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The map label for this gene is nuoM [H]

Identifier: 71892255

GI number: 71892255

Start: 596175

End: 597716

Strand: Reverse

Name: nuoM [H]

Synonym: BPEN_498

Alternate gene names: 71892255

Gene position: 597716-596175 (Counterclockwise)

Preceding gene: 71892256

Following gene: 71892254

Centisome position: 75.5

GC content: 32.17

Gene sequence:

>1542_bases
ATGTTATTAATTATCTTAATATTTATTCCTTTTATTTTTGGACTGTTATGTTGGCAGTCAGAACGTATTGGATGTTGGGT
ACCGCGTTGGATTGCTTTATCTGGAATGAGCATAACATTCATTACTACTTTTTTTTTATGGCAGTACGAGTGCCATGATT
TATTAAATTCGCATCCAACAGAACATGTGTTTCCTAAATGGCAATTAGAATATATATATCCTTGGATCCCAAGATTTGGA
ATTAGCGTTCATTTAGCATTGGATGGATTTTCTTTGTTGATGGTGACATTAACTGGATTTTTAGGATGCATGGCAGTGTT
ATGTTCTTGGTGTGAGATTCAGCGTTATCACGGTCTTTTTTATCTTAATTTATTGTGGATTTTGGGTGGAGTTATTGGTG
TTTTTTTATCAATTGATATGTTTTTGTTCTTTTTTTTCTGGGAAATAATGCTTATTCCGATGTATTTTTTGATATCTTTA
TGGGGACACAAAGAGGTTAATAGAAGCGGTCGCATTAATACTGCTATTAAATTTTTTGTTTATACTCAATTTAGCGGATT
ATTTATGTTAATTTCTATTATTGCTCTTGTTTCTATACATCATGATATGCATGGTGTGTGGTCGTTTAACTATCAAGATT
TATTGAATATGTTGTTGCCAGTGAATGCGGAATATTTAATTATGTTGGGGTTTTTTTTTGCTTTTGCAGTAAAAATGCCA
ATCGTTCCTTTTCATGTTTGGTTACCTGATGTTCATAGTCACGCTCCTACTTCTGGGTCAGTCGATTTAGCAGGAATTTT
ATTAAAAACATCGGCTTATGGATTTTTCCGATTTGTTTTACCGTTATTTCCTTGTGCTTCAAAATCTTTTGCCCCAATTG
CTATGTGTTTAGGTTTGGTAAATATTTTTTATGGAGCTTGTATGGCATTCGCACAAACTGATGTTAAGCGTTTAATTGCA
TATACCAGTATATCTCATATGGGATTTGTATTGATCGCAATTTATAGTGGTACTCACTTATCATATCAGGGTGCTGTGGT
ACAAATGATTTCTCATAGTTTATCTGTTTCTGGAATGTTTATAATTTGCGGTCAATTATATGAGCGAATACATACTCGAG
ATATGCGTTTGATGGGAGGGTTATGGAGTCGCATGCATTTAATTCCTGCTTTTTCTTTATGTTTCGCAGCAGCAACACTT
GGATTGCCTGGTACTGGAAATTTTATAGGAGAAGTGACGATTTTGTTCGGTAATTTTCAATCAGCACCTATAATTACAAT
AATAGCTTGTTTTGGAATAATATTATCATCAATTTATTCTCTTATTTTAATGCAACGCATATATTATGGTCCAATATTGG
TTCCCAGAGTTAATAAGAGCGGGTTATTAAGAAATATGACACTACGGGAAAAGAATATTATTATAATATTGTTATTATGT
ATTTTTTTAATTGGTTTTTTTCCGCAATATATTTTGAATGTTTCATATATGACAATGCACAATCTTTGTCTTTTTTTAAA
AGAATATAACTGTTCAATGTGA

Upstream 100 bases:

>100_bases
TTTATGATCGTCTGTAAATCAGTGTAATATTATTGGTATACAATATAAGGAAATATAAATATTTAATGTATGTGTTTTAG
CGAGAAAAACAAAAAATAAT

Downstream 100 bases:

>100_bases
TTACATTATAACGATATAGGATCTTGATTTGTTATGCTAATAACTTGGACGCACATAATTCTATTGCTGCCTATACTAAT
TATTGGAATGACAACCGTTA

Product: NADH dehydrogenase I chain M, membrane subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M; NUO13 [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MLLIILIFIPFIFGLLCWQSERIGCWVPRWIALSGMSITFITTFFLWQYECHDLLNSHPTEHVFPKWQLEYIYPWIPRFG
ISVHLALDGFSLLMVTLTGFLGCMAVLCSWCEIQRYHGLFYLNLLWILGGVIGVFLSIDMFLFFFFWEIMLIPMYFLISL
WGHKEVNRSGRINTAIKFFVYTQFSGLFMLISIIALVSIHHDMHGVWSFNYQDLLNMLLPVNAEYLIMLGFFFAFAVKMP
IVPFHVWLPDVHSHAPTSGSVDLAGILLKTSAYGFFRFVLPLFPCASKSFAPIAMCLGLVNIFYGACMAFAQTDVKRLIA
YTSISHMGFVLIAIYSGTHLSYQGAVVQMISHSLSVSGMFIICGQLYERIHTRDMRLMGGLWSRMHLIPAFSLCFAAATL
GLPGTGNFIGEVTILFGNFQSAPIITIIACFGIILSSIYSLILMQRIYYGPILVPRVNKSGLLRNMTLREKNIIIILLLC
IFLIGFFPQYILNVSYMTMHNLCLFLKEYNCSM

Sequences:

