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The map label for this gene is chaA [C]

Identifier: 66043935

GI number: 66043935

Start: 756744

End: 757847

Strand: Direct

Name: chaA [C]

Synonym: Psyr_0668

Alternate gene names: 66043935

Gene position: 756744-757847 (Clockwise)

Preceding gene: 66043927

Following gene: 66043945

Centisome position: 12.42

GC content: 59.78

Gene sequence:

>1104_bases
ATGGGCGCATTGCTCAAGCAAGAAAAGTTTCTGTTGCTGGCAATCATTGCCATGTTCGTCGCTTATCCACTGGAGCATGT
GCTGGTAGGCAATGGTCAGGTCGTTGCGCTGGTGTCGGGGCTGGCGCTGGTCGCTTTCATCATCTGCGCCTCGATGCGCG
TTGCGCATCACGCCGAGATGCTCGCGGAAAAGGTCGGCGATCCTTACGGCACGATGATCCTCACGCTCTCGGCGGTAACG
GTCGAAGTGGTGATCCTGGCGATCATGATGAGCAACGAGCCGTCGCCGACGCTGGTACGCGACACGATTTATTCGGCGGT
GATGCTCGACATCAACGGCATCCTCGGCCTTGCGGCGCTGATGGGCGGTATCAAGCACGGCGAGCAGTCGTACAACGACG
ATTCGGCGCGCACCTACAGCGTGATGATCCTCACCGCGATGGGTGTGTCGATGGTCGTACCCGAGTTCATTCCCAAGGGT
GACTGGAAGATCTATTCGGCGTTTACCATTGGCGCGATGATCCTCCTCTACACCCTGTTCCTGCGCATGCAGGTCGGGCC
GCACAGTTACTTTTTCAGCTACAGCTACCCGGAAAAGAAGAAGCGTCAGAGCCAGGGCTCCAATCCGGCTGAAGAGCATG
CGGAACCGGTCAATCTGACCCGCTCAATTGCCACACTGGTTGTCGGCGTGGTGGTGATCGGTGCGCTGGCCGAAGTGATG
TCGAAGACGGTTGACCTGGGCCTGGAAGGCACCGGTGCACCGCCGGTGATGACCGCCATCCTGGTAGCCGCCATCTCTGC
CGCGCCCGAGATCCTCACGGCCCTGCGTGCCGCGTTGGCCAACCGCATGCAGTCGGTGGTCAACATCGCTCTGGGTGCGT
CGCTGTCGACCGTGATCCTGACCGTTCCGGTGATGGAAGCCATGGCACTTTACAGCGGCCAGCCCTTCCAGATGGCCATG
ACTCCGGTGCAGACCGTGATGATCCTCATCACCCTGCTGGTGTCCGCCATCAACCTCAACGACGGCGAAACCAACGCCAT
CGAAGGCATGACCCACTTCGTGCTGTTCGCGACGTTCATCATGCTGTCGTGTCTGGGGCTTTAG

Upstream 100 bases:

>100_bases
TTTTATGAAACCTTTTGTCACACACGCTACTCTGACAGCCTTCACTGTTGGCCACCTTCATGTACATCCGCGGCGATGTC
GCAAGGTTTGGGGAATAAAA

Downstream 100 bases:

>100_bases
GGCCTATTGCCTATCGCTCCCACGCTCTGCGTCGCAAGAGGACGCAGAGCGTCCTGAACGGCATGCCGACGCGGAGCGTC
GCACGATAGTCGAGAGTATC

Product: Sodium/calcium exchanger membrane region

Products: Na (I) [Periplasm]; Ca (II) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGALLKQEKFLLLAIIAMFVAYPLEHVLVGNGQVVALVSGLALVAFIICASMRVAHHAEMLAEKVGDPYGTMILTLSAVT
VEVVILAIMMSNEPSPTLVRDTIYSAVMLDINGILGLAALMGGIKHGEQSYNDDSARTYSVMILTAMGVSMVVPEFIPKG
DWKIYSAFTIGAMILLYTLFLRMQVGPHSYFFSYSYPEKKKRQSQGSNPAEEHAEPVNLTRSIATLVVGVVVIGALAEVM
SKTVDLGLEGTGAPPVMTAILVAAISAAPEILTALRAALANRMQSVVNIALGASLSTVILTVPVMEAMALYSGQPFQMAM
TPVQTVMILITLLVSAINLNDGETNAIEGMTHFVLFATFIMLSCLGL

Sequences:

>Translated_367_residues
MGALLKQEKFLLLAIIAMFVAYPLEHVLVGNGQVVALVSGLALVAFIICASMRVAHHAEMLAEKVGDPYGTMILTLSAVT
VEVVILAIMMSNEPSPTLVRDTIYSAVMLDINGILGLAALMGGIKHGEQSYNDDSARTYSVMILTAMGVSMVVPEFIPKG
DWKIYSAFTIGAMILLYTLFLRMQVGPHSYFFSYSYPEKKKRQSQGSNPAEEHAEPVNLTRSIATLVVGVVVIGALAEVM
SKTVDLGLEGTGAPPVMTAILVAAISAAPEILTALRAALANRMQSVVNIALGASLSTVILTVPVMEAMALYSGQPFQMAM
TPVQTVMILITLLVSAINLNDGETNAIEGMTHFVLFATFIMLSCLGL
>Mature_366_residues
GALLKQEKFLLLAIIAMFVAYPLEHVLVGNGQVVALVSGLALVAFIICASMRVAHHAEMLAEKVGDPYGTMILTLSAVTV
EVVILAIMMSNEPSPTLVRDTIYSAVMLDINGILGLAALMGGIKHGEQSYNDDSARTYSVMILTAMGVSMVVPEFIPKGD
WKIYSAFTIGAMILLYTLFLRMQVGPHSYFFSYSYPEKKKRQSQGSNPAEEHAEPVNLTRSIATLVVGVVVIGALAEVMS
KTVDLGLEGTGAPPVMTAILVAAISAAPEILTALRAALANRMQSVVNIALGASLSTVILTVPVMEAMALYSGQPFQMAMT
PVQTVMILITLLVSAINLNDGETNAIEGMTHFVLFATFIMLSCLGL

Specific function: Possible cation transporter [H]

COG id: COG0387

COG function: function code P; Ca2+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1787468, Length=361, Percent_Identity=29.6398891966759, Blast_Score=160, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320075, Length=310, Percent_Identity=24.8387096774194, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004713
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 39116; Mature: 38985

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCC
>Mature Secondary Structure 
GALLKQEKFLLLAIIAMFVAYPLEHVLVGNGQVVALVSGLALVAFIICASMRVAHHAEM
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAEKVGDPYGTMILTLSAVTVEVVILAIMMSNEPSPTLVRDTIYSAVMLDINGILGLAAL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MGGIKHGEQSYNDDSARTYSVMILTAMGVSMVVPEFIPKGDWKIYSAFTIGAMILLYTLF
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHH
LRMQVGPHSYFFSYSYPEKKKRQSQGSNPAEEHAEPVNLTRSIATLVVGVVVIGALAEVM
HHHHCCCCCEEEECCCCHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SKTVDLGLEGTGAPPVMTAILVAAISAAPEILTALRAALANRMQSVVNIALGASLSTVIL
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TVPVMEAMALYSGQPFQMAMTPVQTVMILITLLVSAINLNDGETNAIEGMTHFVLFATFI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
MLSCLGL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm]; Ca (II) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + Proton [Periplasm] = Proton [Cytoplasm] + Na (I) [Periplasm] Ca (II) [Cytoplasm] + Proton [Periplasm] = Ca (II) [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]