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The map label for this gene is pth [H]

Identifier: 59711370

GI number: 59711370

Start: 833664

End: 834134

Strand: Reverse

Name: pth [H]

Synonym: VF_0763

Alternate gene names: 59711370

Gene position: 834134-833664 (Counterclockwise)

Preceding gene: 59711371

Following gene: 172087678

Centisome position: 28.79

GC content: 40.55

Gene sequence:

>471_bases
ATGCGAGAAGAAGCTAAATTCTTCGGCTTAACTGGTAGGATCCAAAGTAATGGTGATGATCTTCGATTGTTGATCCCAAC
CACTTTTATGAATCTATCAGGTAAAGCTATCGCTGCGATGGCAAAGTTCTATCAGATCAAACCGGAAGAAATTCTTGTTG
CTCATGATGAACTGGATCTCCCTCCTGGTGTTGCTAAATTTAAAAAAGGTGGTGGACACGGTGGCCATAACGGTTTACGT
GACACCATTAGTAAATTAGCGAATACGAAAGAGTTTTACCGCCTTCGTATTGGCATTGGTCATCCTGGCCATAAAGATAA
AGTTGCCGGTTTTGTTTTAGGTAAAGCGCCAACTAAAGAGCAAGAATTAATCGATGCTGCAGTAGATGAATCTACACGCT
GCCTTGATATCCTTCTCAAAGATGGATTAAGCAAAGCACAAAATCGTTTACACACATTCAAAGCTGAATAA

Upstream 100 bases:

>100_bases
TTCTCGTTGGACTAGCAAACCTGGTCTTGAGTATAAAAGAACTCGCCATAATGCTGGTGCATGGGTTGTTGAAGAACTCG
CTCGAGTTCATAATGTTTCT

Downstream 100 bases:

>100_bases
CACAGATAAGGTTTACATCATGGGTTTTAAATGCGGAATCGTTGGTCTTCCAAACGTTGGTAAATCAACACTATTTAACG
CACTAACAAAAGCAGGAATC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MREEAKFFGLTGRIQSNGDDLRLLIPTTFMNLSGKAIAAMAKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLR
DTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKEQELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE

Sequences:

>Translated_156_residues
MREEAKFFGLTGRIQSNGDDLRLLIPTTFMNLSGKAIAAMAKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLR
DTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKEQELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE
>Mature_156_residues
MREEAKFFGLTGRIQSNGDDLRLLIPTTFMNLSGKAIAAMAKFYQIKPEEILVAHDELDLPPGVAKFKKGGGHGGHNGLR
DTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKEQELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=113, Percent_Identity=42.4778761061947, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI1787455, Length=156, Percent_Identity=71.1538461538462, Blast_Score=216, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 17123; Mature: 17123

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREEAKFFGLTGRIQSNGDDLRLLIPTTFMNLSGKAIAAMAKFYQIKPEEILVAHDELDL
CCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHHEEEECCCCCC
PPGVAKFKKGGGHGGHNGLRDTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKE
CCCHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEECCCCCHH
QELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MREEAKFFGLTGRIQSNGDDLRLLIPTTFMNLSGKAIAAMAKFYQIKPEEILVAHDELDL
CCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHHEEEECCCCCC
PPGVAKFKKGGGHGGHNGLRDTISKLANTKEFYRLRIGIGHPGHKDKVAGFVLGKAPTKE
CCCHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEECCCCCHH
QELIDAAVDESTRCLDILLKDGLSKAQNRLHTFKAE
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA