Click here to switch to the map view.

The map label for this gene is hisB [H]

Identifier: 71892239

GI number: 71892239

Start: 573031

End: 574101

Strand: Direct

Name: hisB [H]

Synonym: BPEN_480

Alternate gene names: 71892239

Gene position: 573031-574101 (Clockwise)

Preceding gene: 71892238

Following gene: 71892401

Centisome position: 72.38

GC content: 30.53

Gene sequence:

>1071_bases
ATGAATCATAAAGTTTTATTTATAGATCGTGATGGAACCTTAATTAATGAACCAAAAGACAATTTTCAAATTGATTCTTT
AGACAAATTCTCATTGGAACCATATGTGATTCCTGCTCTTATAGCGTTAAAAAATATAGGTTTTGAATTTGTTATAGTTA
CTAATCAAAATGGATTAGGAAGTGCTTCATTTCCTAAAGAAAAATTTGATAAGCCACATCGTCTAATGATTCAAATATTT
CAATCTCAAGGTATTAAATTCAATCAAATACTAATTTGCCCTCATCTTCCAGAAGAAGAATGTAGTTGTCGTAAACCAAA
AACTGCATTAGTAAATTCTTGGCTAATCGATAACAAATTAAATAAATTTAATAGTTATGTTATCGGAGATCGAAATACTG
ATATGATTTTAGCAACTAATATGGATATTCAAGGAATACAATATAATCGTACTAATTTTGGTTGGAAAAAAATTAAAAAC
TATTTAACGCAACGTCACAGATCAGCACATATTCATCGCATCACTGAAGAAACTAATGTAGACATCACGATATGGTTAGA
TCAAAATAATAAAAGTTACATTAATACTGGGATTAATTTTTTTAATCATATGTTACAGCAAATAGCTGTGCATTCTGGAT
TATGCATGAATATTACGGCAAAAGGCGATTTACATGTAGACGATCATCATACTGTAGAAGATACAGCTTTAACATTAGGA
AAAGCTTTAAACACTGCATTGGGCAACAAATGTGGCATCGGAAGATTTGGATTTACCTTGCCTATGGATGAAAGTATTGC
GCAATGTGTATTAGATCTTTCTGGACGAACATACTTTCACTATGAAGCTAACTATACTTTTCAAAAAATAGGAGATCTTA
GTACTGAAATGATAGAACATTTTTTTCGTTCATTATCTTCAAAAATGGGTTGTACTTTACATTTACAAGCAACTGGCAAG
AATGATCATCATAAAGCAGAAAGTTTATTTAAATCTTTCGGGCGATCGTTACGTCAAGCCATTTACATAGACAATAACAA
TATACCAAGCTCTAAAGGAACATTGCTATGA

Upstream 100 bases:

>100_bases
CGTATCACTGTCGGCACATATAATGAATGCAAACACGTAGTTTCTGTTTTAAAAAAATTACATGTTGCATCTTTATCTAT
ATAGATAAATAGGAGCGCTC

Downstream 100 bases:

>100_bases
ATATAGTTATCATAGACACCAACTGCTCTAATTTATTATCTGTAAAAACCATGCTACATAGATTAGGACACAACCCAATA
ATAAGTGACAGAGCTGATGT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MNHKVLFIDRDGTLINEPKDNFQIDSLDKFSLEPYVIPALIALKNIGFEFVIVTNQNGLGSASFPKEKFDKPHRLMIQIF
QSQGIKFNQILICPHLPEEECSCRKPKTALVNSWLIDNKLNKFNSYVIGDRNTDMILATNMDIQGIQYNRTNFGWKKIKN
YLTQRHRSAHIHRITEETNVDITIWLDQNNKSYINTGINFFNHMLQQIAVHSGLCMNITAKGDLHVDDHHTVEDTALTLG
KALNTALGNKCGIGRFGFTLPMDESIAQCVLDLSGRTYFHYEANYTFQKIGDLSTEMIEHFFRSLSSKMGCTLHLQATGK
NDHHKAESLFKSFGRSLRQAIYIDNNNIPSSKGTLL

Sequences:

>Translated_356_residues
MNHKVLFIDRDGTLINEPKDNFQIDSLDKFSLEPYVIPALIALKNIGFEFVIVTNQNGLGSASFPKEKFDKPHRLMIQIF
QSQGIKFNQILICPHLPEEECSCRKPKTALVNSWLIDNKLNKFNSYVIGDRNTDMILATNMDIQGIQYNRTNFGWKKIKN
YLTQRHRSAHIHRITEETNVDITIWLDQNNKSYINTGINFFNHMLQQIAVHSGLCMNITAKGDLHVDDHHTVEDTALTLG
KALNTALGNKCGIGRFGFTLPMDESIAQCVLDLSGRTYFHYEANYTFQKIGDLSTEMIEHFFRSLSSKMGCTLHLQATGK
NDHHKAESLFKSFGRSLRQAIYIDNNNIPSSKGTLL
>Mature_356_residues
MNHKVLFIDRDGTLINEPKDNFQIDSLDKFSLEPYVIPALIALKNIGFEFVIVTNQNGLGSASFPKEKFDKPHRLMIQIF
QSQGIKFNQILICPHLPEEECSCRKPKTALVNSWLIDNKLNKFNSYVIGDRNTDMILATNMDIQGIQYNRTNFGWKKIKN
YLTQRHRSAHIHRITEETNVDITIWLDQNNKSYINTGINFFNHMLQQIAVHSGLCMNITAKGDLHVDDHHTVEDTALTLG
KALNTALGNKCGIGRFGFTLPMDESIAQCVLDLSGRTYFHYEANYTFQKIGDLSTEMIEHFFRSLSSKMGCTLHLQATGK
NDHHKAESLFKSFGRSLRQAIYIDNNNIPSSKGTLL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=355, Percent_Identity=58.8732394366197, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1786399, Length=146, Percent_Identity=32.1917808219178, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=38.7096774193548, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 40572; Mature: 40572

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKVLFIDRDGTLINEPKDNFQIDSLDKFSLEPYVIPALIALKNIGFEFVIVTNQNGLG
CCCEEEEEECCCCEECCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCC
SASFPKEKFDKPHRLMIQIFQSQGIKFNQILICPHLPEEECSCRKPKTALVNSWLIDNKL
CCCCCHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHH
NKFNSYVIGDRNTDMILATNMDIQGIQYNRTNFGWKKIKNYLTQRHRSAHIHRITEETNV
HHHCCEEECCCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHCCHHEEECCCCCC
DITIWLDQNNKSYINTGINFFNHMLQQIAVHSGLCMNITAKGDLHVDDHHTVEDTALTLG
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHHHHHHHHH
KALNTALGNKCGIGRFGFTLPMDESIAQCVLDLSGRTYFHYEANYTFQKIGDLSTEMIEH
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHCHHHHHHHH
FFRSLSSKMGCTLHLQATGKNDHHKAESLFKSFGRSLRQAIYIDNNNIPSSKGTLL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNHKVLFIDRDGTLINEPKDNFQIDSLDKFSLEPYVIPALIALKNIGFEFVIVTNQNGLG
CCCEEEEEECCCCEECCCCCCCEECCCCCCCCCCHHHHHHHHHHHCCEEEEEEECCCCCC
SASFPKEKFDKPHRLMIQIFQSQGIKFNQILICPHLPEEECSCRKPKTALVNSWLIDNKL
CCCCCHHHCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHH
NKFNSYVIGDRNTDMILATNMDIQGIQYNRTNFGWKKIKNYLTQRHRSAHIHRITEETNV
HHHCCEEECCCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHCCHHEEECCCCCC
DITIWLDQNNKSYINTGINFFNHMLQQIAVHSGLCMNITAKGDLHVDDHHTVEDTALTLG
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCHHHHHHHHH
KALNTALGNKCGIGRFGFTLPMDESIAQCVLDLSGRTYFHYEANYTFQKIGDLSTEMIEH
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHCHHHHHHHH
FFRSLSSKMGCTLHLQATGKNDHHKAESLFKSFGRSLRQAIYIDNNNIPSSKGTLL
HHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]