Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 66044597

GI number: 66044597

Start: 1528101

End: 1529291

Strand: Direct

Name: dxr [H]

Synonym: Psyr_1349

Alternate gene names: 66044597

Gene position: 1528101-1529291 (Clockwise)

Preceding gene: 66044596

Following gene: 66044598

Centisome position: 25.08

GC content: 62.13

Gene sequence:

>1191_bases
GTGAGTGGTCCGCAACAAATCTCCATTCTGGGCGCAACCGGTTCCATAGGGCTGAGCACTCTGGACGTGGTTGCCCGTCA
TCCAGCGCTTTATCAAGTGTTCGCGCTCACAGGCTTCAGTCGTCTGGATGAATTGCTGGCCTTGTGCATCAGGCACACAC
CGCAGTACGCCGTAGTGCCGGATCAGGTGGTCGCTCGCAAACTGCAGGACGACCTGGCAGCGGCCGGGCTCGATACCCGG
GTGCTGGTCGGCGAGGGCGGTCTGTGCGAAGTGGCCGCAGATCCTCGGGTCGATGCAGTCATGGCCGCCATTGTCGGGGC
TGCCGGCTTGCGCCCGACGCTGGCTGCGGTAGAGGCGGGCAAGAAGGTATTGCTGGCCAACAAGGAAGCGCTGGTCATGT
CCGGCGCCCTGTTCATGCAGGCTGTTCGGCAAAATGGCGCTGTGCTGTTGCCGATCGACAGCGAGCACAATGCGATCTTC
CAGTGCCTGCCCGGCGATTTCGCTCGCGGGCTGGGTGCCGTTGGCGTCCGGCGGATCATGTTGACTGCCTCGGGCGGGCC
GTTTCGCGAAACGCCGCTGGAGCAGTTGCACAACGTCACGCCTGAGCAGGCCTGTGCCCATCCGGTCTGGTCGATGGGGC
GCAAGATCTCCGTCGATTCGGCAACCATGATGAACAAGGGGCTTGAGCTCATCGAAGCCTGCTGGCTGTTCGATGCGCGG
CCGGATCAGGTCGAGGTGGTCATTCACCCGCAAAGCGTGATCCACTCGCTGGTCGATTATGTCGATGGCTCGGTGCTGGC
TCAATTGGGCAATCCCGACATGCGTACGCCCATCGCCAATGCATTGGCATGGCCTGCGCGTGTAGACTCTGGCGTTGCGC
CACTGGACCTGTTTCGTATCGGTCAGCTTGATTTTCAGGCGCCGGACGAGGAGCGATTCCCTTGTCTGCGGCTGGCCCGA
CAGGCGGCAGAGGCTGGAGGCAGTGCACCTGCCATGCTCAACGCGGCCAATGAAGTGGCCGTCGCGGCATTCCTCGATGG
GCGTATCCGCTACCTGGAAATCGCCGGTATTATCGAAGAGGTTCTGGATCATGAGCCTGTCACCGCGGTCGAAGGGCTCG
AAGCGGTGTTCGCCGCCGATGCAAAAGCGCGTTTGCTGGCGGGCCAATGGTTTGAAAGACACGGGCGATAG

Upstream 100 bases:

>100_bases
TGCTGCCTGGACACGGCGGGGTACTGGACCGCATCGACAGCCTGACGGCGGCCATTCCGGTATTTGCCGTTCTGCTCTGG
GCCGCTGACTGGGGTGTCAT

Downstream 100 bases:

>100_bases
CGATCTGACAACCCGTCAGGATGTGAGTGAAAGGGTTGATGTGGTGCGTCAACGGCGGGCCTGGAGGCCTGCAATGATTA
ACACACTGGCCGACCAGTCG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSGPQQISILGATGSIGLSTLDVVARHPALYQVFALTGFSRLDELLALCIRHTPQYAVVPDQVVARKLQDDLAAAGLDTR
VLVGEGGLCEVAADPRVDAVMAAIVGAAGLRPTLAAVEAGKKVLLANKEALVMSGALFMQAVRQNGAVLLPIDSEHNAIF
QCLPGDFARGLGAVGVRRIMLTASGGPFRETPLEQLHNVTPEQACAHPVWSMGRKISVDSATMMNKGLELIEACWLFDAR
PDQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPARVDSGVAPLDLFRIGQLDFQAPDEERFPCLRLAR
QAAEAGGSAPAMLNAANEVAVAAFLDGRIRYLEIAGIIEEVLDHEPVTAVEGLEAVFAADAKARLLAGQWFERHGR

Sequences:

>Translated_396_residues
MSGPQQISILGATGSIGLSTLDVVARHPALYQVFALTGFSRLDELLALCIRHTPQYAVVPDQVVARKLQDDLAAAGLDTR
VLVGEGGLCEVAADPRVDAVMAAIVGAAGLRPTLAAVEAGKKVLLANKEALVMSGALFMQAVRQNGAVLLPIDSEHNAIF
QCLPGDFARGLGAVGVRRIMLTASGGPFRETPLEQLHNVTPEQACAHPVWSMGRKISVDSATMMNKGLELIEACWLFDAR
PDQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPARVDSGVAPLDLFRIGQLDFQAPDEERFPCLRLAR
QAAEAGGSAPAMLNAANEVAVAAFLDGRIRYLEIAGIIEEVLDHEPVTAVEGLEAVFAADAKARLLAGQWFERHGR
>Mature_395_residues
SGPQQISILGATGSIGLSTLDVVARHPALYQVFALTGFSRLDELLALCIRHTPQYAVVPDQVVARKLQDDLAAAGLDTRV
LVGEGGLCEVAADPRVDAVMAAIVGAAGLRPTLAAVEAGKKVLLANKEALVMSGALFMQAVRQNGAVLLPIDSEHNAIFQ
CLPGDFARGLGAVGVRRIMLTASGGPFRETPLEQLHNVTPEQACAHPVWSMGRKISVDSATMMNKGLELIEACWLFDARP
DQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPARVDSGVAPLDLFRIGQLDFQAPDEERFPCLRLARQ
AAEAGGSAPAMLNAANEVAVAAFLDGRIRYLEIAGIIEEVLDHEPVTAVEGLEAVFAADAKARLLAGQWFERHGR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=55.8375634517767, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42146; Mature: 42015

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPQQISILGATGSIGLSTLDVVARHPALYQVFALTGFSRLDELLALCIRHTPQYAVVP
CCCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
DQVVARKLQDDLAAAGLDTRVLVGEGGLCEVAADPRVDAVMAAIVGAAGLRPTLAAVEAG
HHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCC
KKVLLANKEALVMSGALFMQAVRQNGAVLLPIDSEHNAIFQCLPGDFARGLGAVGVRRIM
CEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHEEEE
LTASGGPFRETPLEQLHNVTPEQACAHPVWSMGRKISVDSATMMNKGLELIEACWLFDAR
EEECCCCCCCCHHHHHHCCCHHHHHCCHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCC
PDQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPARVDSGVAPLDLFRI
CCCEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHCCHHCCCCCCCHHHHEE
GQLDFQAPDEERFPCLRLARQAAEAGGSAPAMLNAANEVAVAAFLDGRIRYLEIAGIIEE
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCHHEEEEECCCCEEEHHHHHHHHH
VLDHEPVTAVEGLEAVFAADAKARLLAGQWFERHGR
HHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGPQQISILGATGSIGLSTLDVVARHPALYQVFALTGFSRLDELLALCIRHTPQYAVVP
CCCCEEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
DQVVARKLQDDLAAAGLDTRVLVGEGGLCEVAADPRVDAVMAAIVGAAGLRPTLAAVEAG
HHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCC
KKVLLANKEALVMSGALFMQAVRQNGAVLLPIDSEHNAIFQCLPGDFARGLGAVGVRRIM
CEEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHEEEE
LTASGGPFRETPLEQLHNVTPEQACAHPVWSMGRKISVDSATMMNKGLELIEACWLFDAR
EEECCCCCCCCHHHHHHCCCHHHHHCCHHHHCCCEECCCHHHHHHHHHHHHHHHHHCCCC
PDQVEVVIHPQSVIHSLVDYVDGSVLAQLGNPDMRTPIANALAWPARVDSGVAPLDLFRI
CCCEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHCCHHCCCCCCCHHHHEE
GQLDFQAPDEERFPCLRLARQAAEAGGSAPAMLNAANEVAVAAFLDGRIRYLEIAGIIEE
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCHHEEEEECCCCEEEHHHHHHHHH
VLDHEPVTAVEGLEAVFAADAKARLLAGQWFERHGR
HHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA