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The map label for this gene is trxA [H]

Identifier: 71892352

GI number: 71892352

Start: 728530

End: 728856

Strand: Reverse

Name: trxA [H]

Synonym: BPEN_608

Alternate gene names: 71892352

Gene position: 728856-728530 (Counterclockwise)

Preceding gene: 71892353

Following gene: 71892351

Centisome position: 92.07

GC content: 28.75

Gene sequence:

>327_bases
ATGAATCAAATTATCATGCACCTGACAGATTCTAATTTTAAAGAAACGGTGTCAAACTCTACCGATCTTTTTTTAGTTGA
TTTTTGGGCCGAATGGTGTAATCCCTGTAAAGCAATGATACCTATTTTAGAAGATATTTCTGTTGAATTTAATGATACAT
TAAAAGTAGTAAAATTAAACATAGATGAAAATCCAATAACTACAAAAAACTATGGGATTAAGAGTGTTCCTACTTTATTA
TTGATTCGTCATGGAACGGTGTTATCTACTAAAGTAGGGTTGCTGTCCAAACAAAAATTACAAGAATTTTTAAAAATACA
TATATAA

Upstream 100 bases:

>100_bases
TATATAAATAATTTTAAATATTCAACGATATACATAAAATAAATAAGTTAATTATAATGATATATAATGATTAGAAGAAA
ATAAATTATAAGGAGGATAA

Downstream 100 bases:

>100_bases
ATAATGAGCACTTATTTTTAAAACATTTATAATTTTTAAAATTATTTTATATGTTAGTAGACGTTTCTTTAGGATTACAG
TAGAATGACAGCATGTCGTA

Product: thioredoxin 1, redox factor

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MNQIIMHLTDSNFKETVSNSTDLFLVDFWAEWCNPCKAMIPILEDISVEFNDTLKVVKLNIDENPITTKNYGIKSVPTLL
LIRHGTVLSTKVGLLSKQKLQEFLKIHI

Sequences:

>Translated_108_residues
MNQIIMHLTDSNFKETVSNSTDLFLVDFWAEWCNPCKAMIPILEDISVEFNDTLKVVKLNIDENPITTKNYGIKSVPTLL
LIRHGTVLSTKVGLLSKQKLQEFLKIHI
>Mature_108_residues
MNQIIMHLTDSNFKETVSNSTDLFLVDFWAEWCNPCKAMIPILEDISVEFNDTLKVVKLNIDENPITTKNYGIKSVPTLL
LIRHGTVLSTKVGLLSKQKLQEFLKIHI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=34.0425531914894, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=51.8518518518518, Blast_Score=124, Evalue=2e-30,
Organism=Escherichia coli, GI1788936, Length=80, Percent_Identity=32.5, Blast_Score=69, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=34.0425531914894, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=36.4583333333333, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=38.8235294117647, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=33.7078651685393, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=33.7078651685393, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12345; Mature: 12345

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQIIMHLTDSNFKETVSNSTDLFLVDFWAEWCNPCKAMIPILEDISVEFNDTLKVVKLN
CCCEEEEECCCCHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCCCCCEEEEEEE
IDENPITTKNYGIKSVPTLLLIRHGTVLSTKVGLLSKQKLQEFLKIHI
CCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQIIMHLTDSNFKETVSNSTDLFLVDFWAEWCNPCKAMIPILEDISVEFNDTLKVVKLN
CCCEEEEECCCCHHHHHCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCCCCCEEEEEEE
IDENPITTKNYGIKSVPTLLLIRHGTVLSTKVGLLSKQKLQEFLKIHI
CCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]