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The map label for this gene is hom [H]

Identifier: 66044538

GI number: 66044538

Start: 1454782

End: 1456173

Strand: Direct

Name: hom [H]

Synonym: Psyr_1290

Alternate gene names: 66044538

Gene position: 1454782-1456173 (Clockwise)

Preceding gene: 66044537

Following gene: 66044539

Centisome position: 23.87

GC content: 58.55

Gene sequence:

>1392_bases
GTGTCGTCAAAATTTCAGCCGCATGGCGCCATGCGGCAGTTTTTCCACAGCCGATTCAGGTTCGGCTGTTTTTCGGGGAG
TTCATCAGTGAAACCGGTCAAAGTAGGCATATGTGGGCTGGGTACTGTCGGTGGCGGTACCTTCAACGTACTTCAGCGTA
ACGCCGAGGAGATTGCCCGCCGTGCCGGGCGTGGAATCGAAGTGGCGCAAATTGCGGTTCGTACACCAAATCCCAATTGC
CAGATTACCGGTACGCCGACCACCAGCGATGTGTTTGCCATTGCGACCAACCCTGAAATCGACATCGTCGTAGAATTGAT
CGGCGGCTATACCGTTGCCCGCGAACTGGTCCTCAAGGCCATCGAAAACGGCAAGCACGTGGTGACCGCCAACAAGGCGC
TGATCGCGGTGCATGGCAACGAAATCTTCGCCAAGGCGCGTGAGAAGGGCGTGATCGTCGCTTTTGAAGCAGCGGTTGCC
GGTGGCATCCCGGTCATCAAGGCCATTCGTGAAGGCCTGTCGGCGAACCGTATCAACTGGGTTGCCGGCATCATCAACGG
CACCGGCAACTTCATCCTCACCGAAATGCGCGAGAAGGGCCGTACCTTTGCCGATGTTCTGGCCGAAGCTCAGGCCCTGG
GTTATGCCGAAGCCGATCCGACCTTCGACGTTGAAGGTATCGACGCGGCGCACAAACTGACCATTCTGGCATCCATTGCC
TTCGGCATTCCGCTGCAGTTCGACAAGGCCTACACCGAAGGCATTACCAAACTGACCACTGCAGACGTCAATTATGCCGA
AGCGCTGGGCTATCGCATCAAACACCTGGGCGTTGCACGCAGCACGGCTCAAGGCATCGAACTGCGCGTACACCCGACCC
TGATCCCGGCCGATCGCCTGATCGCCAACGTCAACGGCGTCATGAATGCCGTGATGGTCAATGGCGATGCGTCCGGCTCG
ACGCTGTTCTACGGCGCGGGTGCCGGTATGGAGCCTACCGCGTCTTCGGTGGTGGCCGATCTGGTCGATGTGGTCCGTGC
GATGACCTCCGATCCGGAAAACCGGGTCCCTCATCTGGCCTTCCAGCCCGATTCGTTGTCCGCCCACCCGATCCTGCCGA
TCGAAGCCTGCGAAAGCGCCTACTACCTGCGCATTCAGGCCAAGGATCACCCGGGTGTGCTGGCTCAGGTCGCGAGCATC
CTGTCCGAGCGCGGCATCAACATCGAATCGATCATGCAAAAGGATGTCGAAGAACACGATGGCCTGGTGCCGATGATCCT
GTTGACCCACCGGGTAGTGGAGCAGCGTATCAATGACGCCATTCAAGCCCTGGAAGCGTTGCAGGATGTGGTGGGCCCGG
TAGTCCGTATTCGCGTCGAACATCTTAATTAA

Upstream 100 bases:

>100_bases
GGTTATCAGCCTGCGGCTCAGGTTGCCAAGCTGGCATTGAGCGCCAAATAAACCGGTGTTTTCAGGCGCGCCTTGTGCAA
ACAGGGGGCAAGTGGCCGAA

Downstream 100 bases:

>100_bases
GGCAGCGGCAAGCGGTCAGCTACAAGCTACAAGTCAGACGCCGATCGTTTTGGACTTGCAGCTTGCAGCTTCCAGCTTGC
AGCTCGAACCGAAGGTTTGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSSKFQPHGAMRQFFHSRFRFGCFSGSSSVKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAVRTPNPNC
QITGTPTTSDVFAIATNPEIDIVVELIGGYTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVA
GGIPVIKAIREGLSANRINWVAGIINGTGNFILTEMREKGRTFADVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIA
FGIPLQFDKAYTEGITKLTTADVNYAEALGYRIKHLGVARSTAQGIELRVHPTLIPADRLIANVNGVMNAVMVNGDASGS
TLFYGAGAGMEPTASSVVADLVDVVRAMTSDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASI
LSERGINIESIMQKDVEEHDGLVPMILLTHRVVEQRINDAIQALEALQDVVGPVVRIRVEHLN

Sequences:

>Translated_463_residues
MSSKFQPHGAMRQFFHSRFRFGCFSGSSSVKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAVRTPNPNC
QITGTPTTSDVFAIATNPEIDIVVELIGGYTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVA
GGIPVIKAIREGLSANRINWVAGIINGTGNFILTEMREKGRTFADVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIA
FGIPLQFDKAYTEGITKLTTADVNYAEALGYRIKHLGVARSTAQGIELRVHPTLIPADRLIANVNGVMNAVMVNGDASGS
TLFYGAGAGMEPTASSVVADLVDVVRAMTSDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASI
LSERGINIESIMQKDVEEHDGLVPMILLTHRVVEQRINDAIQALEALQDVVGPVVRIRVEHLN
>Mature_462_residues
SSKFQPHGAMRQFFHSRFRFGCFSGSSSVKPVKVGICGLGTVGGGTFNVLQRNAEEIARRAGRGIEVAQIAVRTPNPNCQ
ITGTPTTSDVFAIATNPEIDIVVELIGGYTVARELVLKAIENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAG
GIPVIKAIREGLSANRINWVAGIINGTGNFILTEMREKGRTFADVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIAF
GIPLQFDKAYTEGITKLTTADVNYAEALGYRIKHLGVARSTAQGIELRVHPTLIPADRLIANVNGVMNAVMVNGDASGST
LFYGAGAGMEPTASSVVADLVDVVRAMTSDPENRVPHLAFQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASIL
SERGINIESIMQKDVEEHDGLVPMILLTHRVVEQRINDAIQALEALQDVVGPVVRIRVEHLN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322599, Length=166, Percent_Identity=30.7228915662651, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 49475; Mature: 49344

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00318 HMG_COA_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKFQPHGAMRQFFHSRFRFGCFSGSSSVKPVKVGICGLGTVGGGTFNVLQRNAEEIAR
CCCCCCCCHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHCCHHHHHH
RAGRGIEVAQIAVRTPNPNCQITGTPTTSDVFAIATNPEIDIVVELIGGYTVARELVLKA
HCCCCCEEEEEEEECCCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHH
IENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINW
HHCCCEEEEECCEEEEEECCHHHHHHCCCCEEEEEECHHHCCCHHHHHHHCCCCCCCEEE
VAGIINGTGNFILTEMREKGRTFADVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIA
EEEEECCCCCEEEHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGIPLQFDKAYTEGITKLTTADVNYAEALGYRIKHLGVARSTAQGIELRVHPTLIPADRL
HCCCEEECHHHHHCCCEEEECCCCHHHHHHHHHHHHCCHHCCCCCEEEEEECCCCCHHHH
IANVNGVMNAVMVNGDASGSTLFYGAGAGMEPTASSVVADLVDVVRAMTSDPENRVPHLA
HHHHHHHEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
FQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASILSERGINIESIMQKDVEEHD
ECCCCCCCCCCCCHHHCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GLVPMILLTHRVVEQRINDAIQALEALQDVVGPVVRIRVEHLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
>Mature Secondary Structure 
SSKFQPHGAMRQFFHSRFRFGCFSGSSSVKPVKVGICGLGTVGGGTFNVLQRNAEEIAR
CCCCCCCHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHCCHHHHHH
RAGRGIEVAQIAVRTPNPNCQITGTPTTSDVFAIATNPEIDIVVELIGGYTVARELVLKA
HCCCCCEEEEEEEECCCCCEEEEECCCCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHH
IENGKHVVTANKALIAVHGNEIFAKAREKGVIVAFEAAVAGGIPVIKAIREGLSANRINW
HHCCCEEEEECCEEEEEECCHHHHHHCCCCEEEEEECHHHCCCHHHHHHHCCCCCCCEEE
VAGIINGTGNFILTEMREKGRTFADVLAEAQALGYAEADPTFDVEGIDAAHKLTILASIA
EEEEECCCCCEEEHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FGIPLQFDKAYTEGITKLTTADVNYAEALGYRIKHLGVARSTAQGIELRVHPTLIPADRL
HCCCEEECHHHHHCCCEEEECCCCHHHHHHHHHHHHCCHHCCCCCEEEEEECCCCCHHHH
IANVNGVMNAVMVNGDASGSTLFYGAGAGMEPTASSVVADLVDVVRAMTSDPENRVPHLA
HHHHHHHEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
FQPDSLSAHPILPIEACESAYYLRIQAKDHPGVLAQVASILSERGINIESIMQKDVEEHD
ECCCCCCCCCCCCHHHCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHC
GLVPMILLTHRVVEQRINDAIQALEALQDVVGPVVRIRVEHLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]