>Translated_513_residues
MLLIILIFIPFIFGLLCWQSERIGCWVPRWIALSGMSITFITTFFLWQYECHDLLNSHPTEHVFPKWQLEYIYPWIPRFG
ISVHLALDGFSLLMVTLTGFLGCMAVLCSWCEIQRYHGLFYLNLLWILGGVIGVFLSIDMFLFFFFWEIMLIPMYFLISL
WGHKEVNRSGRINTAIKFFVYTQFSGLFMLISIIALVSIHHDMHGVWSFNYQDLLNMLLPVNAEYLIMLGFFFAFAVKMP
IVPFHVWLPDVHSHAPTSGSVDLAGILLKTSAYGFFRFVLPLFPCASKSFAPIAMCLGLVNIFYGACMAFAQTDVKRLIA
YTSISHMGFVLIAIYSGTHLSYQGAVVQMISHSLSVSGMFIICGQLYERIHTRDMRLMGGLWSRMHLIPAFSLCFAAATL
GLPGTGNFIGEVTILFGNFQSAPIITIIACFGIILSSIYSLILMQRIYYGPILVPRVNKSGLLRNMTLREKNIIIILLLC
IFLIGFFPQYILNVSYMTMHNLCLFLKEYNCSM
>Mature_513_residues
MLLIILIFIPFIFGLLCWQSERIGCWVPRWIALSGMSITFITTFFLWQYECHDLLNSHPTEHVFPKWQLEYIYPWIPRFG
ISVHLALDGFSLLMVTLTGFLGCMAVLCSWCEIQRYHGLFYLNLLWILGGVIGVFLSIDMFLFFFFWEIMLIPMYFLISL
WGHKEVNRSGRINTAIKFFVYTQFSGLFMLISIIALVSIHHDMHGVWSFNYQDLLNMLLPVNAEYLIMLGFFFAFAVKMP
IVPFHVWLPDVHSHAPTSGSVDLAGILLKTSAYGFFRFVLPLFPCASKSFAPIAMCLGLVNIFYGACMAFAQTDVKRLIA
YTSISHMGFVLIAIYSGTHLSYQGAVVQMISHSLSVSGMFIICGQLYERIHTRDMRLMGGLWSRMHLIPAFSLCFAAATL
GLPGTGNFIGEVTILFGNFQSAPIITIIACFGIILSSIYSLILMQRIYYGPILVPRVNKSGLLRNMTLREKNIIIILLLC
IFLIGFFPQYILNVSYMTMHNLCLFLKEYNCSM

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=366, Percent_Identity=33.0601092896175, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788613, Length=502, Percent_Identity=62.9482071713147, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=349, Percent_Identity=23.2091690544413, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788831, Length=183, Percent_Identity=28.4153005464481, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1788829, Length=342, Percent_Identity=26.3157894736842, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI145693160, Length=354, Percent_Identity=26.8361581920904, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788614, Length=520, Percent_Identity=23.4615384615385, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 58552; Mature: 58552

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLIILIFIPFIFGLLCWQSERIGCWVPRWIALSGMSITFITTFFLWQYECHDLLNSHPT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EHVFPKWQLEYIYPWIPRFGISVHLALDGFSLLMVTLTGFLGCMAVLCSWCEIQRYHGLF
CCCCCCEEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLNLLWILGGVIGVFLSIDMFLFFFFWEIMLIPMYFLISLWGHKEVNRSGRINTAIKFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEH
YTQFSGLFMLISIIALVSIHHDMHGVWSFNYQDLLNMLLPVNAEYLIMLGFFFAFAVKMP
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
IVPFHVWLPDVHSHAPTSGSVDLAGILLKTSAYGFFRFVLPLFPCASKSFAPIAMCLGLV
CEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
NIFYGACMAFAQTDVKRLIAYTSISHMGFVLIAIYSGTHLSYQGAVVQMISHSLSVSGMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEECHHHHHHHHHHHCCCHHH
IICGQLYERIHTRDMRLMGGLWSRMHLIPAFSLCFAAATLGLPGTGNFIGEVTILFGNFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCC
SAPIITIIACFGIILSSIYSLILMQRIYYGPILVPRVNKSGLLRNMTLREKNIIIILLLC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEECCCCHHHHHHHH
IFLIGFFPQYILNVSYMTMHNLCLFLKEYNCSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLIILIFIPFIFGLLCWQSERIGCWVPRWIALSGMSITFITTFFLWQYECHDLLNSHPT
CHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
EHVFPKWQLEYIYPWIPRFGISVHLALDGFSLLMVTLTGFLGCMAVLCSWCEIQRYHGLF
CCCCCCEEEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLNLLWILGGVIGVFLSIDMFLFFFFWEIMLIPMYFLISLWGHKEVNRSGRINTAIKFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEH
YTQFSGLFMLISIIALVSIHHDMHGVWSFNYQDLLNMLLPVNAEYLIMLGFFFAFAVKMP
HHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
IVPFHVWLPDVHSHAPTSGSVDLAGILLKTSAYGFFRFVLPLFPCASKSFAPIAMCLGLV
CEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
NIFYGACMAFAQTDVKRLIAYTSISHMGFVLIAIYSGTHLSYQGAVVQMISHSLSVSGMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCEECHHHHHHHHHHHCCCHHH
IICGQLYERIHTRDMRLMGGLWSRMHLIPAFSLCFAAATLGLPGTGNFIGEVTILFGNFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCC
SAPIITIIACFGIILSSIYSLILMQRIYYGPILVPRVNKSGLLRNMTLREKNIIIILLLC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCEECCCCHHHHHHHH
IFLIGFFPQYILNVSYMTMHNLCLFLKEYNCSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]