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The map label for this gene is hlyB [H]

Identifier: 66044123

GI number: 66044123

Start: 989205

End: 990845

Strand: Direct

Name: hlyB [H]

Synonym: Psyr_0868

Alternate gene names: 66044123

Gene position: 989205-990845 (Clockwise)

Preceding gene: 66044120

Following gene: 66044126

Centisome position: 16.23

GC content: 59.35

Gene sequence:

>1641_bases
ATGAAATGGTTTTACAACGCAAGGCTGTCCGCCAAGCTTTTCATGTCTTTTGCGCTGTGTGCGCTTTTCACCCTTGGGGT
GGGCGTAATAGGCAGTCGCGGCATCAGTGCCTTGTCCAGCAGCCTGGATAACGTGTTTACCAACAGCCTGCTGTCGGTCA
CAAAATCCGGAGAGGTCACGGCCTCGGTCATTGCTCAGAACCGTGATCTCTATCGTTTATTGGCCGCCATGGCAGGCAAT
GCGCCGCAAAGCGTCAAGGACGATATTCTCGCGAGCATGAGCGCCAACAAGACTCAAGCTGAAAAAAGCTACGCCACCTA
CCGGGCTACGCCGCTTGACGATGACGAGCGCGCTGCCGGTGATCAGATGGACAGAGACTGGCCTGGCTATCAGGCACTCA
TCGAGCAAGCCAAAAGCGTTGCCCTGTCCGGGGATATTGCCGGGGCAAGAGCGATCATCGACGGTGATGTACGCAGCGGT
TACCTGAAGGTCATGGATCAGCTGACCACCATAGTCAACTCCAATAATCGTCAGGCGGGCGAGGCCGCTGTGGCTTCTGA
CCAGACACAGAACTCTGCGCAACGAAACCTGTACATCGGCATCGGCTTGTCATTCTTTGCCGCGTTTGTGATGGGCCTGT
TCATAAGTCGTGCCATCAGCACACCAATCAACACTGCGGTGACCAATGCCCGGCGAATTGCCAGCGGTGACCTGACCCTG
CCGATTGCCAGTCAATATCACGACGAAGCCGGCATGATGCTGGTCGCTCTGAGCGATATGCAGGACAACCTGAAAAGCAC
GATCGGGCAAATATCCAGTGCTGCCGACCAGTTGGCCTCGGCTGCTGAAGAACTGAATGCCGTGACTGAAGAAAGCAGTC
GCGGTCTGATCCGTCAGAACGATGAGATTCAGCAGGCCGCTTCGGCTGTGAACGAGATGACCGCTGCGGTCGAAGAGGTC
GCGCGTAACGCCATGTCGACGTCGGAAGCGTCCCGCCAGACCAGTACCGACGCTGCCGCCGGTCGTGATCAGGCCCGCGA
TGCGGTGAATGCGATCAACACCGTCAGTGCCGAGATCAGCAGTTCGACCACCATGGTCGAAGAGCTTGCCGGGCGCGTCC
GTGAGATCGGGCAGGTGCTGGACGTGATCCGTGGGATCGCCGAGCAGACCAACCTGCTGGCCCTCAACGCTGCCATCGAG
GCCGCGCGTGCCGGCGAACAGGGGCGCGGCTTTGCTGTGGTGGCAGACGAGGTGCGGGCGCTGGCCGCTCGAACCCAGGC
GTCCACTGGCGAAATCGAAACCATGATCGGCAGTGTTCAGGCCAGTGCCGATCAGGCCGTGCGGGCCATGGCCAACAGCC
GCACCCTGACCAGCAACACGCAAACCCTGGCTCAGGCCACAGGGCAGTCGCTGGAGCGCATTGCGCAGAGCGTCGCCGAG
ATCAACGACCGCAACATGTTGATTGCGACGGCCTCCGAAGAGCAGTCCCACGTTGCGCGCGAGGTGGATCGCAACCTGGT
CAACATTCAGGACCTCTCCGCCCAGACTGCCGCAGGTGCTCATCAGACCAGTGCTTCAAGCCAGGAACTGTCGCGTCTGG
CCATTTCCTTCAACAATCTGGTAGGCAAGTTCAAGGTCTGA

Upstream 100 bases:

>100_bases
CAGAGTGCTCTGAAAATGCCGAAATACACCTATGCAGAGGGCATCAGAATTCCATAAAGTTTTATGGCGTTATGCCATGT
TCGCTCATGAGGGTTCCGCT

Downstream 100 bases:

>100_bases
CGTAAGTCTCAGGCCGTTGTGTTCGGCAGGCGCTTCTGGAAAAAGAAGCGCTTGTTGCCGGGTGGATAGTCGTCAATCTG
GCCGAACTCGGTGTAACCGT

Product: histidine kinase, HAMP region: chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKWFYNARLSAKLFMSFALCALFTLGVGVIGSRGISALSSSLDNVFTNSLLSVTKSGEVTASVIAQNRDLYRLLAAMAGN
APQSVKDDILASMSANKTQAEKSYATYRATPLDDDERAAGDQMDRDWPGYQALIEQAKSVALSGDIAGARAIIDGDVRSG
YLKVMDQLTTIVNSNNRQAGEAAVASDQTQNSAQRNLYIGIGLSFFAAFVMGLFISRAISTPINTAVTNARRIASGDLTL
PIASQYHDEAGMMLVALSDMQDNLKSTIGQISSAADQLASAAEELNAVTEESSRGLIRQNDEIQQAASAVNEMTAAVEEV
ARNAMSTSEASRQTSTDAAAGRDQARDAVNAINTVSAEISSSTTMVEELAGRVREIGQVLDVIRGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRALAARTQASTGEIETMIGSVQASADQAVRAMANSRTLTSNTQTLAQATGQSLERIAQSVAE
INDRNMLIATASEEQSHVAREVDRNLVNIQDLSAQTAAGAHQTSASSQELSRLAISFNNLVGKFKV

Sequences:

>Translated_546_residues
MKWFYNARLSAKLFMSFALCALFTLGVGVIGSRGISALSSSLDNVFTNSLLSVTKSGEVTASVIAQNRDLYRLLAAMAGN
APQSVKDDILASMSANKTQAEKSYATYRATPLDDDERAAGDQMDRDWPGYQALIEQAKSVALSGDIAGARAIIDGDVRSG
YLKVMDQLTTIVNSNNRQAGEAAVASDQTQNSAQRNLYIGIGLSFFAAFVMGLFISRAISTPINTAVTNARRIASGDLTL
PIASQYHDEAGMMLVALSDMQDNLKSTIGQISSAADQLASAAEELNAVTEESSRGLIRQNDEIQQAASAVNEMTAAVEEV
ARNAMSTSEASRQTSTDAAAGRDQARDAVNAINTVSAEISSSTTMVEELAGRVREIGQVLDVIRGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRALAARTQASTGEIETMIGSVQASADQAVRAMANSRTLTSNTQTLAQATGQSLERIAQSVAE
INDRNMLIATASEEQSHVAREVDRNLVNIQDLSAQTAAGAHQTSASSQELSRLAISFNNLVGKFKV
>Mature_546_residues
MKWFYNARLSAKLFMSFALCALFTLGVGVIGSRGISALSSSLDNVFTNSLLSVTKSGEVTASVIAQNRDLYRLLAAMAGN
APQSVKDDILASMSANKTQAEKSYATYRATPLDDDERAAGDQMDRDWPGYQALIEQAKSVALSGDIAGARAIIDGDVRSG
YLKVMDQLTTIVNSNNRQAGEAAVASDQTQNSAQRNLYIGIGLSFFAAFVMGLFISRAISTPINTAVTNARRIASGDLTL
PIASQYHDEAGMMLVALSDMQDNLKSTIGQISSAADQLASAAEELNAVTEESSRGLIRQNDEIQQAASAVNEMTAAVEEV
ARNAMSTSEASRQTSTDAAAGRDQARDAVNAINTVSAEISSSTTMVEELAGRVREIGQVLDVIRGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRALAARTQASTGEIETMIGSVQASADQAVRAMANSRTLTSNTQTLAQATGQSLERIAQSVAE
INDRNMLIATASEEQSHVAREVDRNLVNIQDLSAQTAAGAHQTSASSQELSRLAISFNNLVGKFKV

Specific function: May form a pore through which the hemolysin can be exported [H]

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI2367378, Length=412, Percent_Identity=29.6116504854369, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788194, Length=564, Percent_Identity=27.6595744680851, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787690, Length=461, Percent_Identity=27.9826464208243, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788195, Length=283, Percent_Identity=33.2155477031802, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1789453, Length=275, Percent_Identity=31.6363636363636, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR000727 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 57723; Mature: 57723

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWFYNARLSAKLFMSFALCALFTLGVGVIGSRGISALSSSLDNVFTNSLLSVTKSGEVT
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
ASVIAQNRDLYRLLAAMAGNAPQSVKDDILASMSANKTQAEKSYATYRATPLDDDERAAG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCHHHHCC
DQMDRDWPGYQALIEQAKSVALSGDIAGARAIIDGDVRSGYLKVMDQLTTIVNSNNRQAG
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCC
EAAVASDQTQNSAQRNLYIGIGLSFFAAFVMGLFISRAISTPINTAVTNARRIASGDLTL
CHHHHCCCCCCHHHCEEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEE
PIASQYHDEAGMMLVALSDMQDNLKSTIGQISSAADQLASAAEELNAVTEESSRGLIRQN
CCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DEIQQAASAVNEMTAAVEEVARNAMSTSEASRQTSTDAAAGRDQARDAVNAINTVSAEIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
SSTTMVEELAGRVREIGQVLDVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEEEHHHHHH
LAARTQASTGEIETMIGSVQASADQAVRAMANSRTLTSNTQTLAQATGQSLERIAQSVAE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
INDRNMLIATASEEQSHVAREVDRNLVNIQDLSAQTAAGAHQTSASSQELSRLAISFNNL
CCCCCEEEEECCCHHHHHHHHHHHHHCCHHHCCHHHHCCCHHCCCHHHHHHHHHHHHHHH
VGKFKV
HHCCCC
>Mature Secondary Structure
MKWFYNARLSAKLFMSFALCALFTLGVGVIGSRGISALSSSLDNVFTNSLLSVTKSGEVT
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
ASVIAQNRDLYRLLAAMAGNAPQSVKDDILASMSANKTQAEKSYATYRATPLDDDERAAG
HHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHEECCCCCCHHHHCC
DQMDRDWPGYQALIEQAKSVALSGDIAGARAIIDGDVRSGYLKVMDQLTTIVNSNNRQAG
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCC
EAAVASDQTQNSAQRNLYIGIGLSFFAAFVMGLFISRAISTPINTAVTNARRIASGDLTL
CHHHHCCCCCCHHHCEEEEEECHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEE
PIASQYHDEAGMMLVALSDMQDNLKSTIGQISSAADQLASAAEELNAVTEESSRGLIRQN
CCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DEIQQAASAVNEMTAAVEEVARNAMSTSEASRQTSTDAAAGRDQARDAVNAINTVSAEIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHH
SSTTMVEELAGRVREIGQVLDVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCEEEEHHHHHH
LAARTQASTGEIETMIGSVQASADQAVRAMANSRTLTSNTQTLAQATGQSLERIAQSVAE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
INDRNMLIATASEEQSHVAREVDRNLVNIQDLSAQTAAGAHQTSASSQELSRLAISFNNL
CCCCCEEEEECCCHHHHHHHHHHHHHCCHHHCCHHHHCCCHHCCCHHHHHHHHHHHHHHH
VGKFKV
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2162464; 10952301 [H]