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The map label for this gene is kipI [H]

Identifier: 66045957

GI number: 66045957

Start: 3303315

End: 3304187

Strand: Reverse

Name: kipI [H]

Synonym: Psyr_2721

Alternate gene names: 66045957

Gene position: 3304187-3303315 (Counterclockwise)

Preceding gene: 66045958

Following gene: 66045956

Centisome position: 54.22

GC content: 61.05

Gene sequence:

>873_bases
ATGGCTGATCCGATTCGCTACAGCTTTGGCGCTGATGAACATCTGTTCGCCGAGGTCAGTGACAGTATGTCGCTGGAAGC
ATTTTTCAAGGGGCTGGCGGTGACCCGTGCGGTCGAGCGTCTGGCGCTGGACGGTGTGCTGGACGTGTGCCTGGCCAACG
CGTCATTCCAGATTCGTTTTGACCCGGACCGCATCGCACCACACGTCTTGCTTGAAGCGGTGAGGGCGGCCGAGGCCGGT
GCGGTCGCCGAACGTACCCTGCAGACCCGGATCATCGAGATCCCGGTGCTGTACAACGATCCATGGACCCACGAGACCCT
GATGCGTTTTCGTGACCGCCATCAGGACCCCGGTTCCACCGACCTGGAATACGCTGCGCGCATCAATAACCTGGCGGATG
TCGATGCTTTCATCGCCGCGCACAGCGGCGCACCGTGGTTCGTTTCGATGGTCGGTTTTGTCGCCGGTCTGCCGTTCATG
TTCCAGATGGTGGAACGCGAGCGTCAGCTGCAGGTGCCCAAATACCTGCGTCCGCGCACCGATACTCCCAAGCACACACT
CGGCCACGGCGGCTGCTTCGGCTGCATCTATTCGGTACGCGGAGCGGGCGGTTATCAGATGTTTGGCGTCACTCCTGCGC
CGATCTATGACCCACAGCAGAAGCTGGCCTACCTGAAAGAGCACATGGTGTTCTTCCGGCCGGGCGATATCGTCCAGTTC
AAACCGCTTGACCGGCAAGCCTATGACGAGGCTGTCGCAGAGGTGGAAGCCGGGCGCTTCGACCTGCTCATCCGCCCGGT
CGAGTTTTCCCTGGATGCCTTTCTGGCCGATCCGGTGGGCTATCCCAAGTCGTTGCAGGAGGTGCTGGCATGA

Upstream 100 bases:

>100_bases
GTGCGCCGCGTTGAATAAAAGGCATCATGCGCACAGACGCACGAGCCGTGTTACTGATTTTTGCCTGCCGTTCTACAACG
ATTTCAAGAAAGGAACAGAC

Downstream 100 bases:

>100_bases
TCAAGGTGCTCAAACCCGGTCTGGCCACCTCGGTTCAGGACCTCGGTCGCGAGGGCTATTATCACCTGGGCATTCCGCCC
TCCGGTGCGCTCGACCAGTA

Product: hypothetical protein

Products: NA

Alternate protein names: Sporulation inhibitor kipI [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MADPIRYSFGADEHLFAEVSDSMSLEAFFKGLAVTRAVERLALDGVLDVCLANASFQIRFDPDRIAPHVLLEAVRAAEAG
AVAERTLQTRIIEIPVLYNDPWTHETLMRFRDRHQDPGSTDLEYAARINNLADVDAFIAAHSGAPWFVSMVGFVAGLPFM
FQMVERERQLQVPKYLRPRTDTPKHTLGHGGCFGCIYSVRGAGGYQMFGVTPAPIYDPQQKLAYLKEHMVFFRPGDIVQF
KPLDRQAYDEAVAEVEAGRFDLLIRPVEFSLDAFLADPVGYPKSLQEVLA

Sequences:

>Translated_290_residues
MADPIRYSFGADEHLFAEVSDSMSLEAFFKGLAVTRAVERLALDGVLDVCLANASFQIRFDPDRIAPHVLLEAVRAAEAG
AVAERTLQTRIIEIPVLYNDPWTHETLMRFRDRHQDPGSTDLEYAARINNLADVDAFIAAHSGAPWFVSMVGFVAGLPFM
FQMVERERQLQVPKYLRPRTDTPKHTLGHGGCFGCIYSVRGAGGYQMFGVTPAPIYDPQQKLAYLKEHMVFFRPGDIVQF
KPLDRQAYDEAVAEVEAGRFDLLIRPVEFSLDAFLADPVGYPKSLQEVLA
>Mature_289_residues
ADPIRYSFGADEHLFAEVSDSMSLEAFFKGLAVTRAVERLALDGVLDVCLANASFQIRFDPDRIAPHVLLEAVRAAEAGA
VAERTLQTRIIEIPVLYNDPWTHETLMRFRDRHQDPGSTDLEYAARINNLADVDAFIAAHSGAPWFVSMVGFVAGLPFMF
QMVERERQLQVPKYLRPRTDTPKHTLGHGGCFGCIYSVRGAGGYQMFGVTPAPIYDPQQKLAYLKEHMVFFRPGDIVQFK
PLDRQAYDEAVAEVEAGRFDLLIRPVEFSLDAFLADPVGYPKSLQEVLA

Specific function: Is a potent inhibitor of the autophosphorylation reaction of kinase A and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase

COG id: COG2049

COG function: function code E; Allophanate hydrolase subunit 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786929, Length=155, Percent_Identity=28.3870967741935, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=281, Percent_Identity=22.7758007117438, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003833
- InterPro:   IPR020899
- InterPro:   IPR010016
- InterPro:   IPR002130 [H]

Pfam domain/function: PF02682 AHS1 [H]

EC number: NA

Molecular weight: Translated: 32441; Mature: 32310

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADPIRYSFGADEHLFAEVSDSMSLEAFFKGLAVTRAVERLALDGVLDVCLANASFQIRF
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DPDRIAPHVLLEAVRAAEAGAVAERTLQTRIIEIPVLYNDPWTHETLMRFRDRHQDPGST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHCCCCCCC
DLEYAARINNLADVDAFIAAHSGAPWFVSMVGFVAGLPFMFQMVERERQLQVPKYLRPRT
CHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
DTPKHTLGHGGCFGCIYSVRGAGGYQMFGVTPAPIYDPQQKLAYLKEHMVFFRPGDIVQF
CCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEEECCCCEEEE
KPLDRQAYDEAVAEVEAGRFDLLIRPVEFSLDAFLADPVGYPKSLQEVLA
CCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHHC
>Mature Secondary Structure 
ADPIRYSFGADEHLFAEVSDSMSLEAFFKGLAVTRAVERLALDGVLDVCLANASFQIRF
CCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DPDRIAPHVLLEAVRAAEAGAVAERTLQTRIIEIPVLYNDPWTHETLMRFRDRHQDPGST
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHCCCCCCC
DLEYAARINNLADVDAFIAAHSGAPWFVSMVGFVAGLPFMFQMVERERQLQVPKYLRPRT
CHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
DTPKHTLGHGGCFGCIYSVRGAGGYQMFGVTPAPIYDPQQKLAYLKEHMVFFRPGDIVQF
CCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHEEECCCCEEEE
KPLDRQAYDEAVAEVEAGRFDLLIRPVEFSLDAFLADPVGYPKSLQEVLA
CCCCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]