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The map label for this gene is clpP [H]

Identifier: 54294748

GI number: 54294748

Start: 2042494

End: 2043138

Strand: Reverse

Name: clpP [H]

Synonym: lpl1825

Alternate gene names: 54294748

Gene position: 2043138-2042494 (Counterclockwise)

Preceding gene: 54294749

Following gene: 54294747

Centisome position: 61.07

GC content: 39.84

Gene sequence:

>645_bases
ATGCCAGGCTATTCAGATAATATTATCCGTAATGCAAGCGGATTAATACCAATGGTAATTGAGCAAACCTCGCGAGGTGA
GCGTTCCTATGATATTTACTCAAGATTATTAAAAGAAAGAATTATTTTTCTCTTGGGTGAAGTAGAAGATCATATGGCTA
ACCTGGTTGTGGCTCAGTTGTTGTTTCTGGAGTCTGAAAATCCAGAGAAAGATATATCTCTATATATTAATTCTCCCGGC
GGAGTCGTTACTGCAGGTCTTGCTATCTACGACACCATGCAATTTATTAAGCCAGATGTAAGTACATTATGCATAGGCCA
GGCAGCAAGTGCAGCTGCCTTGCTACTTTGTGCCGGTGCTGATGGCAAACGATTCTGTTTACCTAACTCAAGAGTTATGA
TACATCAGCCCTTGGGTGGCTATAGAGGTCAAGCAACAGACATAGAAATTCATGCTCGAGAGACCTTGGCAGTTAGGGAA
CGTTTGAATAATATTATGGCTAAACACACTAAAAAAACACCTGATCAAATCATGCGTGATACAGAAAGAGATAACTTTAT
GAGCGCTACTCAGGCTATGGAGTATGGTCTAATTGATAAAGTTCTCTATGACAGACAAATTGCTGGACATTCTACAGACT
TATAA

Upstream 100 bases:

>100_bases
CAGATAAAATAGCAGAAGATGCGAAACTTAAATACAAAAATATGGATTATGATTCAGTGATGAATCCCAAAAAGGGCACT
GAGAAAAAAGGAGAGTAAGC

Downstream 100 bases:

>100_bases
CTTTGCTAGATACTCCTAGTTTATCTGAGTATAATATAAGTTGGTTTGATAGTAATGTGGTGGCGCAATATTATCTGATT
GTCTAAAATTTTACATGTAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MPGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPG
GVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGADGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRE
RLNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQIAGHSTDL

Sequences:

>Translated_214_residues
MPGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPG
GVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGADGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRE
RLNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQIAGHSTDL
>Mature_213_residues
PGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPGG
VVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGADGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRER
LNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQIAGHSTDL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=61.1702127659574, Blast_Score=242, Evalue=2e-64,
Organism=Escherichia coli, GI1786641, Length=203, Percent_Identity=73.8916256157635, Blast_Score=319, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI20129427, Length=200, Percent_Identity=60, Blast_Score=248, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23776; Mature: 23644

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQL
CCCCCCCHHHCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLESENPEKDISLYINSPGGVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGA
HHHCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHCCCHHHHHHCCHHHHEEEEEEECC
DGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRERLNNIMAKHTKKTPDQIMRD
CCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TERDNFMSATQAMEYGLIDKVLYDRQIAGHSTDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQL
CCCCCCHHHCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLESENPEKDISLYINSPGGVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGA
HHHCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHCCCHHHHHHCCHHHHEEEEEEECC
DGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRERLNNIMAKHTKKTPDQIMRD
CCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TERDNFMSATQAMEYGLIDKVLYDRQIAGHSTDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA