Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 62185526

GI number: 62185526

Start: 1080854

End: 1082761

Strand: Direct

Name: thrS

Synonym: CAB926

Alternate gene names: 62185526

Gene position: 1080854-1082761 (Clockwise)

Preceding gene: 62185524

Following gene: 62185527

Centisome position: 94.45

GC content: 41.77

Gene sequence:

>1908_bases
ATGATCCGCGTAATTTGCAACAATGAAACTTATGAGCTGCCTCAGGGCACAACAGCTGCTGATTTCGCGAGCAAAATAAA
AAATTCTCATTACTTTGCTGGCGTTGTCATAAACGATCAAATTAAAGATCTGTCTACAACCCTAAACGAAGGAGATACCT
TAAGATTTGTTACCTTTACAGATCCAGAAGGACGAGAAATTTTTTTACATACTTCTGCTCACATTCTAGCTCAGGCTATA
CTACGTTTATGGCCAGATGCTATCCCGACTATAGGTCCTGTTATCGATCAGGGATTTTATTACGATTTCGCCAACCTTTC
TATCAGTGAAGACGACTTCCTAATGATTGAAAATATGATGGGTCAAATAGCTGAAGAAAAGTTTGCGGTGCAGAAAAAAA
CATTTAACAGCAAACACGAGGCCCTAGAAGAATTCGCCCGTAATCCCTTTAAAGTAGAACTCATAAAAGAGCTTCCAGAA
GGAGAGAGCATTACTGCCTACTCCCAAGGGGAATTTATGGATCTCTGTCGGGGGCCACACTTGCCTTCCACTGGCCCTGT
CAAAGCTTTTAAGCTTTTACGCACATCAGCAGCCTATTGGAGGGGAGATCCTCAAAGAGAATCTCTAGTAAGAATCTATG
GTGTGGCTTTCCCTACAACAAAAGAATTAAAAGAGCATCTACACCAGTTGAAAGAAGCAAAAAAACGTGATCACCGCGTT
TTAGGGATGAAACTCGACCTGTTTTCTCAACAAGAGTGTTCCGCAGGCATGCCTTTTTTCCATCCTAGAGGAATGATTAT
CTGGGACGCCCTTATAGGGTATTGGAAACGCTTACATCAACTTGCGGGATATAAGGAAATCCAAACGCCTCAGCTTATGA
GCCGTAGTCTTTGGGAAGTTTCTGGACATTGGAGTAACTATAGAGAAAACATGTACACTCTAAAGATAGAGGATGAGGAC
TACGCAATTAAGCCCATGAATTGCCCTGGGTGTATGTTGTATTATAAAACACGCCTACATAGCTATAAGCAATTTCCCTT
AAGAATTGCAGAGATTGGTCACGTGCATCGCTACGAAGTTTCGGGAGCTCTTTCCGGACTTATGCGCGTACGTGCATTCC
ATCAAGATGACGCGCACGTATTTCTAACCCCTGAACAAGTAGAAGAGGAAACATTAAATATTTTACATTTAGTTTCTGAA
TTATACTCAACGTTTGGGCTAGAGTACCATTTAGAGTTGTCAACACGTCCAGAAAAAGCCACAATTGGCAGTGATGAACT
CTGGGAGTTAGCGACAGCAGCCTTAGAGCGAGCTCTTGTCAATTCACATACTCCTTTCATTATCAATCCTGGAGATGGAG
CTTTTTACGGACCGAAAATTGACATCCATGTGAAGGACGCCATCCAACGTACGTGGCAATGTGGAACCATCCAACTCGAC
ATGTTCCTACCCGAACGATTTGAGTTAGAATACACCAATGCTCAGGGAGAAAAAAGTACTCCTGTGATGTTACATCGGGC
TTTGTTTGGTTCTATTGAAAGATTCTTAGGTATTCTTATAGAGCATTTCAAAGGAAGATTCCCCTTATGGCTCAGTCCTG
AGCATATCAGGGTAATTACTGTGGCAGACCGCCATCAACCTCGAGCTCAAAAGCTGGCCACAGCGTGGCAAAAATTAGGC
TTCGTAGTTACGGTGGATGATTCTAATGAATCTGTAAGTAAAAAAATACGGAATGCACAAAACATGCAAGTCAATTATAT
GGTGACTTTGGGAGATCGGGAAATTGAGCAAAATACCTTAGCAATACGTACCCGAGACAACCGAGTTTTAAATGACATGA
CAGAGGACAAATTCCTAAATACTCTACTTGAAGAAAAGAACTCTTTAAGTTTAACTCCACTATTGTAG

Upstream 100 bases:

>100_bases
TTCCCCACTTAAACACACAGTTTTTTTAAGAAAACGCCCTTGCTTTGATCCAGAAAAACGTTACAATAACAGACCTAGAA
AAACTCTTAATGGAGAGAAG

Downstream 100 bases:

>100_bases
AAAACCCAGATCCAAGGACGAGCGTCTCCAATGAAAACCATCGCTGTCAATAGCTTTAAAGGTGGAACAGCAAAAACATC
GACAACCCTACATTTAGGTG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MIRVICNNETYELPQGTTAADFASKIKNSHYFAGVVINDQIKDLSTTLNEGDTLRFVTFTDPEGREIFLHTSAHILAQAI
LRLWPDAIPTIGPVIDQGFYYDFANLSISEDDFLMIENMMGQIAEEKFAVQKKTFNSKHEALEEFARNPFKVELIKELPE
GESITAYSQGEFMDLCRGPHLPSTGPVKAFKLLRTSAAYWRGDPQRESLVRIYGVAFPTTKELKEHLHQLKEAKKRDHRV
LGMKLDLFSQQECSAGMPFFHPRGMIIWDALIGYWKRLHQLAGYKEIQTPQLMSRSLWEVSGHWSNYRENMYTLKIEDED
YAIKPMNCPGCMLYYKTRLHSYKQFPLRIAEIGHVHRYEVSGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILHLVSE
LYSTFGLEYHLELSTRPEKATIGSDELWELATAALERALVNSHTPFIINPGDGAFYGPKIDIHVKDAIQRTWQCGTIQLD
MFLPERFELEYTNAQGEKSTPVMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHIRVITVADRHQPRAQKLATAWQKLG
FVVTVDDSNESVSKKIRNAQNMQVNYMVTLGDREIEQNTLAIRTRDNRVLNDMTEDKFLNTLLEEKNSLSLTPLL

Sequences:

>Translated_635_residues
MIRVICNNETYELPQGTTAADFASKIKNSHYFAGVVINDQIKDLSTTLNEGDTLRFVTFTDPEGREIFLHTSAHILAQAI
LRLWPDAIPTIGPVIDQGFYYDFANLSISEDDFLMIENMMGQIAEEKFAVQKKTFNSKHEALEEFARNPFKVELIKELPE
GESITAYSQGEFMDLCRGPHLPSTGPVKAFKLLRTSAAYWRGDPQRESLVRIYGVAFPTTKELKEHLHQLKEAKKRDHRV
LGMKLDLFSQQECSAGMPFFHPRGMIIWDALIGYWKRLHQLAGYKEIQTPQLMSRSLWEVSGHWSNYRENMYTLKIEDED
YAIKPMNCPGCMLYYKTRLHSYKQFPLRIAEIGHVHRYEVSGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILHLVSE
LYSTFGLEYHLELSTRPEKATIGSDELWELATAALERALVNSHTPFIINPGDGAFYGPKIDIHVKDAIQRTWQCGTIQLD
MFLPERFELEYTNAQGEKSTPVMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHIRVITVADRHQPRAQKLATAWQKLG
FVVTVDDSNESVSKKIRNAQNMQVNYMVTLGDREIEQNTLAIRTRDNRVLNDMTEDKFLNTLLEEKNSLSLTPLL
>Mature_635_residues
MIRVICNNETYELPQGTTAADFASKIKNSHYFAGVVINDQIKDLSTTLNEGDTLRFVTFTDPEGREIFLHTSAHILAQAI
LRLWPDAIPTIGPVIDQGFYYDFANLSISEDDFLMIENMMGQIAEEKFAVQKKTFNSKHEALEEFARNPFKVELIKELPE
GESITAYSQGEFMDLCRGPHLPSTGPVKAFKLLRTSAAYWRGDPQRESLVRIYGVAFPTTKELKEHLHQLKEAKKRDHRV
LGMKLDLFSQQECSAGMPFFHPRGMIIWDALIGYWKRLHQLAGYKEIQTPQLMSRSLWEVSGHWSNYRENMYTLKIEDED
YAIKPMNCPGCMLYYKTRLHSYKQFPLRIAEIGHVHRYEVSGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILHLVSE
LYSTFGLEYHLELSTRPEKATIGSDELWELATAALERALVNSHTPFIINPGDGAFYGPKIDIHVKDAIQRTWQCGTIQLD
MFLPERFELEYTNAQGEKSTPVMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHIRVITVADRHQPRAQKLATAWQKLG
FVVTVDDSNESVSKKIRNAQNMQVNYMVTLGDREIEQNTLAIRTRDNRVLNDMTEDKFLNTLLEEKNSLSLTPLL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=596, Percent_Identity=40.9395973154362, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI38202255, Length=582, Percent_Identity=42.0962199312715, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI20070344, Length=637, Percent_Identity=37.8335949764521, Blast_Score=424, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=603, Percent_Identity=42.4543946932007, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI71984184, Length=612, Percent_Identity=39.7058823529412, Blast_Score=480, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI71984192, Length=612, Percent_Identity=39.7058823529412, Blast_Score=479, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322112, Length=612, Percent_Identity=40.359477124183, Blast_Score=482, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322654, Length=401, Percent_Identity=39.4014962593516, Blast_Score=293, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24583842, Length=589, Percent_Identity=42.2750424448217, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI28574141, Length=589, Percent_Identity=42.2750424448217, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583839, Length=589, Percent_Identity=42.2750424448217, Blast_Score=501, Evalue=1e-142,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CHLAB (Q5L4T1)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220311.1
- ProteinModelPortal:   Q5L4T1
- SMR:   Q5L4T1
- GeneID:   3338217
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB926
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q5L4T1
- ProtClustDB:   PRK00413
- BioCyc:   CABO218497:CAB926-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73003; Mature: 73003

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVICNNETYELPQGTTAADFASKIKNSHYFAGVVINDQIKDLSTTLNEGDTLRFVTFT
CEEEEECCCCEECCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCEEEEEEEE
DPEGREIFLHTSAHILAQAILRLWPDAIPTIGPVIDQGFYYDFANLSISEDDFLMIENMM
CCCCCEEEEECHHHHHHHHHHHHCCHHCCCHHHHHCCCCEEEECCCEECCCCHHHHHHHH
GQIAEEKFAVQKKTFNSKHEALEEFARNPFKVELIKELPEGESITAYSQGEFMDLCRGPH
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEHHHHHCCCCCCEEEECCCCHHHHHCCCC
LPSTGPVKAFKLLRTSAAYWRGDPQRESLVRIYGVAFPTTKELKEHLHQLKEAKKRDHRV
CCCCCCHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEE
LGMKLDLFSQQECSAGMPFFHPRGMIIWDALIGYWKRLHQLAGYKEIQTPQLMSRSLWEV
EEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGHWSNYRENMYTLKIEDEDYAIKPMNCPGCMLYYKTRLHSYKQFPLRIAEIGHVHRYEV
CCCCHHHCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEH
SGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILHLVSELYSTFGLEYHLELSTRPEKA
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
TIGSDELWELATAALERALVNSHTPFIINPGDGAFYGPKIDIHVKDAIQRTWQCGTIQLD
CCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCEEEEEEHHHHHHCCCCCEEEEE
MFLPERFELEYTNAQGEKSTPVMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHIRVIT
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEE
VADRHQPRAQKLATAWQKLGFVVTVDDSNESVSKKIRNAQNMQVNYMVTLGDREIEQNTL
EECCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCEE
AIRTRDNRVLNDMTEDKFLNTLLEEKNSLSLTPLL
EEEECCCHHHHHHHHHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MIRVICNNETYELPQGTTAADFASKIKNSHYFAGVVINDQIKDLSTTLNEGDTLRFVTFT
CEEEEECCCCEECCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCEEEEEEEE
DPEGREIFLHTSAHILAQAILRLWPDAIPTIGPVIDQGFYYDFANLSISEDDFLMIENMM
CCCCCEEEEECHHHHHHHHHHHHCCHHCCCHHHHHCCCCEEEECCCEECCCCHHHHHHHH
GQIAEEKFAVQKKTFNSKHEALEEFARNPFKVELIKELPEGESITAYSQGEFMDLCRGPH
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEHHHHHCCCCCCEEEECCCCHHHHHCCCC
LPSTGPVKAFKLLRTSAAYWRGDPQRESLVRIYGVAFPTTKELKEHLHQLKEAKKRDHRV
CCCCCCHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEE
LGMKLDLFSQQECSAGMPFFHPRGMIIWDALIGYWKRLHQLAGYKEIQTPQLMSRSLWEV
EEEEEECCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGHWSNYRENMYTLKIEDEDYAIKPMNCPGCMLYYKTRLHSYKQFPLRIAEIGHVHRYEV
CCCCHHHCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEH
SGALSGLMRVRAFHQDDAHVFLTPEQVEEETLNILHLVSELYSTFGLEYHLELSTRPEKA
HHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
TIGSDELWELATAALERALVNSHTPFIINPGDGAFYGPKIDIHVKDAIQRTWQCGTIQLD
CCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCEEEEEEHHHHHHCCCCCEEEEE
MFLPERFELEYTNAQGEKSTPVMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHIRVIT
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEE
VADRHQPRAQKLATAWQKLGFVVTVDDSNESVSKKIRNAQNMQVNYMVTLGDREIEQNTL
EECCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHCCCCCCEEEEEEEECCCCCCCCEE
AIRTRDNRVLNDMTEDKFLNTLLEEKNSLSLTPLL
EEEECCCHHHHHHHHHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA