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The map label for this gene is accC [H]

Identifier: 54295504

GI number: 54295504

Start: 2957648

End: 2959063

Strand: Reverse

Name: accC [H]

Synonym: lpl2591

Alternate gene names: 54295504

Gene position: 2959063-2957648 (Counterclockwise)

Preceding gene: 54295505

Following gene: 54295500

Centisome position: 88.44

GC content: 43.71

Gene sequence:

>1416_bases
ATGTTTAAAAAAATTCTGGTGGCTAATCGCGGTGAGATAGCCCTGCGAATAGTACGTGCTTGCAAGGAGATGGGGATAGC
AGCAGTTACTATTCACAGTGAAGTGGACAGATTTGCCCTGCATGTTAAAAGAGCTTCTCATTCTCACTGTCTTAGTAAAA
AACCTTTAGATGCTTATCTTAACGGACGGCGTATTATTGAGTGTGCCAAGGTGGCCGGTTGTGAAGCAATTCACCCCGGG
TATGGTTTTTTATCTGAAAATGCCGAGTTTGCTGAGGATTGTAATAAGGCGGGTATCGTTTTTATAGGACCGTCTGCTCC
AGTGATAGCCACTATGGGCTCCAAGATTGCAGCAAGAGAAGCGATGATAAAAGCGGGGGTTCCCACCATACCAGGAAGCG
AGGGGAATTTGGAAACTATAGATGATGCTTTACATTGCGCAGAAACTCTAGGGTATCCTGTAATGCTCAAAGCGACTTTT
GGAGGGGGAGGGAGAGGTATCAGATTATGTCATGATGCCAGTCAGATAAAGCAACAGTTTGCTCGCGTGCAATCTGAAGC
AGAAAAATCATTTGGAGACTCCCATATCTACATGGAAAAATACATAGCGAATCCACGCCATATCGAAGTACAAATCCTGG
CAGATCATCATGGGACAGTACTTCATTTGTTTGAACGGGATTGTTCAATACAAAGGCGACATCAGAAACTGGTTGAAATA
GCCCCTTCCCCCCAATTGGATGAGGCGACACGTCAAGTGCTTTTGGAATATGCAGTCAAGGCAGCCAAGGAGGTAGGTTA
TACCAATGCGGGTACTGTTGAATTTATTTTGGATAAAAATAATCGACCTTACTTCATGGAAATGAACACTCGTTTACAAG
TTGAACATCCAATTACAGAACAGATTACTGGTATTGATTTAGTCCAGGAGCAAATTCGAATTGCAGCTGGTCAGCGTCTA
ACTATCTCTCAAGAACAAATTAAATACAATGGTTTTGCCATCGAATTTCGCATTAACGCAGAAGACCCTCAAAACGATTT
TTTACCCAGTTTTGGGCGGATTACCCGATATTACGCCCCGGGAGGACCCGGTGTGAGGACAGATAGCGCAATTTATACTG
GTTACCAGATTCCCCCGGATTATGATTCTTTGTGTGCCAAATTGACCGTATGGGCTTTTGATTGGCCCTCGGTACTTCGA
CGGGCGCGTCGAGCTCTTGAGGAAATGCGCATGTTTGGAGTAAAAACTACCATTCCTTATTATTTAGAAATGATAAAATC
AGAGGAGTTTCAGAAAGGGGTATTCAATACCGGTTTAGTGGAGGCACACCCCGAATGGTTAAAGTATTCAAATAAATCCT
TGCCTCAACACAAGGCAGCGGTTATTGCAGCGGCAATCGCTTTGAATAAAACCTAG

Upstream 100 bases:

>100_bases
AATCCTCAAGCGCATGATGAACATTTAGGATTAATTTACGATGAGGTTGCCGCACGTCGTTCATGGCAAGCAATGAGCCA
GTTTTTACAAGAGATTTTTA

Downstream 100 bases:

>100_bases
AACAGGTTTATCTCTAGGTATCAACATGGGATAAAATAATTTCCAGGCGTTCTTTTATTGAGGTTGCTGGTAATTCTATG
ACAGGGTAGTTAAGGCCAAC

Product: pyruvate carboxylase subunit A

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MFKKILVANRGEIALRIVRACKEMGIAAVTIHSEVDRFALHVKRASHSHCLSKKPLDAYLNGRRIIECAKVAGCEAIHPG
YGFLSENAEFAEDCNKAGIVFIGPSAPVIATMGSKIAAREAMIKAGVPTIPGSEGNLETIDDALHCAETLGYPVMLKATF
GGGGRGIRLCHDASQIKQQFARVQSEAEKSFGDSHIYMEKYIANPRHIEVQILADHHGTVLHLFERDCSIQRRHQKLVEI
APSPQLDEATRQVLLEYAVKAAKEVGYTNAGTVEFILDKNNRPYFMEMNTRLQVEHPITEQITGIDLVQEQIRIAAGQRL
TISQEQIKYNGFAIEFRINAEDPQNDFLPSFGRITRYYAPGGPGVRTDSAIYTGYQIPPDYDSLCAKLTVWAFDWPSVLR
RARRALEEMRMFGVKTTIPYYLEMIKSEEFQKGVFNTGLVEAHPEWLKYSNKSLPQHKAAVIAAAIALNKT

Sequences:

>Translated_471_residues
MFKKILVANRGEIALRIVRACKEMGIAAVTIHSEVDRFALHVKRASHSHCLSKKPLDAYLNGRRIIECAKVAGCEAIHPG
YGFLSENAEFAEDCNKAGIVFIGPSAPVIATMGSKIAAREAMIKAGVPTIPGSEGNLETIDDALHCAETLGYPVMLKATF
GGGGRGIRLCHDASQIKQQFARVQSEAEKSFGDSHIYMEKYIANPRHIEVQILADHHGTVLHLFERDCSIQRRHQKLVEI
APSPQLDEATRQVLLEYAVKAAKEVGYTNAGTVEFILDKNNRPYFMEMNTRLQVEHPITEQITGIDLVQEQIRIAAGQRL
TISQEQIKYNGFAIEFRINAEDPQNDFLPSFGRITRYYAPGGPGVRTDSAIYTGYQIPPDYDSLCAKLTVWAFDWPSVLR
RARRALEEMRMFGVKTTIPYYLEMIKSEEFQKGVFNTGLVEAHPEWLKYSNKSLPQHKAAVIAAAIALNKT
>Mature_471_residues
MFKKILVANRGEIALRIVRACKEMGIAAVTIHSEVDRFALHVKRASHSHCLSKKPLDAYLNGRRIIECAKVAGCEAIHPG
YGFLSENAEFAEDCNKAGIVFIGPSAPVIATMGSKIAAREAMIKAGVPTIPGSEGNLETIDDALHCAETLGYPVMLKATF
GGGGRGIRLCHDASQIKQQFARVQSEAEKSFGDSHIYMEKYIANPRHIEVQILADHHGTVLHLFERDCSIQRRHQKLVEI
APSPQLDEATRQVLLEYAVKAAKEVGYTNAGTVEFILDKNNRPYFMEMNTRLQVEHPITEQITGIDLVQEQIRIAAGQRL
TISQEQIKYNGFAIEFRINAEDPQNDFLPSFGRITRYYAPGGPGVRTDSAIYTGYQIPPDYDSLCAKLTVWAFDWPSVLR
RARRALEEMRMFGVKTTIPYYLEMIKSEEFQKGVFNTGLVEAHPEWLKYSNKSLPQHKAAVIAAAIALNKT

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=467, Percent_Identity=43.8972162740899, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=45.7964601769911, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=45.7964601769911, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=45.7964601769911, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=451, Percent_Identity=48.1152993348115, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI65506442, Length=451, Percent_Identity=48.1152993348115, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI295821183, Length=451, Percent_Identity=48.1152993348115, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI38679960, Length=502, Percent_Identity=31.2749003984064, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI38679974, Length=502, Percent_Identity=31.2749003984064, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI38679971, Length=502, Percent_Identity=31.2749003984064, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI38679977, Length=502, Percent_Identity=31.2749003984064, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI38679967, Length=502, Percent_Identity=31.2749003984064, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=30.5283757338552, Blast_Score=216, Evalue=4e-56,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=49.8871331828442, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17562816, Length=454, Percent_Identity=47.7973568281938, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567343, Length=472, Percent_Identity=45.5508474576271, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71987519, Length=475, Percent_Identity=42.9473684210526, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133931226, Length=522, Percent_Identity=27.9693486590038, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=28.1800391389432, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71997168, Length=505, Percent_Identity=28.1188118811881, Blast_Score=181, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6319695, Length=475, Percent_Identity=45.4736842105263, Blast_Score=403, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321376, Length=475, Percent_Identity=45.8947368421053, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=41.3483146067416, Blast_Score=350, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=28.0392156862745, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323863, Length=434, Percent_Identity=30.8755760368664, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24652212, Length=454, Percent_Identity=47.5770925110132, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652210, Length=454, Percent_Identity=47.5770925110132, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652214, Length=454, Percent_Identity=47.5770925110132, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI19921944, Length=454, Percent_Identity=47.5770925110132, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652216, Length=454, Percent_Identity=47.5770925110132, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281363050, Length=454, Percent_Identity=47.5770925110132, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652224, Length=454, Percent_Identity=47.5770925110132, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652222, Length=454, Percent_Identity=47.5770925110132, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652220, Length=454, Percent_Identity=47.5770925110132, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652218, Length=454, Percent_Identity=47.5770925110132, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=44.4196428571429, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=45.0738916256158, Blast_Score=355, Evalue=4e-98,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=29.0836653386454, Blast_Score=198, Evalue=7e-51,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=29.0836653386454, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=29.0836653386454, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=29.0836653386454, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 52533; Mature: 52533

