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The map label for this gene is tmk

Identifier: 71892180

GI number: 71892180

Start: 489149

End: 489787

Strand: Reverse

Name: tmk

Synonym: BPEN_413

Alternate gene names: 71892180

Gene position: 489787-489149 (Counterclockwise)

Preceding gene: 71892181

Following gene: 71892179

Centisome position: 61.87

GC content: 33.18

Gene sequence:

>639_bases
ATGGACAATAGGTTTATTACGATTGAAGGGTTAGATGGTGCTGGAAAAACTACTATCACTCATAGAGTAAGTAAATACTT
AAATCAATATGGTGTAACCGATATTTTGACCACTCATGAACCCGGAGGGACGCCGGTTTCGGATTTTTTACGTGTATTGA
TTAAATATGGTGGCCCTATGAATGAACCTATTAATAGTATATCAGAATTATTAATGATATATGCTGCGCGATTACAATTA
ATAGAAAATGTTATTAAACCAGCTTTATCTAAAGGTTATTGGGTAATTGGGGATAGATTTGATTTGTCTTCTCAGGCGTA
TCAAGGAGGAGGAAGAGGAATTGATATATTATTGTTACATGCTTTATCAAATAAGATCACAAATACCTTATCTCCAGATT
TGACATTTTATCTTGATATTTCTCCAGAATTAAGCATATCTCGTATAAATCATAGACAGAAATTAGATCGTATTGAACAG
GAGCCTCTAAGTTTTTTTGATCGTGTACGTTCTTGTTACAAAAAATTAGCTTCTGAAAGAAAAAATATTATCACGATTGA
TGCTACTCAGAGTTTAGAAGAAGTTTCCATGTCTATTTATAGACATTTAGATTGGTGGTTCTTGCGTCCGCAGGAATAA

Upstream 100 bases:

>100_bases
ATATATTTTAATTATTGTTTATTTTCATAAATATGTAAAATTTTATAGATTGTAATAAATAATTAAATAAAACGATTACA
CAACCGTATATCAGGATTCA

Downstream 100 bases:

>100_bases
TCTATAATGAGATGGTATCCTTGGCTAGATAGTACTTATAATCAAATATTAAATGCTTATCGACAAGATAGAGGACATCA
TGCTTTACTTTTAAATAGTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MDNRFITIEGLDGAGKTTITHRVSKYLNQYGVTDILTTHEPGGTPVSDFLRVLIKYGGPMNEPINSISELLMIYAARLQL
IENVIKPALSKGYWVIGDRFDLSSQAYQGGGRGIDILLLHALSNKITNTLSPDLTFYLDISPELSISRINHRQKLDRIEQ
EPLSFFDRVRSCYKKLASERKNIITIDATQSLEEVSMSIYRHLDWWFLRPQE

Sequences:

>Translated_212_residues
MDNRFITIEGLDGAGKTTITHRVSKYLNQYGVTDILTTHEPGGTPVSDFLRVLIKYGGPMNEPINSISELLMIYAARLQL
IENVIKPALSKGYWVIGDRFDLSSQAYQGGGRGIDILLLHALSNKITNTLSPDLTFYLDISPELSISRINHRQKLDRIEQ
EPLSFFDRVRSCYKKLASERKNIITIDATQSLEEVSMSIYRHLDWWFLRPQE
>Mature_212_residues
MDNRFITIEGLDGAGKTTITHRVSKYLNQYGVTDILTTHEPGGTPVSDFLRVLIKYGGPMNEPINSISELLMIYAARLQL
IENVIKPALSKGYWVIGDRFDLSSQAYQGGGRGIDILLLHALSNKITNTLSPDLTFYLDISPELSISRINHRQKLDRIEQ
EPLSFFDRVRSCYKKLASERKNIITIDATQSLEEVSMSIYRHLDWWFLRPQE

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=51.6746411483254, Blast_Score=207, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_BLOPB (Q492Q6)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277912.1
- HSSP:   P65248
- ProteinModelPortal:   Q492Q6
- STRING:   Q492Q6
- GeneID:   3562644
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_413
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- ProtClustDB:   PRK00698
- BioCyc:   CBLO291272:BPEN_413-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24190; Mature: 24190

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRFITIEGLDGAGKTTITHRVSKYLNQYGVTDILTTHEPGGTPVSDFLRVLIKYGGPM
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHCCCC
NEPINSISELLMIYAARLQLIENVIKPALSKGYWVIGDRFDLSSQAYQGGGRGIDILLLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCCCCHHHHHHH
ALSNKITNTLSPDLTFYLDISPELSISRINHRQKLDRIEQEPLSFFDRVRSCYKKLASER
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNIITIDATQSLEEVSMSIYRHLDWWFLRPQE
CCEEEEECHHHHHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure
MDNRFITIEGLDGAGKTTITHRVSKYLNQYGVTDILTTHEPGGTPVSDFLRVLIKYGGPM
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHHCCCC
NEPINSISELLMIYAARLQLIENVIKPALSKGYWVIGDRFDLSSQAYQGGGRGIDILLLH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCCCCHHHHHHH
ALSNKITNTLSPDLTFYLDISPELSISRINHRQKLDRIEQEPLSFFDRVRSCYKKLASER
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNIITIDATQSLEEVSMSIYRHLDWWFLRPQE
CCEEEEECHHHHHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA