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The map label for this gene is yeiG [H]

Identifier: 59711251

GI number: 59711251

Start: 703176

End: 704018

Strand: Reverse

Name: yeiG [H]

Synonym: VF_0644

Alternate gene names: 59711251

Gene position: 704018-703176 (Counterclockwise)

Preceding gene: 59711252

Following gene: 59711249

Centisome position: 24.3

GC content: 38.91

Gene sequence:

>843_bases
ATGACAATCGAAAATATCAGCCAAGCAAAAGTTGCGGGTGGTTGGCACAAACAATACACACATACTTCATCATCTCTAAA
CTGCAATATGCGCTTTGCTATTTTCTTACCTGCAAACGCATCTGAAAGTAATCCGGTTCCTGTTTTATACTGGTTATCAG
GCTTAACTTGTACTGATGAAAACTTCATGCAAAAAGCTGGCGCTTTCAAAAAAGCAGCTGAATTAGGTATTGCTATTGTG
GCTATGGATACAAGTCCTCGCGGTGAAGACGTTGCTGATGATGCAGAAGGTGCATACGATTTTGGCCTAGGTGCAGGGTT
CTATTTAAATGCAACTCAAGCTCCTTGGAACCGTCACTATCATATGTATGACTATGTGACAAAAGAGCTACCATCATTAA
TCGAAGAGCACTTCCCTGTATCAGATAAAAAATCGATTTCTGGTCACAGTATGGGTGGTCATGGTGCTATTACCATCGGC
TTAAAAAACCAAGATATGTATCAATCTATTTCTGCCTTTAGTCCTATTGCTAGCCCAATTAACTGTCCTTGGGGACAAAA
AGCGTTAGGTTTATACTTAGGTGATAATAAAGAAGCTTGGTTAGAATACGACAGTTCTGAACTTCTTAAAAAAGGCTCAA
AACTTCCAATCTTAGTTGACCAAGGTGAAGCTGACGGCTTTTTAGAAGAACAATTAAAACCTGAATACCTTCTCTCTTCG
GCAGAGAAATCAGGAACTGATATTGAAGTTAGAATGCAACCAGGCTATGACCATAGCTACTTTTTCATCTCAACATTTAT
TGATGAGCATTTAGAATTCCACGCTTCTCACTTGAATAAATAA

Upstream 100 bases:

>100_bases
GTGTTTCATTCTTTATTTTAAAGCACTTCAAAATCAACCAGTAGATACCTATTCAATACAGTGATCTCGCTGATACGAAT
CAAATATAAAAGGGCTCATC

Downstream 100 bases:

>100_bases
CAACAAAAATAGAAAAAGCCCAGAGAGGATATCTCTGGGCTTTTTTATGTTATTTAGAAAATTAATCTTAGATAAATGCA
AGTATTGGAGAGATACAAAG

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTIENISQAKVAGGWHKQYTHTSSSLNCNMRFAIFLPANASESNPVPVLYWLSGLTCTDENFMQKAGAFKKAAELGIAIV
AMDTSPRGEDVADDAEGAYDFGLGAGFYLNATQAPWNRHYHMYDYVTKELPSLIEEHFPVSDKKSISGHSMGGHGAITIG
LKNQDMYQSISAFSPIASPINCPWGQKALGLYLGDNKEAWLEYDSSELLKKGSKLPILVDQGEADGFLEEQLKPEYLLSS
AEKSGTDIEVRMQPGYDHSYFFISTFIDEHLEFHASHLNK

Sequences:

>Translated_280_residues
MTIENISQAKVAGGWHKQYTHTSSSLNCNMRFAIFLPANASESNPVPVLYWLSGLTCTDENFMQKAGAFKKAAELGIAIV
AMDTSPRGEDVADDAEGAYDFGLGAGFYLNATQAPWNRHYHMYDYVTKELPSLIEEHFPVSDKKSISGHSMGGHGAITIG
LKNQDMYQSISAFSPIASPINCPWGQKALGLYLGDNKEAWLEYDSSELLKKGSKLPILVDQGEADGFLEEQLKPEYLLSS
AEKSGTDIEVRMQPGYDHSYFFISTFIDEHLEFHASHLNK
>Mature_279_residues
TIENISQAKVAGGWHKQYTHTSSSLNCNMRFAIFLPANASESNPVPVLYWLSGLTCTDENFMQKAGAFKKAAELGIAIVA
MDTSPRGEDVADDAEGAYDFGLGAGFYLNATQAPWNRHYHMYDYVTKELPSLIEEHFPVSDKKSISGHSMGGHGAITIGL
KNQDMYQSISAFSPIASPINCPWGQKALGLYLGDNKEAWLEYDSSELLKKGSKLPILVDQGEADGFLEEQLKPEYLLSSA
EKSGTDIEVRMQPGYDHSYFFISTFIDEHLEFHASHLNK

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=49.1166077738516, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI1788477, Length=281, Percent_Identity=53.7366548042705, Blast_Score=310, Evalue=7e-86,
Organism=Escherichia coli, GI1786551, Length=278, Percent_Identity=52.158273381295, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17510185, Length=288, Percent_Identity=50, Blast_Score=259, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6322393, Length=293, Percent_Identity=44.7098976109215, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=47.887323943662, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=47.887323943662, Blast_Score=274, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30989; Mature: 30858

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIENISQAKVAGGWHKQYTHTSSSLNCNMRFAIFLPANASESNPVPVLYWLSGLTCTDE
CCCCCCCHHHHCCCCHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCEECCH
NFMQKAGAFKKAAELGIAIVAMDTSPRGEDVADDAEGAYDFGLGAGFYLNATQAPWNRHY
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCE
HMYDYVTKELPSLIEEHFPVSDKKSISGHSMGGHGAITIGLKNQDMYQSISAFSPIASPI
EHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCC
NCPWGQKALGLYLGDNKEAWLEYDSSELLKKGSKLPILVDQGEADGFLEEQLKPEYLLSS
CCCCCCCEEEEEECCCCCEEEEECHHHHHHCCCCCCEEEECCCCCCHHHHHCCHHHHHHH
AEKSGTDIEVRMQPGYDHSYFFISTFIDEHLEFHASHLNK
HCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIENISQAKVAGGWHKQYTHTSSSLNCNMRFAIFLPANASESNPVPVLYWLSGLTCTDE
CCCCCCHHHHCCCCHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEECCCEECCH
NFMQKAGAFKKAAELGIAIVAMDTSPRGEDVADDAEGAYDFGLGAGFYLNATQAPWNRHY
HHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCCCEEEECCCCCCCCCE
HMYDYVTKELPSLIEEHFPVSDKKSISGHSMGGHGAITIGLKNQDMYQSISAFSPIASPI
EHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCCCC
NCPWGQKALGLYLGDNKEAWLEYDSSELLKKGSKLPILVDQGEADGFLEEQLKPEYLLSS
CCCCCCCEEEEEECCCCCEEEEECHHHHHHCCCCCCEEEECCCCCCHHHHHCCHHHHHHH
AEKSGTDIEVRMQPGYDHSYFFISTFIDEHLEFHASHLNK
HCCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA