AGAGCAACAAGGAACGGATTTCCTGTAGGAACTTATGATGAAATTATTCCCAAATCAGATGTAGTTATTAATTTAACTCC
AGATAAATGTCACACATCAGTGATACGACAAATAGAACCTTTAATGAAACATGGATCCACATTGGGGTATTCACATGGAT
TTCATATTGTAGAAGTTGGAGAAAAAATTCGTCAAGATATTACTGTCATCATGGTCGCTCCAAAATGTCCCGGTACAGAA
GTTCGTCAAGAATATCAACGAGGATTTGGAGTCCCTGCTTTAATTGCCGTACACGAAGAAAACGATACATATGATATGGG
CATGACATTAGCAAAATCCTGGGCATTTGCACTTGGTAGTCATCGCGCTGGGGTATTAGAATCTTCATTTGTAGCAGAAG
TTAAATCAGATCTTATGGGAGAACAAACTATTTTATGTGGAATGTTACAAGCCGGATCCATTCTTTGTTTTGATTATATG
ATTAGTAATGGTGTTAACGCTGCATACGCAGGAAAATTCATTCAATGTGGTTGGGAAGTCATAACTGAAGCATTAAAACA
AGGAGGTATTACGTTAATGATGGATCGATTATCTAACGCTTCTAAAATACGTGCTTTTATATTATCTGAAAAACTAAAAA
ATATATTAAAACCAGTTTTTGAAAAACATATGGAAAATATACTTAATGGAGTATTTTCTAAAGAAATGATGTTGGATTGG
GAAAATAATGATTCTAAATTACTTAAGTGGAGAGAAAAAACCAGTCAACTTCCATTAGAACAAGCTCCAAATTATCAACA
AGAAATTTTGGAACAAACATATTTTGATTATGGGATATTAATGGTAGCTATAATCAAATCAGGTATAGAATTGTCTTTTG
ACACAATGATAAAATCTGGAATAGCACCAGAATCGGCATATTATGAATCATTACATGAGTTACCTTTAATTGCAAATACT
ATAGCTCGTAAAAAATTATATGAAATGAACATGGTAATTTCTGACACCGCAGAATACGGTAATTATTTATTTTGTGATAA
GGTAGTACCTTTGTTAAAAAAGACTATAATACCTAATTTAAGAACAGGAGATTTAGGTATGTCACCCAAGAATGTTAACG
TTGATAACATTGTTTTGCGTAATACTAATGACATGATTCGAAATCACACAATAGAAAAAGTTGGAATTCAACTAAGAAGT
TATATGCAAAACATGAAAAGTTTATCGTTTAATTAA

Upstream 100 bases:

>100_bases
TGTTACAACTAATCCAGTGTTTGAAGTATTTTTAAATTAATAAAACATTGTGATGGAAAATTATTAAATTATTTTTCACA
TTATTTAAAAGAGATATTTT

Downstream 100 bases:

>100_bases
TGATTAAAACAGAACTATATTCTTGTAATTACAGAGATATTATTGCGATGAAAGATCATCGAGTTGACTTCTAAATAAGA
ATGAATTTATTTTGGATAAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MANYFNTLTFIEKLKHLGKCRFMSNNEFSNGIQALLSKKVAIIGCGSQGLNQGLNMRDSGVNITYALRRESILNKQESWA
RATRNGFPVGTYDEIIPKSDVVINLTPDKCHTSVIRQIEPLMKHGSTLGYSHGFHIVEVGEKIRQDITVIMVAPKCPGTE
VRQEYQRGFGVPALIAVHEENDTYDMGMTLAKSWAFALGSHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSILCFDYM
ISNGVNAAYAGKFIQCGWEVITEALKQGGITLMMDRLSNASKIRAFILSEKLKNILKPVFEKHMENILNGVFSKEMMLDW
ENNDSKLLKWREKTSQLPLEQAPNYQQEILEQTYFDYGILMVAIIKSGIELSFDTMIKSGIAPESAYYESLHELPLIANT
IARKKLYEMNMVISDTAEYGNYLFCDKVVPLLKKTIIPNLRTGDLGMSPKNVNVDNIVLRNTNDMIRNHTIEKVGIQLRS
YMQNMKSLSFN

Sequences:

>Translated_491_residues
MANYFNTLTFIEKLKHLGKCRFMSNNEFSNGIQALLSKKVAIIGCGSQGLNQGLNMRDSGVNITYALRRESILNKQESWA
RATRNGFPVGTYDEIIPKSDVVINLTPDKCHTSVIRQIEPLMKHGSTLGYSHGFHIVEVGEKIRQDITVIMVAPKCPGTE
VRQEYQRGFGVPALIAVHEENDTYDMGMTLAKSWAFALGSHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSILCFDYM
ISNGVNAAYAGKFIQCGWEVITEALKQGGITLMMDRLSNASKIRAFILSEKLKNILKPVFEKHMENILNGVFSKEMMLDW
ENNDSKLLKWREKTSQLPLEQAPNYQQEILEQTYFDYGILMVAIIKSGIELSFDTMIKSGIAPESAYYESLHELPLIANT
IARKKLYEMNMVISDTAEYGNYLFCDKVVPLLKKTIIPNLRTGDLGMSPKNVNVDNIVLRNTNDMIRNHTIEKVGIQLRS
YMQNMKSLSFN
>Mature_490_residues
ANYFNTLTFIEKLKHLGKCRFMSNNEFSNGIQALLSKKVAIIGCGSQGLNQGLNMRDSGVNITYALRRESILNKQESWAR
ATRNGFPVGTYDEIIPKSDVVINLTPDKCHTSVIRQIEPLMKHGSTLGYSHGFHIVEVGEKIRQDITVIMVAPKCPGTEV
RQEYQRGFGVPALIAVHEENDTYDMGMTLAKSWAFALGSHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSILCFDYMI
SNGVNAAYAGKFIQCGWEVITEALKQGGITLMMDRLSNASKIRAFILSEKLKNILKPVFEKHMENILNGVFSKEMMLDWE
NNDSKLLKWREKTSQLPLEQAPNYQQEILEQTYFDYGILMVAIIKSGIELSFDTMIKSGIAPESAYYESLHELPLIANTI
ARKKLYEMNMVISDTAEYGNYLFCDKVVPLLKKTIIPNLRTGDLGMSPKNVNVDNIVLRNTNDMIRNHTIEKVGIQLRSY
MQNMKSLSFN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=489, Percent_Identity=66.0531697341513, Blast_Score=683, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=272, Percent_Identity=29.7794117647059, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_BLOPB (Q491Z2)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278087.1
- HSSP:   P05793
- ProteinModelPortal:   Q491Z2
- SMR:   Q491Z2
- STRING:   Q491Z2
- GeneID:   3563082
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_609
- eggNOG:   COG0059
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- ProtClustDB:   PRK05225
- BioCyc:   CBLO291272:BPEN_609-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 55238; Mature: 55107

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLTFIEKLKHLGKCRFMSNNEFSNGIQALLSKKVAIIGCGSQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHCCEEEEECCCHHHHCCCCCCCCC
VNITYALRRESILNKQESWARATRNGFPVGTYDEIIPKSDVVINLTPDKCHTSVIRQIEP
CCEEEEEHHHHHHCHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKHGSTLGYSHGFHIVEVGEKIRQDITVIMVAPKCPGTEVRQEYQRGFGVPALIAVHEE
HHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECC
NDTYDMGMTLAKSWAFALGSHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSILCFDYM
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEHHHH
ISNGVNAAYAGKFIQCGWEVITEALKQGGITLMMDRLSNASKIRAFILSEKLKNILKPVF
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHH
EKHMENILNGVFSKEMMLDWENNDSKLLKWREKTSQLPLEQAPNYQQEILEQTYFDYGIL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHH
MVAIIKSGIELSFDTMIKSGIAPESAYYESLHELPLIANTIARKKLYEMNMVISDTAEYG
HHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHEECHHHHC
NYLFCDKVVPLLKKTIIPNLRTGDLGMSPKNVNVDNIVLRNTNDMIRNHTIEKVGIQLRS
CEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
YMQNMKSLSFN
HHHHHHHCCCC
>Mature Secondary Structure 
ANYFNTLTFIEKLKHLGKCRFMSNNEFSNGIQALLSKKVAIIGCGSQGLNQGLNMRDSG
CCHHHHHHHHHHHHHHHCEEECCCCCHHHHHHHHHHCCEEEEECCCHHHHCCCCCCCCC
VNITYALRRESILNKQESWARATRNGFPVGTYDEIIPKSDVVINLTPDKCHTSVIRQIEP
CCEEEEEHHHHHHCHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKHGSTLGYSHGFHIVEVGEKIRQDITVIMVAPKCPGTEVRQEYQRGFGVPALIAVHEE
HHHCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECC
NDTYDMGMTLAKSWAFALGSHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSILCFDYM
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEHHHH
ISNGVNAAYAGKFIQCGWEVITEALKQGGITLMMDRLSNASKIRAFILSEKLKNILKPVF
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHH
EKHMENILNGVFSKEMMLDWENNDSKLLKWREKTSQLPLEQAPNYQQEILEQTYFDYGIL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHH
MVAIIKSGIELSFDTMIKSGIAPESAYYESLHELPLIANTIARKKLYEMNMVISDTAEYG
HHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHEECHHHHC
NYLFCDKVVPLLKKTIIPNLRTGDLGMSPKNVNVDNIVLRNTNDMIRNHTIEKVGIQLRS
CEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
YMQNMKSLSFN
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA