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The map label for this gene is panE [H]

Identifier: 59711325

GI number: 59711325

Start: 785155

End: 786060

Strand: Reverse

Name: panE [H]

Synonym: VF_0718

Alternate gene names: 59711325

Gene position: 786060-785155 (Counterclockwise)

Preceding gene: 59711326

Following gene: 59711324

Centisome position: 27.13

GC content: 36.53

Gene sequence:

>906_bases
ATGGATTCATCTGTGAATATCACCATTCTTGGTCCTGGTGCAGTCGGCTCTTTATGGGCATGCTATCTGCAAAAAGCAGG
ACACAATATCTGTTTATGGACAAGAAATTCAACACCTTCTGAGCAACTACTTTCATTATCCGCTAATGAAAACTCATCAC
ACCAATTTAAGTGCAATGATAAACAAGCCTTGAACGATTGTGATTTGCTATTAATTACAGTTAAAGCTTGGCAAGTCGAA
AGCGCCTTACTCCCTTTACTTCCATCATTATCAAAAGAAACCATACTGCTATTTATGCATAATGGCATGGGAGCAATTGA
TGACTTAAAAGAACACATTAATCACCACCCAATTTTGCAAGCAACGACGACTCATGGTGCATTAAAAGAAAATAACACTA
ACGTAATCCATACAGGTTATGGAAATGCCTCAGTAGGCCCATTTAACCCACTAGGTAAACAGTGTCAGTTTATTCAAGAT
GTATTAAATCATAGCTTGCCAAGTGTCGATTGGAACCCAGAAATTAATATCGCATTATGGAAAAAACTCGCTATCAACTG
TGCAATTAACCCATTAACAGCAATTCATCAATGTAAGAATGGACAATTAGCACAACCCGACATCCATCAATATGTAATGA
ACATTTGCTCTGAAGTACATCAAGTTCTACAAGAAGAAAATATTGAATGGACAGAGAATGAATTAGTCTCAACGGTCACG
CAAGTAATAACCGCAACGTCTGCTAATTACTCATCAATGAACCGTGACTGTTTTTATCAACGTAAGACTGAAATTGATTT
TATTACTGGCTACTTATTACAGCGAGCCGAATTTCATGGAATTTCAGCACCTACCAATCTATCGTTATATAATCAAATTA
AACAATTAGAAGAGAACACATTATGA

Upstream 100 bases:

>100_bases
TCTAATCTAACTTAGAATACCTATTTTACTAAGGCGCTCACTATGAGCGCCTTTGTTTTTTGTAGCAAACCAATTACACT
GCTTTCATTATTTCTTCTTA

Downstream 100 bases:

>100_bases
CGAAAAAAATTCTCGTATGTATAGCACCCGGCACTGAAGAATTAGAAGCCATTACGGTCATTGATATTCTAGAACGAGCA
AAATTTGATGTAACCGTTGC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MDSSVNITILGPGAVGSLWACYLQKAGHNICLWTRNSTPSEQLLSLSANENSSHQFKCNDKQALNDCDLLLITVKAWQVE
SALLPLLPSLSKETILLFMHNGMGAIDDLKEHINHHPILQATTTHGALKENNTNVIHTGYGNASVGPFNPLGKQCQFIQD
VLNHSLPSVDWNPEINIALWKKLAINCAINPLTAIHQCKNGQLAQPDIHQYVMNICSEVHQVLQEENIEWTENELVSTVT
QVITATSANYSSMNRDCFYQRKTEIDFITGYLLQRAEFHGISAPTNLSLYNQIKQLEENTL

Sequences:

>Translated_301_residues
MDSSVNITILGPGAVGSLWACYLQKAGHNICLWTRNSTPSEQLLSLSANENSSHQFKCNDKQALNDCDLLLITVKAWQVE
SALLPLLPSLSKETILLFMHNGMGAIDDLKEHINHHPILQATTTHGALKENNTNVIHTGYGNASVGPFNPLGKQCQFIQD
VLNHSLPSVDWNPEINIALWKKLAINCAINPLTAIHQCKNGQLAQPDIHQYVMNICSEVHQVLQEENIEWTENELVSTVT
QVITATSANYSSMNRDCFYQRKTEIDFITGYLLQRAEFHGISAPTNLSLYNQIKQLEENTL
>Mature_301_residues
MDSSVNITILGPGAVGSLWACYLQKAGHNICLWTRNSTPSEQLLSLSANENSSHQFKCNDKQALNDCDLLLITVKAWQVE
SALLPLLPSLSKETILLFMHNGMGAIDDLKEHINHHPILQATTTHGALKENNTNVIHTGYGNASVGPFNPLGKQCQFIQD
VLNHSLPSVDWNPEINIALWKKLAINCAINPLTAIHQCKNGQLAQPDIHQYVMNICSEVHQVLQEENIEWTENELVSTVT
QVITATSANYSSMNRDCFYQRKTEIDFITGYLLQRAEFHGISAPTNLSLYNQIKQLEENTL

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=297, Percent_Identity=40.7407407407407, Blast_Score=207, Evalue=5e-55,
Organism=Saccharomyces cerevisiae, GI6321854, Length=334, Percent_Identity=24.251497005988, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33572; Mature: 33572

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSVNITILGPGAVGSLWACYLQKAGHNICLWTRNSTPSEQLLSLSANENSSHQFKCND
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHEEECCCCCCCCEEEECC
KQALNDCDLLLITVKAWQVESALLPLLPSLSKETILLFMHNGMGAIDDLKEHINHHPILQ
HHCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHCCCCCEEE
ATTTHGALKENNTNVIHTGYGNASVGPFNPLGKQCQFIQDVLNHSLPSVDWNPEINIALW
EECCCCCEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHEEH
KKLAINCAINPLTAIHQCKNGQLAQPDIHQYVMNICSEVHQVLQEENIEWTENELVSTVT
HHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QVITATSANYSSMNRDCFYQRKTEIDFITGYLLQRAEFHGISAPTNLSLYNQIKQLEENT
HHHHHCCCCCHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure
MDSSVNITILGPGAVGSLWACYLQKAGHNICLWTRNSTPSEQLLSLSANENSSHQFKCND
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHEEECCCCCCCCEEEECC
KQALNDCDLLLITVKAWQVESALLPLLPSLSKETILLFMHNGMGAIDDLKEHINHHPILQ
HHCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHCCCCCEEE
ATTTHGALKENNTNVIHTGYGNASVGPFNPLGKQCQFIQDVLNHSLPSVDWNPEINIALW
EECCCCCEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEHEEH
KKLAINCAINPLTAIHQCKNGQLAQPDIHQYVMNICSEVHQVLQEENIEWTENELVSTVT
HHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
QVITATSANYSSMNRDCFYQRKTEIDFITGYLLQRAEFHGISAPTNLSLYNQIKQLEENT
HHHHHCCCCCHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]