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The map label for this gene is cysS

Identifier: 62185411

GI number: 62185411

Start: 935046

End: 936476

Strand: Direct

Name: cysS

Synonym: CAB806

Alternate gene names: 62185411

Gene position: 935046-936476 (Clockwise)

Preceding gene: 62185409

Following gene: 62185414

Centisome position: 81.71

GC content: 40.74

Gene sequence:

>1431_bases
ATGAGACAATCATCCGACAACAGACAGAACCTGTATTTATATAATACCGCATCGAGAACAAAAGAACTTTTTTCTCCCTC
TAATGATCCTGTCAAATTGTATACCTGTGGTCCTACAGTATATGACTATGCGCATATCGGAAATTTCCGTACGTATATAT
TTGAAGATTTATTAAAACGGATTCTTTTGTTCTTTGGATACTCTGTAAAGCATGTGATGAATATTACAGATGTTGACGAT
AAGACCTTGGCTGGTGCGTGTAAAAACAATATCTCTTTGGATACCTATACAGCTCCGTTCATACAAGCCTTTTTTAAAGA
CGTTGCCACGCTGCATATCCTACCTGCGGATGCTTATCCCCGTGCTACGCACTATATCCCTCAAATGCTCGTGGCTATCC
GCAAGCTTCTAGATGATGGCATCGCCTATATAGGCCAAGATCACTCGGTTTATTTTTCTATAAAAGAGTTCCCTTCCTAT
GGGAAGTTATCTCAGTTACAGTTACAAAATTTGCAATGTTGCTCTAGGATAGCTTCCGATGAGTATGACAAAGAAAACCT
TTCGGATTTCGTATTATGGAAAGCATACGATAAACATAGAGACGGTCATATTTATTGGGAGAGCCCATTTGGCAAAGGTC
GCCCGGGTTGGCATTTAGAATGTTCTATCATGGCTATGGAACTTCTTGGGCCTTCTATTGATATCCATGCAGGAGGTGTA
GACAACATTTTCCCGCACCATGAAAACGAGATTGCCCAGTCGGAATCTTTATCTCACCAGCCTTTTTCTCGTTACTGGCT
CCATTCTGAACATCTTCTTGTTGATGGGAAAAAGATGTCGAAAAGTTTAGGGAATTTTTTCACGCTAAGAAATTTGTTAG
ATCGTGGATTTTCTGGAGCAGAAATTCGCTATATGCTCTTACAAAGCCATTATAGAATGCAATTGAACTTCACTGAAGAA
GGCCTCATGGCTTGCCGTCAAGCGTTAAAACGCTTACGTGATTTCATTTCTCGATTAGAAAGTCCCTACCCTGAAAGCGC
CACTATTTCTGAAGGTATAGACCAGTGCGGGCAACGGTTTTTACAAGATTTTTCCAACGCTATTGCCAACGATTTAAACA
TAGCGGCCGCGCTTGCATCCCTTTTCGATTTTATTCATCAGACAAACTCACGGATTGATCAATCGCACTTCACACAGGCG
GATAGCCACTATGTTTTGGACATTTTGAAGAAAATTAACACCGTACTTGGTGTTATTCCCTTCTCTACATCCTTAGAAAT
CCCTAGTGAAGTTGCCCGACTTGTTGAAGAACGAGAAATTGCCCGCAAGGAGAAAAACTGGAAGCAAGCGGATGTTCTTC
GGAATCAAATTGCTTCTTTCGGCTATGTTGTTGAAGATACAAAATCAGGGCCTAAAGTAAAAAAATACTAG

Upstream 100 bases:

>100_bases
AAACATTCATTTTTCGTATTGAGGCGTTAGTCTAGCACCTTGAAACAAGCCTAATCTACGCTCTCACCGGTATAAATCTA
GAACCTTTGAGAGTCTGCTC

Downstream 100 bases:

>100_bases
TCCTTTTCTGATTCTAAACGACGCATAGCTGGGAAATACAATACATCACGTATAGAGGCAGCATTTGTAAGAATCATGAC
CAAACGATCGATACCGATAC

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRQSSDNRQNLYLYNTASRTKELFSPSNDPVKLYTCGPTVYDYAHIGNFRTYIFEDLLKRILLFFGYSVKHVMNITDVDD
KTLAGACKNNISLDTYTAPFIQAFFKDVATLHILPADAYPRATHYIPQMLVAIRKLLDDGIAYIGQDHSVYFSIKEFPSY
GKLSQLQLQNLQCCSRIASDEYDKENLSDFVLWKAYDKHRDGHIYWESPFGKGRPGWHLECSIMAMELLGPSIDIHAGGV
DNIFPHHENEIAQSESLSHQPFSRYWLHSEHLLVDGKKMSKSLGNFFTLRNLLDRGFSGAEIRYMLLQSHYRMQLNFTEE
GLMACRQALKRLRDFISRLESPYPESATISEGIDQCGQRFLQDFSNAIANDLNIAAALASLFDFIHQTNSRIDQSHFTQA
DSHYVLDILKKINTVLGVIPFSTSLEIPSEVARLVEEREIARKEKNWKQADVLRNQIASFGYVVEDTKSGPKVKKY

Sequences:

>Translated_476_residues
MRQSSDNRQNLYLYNTASRTKELFSPSNDPVKLYTCGPTVYDYAHIGNFRTYIFEDLLKRILLFFGYSVKHVMNITDVDD
KTLAGACKNNISLDTYTAPFIQAFFKDVATLHILPADAYPRATHYIPQMLVAIRKLLDDGIAYIGQDHSVYFSIKEFPSY
GKLSQLQLQNLQCCSRIASDEYDKENLSDFVLWKAYDKHRDGHIYWESPFGKGRPGWHLECSIMAMELLGPSIDIHAGGV
DNIFPHHENEIAQSESLSHQPFSRYWLHSEHLLVDGKKMSKSLGNFFTLRNLLDRGFSGAEIRYMLLQSHYRMQLNFTEE
GLMACRQALKRLRDFISRLESPYPESATISEGIDQCGQRFLQDFSNAIANDLNIAAALASLFDFIHQTNSRIDQSHFTQA
DSHYVLDILKKINTVLGVIPFSTSLEIPSEVARLVEEREIARKEKNWKQADVLRNQIASFGYVVEDTKSGPKVKKY
>Mature_476_residues
MRQSSDNRQNLYLYNTASRTKELFSPSNDPVKLYTCGPTVYDYAHIGNFRTYIFEDLLKRILLFFGYSVKHVMNITDVDD
KTLAGACKNNISLDTYTAPFIQAFFKDVATLHILPADAYPRATHYIPQMLVAIRKLLDDGIAYIGQDHSVYFSIKEFPSY
GKLSQLQLQNLQCCSRIASDEYDKENLSDFVLWKAYDKHRDGHIYWESPFGKGRPGWHLECSIMAMELLGPSIDIHAGGV
DNIFPHHENEIAQSESLSHQPFSRYWLHSEHLLVDGKKMSKSLGNFFTLRNLLDRGFSGAEIRYMLLQSHYRMQLNFTEE
GLMACRQALKRLRDFISRLESPYPESATISEGIDQCGQRFLQDFSNAIANDLNIAAALASLFDFIHQTNSRIDQSHFTQA
DSHYVLDILKKINTVLGVIPFSTSLEIPSEVARLVEEREIARKEKNWKQADVLRNQIASFGYVVEDTKSGPKVKKY

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=326, Percent_Identity=38.9570552147239, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI21269877, Length=274, Percent_Identity=36.8613138686131, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI10835051, Length=274, Percent_Identity=36.8613138686131, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI303304987, Length=274, Percent_Identity=36.8613138686131, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI62240992, Length=274, Percent_Identity=36.8613138686131, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1786737, Length=476, Percent_Identity=38.0252100840336, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17509795, Length=275, Percent_Identity=34.1818181818182, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17509797, Length=275, Percent_Identity=34.1818181818182, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324082, Length=334, Percent_Identity=34.4311377245509, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19922218, Length=411, Percent_Identity=34.3065693430657, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI19922364, Length=274, Percent_Identity=37.2262773722628, Blast_Score=181, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_CHLAB (Q5L546)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220196.1
- ProteinModelPortal:   Q5L546
- GeneID:   3337329
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB806
- HOGENOM:   HBG327651
- OMA:   IGNLRTY
- ProtClustDB:   PRK00260
- BioCyc:   CABO218497:CAB806-MONOMER
- BRENDA:   6.1.1.16
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 54564; Mature: 54564

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSSDNRQNLYLYNTASRTKELFSPSNDPVKLYTCGPTVYDYAHIGNFRTYIFEDLLKR
CCCCCCCCCEEEEEECHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHH
ILLFFGYSVKHVMNITDVDDKTLAGACKNNISLDTYTAPFIQAFFKDVATLHILPADAYP
HHHHHCCCHHHHEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCC
RATHYIPQMLVAIRKLLDDGIAYIGQDHSVYFSIKEFPSYGKLSQLQLQNLQCCSRIASD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
EYDKENLSDFVLWKAYDKHRDGHIYWESPFGKGRPGWHLECSIMAMELLGPSIDIHAGGV
CCCHHCHHHHEEEHHHHCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHCCCCEEECCCC
DNIFPHHENEIAQSESLSHQPFSRYWLHSEHLLVDGKKMSKSLGNFFTLRNLLDRGFSGA
CCCCCCCCHHHHHHHCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCC
EIRYMLLQSHYRMQLNFTEEGLMACRQALKRLRDFISRLESPYPESATISEGIDQCGQRF
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LQDFSNAIANDLNIAAALASLFDFIHQTNSRIDQSHFTQADSHYVLDILKKINTVLGVIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
FSTSLEIPSEVARLVEEREIARKEKNWKQADVLRNQIASFGYVVEDTKSGPKVKKY
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MRQSSDNRQNLYLYNTASRTKELFSPSNDPVKLYTCGPTVYDYAHIGNFRTYIFEDLLKR
CCCCCCCCCEEEEEECHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHH
ILLFFGYSVKHVMNITDVDDKTLAGACKNNISLDTYTAPFIQAFFKDVATLHILPADAYP
HHHHHCCCHHHHEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCC
RATHYIPQMLVAIRKLLDDGIAYIGQDHSVYFSIKEFPSYGKLSQLQLQNLQCCSRIASD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
EYDKENLSDFVLWKAYDKHRDGHIYWESPFGKGRPGWHLECSIMAMELLGPSIDIHAGGV
CCCHHCHHHHEEEHHHHCCCCCEEEEECCCCCCCCCCEEEHHHHHHHHHCCCCEEECCCC
DNIFPHHENEIAQSESLSHQPFSRYWLHSEHLLVDGKKMSKSLGNFFTLRNLLDRGFSGA
CCCCCCCCHHHHHHHCCCCCCCHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCC
EIRYMLLQSHYRMQLNFTEEGLMACRQALKRLRDFISRLESPYPESATISEGIDQCGQRF
HHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
LQDFSNAIANDLNIAAALASLFDFIHQTNSRIDQSHFTQADSHYVLDILKKINTVLGVIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
FSTSLEIPSEVARLVEEREIARKEKNWKQADVLRNQIASFGYVVEDTKSGPKVKKY
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA