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The map label for this gene is mutL [H]

Identifier: 54295538

GI number: 54295538

Start: 2996243

End: 2997973

Strand: Reverse

Name: mutL [H]

Synonym: lpl2625

Alternate gene names: 54295538

Gene position: 2997973-2996243 (Counterclockwise)

Preceding gene: 54295539

Following gene: 54295537

Centisome position: 89.61

GC content: 40.79

Gene sequence:

>1731_bases
ATGGTCTTAAGGATACATCAACTTTCGCCAGCAATAGCCAATCAGATTGCAGCAGGAGAAGTTATAGAAAGGCCTGCTTC
AGTAGTCAAGGAGCTGCTGGAAAACTCTTTGGATGCTGGTGCCAGTGTGATTGGTGTCGATGTCAATTATGGGGGATTGC
TGCAGATTACAGTTAGTGATAATGGTTCAGGAATCTTTGGAGTCGACTTGCCTTTAGCTGTTGCAGCTCATGCGACCAGT
AAAATCAGAACGCTTGATGATTTATATTCCATTGATAGTATGGGCTTTAGAGGGGAGGCATTGGCAAGTATTGCCTCTGT
TGCCAAAGTGACTATCATTTCAAAGCCTGAGGAGCAGGACAATGCAATGATGTTGCGAGTAGAGGGGGAGAACAGGACTC
TCTCTCCTTGTGCACGCAATATTGGCACTACCATTGATGTTTCTGATTTGTTCTATAATGCCCCAGTTCGTAAGCGGTTT
TTAAAAAATGAAAAACTGGAATTTCAAGCTATTGAAATGGTTGTGAAACGGTTTGCATTAAGTGCCCCCCGGATTGCATT
AACGCTTAAGCATAATAAGAAACTGATTTTTTCATTACCGCCAGCGTTAAGTGAGCAAGCCAAAGCCATTCGTATGGGTC
GAATTTTGGGCAATACTTTCATGAGAGAAGCTATTTTTCTTGATGTGGAGCACAGTGGTATGCGTCTTTATGGCTGGATA
AGCAACCATCGTTTGCAACGCAGCCAGAATGATAGGCAGTGGATTTATGTGAATCAACGCATGGTAAAGGATAAATTACT
CCAACATGCAGTGAAACAAGCTTATGATGGCTTATTGCATGCAGGCAGATTTCCAATTTGTTTGTTGTATTTTACTCTAC
CTGCTTCTGAAGTGGATGTGAATGTACATCCTACAAAACATGAGGTGAGATTCCAACAGCCCCGCCTGGTACATGATTTT
TTTACTTCCCAATTGACGAAAGCGTTGCAGTCGACTCTTGACCATTCAGATACAAGGGAATACGCGTATGCTGCTTCCTC
TAGTAATGAGCAGCAAAATACAGTTTCGGAACCTTCCCATATCTGCAATGACAGAGAGTCCCATGAAGCGGCAAGAGCCT
TATCCCCAAGCTGGAGTGCCAATTCATTATCATCATCTGTAACCAGCAAAGGGTATAAAAAAACCAGCTCTGTCTATCAT
CCAGAAACAGAGTTCCAGTGGGTTATTTTAAATGAGCGATTTATTTTGGTTTTTATAAAGCAACGCCCTTACCTTGCAGA
TTTAGTAGCACTGTTTCAAGAATGGATAGAAAAACAGCTAATGCAAAAAGCATTGCCCTTGGAGAGCCGGCCTTTATTGA
TCTCAATTCGTTATCCATTACCAAACCAATGGATACATAAGCCGGAGCAATTAAAGCGTGAGTTAGCTCGTGTTGGGATA
CAAATTGAGTACTCTAATGCTGATGACTTATTAATTCGCAGCATCCCTTTGAATGCGCCCTATTTAGATGTTCGTCGTTT
TTTTAATATTCTCTGCGAACTGGATTTTTTTGATACTGAGCAATTGATAGCGTTAATTAGCCGTTCTCAAATATTTGACC
CAAAACAATTAACAGTTGAAGAGCGTATTGAAATGAATCAAGTGTTACTGGAACTCTCTCTTAAAGAAGAGAAACATAAT
ATATGTAAAGCGTTAACTATAGATGATTGTCGGATGTTATTGCATGAATAA

Upstream 100 bases:

>100_bases
CTGCTCGATATAGGGTATCTGTGAACGCATTACAATCAATTAACCGCCTTCAGGCAAGGGCAAGGCTTATGCCCGGGCAA
AAATTAGTGATACCTGGCAC

Downstream 100 bases:

>100_bases
GCTAGTGTTTTGTTTAATGGGACCAACTGCTTCAGGAAAGACAGGGTTAGCGTGTGAGTTATTAACCCATTTCCCTTTTG
AAATTATTAGTGTTGATTCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIFGVDLPLAVAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSDTREYAYAASSSNEQQNTVSEPSHICNDRESHEAARALSPSWSANSLSSSVTSKGYKKTSSVYH
PETEFQWVILNERFILVFIKQRPYLADLVALFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKPEQLKRELARVGI
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVEERIEMNQVLLELSLKEEKHN
ICKALTIDDCRMLLHE

Sequences:

>Translated_576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIFGVDLPLAVAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSDTREYAYAASSSNEQQNTVSEPSHICNDRESHEAARALSPSWSANSLSSSVTSKGYKKTSSVYH
PETEFQWVILNERFILVFIKQRPYLADLVALFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKPEQLKRELARVGI
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVEERIEMNQVLLELSLKEEKHN
ICKALTIDDCRMLLHE
>Mature_576_residues
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSDNGSGIFGVDLPLAVAAHATS
KIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQDNAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRF
LKNEKLEFQAIEMVVKRFALSAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDVNVHPTKHEVRFQQPRLVHDF
FTSQLTKALQSTLDHSDTREYAYAASSSNEQQNTVSEPSHICNDRESHEAARALSPSWSANSLSSSVTSKGYKKTSSVYH
PETEFQWVILNERFILVFIKQRPYLADLVALFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKPEQLKRELARVGI
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVEERIEMNQVLLELSLKEEKHN
ICKALTIDDCRMLLHE

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=37.6996805111821, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI4505911, Length=328, Percent_Identity=32.3170731707317, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI189458898, Length=328, Percent_Identity=32.3170731707317, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI189458896, Length=321, Percent_Identity=30.8411214953271, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI310128478, Length=329, Percent_Identity=28.2674772036474, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4505913, Length=329, Percent_Identity=28.2674772036474, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=224, Percent_Identity=33.4821428571429, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI91992162, Length=265, Percent_Identity=27.9245283018868, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI91992160, Length=265, Percent_Identity=27.9245283018868, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI310128480, Length=304, Percent_Identity=25.9868421052632, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1790612, Length=530, Percent_Identity=36.7924528301887, Blast_Score=305, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=33.4365325077399, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562796, Length=349, Percent_Identity=27.2206303724928, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=395, Percent_Identity=33.6708860759494, Blast_Score=187, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=402, Percent_Identity=31.3432835820896, Blast_Score=154, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325093, Length=314, Percent_Identity=28.0254777070064, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323063, Length=101, Percent_Identity=41.5841584158416, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136968, Length=320, Percent_Identity=37.1875, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17136970, Length=358, Percent_Identity=28.2122905027933, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 65472; Mature: 65472

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEC
NGSGIFGVDLPLAVAAHATSKIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQD
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCCC
NAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFAL
CEEEEEECCCCCCCCHHHHHCCCEEEHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHC
SAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEH
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDV
HCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
NVHPTKHEVRFQQPRLVHDFFTSQLTKALQSTLDHSDTREYAYAASSSNEQQNTVSEPSH
EECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCHHHCCCCHH
ICNDRESHEAARALSPSWSANSLSSSVTSKGYKKTSSVYHPETEFQWVILNERFILVFIK
HHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCEEEEEECCCEEEEEEE
QRPYLADLVALFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKPEQLKRELARVGI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHCCCHHHHHHHHHHCCE
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVE
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCHH
ERIEMNQVLLELSLKEEKHNICKALTIDDCRMLLHE
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MVLRIHQLSPAIANQIAAGEVIERPASVVKELLENSLDAGASVIGVDVNYGGLLQITVSD
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEC
NGSGIFGVDLPLAVAAHATSKIRTLDDLYSIDSMGFRGEALASIASVAKVTIISKPEEQD
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCCCC
NAMMLRVEGENRTLSPCARNIGTTIDVSDLFYNAPVRKRFLKNEKLEFQAIEMVVKRFAL
CEEEEEECCCCCCCCHHHHHCCCEEEHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHC
SAPRIALTLKHNKKLIFSLPPALSEQAKAIRMGRILGNTFMREAIFLDVEHSGMRLYGWI
CCCCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEEEEEH
SNHRLQRSQNDRQWIYVNQRMVKDKLLQHAVKQAYDGLLHAGRFPICLLYFTLPASEVDV
HCCHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
NVHPTKHEVRFQQPRLVHDFFTSQLTKALQSTLDHSDTREYAYAASSSNEQQNTVSEPSH
EECCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCHHHCCCCHH
ICNDRESHEAARALSPSWSANSLSSSVTSKGYKKTSSVYHPETEFQWVILNERFILVFIK
HHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCEEEEEECCCEEEEEEE
QRPYLADLVALFQEWIEKQLMQKALPLESRPLLISIRYPLPNQWIHKPEQLKRELARVGI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHCCCHHHHHHHHHHCCE
QIEYSNADDLLIRSIPLNAPYLDVRRFFNILCELDFFDTEQLIALISRSQIFDPKQLTVE
EEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCHH
ERIEMNQVLLELSLKEEKHNICKALTIDDCRMLLHE
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA