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The map label for this gene is dxs [H]

Identifier: 59711318

GI number: 59711318

Start: 777863

End: 779746

Strand: Reverse

Name: dxs [H]

Synonym: VF_0711

Alternate gene names: 59711318

Gene position: 779746-777863 (Counterclockwise)

Preceding gene: 59711319

Following gene: 59711316

Centisome position: 26.91

GC content: 40.71

Gene sequence:

>1884_bases
ATGTCATTAGATATTTCAAAATACCCAATTCTGGCTTTGGCAAATACACCAGATGAATTACGTTCTTTACCAAAAGAGAG
CTTACCAGCATTATGCGATGAGCTACGTACTTACCTTTTAAACTCGGTAAGTAAAACAAGTGGTCACTTAGCATCTGGTC
TTGGTGTCGTAGAGTTAACCGTCGCTTTGCATTACGTTTATAACACCCCATTTGATCAACTTATCTGGGATGTTGGCCAT
CAAGCTTATCCTCATAAGATATTAACAGGACGCCGTGAACAACTTTCAACAATCCGACAAAAAGACGGATTACATCCATT
CCCATGGCGTGGTGAAAGTGAATATGATGTTCTTTCTGTTGGCCACTCATCAACATCTATTAGTGCCGCTTTAGGCCTAG
CTATCTGTGCTGAAAAAGAGCAAGAGAATCGTAAAATAGTCAGTGTTATTGGTGATGGTGCCATTACTGCCGGTATGGCA
TTTGAAGCATTAAATCACGCTGGTGATATTCACCCAGATATGCTTGTTGTTCTAAATGATAATGAAATGTCAATTTCTGA
AAACGTTGGAGCATTAAACAATCAATTAGCGCGTGTACTATCAGGTAGCTTATACACCTCTATTCGTGAAGGCGGTAAAA
AAGTGCTTTCTGGTACGCCTACGATTAAAGAGCTACTAAAACGCACAGAAGAACATTTAAAAGGCATGGTTGTTCCTGGC
ACCATGTTTGAAGAATTAGGCTTTAATTACATTGGCCCGGTAGATGGTCATGACGTTAATGAACTAGTTAGAACCCTTAA
AAATATGCGTAACCTAAAAGGGCCGCAATTTTTACATATCATGACGAAAAAAGGTAAAGGCTATGAGCCTGCTGAGAAAG
ATCCAATCAGCTACCATGGTGTACCTAAGTTTGATCCAAGTAACACTTCATTACCAAAATCGTCTGGTGGTAAACCAACC
TTCTCTGCTGTTTTTGGCGACTTCCTTTGCGATATGGCGAAAGAAGACAGTAAGCTTATGGCCATTACGCCAGCAATGCG
AGAAGGCTCTGGTATGGTTCGTTTCTCTAAGGAATATCCTAACCAGTATTTTGATGCAGCCATTGCAGAACAACACGCAG
TTACTCTAGCGAGTGGGATGGCGATAGCTGGTTATAACCCGATAGTTGCTATCTACTCAACGTTTTTACAACGTGGTTAC
GATCAATTAATTCATGATGTTGCGATTATGGATTTACCCGTAATGTTTGCTATTGACCGTGCAGGTTTAGTCGGTGCAGA
TGGACAAACACACCAAGGCGCCTTTGACATCAGCTTTATGCGCTGTATTCCAAATATGGTTATCATGACACCAAGTGATG
AAAACGAATGCCGCCAAATGCTCTACACAGGCCATAAGCACACTGGCCCTAGCGCTGTTCGTTATCCACGAGGAAGTGCA
ACAGGCATCCAAGTAAATAATGAAATGCAAGCACTTGAAATTGGTAAAGGTCGTTTACTCCGTGAAACTAAAGTGACGGA
AAAAGGAGAACGAGTTGCTATCTTAAACTTCGGTACTTTCTTAGCAAATAGCTTAGAAGCGGCAGAAAAGTTAGATGCTA
CCGTTGCTGATATGCGTTTTGCTAAACCTCTTGATGAAGCACTCATCTGTGAATTAGTAACCAATCACGATGTTTTAGTG
ACTATTGAAGAAAATGCGATTTCAGGTGGTGCAGGTTCAGGTGTCATTGAATTTTTAATGAAAAACCGCCTTGTTAAACC
AGTTCTTCAACTAGGTTTACCAGATGAATTCATAGCTCAAGGTACACAAGAAGAAATGCATACGGAACTAAAACTTGATG
CAAATGGCATTGAGCAACAAATTAGAGATTACCTTGACCTCTAA

Upstream 100 bases:

>100_bases
TGAAGCATTAAACGACATCCCTTATAACACGGATGCAATGCAAGCGTTCGCTCAATACGTTATTGAGCGTAAAAACTAAA
ACAGATAAGCGCTAACTACT

Downstream 100 bases:

>100_bases
TTTCATGCCCATCTTAGTTTCATAAAACAATGCCACCGTTTGGTGGCATTTTTATTTATATTTTATGAAAGCTTAGGAGC
ATCAAAATCAATGGGCTCAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MSLDISKYPILALANTPDELRSLPKESLPALCDELRTYLLNSVSKTSGHLASGLGVVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRREQLSTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAALGLAICAEKEQENRKIVSVIGDGAITAGMA
FEALNHAGDIHPDMLVVLNDNEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHLKGMVVPG
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHGVPKFDPSNTSLPKSSGGKPT
FSAVFGDFLCDMAKEDSKLMAITPAMREGSGMVRFSKEYPNQYFDAAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGY
DQLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
TGIQVNNEMQALEIGKGRLLRETKVTEKGERVAILNFGTFLANSLEAAEKLDATVADMRFAKPLDEALICELVTNHDVLV
TIEENAISGGAGSGVIEFLMKNRLVKPVLQLGLPDEFIAQGTQEEMHTELKLDANGIEQQIRDYLDL

Sequences:

>Translated_627_residues
MSLDISKYPILALANTPDELRSLPKESLPALCDELRTYLLNSVSKTSGHLASGLGVVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRREQLSTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAALGLAICAEKEQENRKIVSVIGDGAITAGMA
FEALNHAGDIHPDMLVVLNDNEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHLKGMVVPG
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHGVPKFDPSNTSLPKSSGGKPT
FSAVFGDFLCDMAKEDSKLMAITPAMREGSGMVRFSKEYPNQYFDAAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGY
DQLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
TGIQVNNEMQALEIGKGRLLRETKVTEKGERVAILNFGTFLANSLEAAEKLDATVADMRFAKPLDEALICELVTNHDVLV
TIEENAISGGAGSGVIEFLMKNRLVKPVLQLGLPDEFIAQGTQEEMHTELKLDANGIEQQIRDYLDL
>Mature_626_residues
SLDISKYPILALANTPDELRSLPKESLPALCDELRTYLLNSVSKTSGHLASGLGVVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRREQLSTIRQKDGLHPFPWRGESEYDVLSVGHSSTSISAALGLAICAEKEQENRKIVSVIGDGAITAGMAF
EALNHAGDIHPDMLVVLNDNEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHLKGMVVPGT
MFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHGVPKFDPSNTSLPKSSGGKPTF
SAVFGDFLCDMAKEDSKLMAITPAMREGSGMVRFSKEYPNQYFDAAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGYD
QLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSAT
GIQVNNEMQALEIGKGRLLRETKVTEKGERVAILNFGTFLANSLEAAEKLDATVADMRFAKPLDEALICELVTNHDVLVT
IEENAISGGAGSGVIEFLMKNRLVKPVLQLGLPDEFIAQGTQEEMHTELKLDANGIEQQIRDYLDL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=590, Percent_Identity=22.2033898305085, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI4507521, Length=590, Percent_Identity=22.2033898305085, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637463, Length=380, Percent_Identity=24.2105263157895, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI225637459, Length=380, Percent_Identity=24.2105263157895, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI225637461, Length=380, Percent_Identity=24.2105263157895, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI133778974, Length=378, Percent_Identity=23.2804232804233, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=74.1214057507987, Blast_Score=980, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=24.5098039215686, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24666278, Length=646, Percent_Identity=23.5294117647059, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551847, Length=650, Percent_Identity=23.2307692307692, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550715, Length=650, Percent_Identity=23.2307692307692, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=23.3273056057866, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68649; Mature: 68518

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDISKYPILALANTPDELRSLPKESLPALCDELRTYLLNSVSKTSGHLASGLGVVELT
CCCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRREQLSTIRQKDGLHPFPWRGESEYDVLSV
HHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
GHSSTSISAALGLAICAEKEQENRKIVSVIGDGAITAGMAFEALNHAGDIHPDMLVVLND
CCCCCHHHHHHHHHHHHCCHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCEECCC
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSNTSLPKSSGGKPTFSAVFGDFLCDMAKEDSKLMAITPAMREGSGMVRFSKEYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCCEEECHHCC
NQYFDAAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGYDQLIHDVAIMDLPVMFAIDR
HHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECC
AGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
TGIQVNNEMQALEIGKGRLLRETKVTEKGERVAILNFGTFLANSLEAAEKLDATVADMRF
CCEEECCCCCEEECCCCCEEEHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
AKPLDEALICELVTNHDVLVTIEENAISGGAGSGVIEFLMKNRLVKPVLQLGLPDEFIAQ
HCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHC
GTQEEMHTELKLDANGIEQQIRDYLDL
CCHHHHHHHEEECCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLDISKYPILALANTPDELRSLPKESLPALCDELRTYLLNSVSKTSGHLASGLGVVELT
CCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHH
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRREQLSTIRQKDGLHPFPWRGESEYDVLSV
HHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
GHSSTSISAALGLAICAEKEQENRKIVSVIGDGAITAGMAFEALNHAGDIHPDMLVVLND
CCCCCHHHHHHHHHHHHCCHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCEECCC
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSNTSLPKSSGGKPTFSAVFGDFLCDMAKEDSKLMAITPAMREGSGMVRFSKEYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCCEEECHHCC
NQYFDAAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGYDQLIHDVAIMDLPVMFAIDR
HHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECC
AGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
TGIQVNNEMQALEIGKGRLLRETKVTEKGERVAILNFGTFLANSLEAAEKLDATVADMRF
CCEEECCCCCEEECCCCCEEEHHHCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
AKPLDEALICELVTNHDVLVTIEENAISGGAGSGVIEFLMKNRLVKPVLQLGLPDEFIAQ
HCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHC
GTQEEMHTELKLDANGIEQQIRDYLDL
CCHHHHHHHEEECCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA