Click here to switch to the map view.

The map label for this gene is thrS [H]

Identifier: 54295556

GI number: 54295556

Start: 3012404

End: 3014317

Strand: Reverse

Name: thrS [H]

Synonym: lpl2643

Alternate gene names: 54295556

Gene position: 3014317-3012404 (Counterclockwise)

Preceding gene: 54295559

Following gene: 54295555

Centisome position: 90.1

GC content: 40.86

Gene sequence:

>1914_bases
ATGCCAAATGTTAAATTACCAGATGGAAATGTAAAACATTTTGAAGCGCCACTCACTATTTATGATGTGGCACATCACAT
TAGCCCTGGATTAGCTAAAGCAGCGATAGCAGGCCGTGTCGATGGCGTCTTGGTAGATACATCCTATCTTATAAAAGAAG
ACTGCTCTTTGATTATAGTAACCGAGAAACATGAAGACAGTCTTGAAGTAATCAGGCATTCTACCGCTCATTTATTAGCC
CAGGCTGTAAAAGCCTTATTTCCATCAGCTCAAGTGACTATAGGTCCTGTAATAGAAGACGGGTTTTATTATGATTTTGC
TTTTGAGCGCTCGTTTACTCCTGATGATTTGAGTTTAATCGAAGTGAAGATGCATGAGCTGGCAAAGGCTAATCTTTCAA
TCACTCGTCGAGAATTACCTAGAAATGAAGCAATACAATATTTTAAGGGTTTAGGCGAAGAATATAAGGCAAAAATTATT
GCTGATATACCCGAAAATGAATCTCTCTCTCTATATAGGCAAGGTGATTTTGAAGATTTGTGTCGAGGTCCACATGTCCC
TTCCACTGGGTTTTTAAAAGCATTTAAATTGACAAAAGTAGCTGGCGCTTATTGGCGTGGTGACTCAAATAACGAAATGT
TGCAGCGAATTTACGGCACTGCCTGGGCTGATAAAAAATCCCTGGAAGAATATTTATATCGTTTGGAAGAAGCAGAAAAA
CGTGATCATCGTAAATTAGGCAAGGCACTGGATTTGTTTCATTTTCAGGATATTGCTCCGGGAATGGTTTTTTGGCACCC
CAAAGGATGGACTATTTATCAAGAGCTAGAGCATTACATGCGAAATCGCCTGGTCGATTTTGGCTATCAGGAAATTAGAA
CACCGCAATTAGTAGACAGATCGTTATGGGAGAAATCAGGTCATTGGGCGAACTTTAGAGATGAAATGTTTGTTACCGAA
ACAGAGAATCGACATTATGCAGTAAAACCTATGAGCTGTCCCTGCCATGTCCAAATTTATAATCATGGTTTGAAAAGTTA
CCGGGATCTTCCTCTCAGACTATCTGAGTTTGGGAATTGTCATCGCTGTGAGCCATCAGGCGCACTGCATGGGCTGATGC
GGGTACGCAATATGGTGCAGGATGATGCTCATATTTTTTGCACTGAGGATCAGATTCAATCTGAAGTGGCTATGATGCTG
GAGTTAGTGCAATCCGTATATAAGGACTTTGGGTTTACTGAAATAAAATACCGATTGGCTTTGCGCCCTGAAAAACGAGT
CGGTTCAGATGACGTTTGGGATAAGGCGGAAACCGCCCTTAAACTGGCTATGCAGGGAAGAAATATTGAGTGGGTGGATG
CGCCTGGAGAAGGAGCATTTTATGGACCTAAAATTGAATGCTCTCTCTCTGATTGTTTAGGTAGAATTTGGCAGTGCGGA
ACGATTCAAGTGGATTTCTCTATGCCTGCACGCCTTGAGGCAAGCTATGTTGCTGAAGATGGAAGCAAGCAAACACCGGT
GATGTTGCATAGAGCCATTTTGGGTTCTTTCGAACGATTTATGGGAATATTAATCGAACATTATGCAGGTAAATTGCCAT
TATGGTTATCCCCAGTGCAAGCGGTTGTGCTTACTATTAGTGAGAAGCAGAATGAGTATGCCGAAAAAGTGAGGAAAACT
TTGCAAAAAAGAGGGGTTCGCGCCAATTTTGACTTGAGAAATGAAAAGATTGGATTTAAAATTCGCGAGCATACTTTACA
AAAAATTCCTTATTTATTGGTTGTTGGCGATAAAGAGGTTGAAAATTGTCAGGTAGCTGTTCGCACTCGAGATGGCATTG
ACCTGGGTGTGATGACAATAGATACAATTTGTGATACCTTAACGCAAGAAATTATCCGTAAAGGATCAATATAA

Upstream 100 bases:

>100_bases
AAATTGGTAAACTACTGCACTGAATTATTAAAGGTTTAAACCCTGCCATGCAGGGTTTTTTTTTAACAAGAACCTGAAAG
ATGGAAAGACGGATAAGATT

Downstream 100 bases:

>100_bases
ATAAACGAACTGGAGGATTAAACCATTAGTGCACCAACTAAGCGTGAAAATGATCGCGCACGAATTAATGAACAGATCAC
TGTACCTGAGGTACGCTTAA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIVTEKHEDSLEVIRHSTAHLLA
QAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLIEVKMHELAKANLSITRRELPRNEAIQYFKGLGEEYKAKII
ADIPENESLSLYRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEYLYRLEEAEK
RDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDRSLWEKSGHWANFRDEMFVTE
TENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMML
ELVQSVYKDFGFTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSDCLGRIWQCG
TIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQAVVLTISEKQNEYAEKVRKT
LQKRGVRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI

Sequences:

>Translated_637_residues
MPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIVTEKHEDSLEVIRHSTAHLLA
QAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLIEVKMHELAKANLSITRRELPRNEAIQYFKGLGEEYKAKII
ADIPENESLSLYRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEYLYRLEEAEK
RDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDRSLWEKSGHWANFRDEMFVTE
TENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMML
ELVQSVYKDFGFTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSDCLGRIWQCG
TIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQAVVLTISEKQNEYAEKVRKT
LQKRGVRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI
>Mature_636_residues
PNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIVTEKHEDSLEVIRHSTAHLLAQ
AVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLIEVKMHELAKANLSITRRELPRNEAIQYFKGLGEEYKAKIIA
DIPENESLSLYRQGDFEDLCRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEYLYRLEEAEKR
DHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDRSLWEKSGHWANFRDEMFVTET
ENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNCHRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMMLE
LVQSVYKDFGFTEIKYRLALRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSDCLGRIWQCGT
IQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQAVVLTISEKQNEYAEKVRKTL
QKRGVRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEVENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=630, Percent_Identity=40.3174603174603, Blast_Score=476, Evalue=1e-134,
Organism=Homo sapiens, GI38570111, Length=628, Percent_Identity=39.0127388535032, Blast_Score=461, Evalue=1e-129,
Organism=Homo sapiens, GI20070344, Length=637, Percent_Identity=37.3626373626374, Blast_Score=410, Evalue=1e-114,
Organism=Escherichia coli, GI1788013, Length=632, Percent_Identity=57.2784810126582, Blast_Score=787, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=624, Percent_Identity=40.3846153846154, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71984192, Length=624, Percent_Identity=40.3846153846154, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322112, Length=635, Percent_Identity=39.2125984251969, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6322654, Length=392, Percent_Identity=38.5204081632653, Blast_Score=292, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24583842, Length=629, Percent_Identity=39.1096979332273, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI28574141, Length=629, Percent_Identity=39.1096979332273, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24583839, Length=629, Percent_Identity=39.1096979332273, Blast_Score=479, Evalue=1e-135,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 72855; Mature: 72724

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIV
CCCCCCCCCCCCEEECCCHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHHHCCCCEEEE
TEKHEDSLEVIRHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCEEEEEEECCCCCCCCHHHH
EVKMHELAKANLSITRRELPRNEAIQYFKGLGEEYKAKIIADIPENESLSLYRQGDFEDL
HHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHCCEEEEECCCCCCEEEEECCCHHHH
CRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEYLYRLEEAEK
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDR
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHH
SLWEKSGHWANFRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNC
HHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEEHHHCCHHHHCCCCCCHHHCCCC
HRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMMLELVQSVYKDFGFTEIKYRLA
CCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
LRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSDCLGRIWQCG
ECCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQ
EEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHH
AVVLTISEKQNEYAEKVRKTLQKRGVRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEV
HHEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCC
ENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI
CCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PNVKLPDGNVKHFEAPLTIYDVAHHISPGLAKAAIAGRVDGVLVDTSYLIKEDCSLIIV
CCCCCCCCCCCEEECCCHHHHHHHHCCCCHHHHHHHCCCCEEEECCHHHHHCCCCEEEE
TEKHEDSLEVIRHSTAHLLAQAVKALFPSAQVTIGPVIEDGFYYDFAFERSFTPDDLSLI
ECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCEEEEEEECCCCCCCCHHHH
EVKMHELAKANLSITRRELPRNEAIQYFKGLGEEYKAKIIADIPENESLSLYRQGDFEDL
HHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHCCEEEEECCCCCCEEEEECCCHHHH
CRGPHVPSTGFLKAFKLTKVAGAYWRGDSNNEMLQRIYGTAWADKKSLEEYLYRLEEAEK
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RDHRKLGKALDLFHFQDIAPGMVFWHPKGWTIYQELEHYMRNRLVDFGYQEIRTPQLVDR
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHCCCHHHHHH
SLWEKSGHWANFRDEMFVTETENRHYAVKPMSCPCHVQIYNHGLKSYRDLPLRLSEFGNC
HHHHCCCCCCCCCCCEEEEECCCCEEEEECCCCCEEEEHHHCCHHHHCCCCCCHHHCCCC
HRCEPSGALHGLMRVRNMVQDDAHIFCTEDQIQSEVAMMLELVQSVYKDFGFTEIKYRLA
CCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
LRPEKRVGSDDVWDKAETALKLAMQGRNIEWVDAPGEGAFYGPKIECSLSDCLGRIWQCG
ECCHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEECCEEEEEHHHHHHHHHCCC
TIQVDFSMPARLEASYVAEDGSKQTPVMLHRAILGSFERFMGILIEHYAGKLPLWLSPVQ
EEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHH
AVVLTISEKQNEYAEKVRKTLQKRGVRANFDLRNEKIGFKIREHTLQKIPYLLVVGDKEV
HHEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEECCCCC
ENCQVAVRTRDGIDLGVMTIDTICDTLTQEIIRKGSI
CCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA