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The map label for this gene is nadC [H]

Identifier: 68535859

GI number: 68535859

Start: 937576

End: 938496

Strand: Direct

Name: nadC [H]

Synonym: jk0784

Alternate gene names: 68535859

Gene position: 937576-938496 (Clockwise)

Preceding gene: 68535858

Following gene: 68535861

Centisome position: 38.07

GC content: 67.97

Gene sequence:

>921_bases
GTGGAAGAGCAAGCAGTGGAACTTCCCTACCCGGCACAGCTGACCGATCCCACCCGCATCCGCGCAGCGTATCTGCGCAT
GGCGAAGGTCGCGTTGGAGGAGGACTTCGGCGACGGCGCGGACGTCAGCACCCTGGCGACCGTACCCGCCGACGCTACCG
GCACGAAGGTCATGCGCGCCCGCCAGGCCGGTGTGATCAGCGGGCTGGATGCGCTGGCCATCGTCGCGGAGGTCGCCGAC
GAGCGGCACGTGGAGCTCGTCCCGCTGGTCGCTGACGGTGACCGCGTGGAGGCCGGGGACGAGGTTGCCCGGGTGGAGGG
AAAGATCCAGCACATCCTCATGCTCGAACGCACATTGCTGAACATCTTGAGCCACGCCTCCGGCATCGCCACGCAGACCC
GCGCGTGGGTCGATGCGGTCGAGGCCGCGGCCACCAGCCCGCAAGGCTGCAAGGTTCGCGATTCCCGCAAGACTCTGCCC
GGCATGCGCATGCTGGAAAAGCGTGCGATCGTCCACGGTGGTGGCTACCCGCACCGCTACAATCTGGGCGACCAGGTGAT
GGTCAAGGACAACCACGTGGAGCTCTCGAATGCAGCCGAGGCGTATGCCCGGGTGCGGGAGTTCTTGGGGGAGGACGCCA
CCACGTGGGTAGAGGTCGAGGTGGATACCCTGGATCAGCTCTCCGACCTGCTGGCGGAGGGCAAGGCTCGCCCGCCGCAG
GTGCTGCTGGATAACTTCACGGTGGAGGACACGCGCAAGGCCGTGGAGCTGCGCGACCAGCTGGCTCCGCAGGTGCTGTT
GGAATCCTCCGGCGGGCTCACTCTGGACGTCGCCGGGGACTACGCCGCCGCGGGCGTGGAGTCCGTGGCCGTGGGCGGGT
TGACCCACAGCGTGCGGGCACTGGACATCGGCCTGGACTAG

Upstream 100 bases:

>100_bases
GCGAGGACGAGGTGACGGTGGACGAGGAGACCGCCGCAGCGGCCCGTCGTTCCGTGGAGCGCATGATCGCCATCGGCAAC
CCGGGAAGCGGGGAGTAGGC

Downstream 100 bases:

>100_bases
GGTCCTGGCCTTTTAGGCTTCCCAGCGTTCCAGCGCCGCCCGTCGGCGCTCGTCGAGTTCTGCGGCTATTTCCGCGTAGC
CCAGCTCCGCGGCGGCGACC

Product: nicotinate-nucleotide pyrophosphorylase (carboxylating)

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MEEQAVELPYPAQLTDPTRIRAAYLRMAKVALEEDFGDGADVSTLATVPADATGTKVMRARQAGVISGLDALAIVAEVAD
ERHVELVPLVADGDRVEAGDEVARVEGKIQHILMLERTLLNILSHASGIATQTRAWVDAVEAAATSPQGCKVRDSRKTLP
GMRMLEKRAIVHGGGYPHRYNLGDQVMVKDNHVELSNAAEAYARVREFLGEDATTWVEVEVDTLDQLSDLLAEGKARPPQ
VLLDNFTVEDTRKAVELRDQLAPQVLLESSGGLTLDVAGDYAAAGVESVAVGGLTHSVRALDIGLD

Sequences:

>Translated_306_residues
MEEQAVELPYPAQLTDPTRIRAAYLRMAKVALEEDFGDGADVSTLATVPADATGTKVMRARQAGVISGLDALAIVAEVAD
ERHVELVPLVADGDRVEAGDEVARVEGKIQHILMLERTLLNILSHASGIATQTRAWVDAVEAAATSPQGCKVRDSRKTLP
GMRMLEKRAIVHGGGYPHRYNLGDQVMVKDNHVELSNAAEAYARVREFLGEDATTWVEVEVDTLDQLSDLLAEGKARPPQ
VLLDNFTVEDTRKAVELRDQLAPQVLLESSGGLTLDVAGDYAAAGVESVAVGGLTHSVRALDIGLD
>Mature_306_residues
MEEQAVELPYPAQLTDPTRIRAAYLRMAKVALEEDFGDGADVSTLATVPADATGTKVMRARQAGVISGLDALAIVAEVAD
ERHVELVPLVADGDRVEAGDEVARVEGKIQHILMLERTLLNILSHASGIATQTRAWVDAVEAAATSPQGCKVRDSRKTLP
GMRMLEKRAIVHGGGYPHRYNLGDQVMVKDNHVELSNAAEAYARVREFLGEDATTWVEVEVDTLDQLSDLLAEGKARPPQ
VLLDNFTVEDTRKAVELRDQLAPQVLLESSGGLTLDVAGDYAAAGVESVAVGGLTHSVRALDIGLD

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=251, Percent_Identity=32.2709163346614, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1786299, Length=278, Percent_Identity=33.0935251798561, Blast_Score=110, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321162, Length=261, Percent_Identity=29.1187739463602, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32835; Mature: 32835

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQAVELPYPAQLTDPTRIRAAYLRMAKVALEEDFGDGADVSTLATVPADATGTKVMRA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHH
RQAGVISGLDALAIVAEVADERHVELVPLVADGDRVEAGDEVARVEGKIQHILMLERTLL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NILSHASGIATQTRAWVDAVEAAATSPQGCKVRDSRKTLPGMRMLEKRAIVHGGGYPHRY
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCEEC
NLGDQVMVKDNHVELSNAAEAYARVREFLGEDATTWVEVEVDTLDQLSDLLAEGKARPPQ
CCCCEEEEECCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCH
VLLDNFTVEDTRKAVELRDQLAPQVLLESSGGLTLDVAGDYAAAGVESVAVGGLTHSVRA
HHCCCCCHHHHHHHHHHHHHHCHHHEEECCCCEEEEECCCHHHHCHHHHHHCCCHHCEEE
LDIGLD
EEECCC
>Mature Secondary Structure
MEEQAVELPYPAQLTDPTRIRAAYLRMAKVALEEDFGDGADVSTLATVPADATGTKVMRA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHH
RQAGVISGLDALAIVAEVADERHVELVPLVADGDRVEAGDEVARVEGKIQHILMLERTLL
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
NILSHASGIATQTRAWVDAVEAAATSPQGCKVRDSRKTLPGMRMLEKRAIVHGGGYPHRY
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCCCEEC
NLGDQVMVKDNHVELSNAAEAYARVREFLGEDATTWVEVEVDTLDQLSDLLAEGKARPPQ
CCCCEEEEECCCEEHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCH
VLLDNFTVEDTRKAVELRDQLAPQVLLESSGGLTLDVAGDYAAAGVESVAVGGLTHSVRA
HHCCCCCHHHHHHHHHHHHHHCHHHEEECCCCEEEEECCCHHHHCHHHHHHCCCHHCEEE
LDIGLD
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 9862811 [H]