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The map label for this gene is rnc [H]

Identifier: 54294754

GI number: 54294754

Start: 2048704

End: 2049378

Strand: Reverse

Name: rnc [H]

Synonym: lpl1831

Alternate gene names: 54294754

Gene position: 2049378-2048704 (Counterclockwise)

Preceding gene: 54294755

Following gene: 54294749

Centisome position: 61.25

GC content: 39.56

Gene sequence:

>675_bases
GTGAAAATTAATTTAGAAAGATTGTGCAGACGTTTAAACTATCATTTTAATAACATGGCCTATTTGAAGCAGGCTTTGAC
GCATTGCAGTGCTGGTAGCGATAATTATGAACGCTTTGAGTTTCTTGGAGATTCGATACTAAGTTTTGTTATTGCCAATG
AGCTATTCAATCGTTTTCCACTTCACAGTGAAGGGCAATTAAGTCGATTGCGCTCTTTTCTTGTTAAAGGTGAAATGTTA
GCAGAAATAGCCAGAGAAATAGGTTTGGGTGATTATCTGTTTCTTGGGCAAGGTGAGTTAAGGAGCGGTGGATTTCGCCG
CACATCTATATTAGCAGATGCCCTTGAGGCTATATTGGCAGCCATTTATTTGGATGGAGGAATGACTGCTGCAAAACAGA
TTATTTTAATGCTTTATAGTTCACGATTGGATGATCCGGATTTAAATCATTGTTTAAAGGATGCAAAGACACAATTACAG
GAGTTTTTGCAAGCATCAAAATTCGCTTTACCTGAATACGTCCTAACCAAGGTTGAGGGGGATGAGCATGCTCAAATCTT
CCATGTAACATGCACAATTGAGGGAGTAAGTCAGGTAGCTTATGGCACAGGGCCTAATAGAAGAAAAGCTGAGCAGTTGG
CAGCAAAAGCCATGTTGGAACAGTTACAAGGTTAA

Upstream 100 bases:

>100_bases
AAATTTAAAATTAAGTTAAAATATCAAGTCATCAAACCTCTAATTTATAATATGAGCTTATTATTTAATTTTGAAGATAA
TTTTGAGGTAATAACAGGTA

Downstream 100 bases:

>100_bases
ATGGTATTGATCAGCAGAACCTATTACTTACTCCAGGTTTTCCAGGGCGTGACATATTCCTAACCACTCTTCTTCTGTCT
TCATTAAAGAAGAATGAGCG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKINLERLCRRLNYHFNNMAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKVEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG

Sequences:

>Translated_224_residues
MKINLERLCRRLNYHFNNMAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKVEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
>Mature_224_residues
MKINLERLCRRLNYHFNNMAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFPLHSEGQLSRLRSFLVKGEML
AEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILAAIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQ
EFLQASKFALPEYVLTKVEGDEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=202, Percent_Identity=32.6732673267327, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI155030234, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI29294649, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI29294651, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1788920, Length=221, Percent_Identity=50.6787330316742, Blast_Score=214, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=27.5555555555556, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=27.5555555555556, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17137682, Length=202, Percent_Identity=29.2079207920792, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25140; Mature: 25140

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINLERLCRRLNYHFNNMAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFP
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LHSEGQLSRLRSFLVKGEMLAEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQEFLQASKFALPEYVLTKVEG
HHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
DEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
CCCCEEEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKINLERLCRRLNYHFNNMAYLKQALTHCSAGSDNYERFEFLGDSILSFVIANELFNRFP
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LHSEGQLSRLRSFLVKGEMLAEIAREIGLGDYLFLGQGELRSGGFRRTSILADALEAILA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHH
AIYLDGGMTAAKQIILMLYSSRLDDPDLNHCLKDAKTQLQEFLQASKFALPEYVLTKVEG
HHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
DEHAQIFHVTCTIEGVSQVAYGTGPNRRKAEQLAAKAMLEQLQG
CCCCEEEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA