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The map label for this gene is hisA

Identifier: 68535866

GI number: 68535866

Start: 945146

End: 945922

Strand: Direct

Name: hisA

Synonym: jk0791

Alternate gene names: 68535866

Gene position: 945146-945922 (Clockwise)

Preceding gene: 68535865

Following gene: 68535867

Centisome position: 38.38

GC content: 67.57

Gene sequence:

>777_bases
ATGGCTTCTACTGATAACTCCCGTGCCCTGACCCTGCTTCCCGCCGTCGACGTAGCCGACGGCCAGGCCGTCCGACTCGT
ACAGGGCGCGGCGGGCACGGAGACCAGCTACGGTGCACCGATTGAGGCCGCTTTGGCCTGGCAGAACGCAGGCGCGGAGT
GGATCCACCTGGTGGACCTTGACGCTGCCTTCGGTAGGGGCAGCAACTTCGAGTTGCTGAAGGAGGTAACCGGCCAGCTG
GACGTGAACGTGGAGCTATCCGGTGGCATCCGTGACGACGAGTCGCTGGAGCGGGCCCTGTCCACCGGCTGCCGCCGGGT
GAACATCGGCACCGCTGCGCTGGAGGATCCGGAGTGGTGCGAGTCCGTCATCTCCCGCTACGGCGACAAGGTGGCCATCG
GCCTGGATACCCGCGAGGTCGACGGCGAGTGGCGCCTGCGCGGCCGCGGCTGGACCTCCGACGGCGGCGAGCTGTGGGAG
GTACTGGAGCGCCTGGATTCCCAGGGCGTTTCCCGCCTGGTGGTCACCGACGTCAGCCGCGACGGCATGCTGAACGGCCC
GAACATCGACCTGCTGCGCGAAGTCGCTGCAGCTACCGACGCGCCGGTTGTGGCCTCCGGCGGGATCTCCAGCCTGGACG
ACATTCGCGCATTGGCGGCCGTGGTGCACGAGGGTGTGGACTCCGCGATCGTGGGCAAGGCCCTGTATGCGGGTAAGTTC
ACCCTGGAGGAGGCTCTGGAAGCGGCTCAGGGAGTGGCAAGGGGGAGCGACATCTAA

Upstream 100 bases:

>100_bases
AGCTGCTGCAGAACTGGGTGGACACGCTCTAGCTCTAGAAATAGCACTAGTTTCATGGATTTGATCTTCGCCGACCTCGA
TACACGTTAGGATTCTCCCT

Downstream 100 bases:

>100_bases
TGACGGCCTTCCACGGACTGCCCCCGGAGGAACTGGATACCCGCTCGCTGCTGGCCATCGCCGAGGCGGCGGTGGACGAA
GCCGAGACGACGTTTACGGC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MASTDNSRALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAFGRGSNFELLKEVTGQL
DVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYGDKVAIGLDTREVDGEWRLRGRGWTSDGGELWE
VLERLDSQGVSRLVVTDVSRDGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKF
TLEEALEAAQGVARGSDI

Sequences:

>Translated_258_residues
MASTDNSRALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAFGRGSNFELLKEVTGQL
DVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYGDKVAIGLDTREVDGEWRLRGRGWTSDGGELWE
VLERLDSQGVSRLVVTDVSRDGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKF
TLEEALEAAQGVARGSDI
>Mature_257_residues
ASTDNSRALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAFGRGSNFELLKEVTGQLD
VNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYGDKVAIGLDTREVDGEWRLRGRGWTSDGGELWEV
LERLDSQGVSRLVVTDVSRDGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFT
LEEALEAAQGVARGSDI

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=247, Percent_Identity=35.6275303643725, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788336, Length=255, Percent_Identity=25.8823529411765, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CORJK (Q4JW54)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250571.1
- ProteinModelPortal:   Q4JW54
- SMR:   Q4JW54
- STRING:   Q4JW54
- GeneID:   3433176
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0791
- NMPDR:   fig|306537.3.peg.1765
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- ProtClustDB:   PRK14024
- BioCyc:   CJEI306537:JK0791-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01919

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 27173; Mature: 27042

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: NA

Important sites: ACT_SITE 17-17 ACT_SITE 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTDNSRALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDL
CCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHEEECCCCCCEEEEEEC
DAAFGRGSNFELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWC
HHHHCCCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHH
ESVISRYGDKVAIGLDTREVDGEWRLRGRGWTSDGGELWEVLERLDSQGVSRLVVTDVSR
HHHHHHCCCEEEEECCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
DGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKF
CCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
TLEEALEAAQGVARGSDI
CHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ASTDNSRALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDL
CCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCHHHHEEECCCCCCEEEEEEC
DAAFGRGSNFELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWC
HHHHCCCCCHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHH
ESVISRYGDKVAIGLDTREVDGEWRLRGRGWTSDGGELWEVLERLDSQGVSRLVVTDVSR
HHHHHHCCCEEEEECCCEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
DGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKF
CCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
TLEEALEAAQGVARGSDI
CHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA