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The map label for this gene is lpxB [H]

Identifier: 66044604

GI number: 66044604

Start: 1536144

End: 1537286

Strand: Direct

Name: lpxB [H]

Synonym: Psyr_1356

Alternate gene names: 66044604

Gene position: 1536144-1537286 (Clockwise)

Preceding gene: 66044603

Following gene: 66044605

Centisome position: 25.21

GC content: 63.34

Gene sequence:

>1143_bases
ATGCCCAGTCCACTCTGTATCGCTCTGGTCGCGGGTGAAGCATCCGGCGATATCCTCGGATCCGGTCTGATGCGTGCCCT
CAAGGTGCGCCATCCCGACATCCGCTTCATTGGTGTCGGCGGTCCGTTGATGGAAGCCGAAGGCATGCAGTCCTCCTTCC
CGATGGAACGCCTGTCGGTGATGGGGCTGGTTGAAGTGCTCGGGCGACTGCGCGAGCTGCTGGCCCGGCGCAAGCTGTTG
GTCCAGACCCTGATCAATGAAAAGCCGGACGTCTTCATCGGCATTGACGCGCCTGACTTCACGCTCAATATCGAACTTCA
GCTACGTCGCGCCGGGATCAAGACTGTGCACTACGTCAGCCCGTCGGTCTGGGCCTGGCGTCAGAAGCGTGTGCTGAAGA
TTCGTGAAGGCTGTGACCTGATGCTGACCCTGTTGCCATTCGAAGCGCGTTTCTACGAAGAGCAGGGCGTACCGGTGCGT
TTTGTCGGTCATCCGCTGGCAGACACAATTCCTCTGGAGTCTGATCGTGCAGGTGCTCGCGCAGGCCTGGGATTGGCGCA
GGAGACGCCGGTTGTCGCGCTGATGCCGGGCAGCCGGGGCGGTGAAGTGGGGCGTCTGGGCGGGTTGTTTTTCGACACGG
CCGAGCGGCTGCTTGCCCGGTGCCCAGAGCTGCGCTTCGTACTGCCCTGCGCCAGCCCGCAGCGACGGGCTCAGGTGGAG
CAGTTGCTGCAGGGGCGTGATCTGCCCGTCACGCTGCTCGACGGCCAGTCGCATGTTGCTCTGGCCGCGTGCGATGCGGT
ACTGATCGCCTCCGGCACCGCGACCCTGGAGGCGCTGCTTTACAAGCGCCCCATGGTAGTTGCCTATCGCCTGGCGCCGC
TGACCTTCTGGATACTCAAGCGAATGGTCAAAAGCCCTTACGTGTCGCTGCCGAACCTGCTGGCCCAGCGTCTGCTGGTG
CCTGAGCTGCTGCAGGACGACGCTACGCCAGAAGCCCTGGCGCGTACGCTGCTGCCATTGATCGACGACGGTCGCGAGCA
AACCGCCGGTTTTGATGCCATTCACCGGATCCTGCGCCGCGATGCGTCCAATCAGGCCGCCGATGCGGTATTGAGCCTGC
TCGGACGGTCGCCTTCACTGTGA

Upstream 100 bases:

>100_bases
AGGCGCTGGCCGATCTGGCAGAGCCTGCGGCGCAGTTTCCTGAAGTGGCCGTATTTCTTCAGTCCATTCAGACGTCGACC
CGCGGCATCATTCGCTAACC

Downstream 100 bases:

>100_bases
GGTCGCCCATGATGCAAACAGGTCTGGATTTTACCCTCGTCGAGGACCTGGTGGCGGGTGTTGATGAAGTGGGTCGCGGC
CCGCTGTGCGGTGCCGTGGT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MPSPLCIALVAGEASGDILGSGLMRALKVRHPDIRFIGVGGPLMEAEGMQSSFPMERLSVMGLVEVLGRLRELLARRKLL
VQTLINEKPDVFIGIDAPDFTLNIELQLRRAGIKTVHYVSPSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEQGVPVR
FVGHPLADTIPLESDRAGARAGLGLAQETPVVALMPGSRGGEVGRLGGLFFDTAERLLARCPELRFVLPCASPQRRAQVE
QLLQGRDLPVTLLDGQSHVALAACDAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRMVKSPYVSLPNLLAQRLLV
PELLQDDATPEALARTLLPLIDDGREQTAGFDAIHRILRRDASNQAADAVLSLLGRSPSL

Sequences:

>Translated_380_residues
MPSPLCIALVAGEASGDILGSGLMRALKVRHPDIRFIGVGGPLMEAEGMQSSFPMERLSVMGLVEVLGRLRELLARRKLL
VQTLINEKPDVFIGIDAPDFTLNIELQLRRAGIKTVHYVSPSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEQGVPVR
FVGHPLADTIPLESDRAGARAGLGLAQETPVVALMPGSRGGEVGRLGGLFFDTAERLLARCPELRFVLPCASPQRRAQVE
QLLQGRDLPVTLLDGQSHVALAACDAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRMVKSPYVSLPNLLAQRLLV
PELLQDDATPEALARTLLPLIDDGREQTAGFDAIHRILRRDASNQAADAVLSLLGRSPSL
>Mature_379_residues
PSPLCIALVAGEASGDILGSGLMRALKVRHPDIRFIGVGGPLMEAEGMQSSFPMERLSVMGLVEVLGRLRELLARRKLLV
QTLINEKPDVFIGIDAPDFTLNIELQLRRAGIKTVHYVSPSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEQGVPVRF
VGHPLADTIPLESDRAGARAGLGLAQETPVVALMPGSRGGEVGRLGGLFFDTAERLLARCPELRFVLPCASPQRRAQVEQ
LLQGRDLPVTLLDGQSHVALAACDAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILKRMVKSPYVSLPNLLAQRLLVP
ELLQDDATPEALARTLLPLIDDGREQTAGFDAIHRILRRDASNQAADAVLSLLGRSPSL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=375, Percent_Identity=53.8666666666667, Blast_Score=374, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41591; Mature: 41460

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPLCIALVAGEASGDILGSGLMRALKVRHPDIRFIGVGGPLMEAEGMQSSFPMERLSV
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
MGLVEVLGRLRELLARRKLLVQTLINEKPDVFIGIDAPDFTLNIELQLRRAGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEEECCCCCEEEECC
PSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEQGVPVRFVGHPLADTIPLESDRAGAR
CCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCH
AGLGLAQETPVVALMPGSRGGEVGRLGGLFFDTAERLLARCPELRFVLPCASPQRRAQVE
HCCCCCCCCCEEEECCCCCCCCCHHHCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
QLLQGRDLPVTLLDGQSHVALAACDAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILK
HHHCCCCCCEEEECCCCCEEHHHHCCCEEECCHHHHHHHHHCCCHHEEHHHHHHHHHHHH
RMVKSPYVSLPNLLAQRLLVPELLQDDATPEALARTLLPLIDDGREQTAGFDAIHRILRR
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHH
DASNQAADAVLSLLGRSPSL
CCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PSPLCIALVAGEASGDILGSGLMRALKVRHPDIRFIGVGGPLMEAEGMQSSFPMERLSV
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
MGLVEVLGRLRELLARRKLLVQTLINEKPDVFIGIDAPDFTLNIELQLRRAGIKTVHYVS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEEEEECCCCCEEEECC
PSVWAWRQKRVLKIREGCDLMLTLLPFEARFYEEQGVPVRFVGHPLADTIPLESDRAGAR
CCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCH
AGLGLAQETPVVALMPGSRGGEVGRLGGLFFDTAERLLARCPELRFVLPCASPQRRAQVE
HCCCCCCCCCEEEECCCCCCCCCHHHCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHH
QLLQGRDLPVTLLDGQSHVALAACDAVLIASGTATLEALLYKRPMVVAYRLAPLTFWILK
HHHCCCCCCEEEECCCCCEEHHHHCCCEEECCHHHHHHHHHCCCHHEEHHHHHHHHHHHH
RMVKSPYVSLPNLLAQRLLVPELLQDDATPEALARTLLPLIDDGREQTAGFDAIHRILRR
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHH
DASNQAADAVLSLLGRSPSL
CCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA