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The map label for this gene is ribA

Identifier: 71892199

GI number: 71892199

Start: 515202

End: 515801

Strand: Direct

Name: ribA

Synonym: BPEN_437

Alternate gene names: 71892199

Gene position: 515202-515801 (Clockwise)

Preceding gene: 71892196

Following gene: 71892200

Centisome position: 65.08

GC content: 31.83

Gene sequence:

>600_bases
ATGCGACTTAGGCGGGTGACAGAAGCAAGATTACCAACACTTTGGGGAAATTTTTTAATAGTAGGATTTGAAGAAAATTT
CACTGGCCATAATCATATTGCATTAATATATGGAAATATCACTGGATCAGATCCAGTATTAACACGAATACATTCTGAAT
GTTTAACAGGAGATGCTTTATTTAGTTCACGTTGTGATTGTGGATTTCAATTAAAAACCGCATTACATTGCATTACAGAA
GAAAAACGCGGTATTCTAATTTATCATCGGCAAGAAGGACGTAATATCGGATTATTGAATAAAATTCGTGCTTATGCATT
GCAAGATAACGGAGCTGATACAGTAGAGGCAAACCAATGTTTAGGTTTTGCTCCCGACGAAAGAGACTTTACTATTTGCG
CAGATATTTTAAAATTACTGCGCGTAAAAAAAATACGTATTTTAACTAATAACCCAAAAAAAGTAGAAATCTTAAATAAA
TCATGTATTAATATTACAGAAAGAGTTCCGTTAATTGTAGGAAGAAACCCAGAAAACTCTAGATATTTAGATACCAAAGC
ATCTAAATTAGGACATTTATTTTATAGTTATCATAAATAA

Upstream 100 bases:

>100_bases
TATATATAACATATTTTGTACTTCAATACTATTATTGAGAAACTATCAATGCTTTAATAAAAATAAACATTCTTGATGAC
ATCTTGAGAGAGGCAATAAC

Downstream 100 bases:

>100_bases
AAATTATAAACGTGATAACGAAAAAAACAAAAATGTTTTTATGTAACAAATTTATTAGTTACTTCTGTATATACAAAATA
ATAATACGCGCATGCTCTGT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MRLRRVTEARLPTLWGNFLIVGFEENFTGHNHIALIYGNITGSDPVLTRIHSECLTGDALFSSRCDCGFQLKTALHCITE
EKRGILIYHRQEGRNIGLLNKIRAYALQDNGADTVEANQCLGFAPDERDFTICADILKLLRVKKIRILTNNPKKVEILNK
SCINITERVPLIVGRNPENSRYLDTKASKLGHLFYSYHK

Sequences:

>Translated_199_residues
MRLRRVTEARLPTLWGNFLIVGFEENFTGHNHIALIYGNITGSDPVLTRIHSECLTGDALFSSRCDCGFQLKTALHCITE
EKRGILIYHRQEGRNIGLLNKIRAYALQDNGADTVEANQCLGFAPDERDFTICADILKLLRVKKIRILTNNPKKVEILNK
SCINITERVPLIVGRNPENSRYLDTKASKLGHLFYSYHK
>Mature_199_residues
MRLRRVTEARLPTLWGNFLIVGFEENFTGHNHIALIYGNITGSDPVLTRIHSECLTGDALFSSRCDCGFQLKTALHCITE
EKRGILIYHRQEGRNIGLLNKIRAYALQDNGADTVEANQCLGFAPDERDFTICADILKLLRVKKIRILTNNPKKVEILNK
SCINITERVPLIVGRNPENSRYLDTKASKLGHLFYSYHK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=74.2268041237113, Blast_Score=308, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319438, Length=170, Percent_Identity=40.5882352941176, Blast_Score=114, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_BLOPB (Q492N9)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277932.1
- ProteinModelPortal:   Q492N9
- SMR:   Q492N9
- STRING:   Q492N9
- GeneID:   3562817
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_437
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- OMA:   QGFILYL
- ProtClustDB:   PRK00393
- BioCyc:   CBLO291272:BPEN_437-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22626; Mature: 22626

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: ACT_SITE 126-126 ACT_SITE 128-128 BINDING 70-70 BINDING 114-114 BINDING 149-149 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRRVTEARLPTLWGNFLIVGFEENFTGHNHIALIYGNITGSDPVLTRIHSECLTGDAL
CCCCHHHHHHCCEECCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHH
FSSRCDCGFQLKTALHCITEEKRGILIYHRQEGRNIGLLNKIRAYALQDNGADTVEANQC
HHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHEEEEECCCCCCCEECCCE
LGFAPDERDFTICADILKLLRVKKIRILTNNPKKVEILNKSCINITERVPLIVGRNPENS
ECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEEECCHHCCHHHCCCEEEECCCCCC
RYLDTKASKLGHLFYSYHK
EEECHHHHHHHHHHHEECC
>Mature Secondary Structure
MRLRRVTEARLPTLWGNFLIVGFEENFTGHNHIALIYGNITGSDPVLTRIHSECLTGDAL
CCCCHHHHHHCCEECCCEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHH
FSSRCDCGFQLKTALHCITEEKRGILIYHRQEGRNIGLLNKIRAYALQDNGADTVEANQC
HHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHEEEEECCCCCCCEECCCE
LGFAPDERDFTICADILKLLRVKKIRILTNNPKKVEILNKSCINITERVPLIVGRNPENS
ECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEEECCHHCCHHHCCCEEEECCCCCC
RYLDTKASKLGHLFYSYHK
EEECHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA