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The map label for this gene is ggt [H]

Identifier: 66043958

GI number: 66043958

Start: 795237

End: 796964

Strand: Direct

Name: ggt [H]

Synonym: Psyr_0691

Alternate gene names: 66043958

Gene position: 795237-796964 (Clockwise)

Preceding gene: 66043957

Following gene: 66043963

Centisome position: 13.05

GC content: 61.63

Gene sequence:

>1728_bases
ATGAAGTTCGAACCCCTCGCCAGATCGTTGATCGCGACGGCATTGATTGTCGCGTATTCCCCCACATTCGCCGCGTCACA
AGCCCCGGTCGCCGCCGAAAACGGCATGGTCGTCACGGCTCAGCACCTGGCTACCCACGTGGGTGTCGATGTACTCAAGG
CTGGTGGTAATGCGGTCGATGCGGCCGTAGCGGTTGGCTACGCGCTGGCGGTGGTCTATCCCGCTGCCGGCAACCTCGGC
GGTGGCGGGTTCATGACCATTCAGCTGGCCGACGGGCGCAAGACCTTCCTCGACTTCCGTGAAAAGGCGCCGTTGGCCGC
GACTGCGAACATGTACCTGGACAAGGACGGCAAAGTCATCCCTGATCTGAGTGCCAAGGGCCATCTGGCCGTCGGCGTGC
CTGGCACCGTGTCCGGTATGGAAATGGCCCTGAGCAAGTACGGCACCCGCAAGCGTGAAGAAGTCATCGCGCCGGCGATC
AAGCTCGCCGAGGACGGTTTTGTACTGGGCCAGGGCGACGTCGATATGCTGTCGAGCGCCACCGATGTGTTCAAGGCGGA
CATGGCCGATTCCGGTTCGATCTTCCTCGACAAGGGCGAGCCGATGCAGGTCGGTCAGAAGCTGGTGCAGAAAGACCTGG
CCAAGACCCTCAAGGAAGTGTCCGAGAAAGGCAGCGACGGTTTCTACAAGGGCTGGGTTGCCAAGGCGCTGGTCGACTCC
AGTCAGGCTGGCAAGGGCATCATCACCCAGGCGGACCTGGACCATTACAAGACCCGCGAGCTGGCGCCGGTCGAATGTGA
TTACCGTGGCTACCACGTGGTCTCGGCACCGCCTCCGAGCTCCGGCGGTGTGGTCATCTGCCAGATTCTGAACATCCTCG
AAGGCTACCCGATGAAAGAGCTGGGCTTTCGCTCGGCGCAGGGTATGCATTATCAGATCGAGGCCATGCGTCATGCCTAC
GCGGACCGCAACAGCTACCTGGGCGATCCGGACTTCGTCAAGAACCCGGTCGAGCACCTGCTGGACGTCAAGTATGCCGC
CAAGTTGCGGGCTGCCATCGATCCGCAAAAGGCCGGTGACTCGAACAAGATCAAACCCGGCGTCGCGCCCCATGAAGGCA
GCAATACCACCCACTATTCGATTGTCGACAAGTGGGGCAATGCGGTTTCGGTGACCTACACCTTGAACAACTGGTTCGGC
GCGGGCGTCATGGCCAGCAAGACCGGCGTGATCCTCAACGACGAAATGGATGACTTCACCGTCAAGGTCGGCGTGCCCAA
CATGTACGGACTGGTGCAGGGCGAAGCCAACGCCATCGCGCCGGGCAAGACGCCGCTGTCGTCGATGAGCCCGACCATTG
TCACCAAGGACGGCAAGGCAGTGATGGTCGTCGGCACGCCGGGCGGCAGCCGCATCATTACCGCCACGCTGCTGACCATG
CTCAATGTCATCGACTACGGCATGAACATTCAGGAAGCGGTGGACGCGCCGCGTTTCCACCAGCAATGGCAGCCTGAAGA
GACCAACATCGATACCTTCGCGGTCAGCCCTGACACGCTGAAGATTCTCCAGAGCTGGGGTCAAAAGTTCGCAGGCCCGC
AGCCGCTCAATCATGTGGCGGCGATTCTGGTGGGCGCGCCTTCGCTGGGTGGCAAGCCGGTCGGTAACAACCGCTTCTAC
GGCGCCAACGACCCGCGTCGCAACACCGGCTTGTCGCTGGGCTACTGA

Upstream 100 bases:

>100_bases
GGGATGCTCGGTACGCTTCGACGAGAAGTGCCGCATCCCTCGTCTAGAGGCTGGCGCTTCACATCAAACGTCCCTGACCC
AGAAAAAGAAGAGATCGACC

Downstream 100 bases:

>100_bases
GTCACGCTGCCAATCACGCCACGGCCCTGAGCTTCAGGGTCGTGGCGTTTTGCTTTCTGCCGCCTGCTCAGTTACGCACC
CAGCGCTGCCTGCTCCAGCC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MKFEPLARSLIATALIVAYSPTFAASQAPVAAENGMVVTAQHLATHVGVDVLKAGGNAVDAAVAVGYALAVVYPAAGNLG
GGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGKVIPDLSAKGHLAVGVPGTVSGMEMALSKYGTRKREEVIAPAI
KLAEDGFVLGQGDVDMLSSATDVFKADMADSGSIFLDKGEPMQVGQKLVQKDLAKTLKEVSEKGSDGFYKGWVAKALVDS
SQAGKGIITQADLDHYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQILNILEGYPMKELGFRSAQGMHYQIEAMRHAY
ADRNSYLGDPDFVKNPVEHLLDVKYAAKLRAAIDPQKAGDSNKIKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNNWFG
AGVMASKTGVILNDEMDDFTVKVGVPNMYGLVQGEANAIAPGKTPLSSMSPTIVTKDGKAVMVVGTPGGSRIITATLLTM
LNVIDYGMNIQEAVDAPRFHQQWQPEETNIDTFAVSPDTLKILQSWGQKFAGPQPLNHVAAILVGAPSLGGKPVGNNRFY
GANDPRRNTGLSLGY

Sequences:

>Translated_575_residues
MKFEPLARSLIATALIVAYSPTFAASQAPVAAENGMVVTAQHLATHVGVDVLKAGGNAVDAAVAVGYALAVVYPAAGNLG
GGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGKVIPDLSAKGHLAVGVPGTVSGMEMALSKYGTRKREEVIAPAI
KLAEDGFVLGQGDVDMLSSATDVFKADMADSGSIFLDKGEPMQVGQKLVQKDLAKTLKEVSEKGSDGFYKGWVAKALVDS
SQAGKGIITQADLDHYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQILNILEGYPMKELGFRSAQGMHYQIEAMRHAY
ADRNSYLGDPDFVKNPVEHLLDVKYAAKLRAAIDPQKAGDSNKIKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNNWFG
AGVMASKTGVILNDEMDDFTVKVGVPNMYGLVQGEANAIAPGKTPLSSMSPTIVTKDGKAVMVVGTPGGSRIITATLLTM
LNVIDYGMNIQEAVDAPRFHQQWQPEETNIDTFAVSPDTLKILQSWGQKFAGPQPLNHVAAILVGAPSLGGKPVGNNRFY
GANDPRRNTGLSLGY
>Mature_575_residues
MKFEPLARSLIATALIVAYSPTFAASQAPVAAENGMVVTAQHLATHVGVDVLKAGGNAVDAAVAVGYALAVVYPAAGNLG
GGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGKVIPDLSAKGHLAVGVPGTVSGMEMALSKYGTRKREEVIAPAI
KLAEDGFVLGQGDVDMLSSATDVFKADMADSGSIFLDKGEPMQVGQKLVQKDLAKTLKEVSEKGSDGFYKGWVAKALVDS
SQAGKGIITQADLDHYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQILNILEGYPMKELGFRSAQGMHYQIEAMRHAY
ADRNSYLGDPDFVKNPVEHLLDVKYAAKLRAAIDPQKAGDSNKIKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNNWFG
AGVMASKTGVILNDEMDDFTVKVGVPNMYGLVQGEANAIAPGKTPLSSMSPTIVTKDGKAVMVVGTPGGSRIITATLLTM
LNVIDYGMNIQEAVDAPRFHQQWQPEETNIDTFAVSPDTLKILQSWGQKFAGPQPLNHVAAILVGAPSLGGKPVGNNRFY
GANDPRRNTGLSLGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=477, Percent_Identity=34.5911949685535, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI73915090, Length=477, Percent_Identity=34.5911949685535, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI73915096, Length=477, Percent_Identity=34.5911949685535, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI73915094, Length=477, Percent_Identity=34.5911949685535, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI113429324, Length=475, Percent_Identity=32.2105263157895, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI113429326, Length=478, Percent_Identity=32.0083682008368, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI109148539, Length=555, Percent_Identity=29.3693693693694, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI153266885, Length=477, Percent_Identity=27.8825995807128, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI153266901, Length=478, Percent_Identity=27.4058577405858, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI153266907, Length=476, Percent_Identity=26.2605042016807, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI30581157, Length=168, Percent_Identity=39.8809523809524, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI30581155, Length=168, Percent_Identity=39.8809523809524, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI218505805, Length=168, Percent_Identity=35.1190476190476, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI310124095, Length=168, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789856, Length=548, Percent_Identity=52.007299270073, Blast_Score=554, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI72000294, Length=559, Percent_Identity=33.6314847942755, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI212646519, Length=559, Percent_Identity=33.6314847942755, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17506189, Length=506, Percent_Identity=33.9920948616601, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17542894, Length=493, Percent_Identity=33.4685598377282, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI193208247, Length=562, Percent_Identity=31.6725978647687, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI193208245, Length=562, Percent_Identity=31.6725978647687, Blast_Score=215, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17564448, Length=433, Percent_Identity=26.0969976905312, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI72001495, Length=233, Percent_Identity=25.3218884120172, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=25.3218884120172, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323330, Length=489, Percent_Identity=30.2658486707566, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161077880, Length=512, Percent_Identity=31.8359375, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI161077878, Length=510, Percent_Identity=31.5686274509804, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI45551474, Length=510, Percent_Identity=31.5686274509804, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24642670, Length=510, Percent_Identity=31.5686274509804, Blast_Score=215, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24642666, Length=510, Percent_Identity=31.5686274509804, Blast_Score=215, Evalue=8e-56,
Organism=Drosophila melanogaster, GI161077496, Length=518, Percent_Identity=32.2393822393822, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI18859893, Length=517, Percent_Identity=31.1411992263056, Blast_Score=202, Evalue=7e-52,
Organism=Drosophila melanogaster, GI18859741, Length=502, Percent_Identity=27.6892430278884, Blast_Score=161, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61001; Mature: 61001

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFEPLARSLIATALIVAYSPTFAASQAPVAAENGMVVTAQHLATHVGVDVLKAGGNAVD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCHHHHHCCCCHHH
AAVAVGYALAVVYPAAGNLGGGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGKVI
HHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCC
PDLSAKGHLAVGVPGTVSGMEMALSKYGTRKREEVIAPAIKLAEDGFVLGQGDVDMLSSA
CCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
TDVFKADMADSGSIFLDKGEPMQVGQKLVQKDLAKTLKEVSEKGSDGFYKGWVAKALVDS
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SQAGKGIITQADLDHYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQILNILEGYPMKE
CCCCCCEEEECCCCHHHCCCCCCCEECCCCEEEEECCCCCCCCEEHHHHHHHHCCCCCHH
LGFRSAQGMHYQIEAMRHAYADRNSYLGDPDFVKNPVEHLLDVKYAAKLRAAIDPQKAGD
HCCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
SNKIKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNNWFGAGVMASKTGVILNDEMDDFT
CCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEEECCCCEEECCCCCCEE
VKVGVPNMYGLVQGEANAIAPGKTPLSSMSPTIVTKDGKAVMVVGTPGGSRIITATLLTM
EEECCCCEEEEEECCCCEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
LNVIDYGMNIQEAVDAPRFHQQWQPEETNIDTFAVSPDTLKILQSWGQKFAGPQPLNHVA
HHHHHCCCCHHHHHCCCHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCHHHHH
AILVGAPSLGGKPVGNNRFYGANDPRRNTGLSLGY
HHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFEPLARSLIATALIVAYSPTFAASQAPVAAENGMVVTAQHLATHVGVDVLKAGGNAVD
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCHHHHHCCCCHHH
AAVAVGYALAVVYPAAGNLGGGGFMTIQLADGRKTFLDFREKAPLAATANMYLDKDGKVI
HHHHHHHHHHHEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEEECCCCCCC
PDLSAKGHLAVGVPGTVSGMEMALSKYGTRKREEVIAPAIKLAEDGFVLGQGDVDMLSSA
CCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHH
TDVFKADMADSGSIFLDKGEPMQVGQKLVQKDLAKTLKEVSEKGSDGFYKGWVAKALVDS
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SQAGKGIITQADLDHYKTRELAPVECDYRGYHVVSAPPPSSGGVVICQILNILEGYPMKE
CCCCCCEEEECCCCHHHCCCCCCCEECCCCEEEEECCCCCCCCEEHHHHHHHHCCCCCHH
LGFRSAQGMHYQIEAMRHAYADRNSYLGDPDFVKNPVEHLLDVKYAAKLRAAIDPQKAGD
HCCCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
SNKIKPGVAPHEGSNTTHYSIVDKWGNAVSVTYTLNNWFGAGVMASKTGVILNDEMDDFT
CCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEEECCCCEEECCCCCCEE
VKVGVPNMYGLVQGEANAIAPGKTPLSSMSPTIVTKDGKAVMVVGTPGGSRIITATLLTM
EEECCCCEEEEEECCCCEECCCCCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
LNVIDYGMNIQEAVDAPRFHQQWQPEETNIDTFAVSPDTLKILQSWGQKFAGPQPLNHVA
HHHHHCCCCHHHHHCCCHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCHHHHH
AILVGAPSLGGKPVGNNRFYGANDPRRNTGLSLGY
HHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]