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The map label for this gene is vllY [H]

Identifier: 66045370

GI number: 66045370

Start: 2489489

End: 2491396

Strand: Direct

Name: vllY [H]

Synonym: Psyr_2130

Alternate gene names: 66045370

Gene position: 2489489-2491396 (Clockwise)

Preceding gene: 66045368

Following gene: 66045371

Centisome position: 40.85

GC content: 61.27

Gene sequence:

>1908_bases
ATGCAGCGTTCAATTGCTACCGTATCCTTGAGCGGTACTCTGCCCGAAAAGCTCGAAGCCATCGCCGCAGCCGGCTTTGA
CGGCGTCGAGATTTTCGAAAACGACTTGTTGTATTACGACGGCAGCCCACGCAACATCAGGCAAATGTGTGCCGACCTGG
GCATCGCCATCACCCTGTTCCAGCCGTTCCGCGATTTCGAAGGCTGCCGCCGTGATCGTCTGCAGCGCAATATCGACCGT
GCCGAACGCAAATTCGATCTGATGCAGGAGCTGGGCACCGATCTGGTGCTGGTCTGCAGCAATGCGTCTGCCGATTCGGT
GGGCGACGAAAACATTCTGCTCGATGACCTGGGCCTGCTCGCCGAGCGCGCGGGTGCCCGTCACCTGCGCGTCGGTTATG
AAGCGCTGGCCTGGGGCAAGCACGTGAACACCTGGCAACAGGTCTGGAACCTGGTGCGCCAGGTCGACCACCCGGCACTA
GGCGTGTTGCTCGACAGTTTTCATACCCTGTCGCTGAAGGGCGATCCGAGCGCCATCGCGCAGATCCCGGGCGACAAGAT
CTTCTTCGTGCAGATGGCCGACGCGCCGCTTCTGGCGATGGATGTGCTGGAGTGGAGCCGCCATTTCCGCTGCTTCCCGG
GTCAGGGTGAATTCGATCTGGCCGGCTTCCTCGCGCCGATCCTGCGCAGTGGCTATACCGGGCCGTTGTCGCTGGAAGTG
TTCAACGATGGCTTCCGTGCAGCGCCGACACGCGCCAATGCCGCGGACGGTCTGCGTTCGCTGCTTTATCTTGAAGAGAA
AACCCGCCAGCTGATGGCGCGTGACGAGCCGGCCGCGGTTCCCGAAATCCTCTTCAATCCGCCTGCGGCCAGTACCTACA
ATGGCGTCGAGTTCCTCGAGTTTGCCGTTGACGAGAGCCACGGCGCTCGCCTGTCGGGCTGGCTGCAACGGCTGGGCTTT
GCCAAGCTGGGTCAGCATCGCTCCAAGGCGGTCAGTCTGCTGGGGCAGGGCGATATCAGGATTGTGCTCAATGCCGAACC
CTATTCCTTCGCCCACAGTTTTTTCGAGGCGCACGGCCCTTCGTTGTGCGCCACCGCCTTGCGCGTCGACGACGGTCATC
AGTCGCTGGAACGCGCGCGTGCTTTCAAGGGCCAGCCCTATCGTGGCCTGGTCGGTCCCAATGAACGGGAGATTCCGTCG
GTCCGCGCGCCCGACGGCAGCCTGATCTATCTGGTGGATAACGCCGCACCGGGAGAATCGATTTACGACAGCGATTTTGT
CGTCGATCCGCAAGCCGTCGCCAAGGGCGGGTTGCAGCGTATCGACCACATGGCCATGGCGCTGCCGGCCGACAGTCTGG
ACAGCTGGGTTTTGTTCTACAAAAGCATTCTGGATTTCGAGGCTGACGACGAAGTGGTCTTGCCCGACCCCTACGGCCTG
GTCAAGAGCCGGGCGCTGCGCAGCCGTTGCAGCACCGTGCGCTTGCCGTTGAATATTTCCGAAAATCGCAACACGGCCAT
TTCCCATGCGCTGTCGAGCTATCGCGGCTCGGGTGTGCACCACATCGCATTTTCCTGCGAAGACATCTTTGCCGAGGTAA
GCCGCGCCAAGGAAGCGGGCGTACCGTTGCTGGACATCCCGCTCAACTACTACGATGACCTGGCGGCGCGCTTCGATTTC
GACGAGGAGTTTCTCAGCGAACTGGCGTATTACAACGTGCTCTATGACCGCGATGCGCAGGGTGGCGAGTTGTTCCACGT
CTACACCGATGCGTTCGACGGGCGCTTCTTCTTCGAAATCCTGCAGCGCAAGAACGGTTACGCAGGGTATGGCGCTGCCA
ACGTCCCGGTGCGTCTGGCTGCGATGGCCAAGGCGCGCAATGTGGCAGCACGTCAGGCGCGTCTGTAA

Upstream 100 bases:

>100_bases
TACTTTACTCGCACCTCTGAATAAGGCCGGGAAAGGCCAGGAATGCGGTGCTGTCCAGTCGCGATCCAAGCAGGTCGCGT
TCATCCAGGAGCTGAAAAGC

Downstream 100 bases:

>100_bases
GGCGAATCCGATTGCAGGGCCGCTGCGAGGGTTCGACGCCCTCGCGGCTTCCCTCGGTTGCCGGTCGGCTTCATACTCCG
CGCATCACTCGTGGTCATGA

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPRNIRQMCADLGIAITLFQPFRDFEGCRRDRLQRNIDR
AERKFDLMQELGTDLVLVCSNASADSVGDENILLDDLGLLAERAGARHLRVGYEALAWGKHVNTWQQVWNLVRQVDHPAL
GVLLDSFHTLSLKGDPSAIAQIPGDKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGEFDLAGFLAPILRSGYTGPLSLEV
FNDGFRAAPTRANAADGLRSLLYLEEKTRQLMARDEPAAVPEILFNPPAASTYNGVEFLEFAVDESHGARLSGWLQRLGF
AKLGQHRSKAVSLLGQGDIRIVLNAEPYSFAHSFFEAHGPSLCATALRVDDGHQSLERARAFKGQPYRGLVGPNEREIPS
VRAPDGSLIYLVDNAAPGESIYDSDFVVDPQAVAKGGLQRIDHMAMALPADSLDSWVLFYKSILDFEADDEVVLPDPYGL
VKSRALRSRCSTVRLPLNISENRNTAISHALSSYRGSGVHHIAFSCEDIFAEVSRAKEAGVPLLDIPLNYYDDLAARFDF
DEEFLSELAYYNVLYDRDAQGGELFHVYTDAFDGRFFFEILQRKNGYAGYGAANVPVRLAAMAKARNVAARQARL

Sequences:

>Translated_635_residues
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPRNIRQMCADLGIAITLFQPFRDFEGCRRDRLQRNIDR
AERKFDLMQELGTDLVLVCSNASADSVGDENILLDDLGLLAERAGARHLRVGYEALAWGKHVNTWQQVWNLVRQVDHPAL
GVLLDSFHTLSLKGDPSAIAQIPGDKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGEFDLAGFLAPILRSGYTGPLSLEV
FNDGFRAAPTRANAADGLRSLLYLEEKTRQLMARDEPAAVPEILFNPPAASTYNGVEFLEFAVDESHGARLSGWLQRLGF
AKLGQHRSKAVSLLGQGDIRIVLNAEPYSFAHSFFEAHGPSLCATALRVDDGHQSLERARAFKGQPYRGLVGPNEREIPS
VRAPDGSLIYLVDNAAPGESIYDSDFVVDPQAVAKGGLQRIDHMAMALPADSLDSWVLFYKSILDFEADDEVVLPDPYGL
VKSRALRSRCSTVRLPLNISENRNTAISHALSSYRGSGVHHIAFSCEDIFAEVSRAKEAGVPLLDIPLNYYDDLAARFDF
DEEFLSELAYYNVLYDRDAQGGELFHVYTDAFDGRFFFEILQRKNGYAGYGAANVPVRLAAMAKARNVAARQARL
>Mature_635_residues
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPRNIRQMCADLGIAITLFQPFRDFEGCRRDRLQRNIDR
AERKFDLMQELGTDLVLVCSNASADSVGDENILLDDLGLLAERAGARHLRVGYEALAWGKHVNTWQQVWNLVRQVDHPAL
GVLLDSFHTLSLKGDPSAIAQIPGDKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGEFDLAGFLAPILRSGYTGPLSLEV
FNDGFRAAPTRANAADGLRSLLYLEEKTRQLMARDEPAAVPEILFNPPAASTYNGVEFLEFAVDESHGARLSGWLQRLGF
AKLGQHRSKAVSLLGQGDIRIVLNAEPYSFAHSFFEAHGPSLCATALRVDDGHQSLERARAFKGQPYRGLVGPNEREIPS
VRAPDGSLIYLVDNAAPGESIYDSDFVVDPQAVAKGGLQRIDHMAMALPADSLDSWVLFYKSILDFEADDEVVLPDPYGL
VKSRALRSRCSTVRLPLNISENRNTAISHALSSYRGSGVHHIAFSCEDIFAEVSRAKEAGVPLLDIPLNYYDDLAARFDF
DEEFLSELAYYNVLYDRDAQGGELFHVYTDAFDGRFFFEILQRKNGYAGYGAANVPVRLAAMAKARNVAARQARL

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=220, Percent_Identity=25, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4504477, Length=220, Percent_Identity=25, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555220, Length=197, Percent_Identity=28.4263959390863, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356105, Length=196, Percent_Identity=29.5918367346939, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24667510, Length=196, Percent_Identity=29.5918367346939, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 70250; Mature: 70250

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPRNIRQMCADLGIAITLF
CCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCEEEECCCCHHHHHHHHHCCEEEEEE
QPFRDFEGCRRDRLQRNIDRAERKFDLMQELGTDLVLVCSNASADSVGDENILLDDLGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHHHH
AERAGARHLRVGYEALAWGKHVNTWQQVWNLVRQVDHPALGVLLDSFHTLSLKGDPSAIA
HHHCCCCEEHHCHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCHHHH
QIPGDKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGEFDLAGFLAPILRSGYTGPLSLEV
CCCCCEEEEEEECCCCHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FNDGFRAAPTRANAADGLRSLLYLEEKTRQLMARDEPAAVPEILFNPPAASTYNGVEFLE
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHH
FAVDESHGARLSGWLQRLGFAKLGQHRSKAVSLLGQGDIRIVLNAEPYSFAHSFFEAHGP
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCC
SLCATALRVDDGHQSLERARAFKGQPYRGLVGPNEREIPSVRAPDGSLIYLVDNAAPGES
HHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
IYDSDFVVDPQAVAKGGLQRIDHMAMALPADSLDSWVLFYKSILDFEADDEVVLPDPYGL
CCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEECCCCHHH
VKSRALRSRCSTVRLPLNISENRNTAISHALSSYRGSGVHHIAFSCEDIFAEVSRAKEAG
HHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCC
VPLLDIPLNYYDDLAARFDFDEEFLSELAYYNVLYDRDAQGGELFHVYTDAFDGRFFFEI
CCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCEEEEEECCCCCHHHHHH
LQRKNGYAGYGAANVPVRLAAMAKARNVAARQARL
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQRSIATVSLSGTLPEKLEAIAAAGFDGVEIFENDLLYYDGSPRNIRQMCADLGIAITLF
CCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCEEEECCCCHHHHHHHHHCCEEEEEE
QPFRDFEGCRRDRLQRNIDRAERKFDLMQELGTDLVLVCSNASADSVGDENILLDDLGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHHHHHH
AERAGARHLRVGYEALAWGKHVNTWQQVWNLVRQVDHPALGVLLDSFHTLSLKGDPSAIA
HHHCCCCEEHHCHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHCCEEEEECCCCHHHH
QIPGDKIFFVQMADAPLLAMDVLEWSRHFRCFPGQGEFDLAGFLAPILRSGYTGPLSLEV
CCCCCEEEEEEECCCCHHHHHHHHHHHCEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEE
FNDGFRAAPTRANAADGLRSLLYLEEKTRQLMARDEPAAVPEILFNPPAASTYNGVEFLE
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHHHH
FAVDESHGARLSGWLQRLGFAKLGQHRSKAVSLLGQGDIRIVLNAEPYSFAHSFFEAHGP
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCC
SLCATALRVDDGHQSLERARAFKGQPYRGLVGPNEREIPSVRAPDGSLIYLVDNAAPGES
HHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCC
IYDSDFVVDPQAVAKGGLQRIDHMAMALPADSLDSWVLFYKSILDFEADDEVVLPDPYGL
CCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEECCCCHHH
VKSRALRSRCSTVRLPLNISENRNTAISHALSSYRGSGVHHIAFSCEDIFAEVSRAKEAG
HHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCC
VPLLDIPLNYYDDLAARFDFDEEFLSELAYYNVLYDRDAQGGELFHVYTDAFDGRFFFEI
CCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCEEEEEECCCCCHHHHHH
LQRKNGYAGYGAANVPVRLAAMAKARNVAARQARL
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA