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The map label for this gene is thrC [H]

Identifier: 66044539

GI number: 66044539

Start: 1456278

End: 1457687

Strand: Direct

Name: thrC [H]

Synonym: Psyr_1291

Alternate gene names: 66044539

Gene position: 1456278-1457687 (Clockwise)

Preceding gene: 66044538

Following gene: 66044540

Centisome position: 23.9

GC content: 58.79

Gene sequence:

>1410_bases
ATGCGCTATATCAGTACTCGCGGGCAAGCGCCTGCATTGAATTTCGAAGACGTGCTGTTGACTGGTCTGGCCAGCGATGG
TGGCCTCTATGTGCCGGAAAACCTGCCGCGCTTCACGCAGGAAGAGATCGCTTCCTGGGCAGGTCTGCCTTATCACGAAC
TCGCCTTCCGGGTGATGCGCCCCTTCGTGGCGGGCAGCATTCCGGATGCCGACTTCAAAAAGATTCTCGAAGAGACCTAC
GGCGTGTTTGCCCACAGTGCTGTTGCGCCGCTGCGCCAGCTGCATGGCAACGAGTGGGTACTCGAACTGTTCCATGGCCC
GACGCTGGCGTTCAAGGACTTCGCACTGCAACTGCTCGGCCGCCTGCTTGACTATATTCTGGCCAAGCGTGGCCAGCGTG
TCGTGATCATCGGTGCAACCTCGGGCGACACCGGTTCTGCGGCCATCGAAGGCTGCCGTCGCTGCGACAACGTCGACATC
TTCATCCTGCACCCGAACAACCGGGTGTCCGATGTACAACGTCGGCAGATGACCACTATCTTCGGTGACAACATCCATAA
CATCGCAGTCGAAGGCAACTTCGACGACTGCCAGGAAATGGTCAAGGCCAGCTTCGCTGACCAGAGCTTCTTGAAGGGCA
CACCGTTGGTCGCGGTCAACTCGATCAACTGGGCGCGGATCATGGCTCAGATCGTCTACTACTTCCACGCGTCGCTGCAG
TTGGGCGGACCTGCGCGTTCGGTATCGTTCTCGGTACCGACCGGTAATTTCGGCGATATCTTTGCCGGTTATCTGGCGCG
CAATATGGGCCTGCCGATCAATCAGTTGATCGTTGCCACCAACCGCAACGACATCCTGCACCGCTTCATGAGCGGCAATC
AGTACGTCAAGGAAACCCTGCACGCCACGCTGTCGCCTTCCATGGACATCATGGTGTCGTCCAACTTCGAGCGCCTGCTG
TTCGACATGCACGGTCGCAACGGCGCTGCCATTGCCGAGTTGATGAGCACGTTCCGCCAGGGTGGCGGTTTCAGCGTCGA
GGAAGAGCGCTGGACCGAGACCCGCAAACTGTTCGATTCGCTGGCAGTCAGTGACGAGGACACCTGCACGACCATCGCCG
AAGTGTTCGCCAGCACTGGCGAGTTGCTCGACCCGCATACCGCTATCGGGGTGAAGGCTGCGCGTGAATGCCGACGCAGT
CTGGACACGCCGATGGTGATTCTGGGCACCGCGCATCCGGTCAAGTTTCCGGAAGCGGTTGAGAAAGCCGGTGTAGGAAA
AGCGCTTGAACTACCTGCACATTTGTCTGATTTGTTCGAGCGCGACGAGCGCTGTACGGTTCTGCCAAATGACCTGAAAG
CCATACAGGCGTTTGTCAGCCAGCACGGCAATCGCGGCAAACCGCTCTGA

Upstream 100 bases:

>100_bases
GCGGCAAGCGGTCAGCTACAAGCTACAAGTCAGACGCCGATCGTTTTGGACTTGCAGCTTGCAGCTTCCAGCTTGCAGCT
CGAACCGAAGGTTTGATCCC

Downstream 100 bases:

>100_bases
CAGAAGCGTTGTGTAACAACTTTAGGCCCGCCATCTGGCGGGCCTTTCTGTTTCTACGTGCCAAACTTCGCTGGTTTTTC
GAACCATAGAGTCGGGTCAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRYISTRGQAPALNFEDVLLTGLASDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMRPFVAGSIPDADFKKILEETY
GVFAHSAVAPLRQLHGNEWVLELFHGPTLAFKDFALQLLGRLLDYILAKRGQRVVIIGATSGDTGSAAIEGCRRCDNVDI
FILHPNNRVSDVQRRQMTTIFGDNIHNIAVEGNFDDCQEMVKASFADQSFLKGTPLVAVNSINWARIMAQIVYYFHASLQ
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETLHATLSPSMDIMVSSNFERLL
FDMHGRNGAAIAELMSTFRQGGGFSVEEERWTETRKLFDSLAVSDEDTCTTIAEVFASTGELLDPHTAIGVKAARECRRS
LDTPMVILGTAHPVKFPEAVEKAGVGKALELPAHLSDLFERDERCTVLPNDLKAIQAFVSQHGNRGKPL

Sequences:

>Translated_469_residues
MRYISTRGQAPALNFEDVLLTGLASDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMRPFVAGSIPDADFKKILEETY
GVFAHSAVAPLRQLHGNEWVLELFHGPTLAFKDFALQLLGRLLDYILAKRGQRVVIIGATSGDTGSAAIEGCRRCDNVDI
FILHPNNRVSDVQRRQMTTIFGDNIHNIAVEGNFDDCQEMVKASFADQSFLKGTPLVAVNSINWARIMAQIVYYFHASLQ
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETLHATLSPSMDIMVSSNFERLL
FDMHGRNGAAIAELMSTFRQGGGFSVEEERWTETRKLFDSLAVSDEDTCTTIAEVFASTGELLDPHTAIGVKAARECRRS
LDTPMVILGTAHPVKFPEAVEKAGVGKALELPAHLSDLFERDERCTVLPNDLKAIQAFVSQHGNRGKPL
>Mature_469_residues
MRYISTRGQAPALNFEDVLLTGLASDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMRPFVAGSIPDADFKKILEETY
GVFAHSAVAPLRQLHGNEWVLELFHGPTLAFKDFALQLLGRLLDYILAKRGQRVVIIGATSGDTGSAAIEGCRRCDNVDI
FILHPNNRVSDVQRRQMTTIFGDNIHNIAVEGNFDDCQEMVKASFADQSFLKGTPLVAVNSINWARIMAQIVYYFHASLQ
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETLHATLSPSMDIMVSSNFERLL
FDMHGRNGAAIAELMSTFRQGGGFSVEEERWTETRKLFDSLAVSDEDTCTTIAEVFASTGELLDPHTAIGVKAARECRRS
LDTPMVILGTAHPVKFPEAVEKAGVGKALELPAHLSDLFERDERCTVLPNDLKAIQAFVSQHGNRGKPL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=457, Percent_Identity=37.199124726477, Blast_Score=305, Evalue=8e-83,
Organism=Homo sapiens, GI153792148, Length=453, Percent_Identity=35.5408388520971, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI1786185, Length=463, Percent_Identity=33.6933045356371, Blast_Score=236, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6319901, Length=460, Percent_Identity=42.8260869565217, Blast_Score=358, Evalue=1e-100,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 51748; Mature: 51748

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYISTRGQAPALNFEDVLLTGLASDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMR
CCCCCCCCCCCCCCHHHHHHEEECCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
PFVAGSIPDADFKKILEETYGVFAHSAVAPLRQLHGNEWVLELFHGPTLAFKDFALQLLG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
RLLDYILAKRGQRVVIIGATSGDTGSAAIEGCRRCDNVDIFILHPNNRVSDVQRRQMTTI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
FGDNIHNIAVEGNFDDCQEMVKASFADQSFLKGTPLVAVNSINWARIMAQIVYYFHASLQ
HCCCCEEEEEECCHHHHHHHHHHHHCCHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHE
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETL
ECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHEEEECCCHHHHHHHHCCCHHHHHHH
HATLSPSMDIMVSSNFERLLFDMHGRNGAAIAELMSTFRQGGGFSVEEERWTETRKLFDS
HHHCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVSDEDTCTTIAEVFASTGELLDPHTAIGVKAARECRRSLDTPMVILGTAHPVKFPEAV
HCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
EKAGVGKALELPAHLSDLFERDERCTVLPNDLKAIQAFVSQHGNRGKPL
HHCCCCCCEECCHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRYISTRGQAPALNFEDVLLTGLASDGGLYVPENLPRFTQEEIASWAGLPYHELAFRVMR
CCCCCCCCCCCCCCHHHHHHEEECCCCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
PFVAGSIPDADFKKILEETYGVFAHSAVAPLRQLHGNEWVLELFHGPTLAFKDFALQLLG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
RLLDYILAKRGQRVVIIGATSGDTGSAAIEGCRRCDNVDIFILHPNNRVSDVQRRQMTTI
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
FGDNIHNIAVEGNFDDCQEMVKASFADQSFLKGTPLVAVNSINWARIMAQIVYYFHASLQ
HCCCCEEEEEECCHHHHHHHHHHHHCCHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHE
LGGPARSVSFSVPTGNFGDIFAGYLARNMGLPINQLIVATNRNDILHRFMSGNQYVKETL
ECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHEEEECCCHHHHHHHHCCCHHHHHHH
HATLSPSMDIMVSSNFERLLFDMHGRNGAAIAELMSTFRQGGGFSVEEERWTETRKLFDS
HHHCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LAVSDEDTCTTIAEVFASTGELLDPHTAIGVKAARECRRSLDTPMVILGTAHPVKFPEAV
HCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHH
EKAGVGKALELPAHLSDLFERDERCTVLPNDLKAIQAFVSQHGNRGKPL
HHCCCCCCEECCHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]