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The map label for this gene is engA

Identifier: 62185493

GI number: 62185493

Start: 1040610

End: 1042034

Strand: Direct

Name: engA

Synonym: CAB891

Alternate gene names: 62185493

Gene position: 1040610-1042034 (Clockwise)

Preceding gene: 62185492

Following gene: 62185497

Centisome position: 90.93

GC content: 39.51

Gene sequence:

>1425_bases
ATGCTACGAATTGCTATTTTAGGAAGACCCAATGTAGGGAAATCTTCTCTTTTCAATCGCATGTGCAAACGATCTTTGGC
TATAGTCAACTCACAAGAAGGAACGACACGAGACCGACTATACGGAGAGATACGTGGATGGGGAATCCCTGTACAAGTCA
TCGATACGGGAGGAGTAGATAAAGATTCTGAAGATCACTTCCAAAAACATATTTACAAGCAGGCGTTAGCTGGAGCAAAC
GAAGCGGATATATTACTGCTCGTCATTGATATCCGCTGTGGGATTACAGAATTAGATGCAGAGATTGCGAAACAGCTGCT
CTACTTAAAGAAACCTTTGATCCTCGTCGCAAATAAAGCAGATACACTAAAAGATGAATACCGTGTTCATGAACTATACA
AAATAGGAATCTCTGAGATTGTTACTGTATCGGCAAGTCACGATAAACATATCGACAAGCTTATACACAAAATTAAAACT
CTCGCTAATGTTCCTGAAGTTGTTGAGGAACCTAGAGAGGAGATGCATGAGGAAGAAGTTCCTGGCATGGAGTTCCCAGA
AACCAAAGAATTTCTATCCGATGACGAAGACGAAGACACCGCCTTTTCCCAGTCTTCAGTAGCAGATAAGCCCCTAAAAA
TTGCTCTTATAGGTCGTCCTAATGTCGGGAAGTCCTCGATCATTAACGCACTATTAAATGAAGAGCGTTGCATCATTGAT
AATGTCCCTGGAACTACTCGTGACAATATCGATATTCTTTATTCTCATAATGACCGGTCGTATCTATTTATAGACACCGC
GGGTCTGAGAAAAATGAAAAGCGTGAAAAATTCTATAGAATGGATCTCTTCTTCCAGAACAGAAAAAGCTATAGCGCGTG
CCGATATTTGCTTACTCGTCATTGATGCTACGCATCACCTATCTTCTTATGATAAACGCATTCTTTCTCTGATATCTAAA
CAGAAAAAGCCCCACATCATTCTTGTGAACAAATGGGATTTGATTGAAGGCGTGCGGATGGAACATTACATTCGCGACTT
ACGTGCTACAGATATGTATATTGGTCAATCGAAGATCCTTTGCATATCTGCGGCGACAAAACGCAACCTACGTCAGATCT
TCTCATCGATTGATGAACTCCATACAACAGTATCAAGTAAAGTCCCCACGCCGGTAGTGAATAAAACACTCGCCCTAGCT
CTACAGAAACATCATCCCCAAGTCATTAACGGAAGAAGACTACGTGTGTACTACGCTATTCATAAAACAGCAACACCCTT
CCAGTTCTTACTATTTATTAATGCGAAGTCCTTATTAACTAAACATTACGAGTGTTATTTAAAAAATACTTTAAAATCAG
CATTTAATTTATACGGTGTTCCTTTTGATTTAGAATTTAAAGAAAAAACGAAAAGAACAAATTAA

Upstream 100 bases:

>100_bases
TCCCTTAAACACGTCATCAATTTTATTTCTTTAGATTTAATTTTTTAGCTCTTATTATTTTTCCTATAATTATTCAAAAC
TTAGATTAATTGAGCTTATC

Downstream 100 bases:

>100_bases
TTTGTTTAAAAAATGAATATTATTAAAAAAATAATAATAACAAATTAATTATTTCTTGGAGACTTTAACCATGAACCATG
ATCGTTACGATATGTCAGAA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MLRIAILGRPNVGKSSLFNRMCKRSLAIVNSQEGTTRDRLYGEIRGWGIPVQVIDTGGVDKDSEDHFQKHIYKQALAGAN
EADILLLVIDIRCGITELDAEIAKQLLYLKKPLILVANKADTLKDEYRVHELYKIGISEIVTVSASHDKHIDKLIHKIKT
LANVPEVVEEPREEMHEEEVPGMEFPETKEFLSDDEDEDTAFSQSSVADKPLKIALIGRPNVGKSSIINALLNEERCIID
NVPGTTRDNIDILYSHNDRSYLFIDTAGLRKMKSVKNSIEWISSSRTEKAIARADICLLVIDATHHLSSYDKRILSLISK
QKKPHIILVNKWDLIEGVRMEHYIRDLRATDMYIGQSKILCISAATKRNLRQIFSSIDELHTTVSSKVPTPVVNKTLALA
LQKHHPQVINGRRLRVYYAIHKTATPFQFLLFINAKSLLTKHYECYLKNTLKSAFNLYGVPFDLEFKEKTKRTN

Sequences:

>Translated_474_residues
MLRIAILGRPNVGKSSLFNRMCKRSLAIVNSQEGTTRDRLYGEIRGWGIPVQVIDTGGVDKDSEDHFQKHIYKQALAGAN
EADILLLVIDIRCGITELDAEIAKQLLYLKKPLILVANKADTLKDEYRVHELYKIGISEIVTVSASHDKHIDKLIHKIKT
LANVPEVVEEPREEMHEEEVPGMEFPETKEFLSDDEDEDTAFSQSSVADKPLKIALIGRPNVGKSSIINALLNEERCIID
NVPGTTRDNIDILYSHNDRSYLFIDTAGLRKMKSVKNSIEWISSSRTEKAIARADICLLVIDATHHLSSYDKRILSLISK
QKKPHIILVNKWDLIEGVRMEHYIRDLRATDMYIGQSKILCISAATKRNLRQIFSSIDELHTTVSSKVPTPVVNKTLALA
LQKHHPQVINGRRLRVYYAIHKTATPFQFLLFINAKSLLTKHYECYLKNTLKSAFNLYGVPFDLEFKEKTKRTN
>Mature_474_residues
MLRIAILGRPNVGKSSLFNRMCKRSLAIVNSQEGTTRDRLYGEIRGWGIPVQVIDTGGVDKDSEDHFQKHIYKQALAGAN
EADILLLVIDIRCGITELDAEIAKQLLYLKKPLILVANKADTLKDEYRVHELYKIGISEIVTVSASHDKHIDKLIHKIKT
LANVPEVVEEPREEMHEEEVPGMEFPETKEFLSDDEDEDTAFSQSSVADKPLKIALIGRPNVGKSSIINALLNEERCIID
NVPGTTRDNIDILYSHNDRSYLFIDTAGLRKMKSVKNSIEWISSSRTEKAIARADICLLVIDATHHLSSYDKRILSLISK
QKKPHIILVNKWDLIEGVRMEHYIRDLRATDMYIGQSKILCISAATKRNLRQIFSSIDELHTTVSSKVPTPVVNKTLALA
LQKHHPQVINGRRLRVYYAIHKTATPFQFLLFINAKSLLTKHYECYLKNTLKSAFNLYGVPFDLEFKEKTKRTN

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=465, Percent_Identity=33.9784946236559, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI2367268, Length=166, Percent_Identity=31.9277108433735, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507259, Length=102, Percent_Identity=38.2352941176471, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=196, Percent_Identity=32.6530612244898, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45550813, Length=186, Percent_Identity=32.258064516129, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_CHLAB (Q5L4W4)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220278.1
- HSSP:   P38424
- ProteinModelPortal:   Q5L4W4
- SMR:   Q5L4W4
- GeneID:   3337827
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB891
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- BioCyc:   CABO218497:CAB891-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 53879; Mature: 53879

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAILGRPNVGKSSLFNRMCKRSLAIVNSQEGTTRDRLYGEIRGWGIPVQVIDTGGVD
CEEEEEECCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCEEEEEECCCCC
KDSEDHFQKHIYKQALAGANEADILLLVIDIRCGITELDAEIAKQLLYLKKPLILVANKA
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCC
DTLKDEYRVHELYKIGISEIVTVSASHDKHIDKLIHKIKTLANVPEVVEEPREEMHEEEV
HHHHHHHHHHHHHHHCHHHEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
PGMEFPETKEFLSDDEDEDTAFSQSSVADKPLKIALIGRPNVGKSSIINALLNEERCIID
CCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEE
NVPGTTRDNIDILYSHNDRSYLFIDTAGLRKMKSVKNSIEWISSSRTEKAIARADICLLV
CCCCCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEE
IDATHHLSSYDKRILSLISKQKKPHIILVNKWDLIEGVRMEHYIRDLRATDMYIGQSKIL
EECHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEE
CISAATKRNLRQIFSSIDELHTTVSSKVPTPVVNKTLALALQKHHPQVINGRRLRVYYAI
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEE
HKTATPFQFLLFINAKSLLTKHYECYLKNTLKSAFNLYGVPFDLEFKEKTKRTN
ECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MLRIAILGRPNVGKSSLFNRMCKRSLAIVNSQEGTTRDRLYGEIRGWGIPVQVIDTGGVD
CEEEEEECCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCCEEEEEECCCCC
KDSEDHFQKHIYKQALAGANEADILLLVIDIRCGITELDAEIAKQLLYLKKPLILVANKA
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCC
DTLKDEYRVHELYKIGISEIVTVSASHDKHIDKLIHKIKTLANVPEVVEEPREEMHEEEV
HHHHHHHHHHHHHHHCHHHEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
PGMEFPETKEFLSDDEDEDTAFSQSSVADKPLKIALIGRPNVGKSSIINALLNEERCIID
CCCCCCCHHHHHCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEE
NVPGTTRDNIDILYSHNDRSYLFIDTAGLRKMKSVKNSIEWISSSRTEKAIARADICLLV
CCCCCCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEE
IDATHHLSSYDKRILSLISKQKKPHIILVNKWDLIEGVRMEHYIRDLRATDMYIGQSKIL
EECHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEE
CISAATKRNLRQIFSSIDELHTTVSSKVPTPVVNKTLALALQKHHPQVINGRRLRVYYAI
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEE
HKTATPFQFLLFINAKSLLTKHYECYLKNTLKSAFNLYGVPFDLEFKEKTKRTN
ECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA