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The map label for this gene is clpP

Identifier: 62185490

GI number: 62185490

Start: 1037333

End: 1037950

Strand: Direct

Name: clpP

Synonym: CAB888

Alternate gene names: 62185490

Gene position: 1037333-1037950 (Clockwise)

Preceding gene: 62185489

Following gene: 62185491

Centisome position: 90.65

GC content: 41.1

Gene sequence:

>618_bases
ATGCAAATGACATTGGTGCCTTATGTGGTCGAGGATACAGGTCGTGGCGAGCGTGCCATGGATATTTACTCGCGTCTTTT
AAAAGATCGCATTGTAATGATTGGCCAAGAAATTACCGAGCCCCTCGCTAATACCGTCATAGCACAACTACTTTTCCTCA
TGTCCGAAGATCCTAAAAAGGACATTAAAGTTTTCATTAACTCCCCAGGAGGGTATATCACAGCTGGATTGGCTATCTAT
GATACTATTCGTTTCTTAGGTTGTGATGTAAATACTTATTGCATAGGTCAAGCGGCTTCTATGGGAGCTTTACTACTTTC
TGCAGGGACTAAAGGTAAGCGTTATGCTCTACCTCACAGTCGGATGATGATCCATCAGCCTTCAGGAGGAATTATAGGAA
CTTCTGCTGATATTCAGTTACAAGCTGCAGAAATCTTAACATTAAAAAAACACCTTGCAAACATTCTTTCCGAGTGCACA
GGACAACCTGTAGAAAAAATCATAGAAGATTCTGAAAGAGATTTCTTTATGGGAGCTGAAGACGCAATCTCCTATGGTTT
AATTGATAAAGTGGTCTCTTCAGCAAAAGACACGAAAGATAAGGACACCATCTCCTAG

Upstream 100 bases:

>100_bases
TTTTCAAGTAAAACAGCATAAAAAAATAAATATGTGTATTGTTGGAATTGCTTTTCCGCTTCTGGGTATATAGGCGGAGA
AGAAACTATTTTGAGAGGAA

Downstream 100 bases:

>100_bases
AGAGTCATTATGAACAAAAAAAATCTCACCATCTGCTCTTTTTGTGGGCGTTCTGAAAAAGATGTGGAAAAATTGATAGC
AGGTCCCTCTGTCTATATTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MQMTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPKKDIKVFINSPGGYITAGLAIY
DTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLANILSECT
GQPVEKIIEDSERDFFMGAEDAISYGLIDKVVSSAKDTKDKDTIS

Sequences:

>Translated_205_residues
MQMTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPKKDIKVFINSPGGYITAGLAIY
DTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLANILSECT
GQPVEKIIEDSERDFFMGAEDAISYGLIDKVVSSAKDTKDKDTIS
>Mature_205_residues
MQMTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPKKDIKVFINSPGGYITAGLAIY
DTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLANILSECT
GQPVEKIIEDSERDFFMGAEDAISYGLIDKVVSSAKDTKDKDTIS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=203, Percent_Identity=54.1871921182266, Blast_Score=219, Evalue=1e-57,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=53.125, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=203, Evalue=6e-53,
Organism=Drosophila melanogaster, GI20129427, Length=197, Percent_Identity=50.761421319797, Blast_Score=207, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_CHLAB (Q5L4W7)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220275.1
- ProteinModelPortal:   Q5L4W7
- SMR:   Q5L4W7
- MEROPS:   S14.001
- GeneID:   3337633
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB888
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   CABO218497:CAB888-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22364; Mature: 22364

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 100-100 ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPKK
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIKVFINSPGGYITAGLAIYDTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHS
CEEEEEECCCCEEEHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHEECCCCCCEEECCCC
RMMIHQPSGGIIGTSADIQLQAAEILTLKKHLANILSECTGQPVEKIIEDSERDFFMGAE
CEEEECCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEECCHH
DAISYGLIDKVVSSAKDTKDKDTIS
HHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQMTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPKK
CCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIKVFINSPGGYITAGLAIYDTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHS
CEEEEEECCCCEEEHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHEECCCCCCEEECCCC
RMMIHQPSGGIIGTSADIQLQAAEILTLKKHLANILSECTGQPVEKIIEDSERDFFMGAE
CEEEECCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEECCHH
DAISYGLIDKVVSSAKDTKDKDTIS
HHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA