Click here to switch to the map view.

The map label for this gene is mmsB [H]

Identifier: 66043957

GI number: 66043957

Start: 794145

End: 795032

Strand: Direct

Name: mmsB [H]

Synonym: Psyr_0690

Alternate gene names: 66043957

Gene position: 794145-795032 (Clockwise)

Preceding gene: 66043956

Following gene: 66043958

Centisome position: 13.03

GC content: 63.63

Gene sequence:

>888_bases
ATGAACATCGCATTTATCGGTCTGGGCAATATGGGCGCGCCCATGGCCCGCAACCTGATCAGAGCCGGTCACGCCTTGCA
GGTGTTCGACCTCAACAAGAGCGTACTGGCTGAATTCGCCGAGCTGGGCGCACAGGTCAGCGATTCACCCGCACAGGCGG
CCCAAGGCACTGAACTGGTCATCACCATGCTGCCCGCCGCGGCGCACGTGCGCAGCGTGTACCTGAATGACGACGGCGTT
TTGAAGGGGATCTCGCCCGGAGTTCCGGCGGTTGATTGCAGCACCATCGACCCGCAGACCATTCGCGACATCGCCGCGGT
CGCTGCGCAGCAAGGCGTGGTGTTGGGCGATGCGCCGGTGTCGGGCGGCACCGGTGGGGCGCAGGCCGGTACGTTGACCT
TCATGGTCGGAGGCTCTGCCGGTCATTTCGCTGTGCTCAAACCAGTGCTGGAACAGATGGGCCGCAACATCGTGCATTGT
GGTGACGTGGGCACCGGCCAGATCGCCAAGATCTGCAACAACATGCTGCTGGCGATTTCCATGATCGGCGTGGCCGAGTC
CATGGCCTTGGGCAATGCGCTGGGTATCGACACCGAAGTGCTGGCCGGCATCATCAATACCTCGACCGGTCGCTGCTGGA
GTTCCGAGGCCTATAACCCGTGGCCCGGCATCGTCGAAAGCGCGCCCTCGTCACGCGGTTACAGCGGCGGCTTTGGCGCC
GAACTGATGCTCAAGGACCTGGGCCTGGCAACCGAGGCCGCGCGCTCGGCGCATCAACCGGTCATCCTCGGCGCAGTGGC
GCAACAGCTGTACCAGGCGATGAGCCTGCGTGGCGATGGCGGCAAGGATTTCTCGGCGATCATTGAGGGGTATCGCCCGA
AAGCGTAG

Upstream 100 bases:

>100_bases
CACCAGTCGCTGGTTCGATGACGACAGCGTCAACGATGGCGTGAACACCACGATCAATCTGCGCTGAGCGCTGGCGGTCA
ATTCGTCCGGGAGAACAACC

Downstream 100 bases:

>100_bases
GTGTCGCACGTGTCGGGGATAAGCGGGGCGTTAATGTGTATCCGGTTTTTACAGTAGGAAAACGTGGCAGAACCGGATAC
TTTGGACTTCGTCAGACCCG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MNIAFIGLGNMGAPMARNLIRAGHALQVFDLNKSVLAEFAELGAQVSDSPAQAAQGTELVITMLPAAAHVRSVYLNDDGV
LKGISPGVPAVDCSTIDPQTIRDIAAVAAQQGVVLGDAPVSGGTGGAQAGTLTFMVGGSAGHFAVLKPVLEQMGRNIVHC
GDVGTGQIAKICNNMLLAISMIGVAESMALGNALGIDTEVLAGIINTSTGRCWSSEAYNPWPGIVESAPSSRGYSGGFGA
ELMLKDLGLATEAARSAHQPVILGAVAQQLYQAMSLRGDGGKDFSAIIEGYRPKA

Sequences:

>Translated_295_residues
MNIAFIGLGNMGAPMARNLIRAGHALQVFDLNKSVLAEFAELGAQVSDSPAQAAQGTELVITMLPAAAHVRSVYLNDDGV
LKGISPGVPAVDCSTIDPQTIRDIAAVAAQQGVVLGDAPVSGGTGGAQAGTLTFMVGGSAGHFAVLKPVLEQMGRNIVHC
GDVGTGQIAKICNNMLLAISMIGVAESMALGNALGIDTEVLAGIINTSTGRCWSSEAYNPWPGIVESAPSSRGYSGGFGA
ELMLKDLGLATEAARSAHQPVILGAVAQQLYQAMSLRGDGGKDFSAIIEGYRPKA
>Mature_295_residues
MNIAFIGLGNMGAPMARNLIRAGHALQVFDLNKSVLAEFAELGAQVSDSPAQAAQGTELVITMLPAAAHVRSVYLNDDGV
LKGISPGVPAVDCSTIDPQTIRDIAAVAAQQGVVLGDAPVSGGTGGAQAGTLTFMVGGSAGHFAVLKPVLEQMGRNIVHC
GDVGTGQIAKICNNMLLAISMIGVAESMALGNALGIDTEVLAGIINTSTGRCWSSEAYNPWPGIVESAPSSRGYSGGFGA
ELMLKDLGLATEAARSAHQPVILGAVAQQLYQAMSLRGDGGKDFSAIIEGYRPKA

Specific function: Unknown

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=290, Percent_Identity=49.6551724137931, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI40556376, Length=290, Percent_Identity=25.8620689655172, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=37.1621621621622, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=31.5068493150685, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=31.8791946308725, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789092, Length=291, Percent_Identity=31.2714776632302, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17557316, Length=292, Percent_Identity=48.2876712328767, Blast_Score=269, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24655230, Length=288, Percent_Identity=48.6111111111111, Blast_Score=280, Evalue=6e-76,
Organism=Drosophila melanogaster, GI19922568, Length=288, Percent_Identity=48.6111111111111, Blast_Score=280, Evalue=6e-76,
Organism=Drosophila melanogaster, GI28574115, Length=293, Percent_Identity=23.2081911262799, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655240, Length=64, Percent_Identity=53.125, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30116; Mature: 30116

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAFIGLGNMGAPMARNLIRAGHALQVFDLNKSVLAEFAELGAQVSDSPAQAAQGTELV
CEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHCCCEEE
ITMLPAAAHVRSVYLNDDGVLKGISPGVPAVDCSTIDPQTIRDIAAVAAQQGVVLGDAPV
EEECCHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCC
SGGTGGAQAGTLTFMVGGSAGHFAVLKPVLEQMGRNIVHCGDVGTGQIAKICNNMLLAIS
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
MIGVAESMALGNALGIDTEVLAGIINTSTGRCWSSEAYNPWPGIVESAPSSRGYSGGFGA
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCHHHCCCCCCCCCCCCCH
ELMLKDLGLATEAARSAHQPVILGAVAQQLYQAMSLRGDGGKDFSAIIEGYRPKA
HHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MNIAFIGLGNMGAPMARNLIRAGHALQVFDLNKSVLAEFAELGAQVSDSPAQAAQGTELV
CEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHCCCEEE
ITMLPAAAHVRSVYLNDDGVLKGISPGVPAVDCSTIDPQTIRDIAAVAAQQGVVLGDAPV
EEECCHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCC
SGGTGGAQAGTLTFMVGGSAGHFAVLKPVLEQMGRNIVHCGDVGTGQIAKICNNMLLAIS
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHH
MIGVAESMALGNALGIDTEVLAGIINTSTGRCWSSEAYNPWPGIVESAPSSRGYSGGFGA
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEECCCCCCCCCCHHHCCCCCCCCCCCCCH
ELMLKDLGLATEAARSAHQPVILGAVAQQLYQAMSLRGDGGKDFSAIIEGYRPKA
HHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]