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILVANRGEIALRIVRACKEMGIAAVTIHSEVDRFALHVKRASHSHCLSKKPLDAYL
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCHHHHCCCCCHHHHH
NGRRIIECAKVAGCEAIHPGYGFLSENAEFAEDCNKAGIVFIGPSAPVIATMGSKIAARE
CCCHHHHHHHHCCCCEECCCCCCCCCCCHHHHCCCCCCEEEECCCCCEEECCCCHHHHHH
AMIKAGVPTIPGSEGNLETIDDALHCAETLGYPVMLKATFGGGGRGIRLCHDASQIKQQF
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHH
ARVQSEAEKSFGDSHIYMEKYIANPRHIEVQILADHHGTVLHLFERDCSIQRRHQKLVEI
HHHHHHHHHCCCCCEEHHHHHCCCCCEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHHC
APSPQLDEATRQVLLEYAVKAAKEVGYTNAGTVEFILDKNNRPYFMEMNTRLQVEHPITE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCEEEECCCHHH
QITGIDLVQEQIRIAAGQRLTISQEQIKYNGFAIEFRINAEDPQNDFLPSFGRITRYYAP
HHHHHHHHHHHHHHHCCCEEEEEHHHEEECCEEEEEEECCCCCCCCCCCCHHHEEEEECC
GGPGVRTDSAIYTGYQIPPDYDSLCAKLTVWAFDWPSVLRRARRALEEMRMFGVKTTIPY
CCCCCCCCCEEEECCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHH
YLEMIKSEEFQKGVFNTGLVEAHPEWLKYSNKSLPQHKAAVIAAAIALNKT
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKKILVANRGEIALRIVRACKEMGIAAVTIHSEVDRFALHVKRASHSHCLSKKPLDAYL
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCHHHHCCCCCHHHHH
NGRRIIECAKVAGCEAIHPGYGFLSENAEFAEDCNKAGIVFIGPSAPVIATMGSKIAARE
CCCHHHHHHHHCCCCEECCCCCCCCCCCHHHHCCCCCCEEEECCCCCEEECCCCHHHHHH
AMIKAGVPTIPGSEGNLETIDDALHCAETLGYPVMLKATFGGGGRGIRLCHDASQIKQQF
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCHHHHHHHH
ARVQSEAEKSFGDSHIYMEKYIANPRHIEVQILADHHGTVLHLFERDCSIQRRHQKLVEI
HHHHHHHHHCCCCCEEHHHHHCCCCCEEEEEEEECCCCCEEEEEHHCCHHHHHHHHHHHC
APSPQLDEATRQVLLEYAVKAAKEVGYTNAGTVEFILDKNNRPYFMEMNTRLQVEHPITE
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCEEEECCCHHH
QITGIDLVQEQIRIAAGQRLTISQEQIKYNGFAIEFRINAEDPQNDFLPSFGRITRYYAP
HHHHHHHHHHHHHHHCCCEEEEEHHHEEECCEEEEEEECCCCCCCCCCCCHHHEEEEECC
GGPGVRTDSAIYTGYQIPPDYDSLCAKLTVWAFDWPSVLRRARRALEEMRMFGVKTTIPY
CCCCCCCCCEEEECCCCCCCHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHCCHHHHHH
YLEMIKSEEFQKGVFNTGLVEAHPEWLKYSNKSLPQHKAAVIAAAIALNKT
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]