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The map label for this gene is cynR [H]

Identifier: 66045420

GI number: 66045420

Start: 2534124

End: 2535047

Strand: Direct

Name: cynR [H]

Synonym: Psyr_2180

Alternate gene names: 66045420

Gene position: 2534124-2535047 (Clockwise)

Preceding gene: 66045409

Following gene: 66045421

Centisome position: 41.59

GC content: 54.44

Gene sequence:

>924_bases
ATGGATGTCGTTCAACTCAAAACCTTGATTCATGTGGCCGAGCTAGGCAGTCTCAGCAAGGCCTCAGACCGGCTTCACAT
CGCACAACCGGCACTCAGCCGACAAATTCGAATGCTAGAAAAAGAACTCGGCACCTACCTGTTTGATCGGCATGGACGAG
GCATGGAGATTACCGATGCTGGTCGCGAGGTGCTGGCGCATGCCACTCGAATCATGGAAGAAATGGAATCCATTCGAAGT
TCAGTGGTGGGCGGAAAGACCTCTTTTCGGGGAACGGTCGTCATCGGTACGACGCCGACGGTAGCGGAAATTGTCACCGT
TCCTTTAGTGCGCAAAATCAAAGAGGCGCATCCGAATCTTGCCGTCAGGTTTTCCTCGGCCTTCAGCGGTTATCTGCTGG
ATTGGGTTCAGCGTGGCGAATTGGAACTGGCGATTTCTTACGATCCCCAACCCCTGCATACGCTGCGTATCGTGCCGGTG
ATGATGGAAAACTTGCTGCTGGTCGGACCTGCCAGTGCCAAGCTGCGCCTGGATGTGCCGGTGTCATTCGAGTCTTTGGC
CGAGCAGCAGTTGGTGTTGCCAAGCGCCCGCCACAGTCTTCGCGTGATTCTGGATAATTGTGCGCGAGAAGTCGGCATCA
AGCTCAAAACCAGCGTTGAAGCTGACTCCTTCGGCGCGATGATTGACCTGGTTCGTAATGGCTTCGGTTTGACAGCTTTG
CCACTGGCATCAATTTACGCCCAAATCGAAGCTGGTGTGCTCAGTGCCGCCCCCTTGGTTGACCCTATTCCCATGCGCAA
ACTTGTTCAGGTTTTTCCTGCCGACAGGCGTGTCAGTCCGGCTGCCAAATTCGTCGGGGATGCCTTCATCGAAATTGCTG
CCGACCTGGTCAATCGTAAGATTTGGGCTGGGCACATGCTTTGA

Upstream 100 bases:

>100_bases
TGCGACGCGGGCCCTGTGGCATTTCAGGAAACGCTAATGCGTTTACACTCATACTACTTCGACGCATTTCGCGCCGAGCC
CGACTTTGACTGGCCTGGTA

Downstream 100 bases:

>100_bases
GCCAACGGATTCGTTGGCCAGGTGAATCGTTCGTTTAAACGTAATTGCTCAGCTACTCACTCTATCCGCCTTTCTCACCA
CTGATGACATTGTCTTGAAT

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MDVVQLKTLIHVAELGSLSKASDRLHIAQPALSRQIRMLEKELGTYLFDRHGRGMEITDAGREVLAHATRIMEEMESIRS
SVVGGKTSFRGTVVIGTTPTVAEIVTVPLVRKIKEAHPNLAVRFSSAFSGYLLDWVQRGELELAISYDPQPLHTLRIVPV
MMENLLLVGPASAKLRLDVPVSFESLAEQQLVLPSARHSLRVILDNCAREVGIKLKTSVEADSFGAMIDLVRNGFGLTAL
PLASIYAQIEAGVLSAAPLVDPIPMRKLVQVFPADRRVSPAAKFVGDAFIEIAADLVNRKIWAGHML

Sequences:

>Translated_307_residues
MDVVQLKTLIHVAELGSLSKASDRLHIAQPALSRQIRMLEKELGTYLFDRHGRGMEITDAGREVLAHATRIMEEMESIRS
SVVGGKTSFRGTVVIGTTPTVAEIVTVPLVRKIKEAHPNLAVRFSSAFSGYLLDWVQRGELELAISYDPQPLHTLRIVPV
MMENLLLVGPASAKLRLDVPVSFESLAEQQLVLPSARHSLRVILDNCAREVGIKLKTSVEADSFGAMIDLVRNGFGLTAL
PLASIYAQIEAGVLSAAPLVDPIPMRKLVQVFPADRRVSPAAKFVGDAFIEIAADLVNRKIWAGHML
>Mature_307_residues
MDVVQLKTLIHVAELGSLSKASDRLHIAQPALSRQIRMLEKELGTYLFDRHGRGMEITDAGREVLAHATRIMEEMESIRS
SVVGGKTSFRGTVVIGTTPTVAEIVTVPLVRKIKEAHPNLAVRFSSAFSGYLLDWVQRGELELAISYDPQPLHTLRIVPV
MMENLLLVGPASAKLRLDVPVSFESLAEQQLVLPSARHSLRVILDNCAREVGIKLKTSVEADSFGAMIDLVRNGFGLTAL
PLASIYAQIEAGVLSAAPLVDPIPMRKLVQVFPADRRVSPAAKFVGDAFIEIAADLVNRKIWAGHML

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=291, Percent_Identity=30.9278350515464, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788297, Length=307, Percent_Identity=27.0358306188925, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI145693105, Length=296, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790399, Length=272, Percent_Identity=25.7352941176471, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787530, Length=280, Percent_Identity=25.7142857142857, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787601, Length=255, Percent_Identity=26.2745098039216, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788748, Length=283, Percent_Identity=22.6148409893993, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787806, Length=262, Percent_Identity=25.5725190839695, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1790208, Length=173, Percent_Identity=29.4797687861272, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789506, Length=269, Percent_Identity=24.907063197026, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787589, Length=307, Percent_Identity=25.4071661237785, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367136, Length=303, Percent_Identity=25.0825082508251, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788481, Length=284, Percent_Identity=25, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=181, Percent_Identity=25.9668508287293, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786401, Length=303, Percent_Identity=24.7524752475248, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788626, Length=146, Percent_Identity=26.027397260274, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48994962, Length=182, Percent_Identity=26.3736263736264, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082132, Length=282, Percent_Identity=21.2765957446809, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33569; Mature: 33569

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVVQLKTLIHVAELGSLSKASDRLHIAQPALSRQIRMLEKELGTYLFDRHGRGMEITDA
CCHHHHHHHHHHHHHCCCCHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
GREVLAHATRIMEEMESIRSSVVGGKTSFRGTVVIGTTPTVAEIVTVPLVRKIKEAHPNL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCE
AVRFSSAFSGYLLDWVQRGELELAISYDPQPLHTLRIVPVMMENLLLVGPASAKLRLDVP
EEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCEEEECCCCCEEEEECC
VSFESLAEQQLVLPSARHSLRVILDNCAREVGIKLKTSVEADSFGAMIDLVRNGFGLTAL
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCHHH
PLASIYAQIEAGVLSAAPLVDPIPMRKLVQVFPADRRVSPAAKFVGDAFIEIAADLVNRK
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
IWAGHML
HHCCCCC
>Mature Secondary Structure
MDVVQLKTLIHVAELGSLSKASDRLHIAQPALSRQIRMLEKELGTYLFDRHGRGMEITDA
CCHHHHHHHHHHHHHCCCCHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
GREVLAHATRIMEEMESIRSSVVGGKTSFRGTVVIGTTPTVAEIVTVPLVRKIKEAHPNL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCE
AVRFSSAFSGYLLDWVQRGELELAISYDPQPLHTLRIVPVMMENLLLVGPASAKLRLDVP
EEEECCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHCEEEECCCCCEEEEECC
VSFESLAEQQLVLPSARHSLRVILDNCAREVGIKLKTSVEADSFGAMIDLVRNGFGLTAL
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCHHH
PLASIYAQIEAGVLSAAPLVDPIPMRKLVQVFPADRRVSPAAKFVGDAFIEIAADLVNRK
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
IWAGHML
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]