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The map label for this gene is fpg [H]

Identifier: 57650560

GI number: 57650560

Start: 1766901

End: 1767773

Strand: Reverse

Name: fpg [H]

Synonym: SACOL1736

Alternate gene names: 57650560

Gene position: 1767773-1766901 (Counterclockwise)

Preceding gene: 57650561

Following gene: 57650559

Centisome position: 62.92

GC content: 32.07

Gene sequence:

>873_bases
ATGCCCGAATTACCAGAAGTAGAACATGTAAAAAGAGGAATTGAACCCTACGTTATAAATCAAAAAATTGAACACGTTAT
ATTTTCGGATAAAGTAATCGAAGGTAAAGCTCAAGGCAAGGAAACAATTATAAAAGGAATTGAATTAGATACTTTTAAAA
CTTTATCGGAAGGCTATACCATTACAAATGTAGAACGAAGAAGTAAATATATCGTTTTTCAGCTAGATAATAAACGAGAA
CAACGTACATTAATTAGTCATTTAGGTATGGCGGGCGGTTTTTTCATTGTAGATGAACTTGAAGATATTATGATACCTAA
TTATCGTAAGCATTGGCATGTTATTTTTGAGTTGTCAAATGACAAAAAGTTAATTTATTCAGATATACGTCGTTTTGGAG
AAATTAGAAATGTTGCGTCTGTAGCATCTTATCCTTCATTTTTAGAAATAGCGCCTGAACCTTTTTCAAATGAAGCATTG
ACGTATTATTTAAATCGAATTCATCAACAGTCTAATAAGAATAAACCAATCAAACAAGTGATTTTGGATCATAAAGTAAT
CGCAGGTTGTGGAAATATTTACGCATGTGAAGCGTTGTTTCGTGCAGGTGTTTTACCAGATAAAAAAGTAAAAGACTTAA
CACACCAACAACAAGAAATGGTTTTTTATTATGTTAGAGAAGTACTAGAAGAAGGTATTAAATATGGCGGTACAAGTATT
TCAGATTATCGTCATGCTGATGGAAAAACTGGTGAGATGCAATTGCATCTTAATGTATATAAGCAGCCGGTATGCAAAGT
GTGTGGAAGTCAAATTGAAACAAAAATCATCGCGACAAGAAATAGTCATTATTGTCCAGTATGTCAAAAATAA

Upstream 100 bases:

>100_bases
AGAGATAATGGAAAATGCATTGCAATTAGATGTTCCATTAAAAGTAGACTCAAGTTATGGTGCAACCTGGTATGATGCAA
AATAAAGTGAGGTTAATGGT

Downstream 100 bases:

>100_bases
AGAAAGAGTGAAATTATGCCGAAAGTTATTGGTCTAACAGGTGGAATCGCCTCAGGAAAATCAACAGTATCAGAACTCTT
ATCCGTATTCGGTTTTAAAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MPELPEVEHVKRGIEPYVINQKIEHVIFSDKVIEGKAQGKETIIKGIELDTFKTLSEGYTITNVERRSKYIVFQLDNKRE
QRTLISHLGMAGGFFIVDELEDIMIPNYRKHWHVIFELSNDKKLIYSDIRRFGEIRNVASVASYPSFLEIAPEPFSNEAL
TYYLNRIHQQSNKNKPIKQVILDHKVIAGCGNIYACEALFRAGVLPDKKVKDLTHQQQEMVFYYVREVLEEGIKYGGTSI
SDYRHADGKTGEMQLHLNVYKQPVCKVCGSQIETKIIATRNSHYCPVCQK

Sequences:

>Translated_290_residues
MPELPEVEHVKRGIEPYVINQKIEHVIFSDKVIEGKAQGKETIIKGIELDTFKTLSEGYTITNVERRSKYIVFQLDNKRE
QRTLISHLGMAGGFFIVDELEDIMIPNYRKHWHVIFELSNDKKLIYSDIRRFGEIRNVASVASYPSFLEIAPEPFSNEAL
TYYLNRIHQQSNKNKPIKQVILDHKVIAGCGNIYACEALFRAGVLPDKKVKDLTHQQQEMVFYYVREVLEEGIKYGGTSI
SDYRHADGKTGEMQLHLNVYKQPVCKVCGSQIETKIIATRNSHYCPVCQK
>Mature_289_residues
PELPEVEHVKRGIEPYVINQKIEHVIFSDKVIEGKAQGKETIIKGIELDTFKTLSEGYTITNVERRSKYIVFQLDNKREQ
RTLISHLGMAGGFFIVDELEDIMIPNYRKHWHVIFELSNDKKLIYSDIRRFGEIRNVASVASYPSFLEIAPEPFSNEALT
YYLNRIHQQSNKNKPIKQVILDHKVIAGCGNIYACEALFRAGVLPDKKVKDLTHQQQEMVFYYVREVLEEGIKYGGTSIS
DYRHADGKTGEMQLHLNVYKQPVCKVCGSQIETKIIATRNSHYCPVCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=293, Percent_Identity=35.4948805460751, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786932, Length=302, Percent_Identity=22.8476821192053, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 33412; Mature: 33281

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEHVKRGIEPYVINQKIEHVIFSDKVIEGKAQGKETIIKGIELDTFKTLSEGYT
CCCCCCHHHHHCCCCCEEEHHHHHHHHHCCCEECCCCCCHHHHHHCCCCHHHHHHHCCCE
ITNVERRSKYIVFQLDNKREQRTLISHLGMAGGFFIVDELEDIMIPNYRKHWHVIFELSN
EEEECCCCEEEEEEECCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCEEEEEEECC
DKKLIYSDIRRFGEIRNVASVASYPSFLEIAPEPFSNEALTYYLNRIHQQSNKNKPIKQV
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
ILDHKVIAGCGNIYACEALFRAGVLPDKKVKDLTHQQQEMVFYYVREVLEEGIKYGGTSI
HHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDYRHADGKTGEMQLHLNVYKQPVCKVCGSQIETKIIATRNSHYCPVCQK
CCHHCCCCCCCEEEEEEEHHHHHHHHHCCHHHHEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEHVKRGIEPYVINQKIEHVIFSDKVIEGKAQGKETIIKGIELDTFKTLSEGYT
CCCCCHHHHHCCCCCEEEHHHHHHHHHCCCEECCCCCCHHHHHHCCCCHHHHHHHCCCE
ITNVERRSKYIVFQLDNKREQRTLISHLGMAGGFFIVDELEDIMIPNYRKHWHVIFELSN
EEEECCCCEEEEEEECCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCCEEEEEEECC
DKKLIYSDIRRFGEIRNVASVASYPSFLEIAPEPFSNEALTYYLNRIHQQSNKNKPIKQV
CCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
ILDHKVIAGCGNIYACEALFRAGVLPDKKVKDLTHQQQEMVFYYVREVLEEGIKYGGTSI
HHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDYRHADGKTGEMQLHLNVYKQPVCKVCGSQIETKIIATRNSHYCPVCQK
CCHHCCCCCCCEEEEEEEHHHHHHHHHCCHHHHEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA