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The map label for this gene is pyrD [H]

Identifier: 66045346

GI number: 66045346

Start: 2458192

End: 2459223

Strand: Direct

Name: pyrD [H]

Synonym: Psyr_2106

Alternate gene names: 66045346

Gene position: 2458192-2459223 (Clockwise)

Preceding gene: 66045343

Following gene: 66045348

Centisome position: 40.34

GC content: 63.08

Gene sequence:

>1032_bases
ATGTATAACCTGGCCCGCCAGTTACTGTTCAAACTTTCCCCGGAAACCTCTCATGACCTGTCGCTGGACCTGATCGGTGC
AGGCGGACGGCTGGGCCTCAACGGCCTGCTGAGCAAGTCCCCGGCGAAGTTGCCGGTCAGTGTGATGGGCCTTGAGTTTC
CCAACCCCGTGGGGCTGGCAGCCGGCCTGGACAAGAATGGTGCGGCCATCGATGGCTTCGCGCAACTGGGCTTCGGTTTC
GTCGAGATCGGCACGGTGACGCCACGTGCGCAGCCGGGCAATCCCAAGCCGCGTATTTTCCGCCTGCCCAACGCCGAGGC
GATCATCAATCGCATGGGCTTCAACAATCTGGGTGTCGACAACCTGGTGTCCCGTGTCGAAGCGGCAAAGTATCGCGGCG
TTCTGGGCATCAATATCGGCAAGAACTTCGACACGCCGGTCGAGCGCGCGGTCGACGATTACCTGATCTGTCTGGACAAG
GTCTATGCCCATGCCAGCTACGTCACGGTCAACGTCAGTTCGCCCAACACGCCGGGGCTGCGCAGCCTGCAGTTCGGCGA
TTCGCTCAAGCAACTGCTCCAGGCCCTGAGCCTGCGCCAGCAGGAACTGACGCAACGGCATGGCAGGCGTGTGCCGCTGG
CGATCAAGATTGCCCCGGACATGACCGACGAAGAGACCGTGCTGGTCGCTGCTGCGCTGATCGAGTCCGGGATGGACGCA
GTCATTGCCACCAACACCACGCTGAGCCGCCAAGGCGTCGAAGGCCTTCCGCATGCTGATCAGGCGGGCGGTTTATCGGG
CGCGCCGGTTCGGGAAAAAAGCACGCACATCGTCAAGGTTCTGGCCGGTGAGCTCGCGGGTCGTCTGCCGATCATCGCCG
CCGGGGGGATCACCGAAGGCCGGCATGCCGCCGAGAAGATCGCGGCGGGTGCCAGTCTGGTGCAGATCTATTCGGGGTTC
ATCTACAAGGGCCCTGCGCTGATTCGCGAGTCGGTGGATGCCATTGCGGCAATGCCTCGCGCCGCACGCTGA

Upstream 100 bases:

>100_bases
GGGAGGGCGAGCAACAAGTTTGTCGCGCGCCTCGCCTGACAGGCCCGCACACGTCTATAATCGCCACCCTGAATTCAGCT
GCTCACGAGCCCATCCCGCC

Downstream 100 bases:

>100_bases
ACCCGGGGTAAAAAAAGGGGCTCTGCAAGAGAGCCCCTGGGCGTTGGCCCGCCGCCCGGGTCGGGCGTGCATGGTGCAGG
TGTGAATCAGTCAGTCATGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MYNLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLSKSPAKLPVSVMGLEFPNPVGLAAGLDKNGAAIDGFAQLGFGF
VEIGTVTPRAQPGNPKPRIFRLPNAEAIINRMGFNNLGVDNLVSRVEAAKYRGVLGINIGKNFDTPVERAVDDYLICLDK
VYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLQALSLRQQELTQRHGRRVPLAIKIAPDMTDEETVLVAAALIESGMDA
VIATNTTLSRQGVEGLPHADQAGGLSGAPVREKSTHIVKVLAGELAGRLPIIAAGGITEGRHAAEKIAAGASLVQIYSGF
IYKGPALIRESVDAIAAMPRAAR

Sequences:

>Translated_343_residues
MYNLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLSKSPAKLPVSVMGLEFPNPVGLAAGLDKNGAAIDGFAQLGFGF
VEIGTVTPRAQPGNPKPRIFRLPNAEAIINRMGFNNLGVDNLVSRVEAAKYRGVLGINIGKNFDTPVERAVDDYLICLDK
VYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLQALSLRQQELTQRHGRRVPLAIKIAPDMTDEETVLVAAALIESGMDA
VIATNTTLSRQGVEGLPHADQAGGLSGAPVREKSTHIVKVLAGELAGRLPIIAAGGITEGRHAAEKIAAGASLVQIYSGF
IYKGPALIRESVDAIAAMPRAAR
>Mature_343_residues
MYNLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLSKSPAKLPVSVMGLEFPNPVGLAAGLDKNGAAIDGFAQLGFGF
VEIGTVTPRAQPGNPKPRIFRLPNAEAIINRMGFNNLGVDNLVSRVEAAKYRGVLGINIGKNFDTPVERAVDDYLICLDK
VYAHASYVTVNVSSPNTPGLRSLQFGDSLKQLLQALSLRQQELTQRHGRRVPLAIKIAPDMTDEETVLVAAALIESGMDA
VIATNTTLSRQGVEGLPHADQAGGLSGAPVREKSTHIVKVLAGELAGRLPIIAAGGITEGRHAAEKIAAGASLVQIYSGF
IYKGPALIRESVDAIAAMPRAAR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=42.7272727272727, Blast_Score=240, Evalue=2e-63,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=57.910447761194, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17509475, Length=329, Percent_Identity=42.2492401215805, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI281361352, Length=301, Percent_Identity=40.531561461794, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17137316, Length=301, Percent_Identity=40.531561461794, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36207; Mature: 36207

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLSKSPAKLPVSVMGLEFPNPVGLA
CCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCCC
AGLDKNGAAIDGFAQLGFGFVEIGTVTPRAQPGNPKPRIFRLPNAEAIINRMGFNNLGVD
CCCCCCCCEECHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCHH
NLVSRVEAAKYRGVLGINIGKNFDTPVERAVDDYLICLDKVYAHASYVTVNVSSPNTPGL
HHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCC
RSLQFGDSLKQLLQALSLRQQELTQRHGRRVPLAIKIAPDMTDEETVLVAAALIESGMDA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCE
VIATNTTLSRQGVEGLPHADQAGGLSGAPVREKSTHIVKVLAGELAGRLPIIAAGGITEG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC
RHAAEKIAAGASLVQIYSGFIYKGPALIRESVDAIAAMPRAAR
HHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYNLARQLLFKLSPETSHDLSLDLIGAGGRLGLNGLLSKSPAKLPVSVMGLEFPNPVGLA
CCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCEEEEECCCCCCCCCC
AGLDKNGAAIDGFAQLGFGFVEIGTVTPRAQPGNPKPRIFRLPNAEAIINRMGFNNLGVD
CCCCCCCCEECHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHCCCCCCCHH
NLVSRVEAAKYRGVLGINIGKNFDTPVERAVDDYLICLDKVYAHASYVTVNVSSPNTPGL
HHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCC
RSLQFGDSLKQLLQALSLRQQELTQRHGRRVPLAIKIAPDMTDEETVLVAAALIESGMDA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCE
VIATNTTLSRQGVEGLPHADQAGGLSGAPVREKSTHIVKVLAGELAGRLPIIAAGGITEG
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC
RHAAEKIAAGASLVQIYSGFIYKGPALIRESVDAIAAMPRAAR
HHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA