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The map label for this gene is hisD

Identifier: 68535861

GI number: 68535861

Start: 939830

End: 941182

Strand: Direct

Name: hisD

Synonym: jk0786

Alternate gene names: 68535861

Gene position: 939830-941182 (Clockwise)

Preceding gene: 68535859

Following gene: 68535862

Centisome position: 38.17

GC content: 68.07

Gene sequence:

>1353_bases
ATGACTAGCGCCCAGCTGGACTTTAGCCGGATCGATCTGCGGGGGCAGGCCCCGACTACCGCCGAGCTGCGCCATCGGCT
GCCGCGCGGGGGCACGGACGTGGACTCGGTGATCCCCACCGTCGCACCGATCGTCGACCAGGTGCGCGAGGGCGGGGCAC
GCGCGGCGCTGGAGATCGGACAGCGTTTCGATGGCGTGACCCCGGATTCGGTGCGGGTCCCTGCCGAGGTTATTGACGCC
GCCGTGGGGACTTTGGCCGACGACGTCATCGCAGCACTCGAGGAGGCCATCAAGCGGGTGCGTGCATTCCACTCCGCCAT
CCGGCCTGAAGACAAGCAGGTGGAGGTCGCGCCGGGCGGCATTGTGACCGAGCGTTTCATCCCCGTCCAGCGCGTAGGCC
TGTACGCGCCGGGCGGAAACGCGGTGTACCCGTCGAGCGTGATCATGAACGTCGTGCCAGCTCAGGAGGCCGGAGTGGAG
TCCCTCGTAGTGGCCTCCCCACCGCAGGAGGGCGGCTGGCCGCACCCGACCGTGCTGGCAGCCTGCAAGCTGCTCGGCGT
GGACGAGGTCTGGGCTGTCGGCGGTGCGCAGGCCGTGGCACTGCTGGCGCACGGCTCCACCGCGGAAGGCGGCGAGGAGC
TGGAGCCGGTGGACATGGTGACCGGACCGGGCAACATCTTCGTCACCGCCGCCAAGCGGCTGTGTCGCTCCGTAGTGGGC
ATCGACTCCGAAGCGGGGCCGACCGAGATCGCCGTGCTGGCCGATGAGAGCGCCAACGCGGTGGAGATCGCCTACGACCT
GATTAGTCAGGCGGAGCACGACACGATGGCGGCCTCCGTGCTGATCACGGACAGTGAGAAGCTGGCCGACGAGGTCGTGG
CTGAGATGAACGAGCGCTACCACATCACCGAAAACTCCGAGCGCGTCGCCGAGGCCTTGAGCGGACAGCAGTCCGGAGTG
GTGCTCGTGGACGACATCGCCGCGGGCATCCGCGCGGCGAACGCCTATGGCGCCGAGCACCTGGAGATCCACACCGAGGA
CGCCCACGGGGTAGCAGCGCAGATCACCAACGCCGGCGCGATCTTCATCGGCCGCTTCAGCCCGGTACCGCTGGGAGACT
ATGCCGCTGGCTCCAACCACGTGTTGCCGACCTCCGGGACGGCGCGGCACTCCTCGGGGCTGTCCACGCTGACTTTCCTG
AAGTCCGTGCACGTCATCGACTACAACGAGGAAGGCCTGCGGGGCGTGGCCGACACGGTAATCACCCTGTCGAAGTCCGA
GGGGCTGCCCGCCCACGGTGAAGCCATCAGTGCACGCACCAGCACCGCAAACACCAACGGAACGGAGGTCTAG

Upstream 100 bases:

>100_bases
GAGCAGTGAAAGGAGTGTCTGGGCCATGGCGTAAACTCTAGCCCAGTACATAACCGTAAATAATTATTCAGAATTAATCA
GTAAGGAAGCTGCGTACACG

Downstream 100 bases:

>100_bases
ACCATGGCCGAGCAGAACAACCAGATCTCCCTGGCCGACCTGCCACTGCGCGAGGAGCTGCGCGGCAAGTCCGCCTATGG
AGCCCCGCAGCTTTCCGTAG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTSAQLDFSRIDLRGQAPTTAELRHRLPRGGTDVDSVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSVRVPAEVIDA
AVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQRVGLYAPGGNAVYPSSVIMNVVPAQEAGVE
SLVVASPPQEGGWPHPTVLAACKLLGVDEVWAVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVVG
IDSEAGPTEIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSERVAEALSGQQSGV
VLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSPVPLGDYAAGSNHVLPTSGTARHSSGLSTLTFL
KSVHVIDYNEEGLRGVADTVITLSKSEGLPAHGEAISARTSTANTNGTEV

Sequences:

>Translated_450_residues
MTSAQLDFSRIDLRGQAPTTAELRHRLPRGGTDVDSVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSVRVPAEVIDA
AVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQRVGLYAPGGNAVYPSSVIMNVVPAQEAGVE
SLVVASPPQEGGWPHPTVLAACKLLGVDEVWAVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVVG
IDSEAGPTEIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSERVAEALSGQQSGV
VLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSPVPLGDYAAGSNHVLPTSGTARHSSGLSTLTFL
KSVHVIDYNEEGLRGVADTVITLSKSEGLPAHGEAISARTSTANTNGTEV
>Mature_449_residues
TSAQLDFSRIDLRGQAPTTAELRHRLPRGGTDVDSVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSVRVPAEVIDAA
VGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQRVGLYAPGGNAVYPSSVIMNVVPAQEAGVES
LVVASPPQEGGWPHPTVLAACKLLGVDEVWAVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVVGI
DSEAGPTEIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSERVAEALSGQQSGVV
LVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSPVPLGDYAAGSNHVLPTSGTARHSSGLSTLTFLK
SVHVIDYNEEGLRGVADTVITLSKSEGLPAHGEAISARTSTANTNGTEV

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=37.7450980392157, Blast_Score=242, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=36.4734299516908, Blast_Score=243, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_CORJK (Q4JW59)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250566.1
- ProteinModelPortal:   Q4JW59
- SMR:   Q4JW59
- STRING:   Q4JW59
- GeneID:   3433179
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0786
- NMPDR:   fig|306537.3.peg.1760
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   CJEI306537:JK0786-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46776; Mature: 46645

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 339-339 ACT_SITE 340-340 BINDING 135-135 BINDING 197-197 BINDING 225-225 BINDING 248-248 BINDING 270-270 BINDING 273-273 BINDING 340-340 BINDING 373-373 BINDING 427-427 BINDING 432-432

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAQLDFSRIDLRGQAPTTAELRHRLPRGGTDVDSVIPTVAPIVDQVREGGARAALEIG
CCCCCCCHHEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QRFDGVTPDSVRVPAEVIDAAVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGG
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
IVTERFIPVQRVGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQEGGWPHPTVLA
EEHHHCCCHHHHEEECCCCCCCCCHHHHHEECCCHHCCCCEEEEECCCCCCCCCCHHHHH
ACKLLGVDEVWAVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVVG
HHHHCCCHHHHHCCCHHEEEEEECCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHC
IDSEAGPTEIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERY
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHCCCE
HITENSERVAEALSGQQSGVVLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGA
EECCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCE
IFIGRFSPVPLGDYAAGSNHVLPTSGTARHSSGLSTLTFLKSVHVIDYNEEGLRGVADTV
EEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHH
ITLSKSEGLPAHGEAISARTSTANTNGTEV
EEEECCCCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TSAQLDFSRIDLRGQAPTTAELRHRLPRGGTDVDSVIPTVAPIVDQVREGGARAALEIG
CCCCCCHHEEEECCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHH
QRFDGVTPDSVRVPAEVIDAAVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGG
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
IVTERFIPVQRVGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQEGGWPHPTVLA
EEHHHCCCHHHHEEECCCCCCCCCHHHHHEECCCHHCCCCEEEEECCCCCCCCCCHHHHH
ACKLLGVDEVWAVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVVG
HHHHCCCHHHHHCCCHHEEEEEECCCCCCCCCCCCCCEEEECCCCEEEHHHHHHHHHHHC
IDSEAGPTEIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERY
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHHCCCE
HITENSERVAEALSGQQSGVVLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGA
EECCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCE
IFIGRFSPVPLGDYAAGSNHVLPTSGTARHSSGLSTLTFLKSVHVIDYNEEGLRGVADTV
EEEECCCCCCCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHH
ITLSKSEGLPAHGEAISARTSTANTNGTEV
EEEECCCCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA