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The map label for this gene is clpX

Identifier: 62185491

GI number: 62185491

Start: 1037960

End: 1039225

Strand: Direct

Name: clpX

Synonym: CAB889

Alternate gene names: 62185491

Gene position: 1037960-1039225 (Clockwise)

Preceding gene: 62185490

Following gene: 62185492

Centisome position: 90.7

GC content: 40.21

Gene sequence:

>1266_bases
ATGAACAAAAAAAATCTCACCATCTGCTCTTTTTGTGGGCGTTCTGAAAAAGATGTGGAAAAATTGATAGCAGGTCCCTC
TGTCTATATTTGTGATTACTGTATTAAGTTGTGCTCAGGGATTTTAGATAAAAAGCCAACATCTACATCATCCTCAGGAG
CATCCACAGAAACAGCCCCTCAGCATCCGGATCTTCAAGTGCTCACTCCAAAAGAGATCAAAAAACATATTGATAAGTAT
GTTGTCGGTCAAGAAAGAGCAAAGAAAACCATCGCTGTCGCTGTATACAATCACTACAAACGTATACGTGCTTTATTAAA
CAACAAACACGTCAGCTATGGAAAGTCCAATGTTTTGCTTTTGGGCCCTACAGGATCGGGAAAAACCCTTATTGCTAAAA
CTTTAGCAAAAATCTTAGATGTACCTTTCACAATTGCTGATGCAACTACGCTTACCGAAGCGGGCTATGTCGGCGAAGAT
GTGGAAAACATTGTTTTACGACTATTACAAGCTGCGGATTACGATGTCGCAAGAGCAGAACGGGGTATCATTTACATCGA
CGAAATTGATAAAATTGGTAGAACTACAGCGAATGTTTCCATCACCCGAGATGTTTCTGGCGAAGGTGTTCAACAAGCTC
TATTAAAAATTATAGAAGGTACTACCGCCAATGTCCCTCCTAAAGGAGGACGTAAACACCCTAACCAAGAGTATATCCGT
GTAAATACGGAGAACATTCTTTTCATAGTTGGTGGTGCTTTCGTAAATTTAGACAAGATTATCGCCAAACGCTTAGGGAA
AACTACCATAGGTTTCTCTGATGACCTCGGAGATTTCTCTCAAAAGGATCGTGATCACCTACTCACAAAAGTAGAAACAG
AAGACCTGATTGCTTTTGGTATGATTCCTGAGTTTGTTGGTCGATTCAATTGTATTGTGAACTGCGAAGAGCTTTCCTTG
GATGAACTCGTGGCTATTCTTACCGAACCCACCAATGCCATTGTGAAGCAGTATATCGAGTTATTCTCAGAAGAAAATGT
AAAGTTGATCTTCGAAAAAGAAGCTCTGTATGCTATAGCGAAAAAAGCCAAGCTGGCGAAAACTGGAGCCAGAGCTTTAG
GTATGATTTTAGAAAACTTACTCCGAGATCTAATGTTTGAGATCCCTTCTGATCCTACAGTAGAAGCTATACGGATTCAA
GAAGACACGATCTTAGAGAATAAAGCTCCGGTAATTATCAGAAGAGCTCCAGAAGCTATAGCTTAA

Upstream 100 bases:

>100_bases
TATGGGAGCTGAAGACGCAATCTCCTATGGTTTAATTGATAAAGTGGTCTCTTCAGCAAAAGACACGAAAGATAAGGACA
CCATCTCCTAGAGAGTCATT

Downstream 100 bases:

>100_bases
ATTTCTCTTCTTCGTTATTTAGGGATGTAATGACAACAATCGCCCTAGAAGCTGCAAAAAAGATTCTCCTGAAATTGCGT
AATGCCGGCTACCAAGCCTA

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNKKNLTICSFCGRSEKDVEKLIAGPSVYICDYCIKLCSGILDKKPTSTSSSGASTETAPQHPDLQVLTPKEIKKHIDKY
VVGQERAKKTIAVAVYNHYKRIRALLNNKHVSYGKSNVLLLGPTGSGKTLIAKTLAKILDVPFTIADATTLTEAGYVGED
VENIVLRLLQAADYDVARAERGIIYIDEIDKIGRTTANVSITRDVSGEGVQQALLKIIEGTTANVPPKGGRKHPNQEYIR
VNTENILFIVGGAFVNLDKIIAKRLGKTTIGFSDDLGDFSQKDRDHLLTKVETEDLIAFGMIPEFVGRFNCIVNCEELSL
DELVAILTEPTNAIVKQYIELFSEENVKLIFEKEALYAIAKKAKLAKTGARALGMILENLLRDLMFEIPSDPTVEAIRIQ
EDTILENKAPVIIRRAPEAIA

Sequences:

>Translated_421_residues
MNKKNLTICSFCGRSEKDVEKLIAGPSVYICDYCIKLCSGILDKKPTSTSSSGASTETAPQHPDLQVLTPKEIKKHIDKY
VVGQERAKKTIAVAVYNHYKRIRALLNNKHVSYGKSNVLLLGPTGSGKTLIAKTLAKILDVPFTIADATTLTEAGYVGED
VENIVLRLLQAADYDVARAERGIIYIDEIDKIGRTTANVSITRDVSGEGVQQALLKIIEGTTANVPPKGGRKHPNQEYIR
VNTENILFIVGGAFVNLDKIIAKRLGKTTIGFSDDLGDFSQKDRDHLLTKVETEDLIAFGMIPEFVGRFNCIVNCEELSL
DELVAILTEPTNAIVKQYIELFSEENVKLIFEKEALYAIAKKAKLAKTGARALGMILENLLRDLMFEIPSDPTVEAIRIQ
EDTILENKAPVIIRRAPEAIA
>Mature_421_residues
MNKKNLTICSFCGRSEKDVEKLIAGPSVYICDYCIKLCSGILDKKPTSTSSSGASTETAPQHPDLQVLTPKEIKKHIDKY
VVGQERAKKTIAVAVYNHYKRIRALLNNKHVSYGKSNVLLLGPTGSGKTLIAKTLAKILDVPFTIADATTLTEAGYVGED
VENIVLRLLQAADYDVARAERGIIYIDEIDKIGRTTANVSITRDVSGEGVQQALLKIIEGTTANVPPKGGRKHPNQEYIR
VNTENILFIVGGAFVNLDKIIAKRLGKTTIGFSDDLGDFSQKDRDHLLTKVETEDLIAFGMIPEFVGRFNCIVNCEELSL
DELVAILTEPTNAIVKQYIELFSEENVKLIFEKEALYAIAKKAKLAKTGARALGMILENLLRDLMFEIPSDPTVEAIRIQ
EDTILENKAPVIIRRAPEAIA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=344, Percent_Identity=47.3837209302326, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1786642, Length=416, Percent_Identity=57.2115384615385, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1790366, Length=105, Percent_Identity=42.8571428571429, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982908, Length=319, Percent_Identity=44.2006269592476, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71982905, Length=319, Percent_Identity=44.2006269592476, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI71988663, Length=414, Percent_Identity=37.43961352657, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71988660, Length=254, Percent_Identity=39.3700787401575, Blast_Score=176, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319704, Length=407, Percent_Identity=39.5577395577396, Blast_Score=243, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24648291, Length=322, Percent_Identity=46.583850931677, Blast_Score=281, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24648289, Length=322, Percent_Identity=46.583850931677, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_CHLAB (Q5L4W6)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220276.1
- HSSP:   O25926
- ProteinModelPortal:   Q5L4W6
- GeneID:   3337635
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB889
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   CABO218497:CAB889-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46357; Mature: 46357

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNLTICSFCGRSEKDVEKLIAGPSVYICDYCIKLCSGILDKKPTSTSSSGASTETAP
CCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QHPDLQVLTPKEIKKHIDKYVVGQERAKKTIAVAVYNHYKRIRALLNNKHVSYGKSNVLL
CCCCEEEECHHHHHHHHHHHHHCHHHHHHEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LGPTGSGKTLIAKTLAKILDVPFTIADATTLTEAGYVGEDVENIVLRLLQAADYDVARAE
ECCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHC
RGIIYIDEIDKIGRTTANVSITRDVSGEGVQQALLKIIEGTTANVPPKGGRKHPNQEYIR
CCEEEEECHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
VNTENILFIVGGAFVNLDKIIAKRLGKTTIGFSDDLGDFSQKDRDHLLTKVETEDLIAFG
EECCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
MIPEFVGRFNCIVNCEELSLDELVAILTEPTNAIVKQYIELFSEENVKLIFEKEALYAIA
HHHHHHHHHHEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHH
KKAKLAKTGARALGMILENLLRDLMFEIPSDPTVEAIRIQEDTILENKAPVIIRRAPEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCEEEECCCCCC
A
C
>Mature Secondary Structure
MNKKNLTICSFCGRSEKDVEKLIAGPSVYICDYCIKLCSGILDKKPTSTSSSGASTETAP
CCCCCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
QHPDLQVLTPKEIKKHIDKYVVGQERAKKTIAVAVYNHYKRIRALLNNKHVSYGKSNVLL
CCCCEEEECHHHHHHHHHHHHHCHHHHHHEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEE
LGPTGSGKTLIAKTLAKILDVPFTIADATTLTEAGYVGEDVENIVLRLLQAADYDVARAE
ECCCCCCCHHHHHHHHHHHCCCEEECCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHC
RGIIYIDEIDKIGRTTANVSITRDVSGEGVQQALLKIIEGTTANVPPKGGRKHPNQEYIR
CCEEEEECHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEE
VNTENILFIVGGAFVNLDKIIAKRLGKTTIGFSDDLGDFSQKDRDHLLTKVETEDLIAFG
EECCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
MIPEFVGRFNCIVNCEELSLDELVAILTEPTNAIVKQYIELFSEENVKLIFEKEALYAIA
HHHHHHHHHHEEEEHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHH
KKAKLAKTGARALGMILENLLRDLMFEIPSDPTVEAIRIQEDTILENKAPVIIRRAPEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCEEEECCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA