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The map label for this gene is prs [H]

Identifier: 59711371

GI number: 59711371

Start: 834435

End: 835433

Strand: Reverse

Name: prs [H]

Synonym: VF_0764

Alternate gene names: 59711371

Gene position: 835433-834435 (Counterclockwise)

Preceding gene: 59711372

Following gene: 59711370

Centisome position: 28.83

GC content: 43.34

Gene sequence:

>999_bases
ATGCAAAATATAAAATTCTCACAATTTGGACGCAACCCTGAGGTTTCCACCGTGCCTGACATGAAGCTATTTGCTGGTAA
TGCAACTCCTGAACTAGCCCAACGTATCGCTGATCGACTATATATTTCACTTGGTGACGCTACTGTAGATCGTTTTTCTG
ACGGCGAAGTAGCCGTTCAAATTAACGAGAATGTACGTGGTAGTGATGTTTTCATCATTCAATCGACTTGTGCTCCTACT
AATGACAACATTATGGAATTAGTAGTGATGATTGATGCACTTCGTCGTGCTTCTGCTGGCCGTATTACTGCGGTAATCCC
ATACTTTGGTTACGCTCGTCAAGATCGTCGTGTACGTTCTGCTCGTGTACCAATCACTGCAAAAGTTATTGCTGATATGC
TTTCAAACGTTGGTGTTGACCGCGTTTTAACTATCGACCTTCACGCTGAACAAATTCAAGGTTTCTTCGACGTACCTGTA
GACAACATCTTCGGTACTCCTGTACTGCTTGATGACATGCGTACTCGTGGTTTAGAAAACCCTGTTGTTGTTTCTCCTGA
CCTAGGCGGTGTTGTTCGTGCTCGTGCAACAGCAAAAGCATTAGGTGATGTTGATATCGCTATCGTTGATAAGCGCCGTC
CACGTGCTAACGTTTCTGAAGTAATGAACCTAATTGGTGATGTTGACGGTCGTGATTGTGTAATCGTTGATGACATGATC
GATACTGGCGGTACATTATGTAAAGCTGCTGAAGCGCTTAAAGAGCGTGGCGCAAAACGTGTATTTGCATACGCAACTCA
CGCAGTATTCTCTGGTAGTGCACCACAAAACATTGCAAACTCAGTTCTTGACCAAGTTATCGTAACTGACTCAATTACTC
TTTCTAAAGAAATGGCAGCAACAGGTAAAGTAACTGAACTTAGCCTTTCTCGCATGCTAGCTGAAGCGATTCGTCGTATC
AGCAATGAAGAGTCTATCTCTGCAATGTTTGATCACTAA

Upstream 100 bases:

>100_bases
AAGATGTTTATTCTTTAATCCCTGATAATGCAACCGGATTTATCGCCCGAGGTATGAATACTTCGCCACTCAACCGAACA
CTGGAAGAGTATAAATCATT

Downstream 100 bases:

>100_bases
TCAAACAGAAATCTATTCAAACGCCCTGCCTTTGCGGGGCGTTTTTGTATTTGGAATTCTTGTGGTAATATGGCGCGCCT
TTTTAATGGTGCATACTAAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MQNIKFSQFGRNPEVSTVPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFIIQSTCAPT
NDNIMELVVMIDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVIADMLSNVGVDRVLTIDLHAEQIQGFFDVPV
DNIFGTPVLLDDMRTRGLENPVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVDGRDCVIVDDMI
DTGGTLCKAAEALKERGAKRVFAYATHAVFSGSAPQNIANSVLDQVIVTDSITLSKEMAATGKVTELSLSRMLAEAIRRI
SNEESISAMFDH

Sequences:

>Translated_332_residues
MQNIKFSQFGRNPEVSTVPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFIIQSTCAPT
NDNIMELVVMIDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVIADMLSNVGVDRVLTIDLHAEQIQGFFDVPV
DNIFGTPVLLDDMRTRGLENPVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVDGRDCVIVDDMI
DTGGTLCKAAEALKERGAKRVFAYATHAVFSGSAPQNIANSVLDQVIVTDSITLSKEMAATGKVTELSLSRMLAEAIRRI
SNEESISAMFDH
>Mature_332_residues
MQNIKFSQFGRNPEVSTVPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQINENVRGSDVFIIQSTCAPT
NDNIMELVVMIDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVIADMLSNVGVDRVLTIDLHAEQIQGFFDVPV
DNIFGTPVLLDDMRTRGLENPVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVDGRDCVIVDDMI
DTGGTLCKAAEALKERGAKRVFAYATHAVFSGSAPQNIANSVLDQVIVTDSITLSKEMAATGKVTELSLSRMLAEAIRRI
SNEESISAMFDH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=47.9495268138801, Blast_Score=304, Evalue=6e-83,
Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=47.3186119873817, Blast_Score=300, Evalue=9e-82,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=47.0219435736677, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=46.3722397476341, Blast_Score=297, Evalue=8e-81,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.1516034985423, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=35.8600583090379, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=30.3448275862069, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=30.3448275862069, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=30.3448275862069, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=30.3448275862069, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=80.6349206349206, Blast_Score=526, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17554702, Length=317, Percent_Identity=45.4258675078864, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=45.4258675078864, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=45.4258675078864, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=45.5128205128205, Blast_Score=290, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=33.9233038348083, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=45.3968253968254, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=44.620253164557, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=46.8152866242038, Blast_Score=265, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=42.0289855072464, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=42.3423423423423, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=46.6876971608833, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=43.6578171091445, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24651458, Length=360, Percent_Identity=31.9444444444444, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24651456, Length=360, Percent_Identity=31.9444444444444, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI281362873, Length=360, Percent_Identity=31.9444444444444, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24651454, Length=360, Percent_Identity=31.9444444444444, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24651462, Length=378, Percent_Identity=31.4814814814815, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24651464, Length=378, Percent_Identity=31.4814814814815, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI45552010, Length=378, Percent_Identity=31.4814814814815, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36038; Mature: 36038

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIKFSQFGRNPEVSTVPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQ
CCCCCCHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHEEEECCHHHHCCCCCEEEEE
INENVRGSDVFIIQSTCAPTNDNIMELVVMIDALRRASAGRITAVIPYFGYARQDRRVRS
ECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
ARVPITAKVIADMLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLDDMRTRGLEN
HCCCCHHHHHHHHHHCCCCCEEEEEEEEHHHHCCEECCCHHHHCCCCEEEHHHHHCCCCC
PVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVDGRDCVIVDDMI
CEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCC
DTGGTLCKAAEALKERGAKRVFAYATHAVFSGSAPQNIANSVLDQVIVTDSITLSKEMAA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHC
TGKVTELSLSRMLAEAIRRISNEESISAMFDH
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure
MQNIKFSQFGRNPEVSTVPDMKLFAGNATPELAQRIADRLYISLGDATVDRFSDGEVAVQ
CCCCCCHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHEEEECCHHHHCCCCCEEEEE
INENVRGSDVFIIQSTCAPTNDNIMELVVMIDALRRASAGRITAVIPYFGYARQDRRVRS
ECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHH
ARVPITAKVIADMLSNVGVDRVLTIDLHAEQIQGFFDVPVDNIFGTPVLLDDMRTRGLEN
HCCCCHHHHHHHHHHCCCCCEEEEEEEEHHHHCCEECCCHHHHCCCCEEEHHHHHCCCCC
PVVVSPDLGGVVRARATAKALGDVDIAIVDKRRPRANVSEVMNLIGDVDGRDCVIVDDMI
CEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCC
DTGGTLCKAAEALKERGAKRVFAYATHAVFSGSAPQNIANSVLDQVIVTDSITLSKEMAA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHC
TGKVTELSLSRMLAEAIRRISNEESISAMFDH
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]