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The map label for this gene is tig [H]

Identifier: 54294749

GI number: 54294749

Start: 2043141

End: 2044472

Strand: Reverse

Name: tig [H]

Synonym: lpl1826

Alternate gene names: 54294749

Gene position: 2044472-2043141 (Counterclockwise)

Preceding gene: 54294754

Following gene: 54294748

Centisome position: 61.11

GC content: 38.81

Gene sequence:

>1332_bases
ATGCAAGTTTCTGTTGAGACCCTAGAAGGTTTGGAGCGTAAGGTTACAGTTTCTGTACCTACAGAGAAAGTTGAGGAAGA
GGTGAGCTCGCGTCTCAGAAATCTTGCTCGCAAAGTGAAAATAGATGGTTTTCGTCCAGGCAAAGTCCCTTTTAATGTTG
TAAAAAGCCGTTTCTCTGATAGTGTGCGTGAAGAAGTTGCCCGGGAAATGGTCCAATCTACCTTATATGAAGCCTTACAA
AAAAATGAATTGGTTCCAGCAGGTTATCCTCATGTTGAGCCTTTAGAAATCGAACCAGGTAAGGATTTTAAATACACTGC
TGTATTTGAAGTTATGCCTGTTTTTGAAGTTGTCGAGCTCAATCAAGCTCCAGTGGAATTAATTCAATCTGAAGTCAGTG
ATAAAGATGTTGACAACATGATTGAAAAATTACGAGAGCAAAACAAAGAGTGGCATGAAGTAACTCATGCGGTCAAAAAA
GGTGATAAAGTTGTTATTGATTTTCAGGGATTTTTGGATGATAAGCCATTCCAGGGCGGCAGTGCTGAAGGATATGAGCT
TGTAATTGGTTCTGGTTCGATGATTCCCGGATTTGAAGATGGGATTATTGGTGGGAAAATTGACAAACCATTAGACATCA
AAGTGAGTTTCCCGGAAGATTATGGCCATAAAGATTTGGCTGGGAAGGAAGCAACGTTCAAGATCACTATCAAAAAGATT
ATGGAAGGCAAGTTGCCTGCTTTGGATGAGGCATTTGCGGAGAAATTTAATATAAAAGAAGGTGGTATAGAGTCTCTTAA
AAAGGATATTAGGGAAAATATGGCGCGTGAATTGGAACGTCGCGTTAACATGATGAACAGAGAGAAACTGTTTGATTCAT
TAATGTCTGTGAATCATGTTGAGTTGCCAATAGCTTTGATAGATAAAGAAATTGAGCATTTAAAGCATGATATGTATCAC
CGATTGTTTGGTCACGAACATAAAGACGATGAAAAAATTCCTGATTTCCCAAGGGAGTTATTTGAAGAACAAGCCAAGCG
ACGCGTACACTTGGGCTTACTTTTTGCCGAGTATGTAAAAAAACACGAAATTGTTGCAGACAACGACAAAGTTAATGCTA
TGATTGATAAATTTGCCAGTGCTTACGAAAGTCCTGATGAGCTTCGCGCGTGGTATCAAAGCAGCAAAGAACATATGGCT
GAAGTTGAAGCATTAGTTATGGAAGATATGGTTGCAGATAAAATAGCAGAAGATGCGAAACTTAAATACAAAAATATGGA
TTATGATTCAGTGATGAATCCCAAAAAGGGCACTGAGAAAAAAGGAGAGTAA

Upstream 100 bases:

>100_bases
ATTGGTAGACGCACTGGATTTAGGTTCCAGCGGGGCGACCCGTGAGAGTTCGAGTCTCTCCTTTCGCACCATTTCATGAT
AACTTCCGAGAGGTGAATTA

Downstream 100 bases:

>100_bases
GCATGCCAGGCTATTCAGATAATATTATCCGTAATGCAAGCGGATTAATACCAATGGTAATTGAGCAAACCTCGCGAGGT
GAGCGTTCCTATGATATTTA

Product: trigger factor

Products: peptidylproline (w =0) [C]

Alternate protein names: TF [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MQVSVETLEGLERKVTVSVPTEKVEEEVSSRLRNLARKVKIDGFRPGKVPFNVVKSRFSDSVREEVAREMVQSTLYEALQ
KNELVPAGYPHVEPLEIEPGKDFKYTAVFEVMPVFEVVELNQAPVELIQSEVSDKDVDNMIEKLREQNKEWHEVTHAVKK
GDKVVIDFQGFLDDKPFQGGSAEGYELVIGSGSMIPGFEDGIIGGKIDKPLDIKVSFPEDYGHKDLAGKEATFKITIKKI
MEGKLPALDEAFAEKFNIKEGGIESLKKDIRENMARELERRVNMMNREKLFDSLMSVNHVELPIALIDKEIEHLKHDMYH
RLFGHEHKDDEKIPDFPRELFEEQAKRRVHLGLLFAEYVKKHEIVADNDKVNAMIDKFASAYESPDELRAWYQSSKEHMA
EVEALVMEDMVADKIAEDAKLKYKNMDYDSVMNPKKGTEKKGE

Sequences:

>Translated_443_residues
MQVSVETLEGLERKVTVSVPTEKVEEEVSSRLRNLARKVKIDGFRPGKVPFNVVKSRFSDSVREEVAREMVQSTLYEALQ
KNELVPAGYPHVEPLEIEPGKDFKYTAVFEVMPVFEVVELNQAPVELIQSEVSDKDVDNMIEKLREQNKEWHEVTHAVKK
GDKVVIDFQGFLDDKPFQGGSAEGYELVIGSGSMIPGFEDGIIGGKIDKPLDIKVSFPEDYGHKDLAGKEATFKITIKKI
MEGKLPALDEAFAEKFNIKEGGIESLKKDIRENMARELERRVNMMNREKLFDSLMSVNHVELPIALIDKEIEHLKHDMYH
RLFGHEHKDDEKIPDFPRELFEEQAKRRVHLGLLFAEYVKKHEIVADNDKVNAMIDKFASAYESPDELRAWYQSSKEHMA
EVEALVMEDMVADKIAEDAKLKYKNMDYDSVMNPKKGTEKKGE
>Mature_443_residues
MQVSVETLEGLERKVTVSVPTEKVEEEVSSRLRNLARKVKIDGFRPGKVPFNVVKSRFSDSVREEVAREMVQSTLYEALQ
KNELVPAGYPHVEPLEIEPGKDFKYTAVFEVMPVFEVVELNQAPVELIQSEVSDKDVDNMIEKLREQNKEWHEVTHAVKK
GDKVVIDFQGFLDDKPFQGGSAEGYELVIGSGSMIPGFEDGIIGGKIDKPLDIKVSFPEDYGHKDLAGKEATFKITIKKI
MEGKLPALDEAFAEKFNIKEGGIESLKKDIRENMARELERRVNMMNREKLFDSLMSVNHVELPIALIDKEIEHLKHDMYH
RLFGHEHKDDEKIPDFPRELFEEQAKRRVHLGLLFAEYVKKHEIVADNDKVNAMIDKFASAYESPDELRAWYQSSKEHMA
EVEALVMEDMVADKIAEDAKLKYKNMDYDSVMNPKKGTEKKGE

Specific function: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation [H]

COG id: COG0544

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786640, Length=435, Percent_Identity=40.6896551724138, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: 1070 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 500 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 340 Molecules/Cell In: Growth-Phase, Mini

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR005215
- InterPro:   IPR008880
- InterPro:   IPR008881 [H]

Pfam domain/function: PF00254 FKBP_C; PF05698 Trigger_C; PF05697 Trigger_N [H]

EC number: NA

Molecular weight: Translated: 50715; Mature: 50715

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVSVETLEGLERKVTVSVPTEKVEEEVSSRLRNLARKVKIDGFRPGKVPFNVVKSRFSD
CCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
SVREEVAREMVQSTLYEALQKNELVPAGYPHVEPLEIEPGKDFKYTAVFEVMPVFEVVEL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
NQAPVELIQSEVSDKDVDNMIEKLREQNKEWHEVTHAVKKGDKVVIDFQGFLDDKPFQGG
CHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
SAEGYELVIGSGSMIPGFEDGIIGGKIDKPLDIKVSFPEDYGHKDLAGKEATFKITIKKI
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHH
MEGKLPALDEAFAEKFNIKEGGIESLKKDIRENMARELERRVNMMNREKLFDSLMSVNHV
HCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ELPIALIDKEIEHLKHDMYHRLFGHEHKDDEKIPDFPRELFEEQAKRRVHLGLLFAEYVK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KHEIVADNDKVNAMIDKFASAYESPDELRAWYQSSKEHMAEVEALVMEDMVADKIAEDAK
HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKYKNMDYDSVMNPKKGTEKKGE
HHCCCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQVSVETLEGLERKVTVSVPTEKVEEEVSSRLRNLARKVKIDGFRPGKVPFNVVKSRFSD
CCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
SVREEVAREMVQSTLYEALQKNELVPAGYPHVEPLEIEPGKDFKYTAVFEVMPVFEVVEL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
NQAPVELIQSEVSDKDVDNMIEKLREQNKEWHEVTHAVKKGDKVVIDFQGFLDDKPFQGG
CHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
SAEGYELVIGSGSMIPGFEDGIIGGKIDKPLDIKVSFPEDYGHKDLAGKEATFKITIKKI
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEHHHH
MEGKLPALDEAFAEKFNIKEGGIESLKKDIRENMARELERRVNMMNREKLFDSLMSVNHV
HCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ELPIALIDKEIEHLKHDMYHRLFGHEHKDDEKIPDFPRELFEEQAKRRVHLGLLFAEYVK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KHEIVADNDKVNAMIDKFASAYESPDELRAWYQSSKEHMAEVEALVMEDMVADKIAEDAK
HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKYKNMDYDSVMNPKKGTEKKGE
HHCCCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: peptidylproline (w =180) [C]

Specific reaction: peptidylproline (w =180) = peptidylproline (w =0) [C]

General reaction: Isomerases; cis-trans-Isomerases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA