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The map label for this gene is lpxB

Identifier: 62185371

GI number: 62185371

Start: 879519

End: 881402

Strand: Direct

Name: lpxB

Synonym: CAB759

Alternate gene names: 62185371

Gene position: 879519-881402 (Clockwise)

Preceding gene: 62185370

Following gene: 62185378

Centisome position: 76.86

GC content: 38.8

Gene sequence:

>1884_bases
ATGTTTCCTCTTTATCTGGTTCGTCTACTGTATCCTATAGGACTAATAGCTAATCTATTTTTTGGCTTTGCGTTTACTCT
CCAGTGGTTTCTAAGTGAAAGACACAAAAGAGCTTGTGTCCCTAAGGCTTTTTGGATCTTTTCATCCATAGGGGCGATTT
TGATGATTGCTCACGGCTTTATTCAAAGTCAATTTCCTATAGCACTTCTCCACGGGGCAAATTTGGTTATCTATTTTAGG
AACCTAAATATCTCTTCTTCCCGTAAGCTCTCTTTAAAAACAACTTTGATCATTCTTGCTGTAACACTGCTTCTCACTGC
ATTACCTTTTGCCTTAGAAGCTTACTATCATCCTAACATGCAGTGGATGGCTTCTCCTAATATCTTTCACCTTCCTCTAC
CCCCACCGAATATGTATTGGCATATGATTGGTTGTTTAGGATTGTTCACTTTTTCGTGTAGATTCTTTATTCAATGGTGC
CACTTAGAAATGAATAATCAATCGACATTACCGGTGCTATTCTGGCAGGTAGGTTTTGTGGGAGGTTTCCTGGCCTTTCT
TTATTTTATACGCACAGGAGATCCTGTAAATATTCTGAGTTATGGTTGTGGATTGTTTCCCTCCATAGCTAATTTACGCA
TTATATATAAGAAATCACGTCTTTCGGAATTTCACAACCCCAGCTACTTCATATCTGCTGGAGAAGCTAGTGGCGACACT
TTAGGCAGCGACCTTCTTCGCCATATCAAAGCTCTTCATCCCGATAAGCGTTGTTTTGGTGTTGGAGGACCTTTAATGCG
CCAAGAAGGTCTTGAACCTCTAATCCACATGGAAGAGTTTCAAGTGTCAGGATTCTTAGAAATCCTCACCTCTATCTTTA
CTCTGATTAAGAAATACCGAAAGTTATACAAAGCTATTCTTAAAGAAAATCCTGAGATAGTCTTCTGCATAGATTTCCCA
GACTTTCATTTTTTCCTTATTAAAAAGCTAAGAAAATGCGGTTATACAGGAAAAATCGTTCACTATGTCTGTCCGAGTAT
TTGGGCATGGCGACCTAAAAGAAAAAAGATCCTAGAAAAGTATTTAGATACCCTTTTGCTCATACTTCCTTTTGAAAATG
AGCTTTTCATAAACTCCCCTTTAAAAACGATCTATCTAGGACATCCTTTAGTAAAGACGATATCGAATTTCCAACATTGC
CCATCCTGGAAACAAGCTCTCGCTATTTCTGATCAACCTATTGTTGCCCTGTTTCCGGGTAGCCGACCTGGGGATATTCT
CAGAAATTTACAAGTACACATTCGTGCATTTCTTGCCTCATCATTAGCAGAATCACATCAGCTTCTGGTATCTTCTTACA
ACCTGAAACACGATCAGACCATCCTCGACCTCTTAGAAAAAGAAGGTTGTTGTGGTAAAACTGTCCCGGCGATGTACCGT
TATCACCTTATGCGAGATTGCGATTGTGCCTTAGCAAAATGTGGAACTATTGCTCTGGAAGCCGCTTTAAATCAAACACC
CACAATTGTCACCTGTCTTCTTCGACCTTTTGATATCTTTTTAGCCAAGTATATCTTTAAGATCTTTATGTCTGCATATT
CCCTCCCAAATATCATTACCAAATCGATTATCTTCCCAGAATTTATAGGAGGTAAATCTGACTTTACTCCTGAAGAAGTA
GCAGCAGCTATAGATATCCTTGCTAATCCTAAATCTAGAGAAAAACAAAAACGTGCGTGTCAGACACTTCTTGAAACAAT
GGAAACAAATGTGGTGACGGTTCAAGAATGTTTACAAACTATACACTCATTAAAAAGTCGTTTTCATACAGAAAATGATT
GCTTAGGGAACTACGTCCAGAAGAATGTTAGGCCGAGTTTTTAA

Upstream 100 bases:

>100_bases
TTAGTTTATCCTAAGCTAGATAAAATACTTGCTGCTTGGATAAAGCATTACCAAGCATTACAATTTAAAAAGGAACTTCC
TTCTTGAGTTTAAACTAGCC

Downstream 100 bases:

>100_bases
CTTTTTCTATGATGTCTGACTACAACAAGTAGTGCTTTTCTCCCTACATAGATGGGAACAGGGTGACGGGGAAAGATGAA
TAATCTGAGATGATCGAATG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MFPLYLVRLLYPIGLIANLFFGFAFTLQWFLSERHKRACVPKAFWIFSSIGAILMIAHGFIQSQFPIALLHGANLVIYFR
NLNISSSRKLSLKTTLIILAVTLLLTALPFALEAYYHPNMQWMASPNIFHLPLPPPNMYWHMIGCLGLFTFSCRFFIQWC
HLEMNNQSTLPVLFWQVGFVGGFLAFLYFIRTGDPVNILSYGCGLFPSIANLRIIYKKSRLSEFHNPSYFISAGEASGDT
LGSDLLRHIKALHPDKRCFGVGGPLMRQEGLEPLIHMEEFQVSGFLEILTSIFTLIKKYRKLYKAILKENPEIVFCIDFP
DFHFFLIKKLRKCGYTGKIVHYVCPSIWAWRPKRKKILEKYLDTLLLILPFENELFINSPLKTIYLGHPLVKTISNFQHC
PSWKQALAISDQPIVALFPGSRPGDILRNLQVHIRAFLASSLAESHQLLVSSYNLKHDQTILDLLEKEGCCGKTVPAMYR
YHLMRDCDCALAKCGTIALEAALNQTPTIVTCLLRPFDIFLAKYIFKIFMSAYSLPNIITKSIIFPEFIGGKSDFTPEEV
AAAIDILANPKSREKQKRACQTLLETMETNVVTVQECLQTIHSLKSRFHTENDCLGNYVQKNVRPSF

Sequences:

>Translated_627_residues
MFPLYLVRLLYPIGLIANLFFGFAFTLQWFLSERHKRACVPKAFWIFSSIGAILMIAHGFIQSQFPIALLHGANLVIYFR
NLNISSSRKLSLKTTLIILAVTLLLTALPFALEAYYHPNMQWMASPNIFHLPLPPPNMYWHMIGCLGLFTFSCRFFIQWC
HLEMNNQSTLPVLFWQVGFVGGFLAFLYFIRTGDPVNILSYGCGLFPSIANLRIIYKKSRLSEFHNPSYFISAGEASGDT
LGSDLLRHIKALHPDKRCFGVGGPLMRQEGLEPLIHMEEFQVSGFLEILTSIFTLIKKYRKLYKAILKENPEIVFCIDFP
DFHFFLIKKLRKCGYTGKIVHYVCPSIWAWRPKRKKILEKYLDTLLLILPFENELFINSPLKTIYLGHPLVKTISNFQHC
PSWKQALAISDQPIVALFPGSRPGDILRNLQVHIRAFLASSLAESHQLLVSSYNLKHDQTILDLLEKEGCCGKTVPAMYR
YHLMRDCDCALAKCGTIALEAALNQTPTIVTCLLRPFDIFLAKYIFKIFMSAYSLPNIITKSIIFPEFIGGKSDFTPEEV
AAAIDILANPKSREKQKRACQTLLETMETNVVTVQECLQTIHSLKSRFHTENDCLGNYVQKNVRPSF
>Mature_627_residues
MFPLYLVRLLYPIGLIANLFFGFAFTLQWFLSERHKRACVPKAFWIFSSIGAILMIAHGFIQSQFPIALLHGANLVIYFR
NLNISSSRKLSLKTTLIILAVTLLLTALPFALEAYYHPNMQWMASPNIFHLPLPPPNMYWHMIGCLGLFTFSCRFFIQWC
HLEMNNQSTLPVLFWQVGFVGGFLAFLYFIRTGDPVNILSYGCGLFPSIANLRIIYKKSRLSEFHNPSYFISAGEASGDT
LGSDLLRHIKALHPDKRCFGVGGPLMRQEGLEPLIHMEEFQVSGFLEILTSIFTLIKKYRKLYKAILKENPEIVFCIDFP
DFHFFLIKKLRKCGYTGKIVHYVCPSIWAWRPKRKKILEKYLDTLLLILPFENELFINSPLKTIYLGHPLVKTISNFQHC
PSWKQALAISDQPIVALFPGSRPGDILRNLQVHIRAFLASSLAESHQLLVSSYNLKHDQTILDLLEKEGCCGKTVPAMYR
YHLMRDCDCALAKCGTIALEAALNQTPTIVTCLLRPFDIFLAKYIFKIFMSAYSLPNIITKSIIFPEFIGGKSDFTPEEV
AAAIDILANPKSREKQKRACQTLLETMETNVVTVQECLQTIHSLKSRFHTENDCLGNYVQKNVRPSF

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=331, Percent_Identity=31.4199395770393, Blast_Score=141, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CHLAB (Q5L586)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_220156.1
- ProteinModelPortal:   Q5L586
- GeneID:   3337870
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB759
- HOGENOM:   HBG414066
- OMA:   CALAKCG
- PhylomeDB:   Q5L586
- ProtClustDB:   PRK01021
- BioCyc:   CABO218497:CAB759-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- InterPro:   IPR011499
- ProDom:   PD339292
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF07578 LAB_N; PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 71610; Mature: 71610

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPLYLVRLLYPIGLIANLFFGFAFTLQWFLSERHKRACVPKAFWIFSSIGAILMIAHGF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IQSQFPIALLHGANLVIYFRNLNISSSRKLSLKTTLIILAVTLLLTALPFALEAYYHPNM
HHCCCCEEEEECCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QWMASPNIFHLPLPPPNMYWHMIGCLGLFTFSCRFFIQWCHLEMNNQSTLPVLFWQVGFV
CEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
GGFLAFLYFIRTGDPVNILSYGCGLFPSIANLRIIYKKSRLSEFHNPSYFISAGEASGDT
HHHHHHHHHHHCCCCHHHHHHCCCCCHHHHCEEEEEEHHHHHHHCCCCEEEECCCCCCCH
LGSDLLRHIKALHPDKRCFGVGGPLMRQEGLEPLIHMEEFQVSGFLEILTSIFTLIKKYR
HHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLYKAILKENPEIVFCIDFPDFHFFLIKKLRKCGYTGKIVHYVCPSIWAWRPKRKKILEK
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHCCCCHHHHHHHH
YLDTLLLILPFENELFINSPLKTIYLGHPLVKTISNFQHCPSWKQALAISDQPIVALFPG
HHHHHEEEECCCCCEEECCCHHHEEECCHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCC
SRPGDILRNLQVHIRAFLASSLAESHQLLVSSYNLKHDQTILDLLEKEGCCGKTVPAMYR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHH
YHLMRDCDCALAKCGTIALEAALNQTPTIVTCLLRPFDIFLAKYIFKIFMSAYSLPNIIT
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KSIIFPEFIGGKSDFTPEEVAAAIDILANPKSREKQKRACQTLLETMETNVVTVQECLQT
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IHSLKSRFHTENDCLGNYVQKNVRPSF
HHHHHHHCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFPLYLVRLLYPIGLIANLFFGFAFTLQWFLSERHKRACVPKAFWIFSSIGAILMIAHGF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
IQSQFPIALLHGANLVIYFRNLNISSSRKLSLKTTLIILAVTLLLTALPFALEAYYHPNM
HHCCCCEEEEECCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QWMASPNIFHLPLPPPNMYWHMIGCLGLFTFSCRFFIQWCHLEMNNQSTLPVLFWQVGFV
CEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
GGFLAFLYFIRTGDPVNILSYGCGLFPSIANLRIIYKKSRLSEFHNPSYFISAGEASGDT
HHHHHHHHHHHCCCCHHHHHHCCCCCHHHHCEEEEEEHHHHHHHCCCCEEEECCCCCCCH
LGSDLLRHIKALHPDKRCFGVGGPLMRQEGLEPLIHMEEFQVSGFLEILTSIFTLIKKYR
HHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLYKAILKENPEIVFCIDFPDFHFFLIKKLRKCGYTGKIVHYVCPSIWAWRPKRKKILEK
HHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHCCCCHHHHHHHH
YLDTLLLILPFENELFINSPLKTIYLGHPLVKTISNFQHCPSWKQALAISDQPIVALFPG
HHHHHEEEECCCCCEEECCCHHHEEECCHHHHHHHHHHCCCCHHHHHCCCCCCEEEECCC
SRPGDILRNLQVHIRAFLASSLAESHQLLVSSYNLKHDQTILDLLEKEGCCGKTVPAMYR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHH
YHLMRDCDCALAKCGTIALEAALNQTPTIVTCLLRPFDIFLAKYIFKIFMSAYSLPNIIT
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KSIIFPEFIGGKSDFTPEEVAAAIDILANPKSREKQKRACQTLLETMETNVVTVQECLQT
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IHSLKSRFHTENDCLGNYVQKNVRPSF
HHHHHHHCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA