| Definition | Legionella pneumophila str. Lens, complete genome. |
|---|---|
| Accession | NC_006369 |
| Length | 3,345,687 |
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The map label for this gene is pleD [H]
Identifier: 54293727
GI number: 54293727
Start: 885911
End: 887461
Strand: Direct
Name: pleD [H]
Synonym: lpl0780
Alternate gene names: 54293727
Gene position: 885911-887461 (Clockwise)
Preceding gene: 54293726
Following gene: 54293728
Centisome position: 26.48
GC content: 34.95
Gene sequence:
>1551_bases ATGATAGATCAAGAATTAAAGAAAAAAATTGTTAACACAATTAGCCAATATGAGCATAAGTGTGACAAGATGCAAAATCA AATTAATACACTCAGAAGTGTAATTAATCAATTGATCATTAATCCTATTGGAATCAATTATGAATTGGATGATCGCCTTT CGCAACTAAGAAATTATTTGGATACGGAGTTTGAACCCGCTGTCATAGAAAAAAAAGTGAAACGTTTGGCAGAAATACTT TCCAAAATGCAAAGGAAAAAAGCGGAAAATTCTCGTTTAGTCAATGGACTAATCAAACAGGGAGTGGAGTCCATTGGTCG TATTGCCAATAAATCTCAGGATAAGAGGGCCGTTACAAAATTACAAAAAATGCTGGATACCGAGATGGAAAGCCATGCGA TTTTGATTTGTTTTAATCAAGTCTTAACTCAATGCATTTCTTCTGTGATTAAGGAGCTTGAGGAGTTACCACAAATTACA AAAGTCGATACCCCCCAAACAAGTTATCAGTCTGAGATTAGTTTAAAAGTAAATGACAGCTTGCAACAATTACTTAACCA TTTATCTATCCCTCAGGACTTGGATTCCAAGAGGGGAATCATAAAAACAAATTTGGAACATGCACTCACTGATGAAGAGC TTAGCACTATTATTGACAATTTGACGGAATTAGTCGTTGAGTCATTTAATGTTGAGCAGAATCGATTCAAAGGGTTTCTT CAACAGTTAACCGATCAGCTTAATGATTTTGAAATCTATTTAAGAGTATCAGGAGATGCTCGCAAAAAGGCAAGTGAAGA CAGTCGTTTATTAGAGTGTGGGATTCAGGATAATCTTGATCAAATCAAGAATCATTTAGATACCTCTAAAACGATTGAGG AATTATCCTCAAAGGTGAGCCAAAATATAAAAATGATTGGTGACAGGTTAAAAGAATATCGACACAATGAAAAAATCCGA GAGGAAGAATATGCAAAGCAAGTATCTGAGTTGCAAGCCAGATTACAGGAATCCGAGCAAAATGCAGAAGAAATAAAAAA TTTGCTTGCTTTTCAGAAATACAGAATTAACCACGACAGTTTAACAGGTTTACCTAATAGAGAATCTTATGAAGAGCATA TTCTGGACTCATTTCAGCGCTGGAAACGAAGTTCAAGCGTATTGTCTCTTGCTGTGTGTGACATCGATCATTTTAAATGT ATTAATGATAATTTTGGCCATCTTGCAGGAGATAAAGTTCTTAAAAAGGTAGCTATGATTTTTAAATCATCGATCAGGAC GGTTGATTTTATCGCTCGAATAGGTGGTGAGGAATTTGTGTTTATCTTTGAACAAACCAGCAGCAAGGAAGCTTTTGGAG TTTTGGAGAAATTACGTAAATTAGTTGAAGATTGTTTGTTTTATTATCGAGACAAAAAAGTCGATGTTACGGTTTCTTTT GGACTAACTACGGTAACCGAAGAAGATGATATTGAATCTTTATTTATGCGGGCAGACAATGCCATGTATAAAGCTAAAAA GGCAGGAAAGAACAGGGTAGAAATATTATAG
Upstream 100 bases:
>100_bases CAAACCAAAAAACCTCCTTTTTGTGATGGATCGCATGCAAAGGTTTTGCTTGAAGTGCTTAAAAACAGGCAAAATAAATG AACAGGAAAGGAAGTCTTAA
Downstream 100 bases:
>100_bases TGGAATATATTTCCAACAATTTTTAATTATACTATTTTCGGAGTAAATCCATGGTAACAGATGATTTTCCTCTGATAACG ATTTTTAAATGAACTTGATC
Product: hypothetical protein
Products: NA
Alternate protein names: Stalked cell differentiation-controlling protein; Diguanylate cyclase; DGC; Diguanylate kinase [H]
Number of amino acids: Translated: 516; Mature: 516
Protein sequence:
>516_residues MIDQELKKKIVNTISQYEHKCDKMQNQINTLRSVINQLIINPIGINYELDDRLSQLRNYLDTEFEPAVIEKKVKRLAEIL SKMQRKKAENSRLVNGLIKQGVESIGRIANKSQDKRAVTKLQKMLDTEMESHAILICFNQVLTQCISSVIKELEELPQIT KVDTPQTSYQSEISLKVNDSLQQLLNHLSIPQDLDSKRGIIKTNLEHALTDEELSTIIDNLTELVVESFNVEQNRFKGFL QQLTDQLNDFEIYLRVSGDARKKASEDSRLLECGIQDNLDQIKNHLDTSKTIEELSSKVSQNIKMIGDRLKEYRHNEKIR EEEYAKQVSELQARLQESEQNAEEIKNLLAFQKYRINHDSLTGLPNRESYEEHILDSFQRWKRSSSVLSLAVCDIDHFKC INDNFGHLAGDKVLKKVAMIFKSSIRTVDFIARIGGEEFVFIFEQTSSKEAFGVLEKLRKLVEDCLFYYRDKKVDVTVSF GLTTVTEEDDIESLFMRADNAMYKAKKAGKNRVEIL
Sequences:
>Translated_516_residues MIDQELKKKIVNTISQYEHKCDKMQNQINTLRSVINQLIINPIGINYELDDRLSQLRNYLDTEFEPAVIEKKVKRLAEIL SKMQRKKAENSRLVNGLIKQGVESIGRIANKSQDKRAVTKLQKMLDTEMESHAILICFNQVLTQCISSVIKELEELPQIT KVDTPQTSYQSEISLKVNDSLQQLLNHLSIPQDLDSKRGIIKTNLEHALTDEELSTIIDNLTELVVESFNVEQNRFKGFL QQLTDQLNDFEIYLRVSGDARKKASEDSRLLECGIQDNLDQIKNHLDTSKTIEELSSKVSQNIKMIGDRLKEYRHNEKIR EEEYAKQVSELQARLQESEQNAEEIKNLLAFQKYRINHDSLTGLPNRESYEEHILDSFQRWKRSSSVLSLAVCDIDHFKC INDNFGHLAGDKVLKKVAMIFKSSIRTVDFIARIGGEEFVFIFEQTSSKEAFGVLEKLRKLVEDCLFYYRDKKVDVTVSF GLTTVTEEDDIESLFMRADNAMYKAKKAGKNRVEIL >Mature_516_residues MIDQELKKKIVNTISQYEHKCDKMQNQINTLRSVINQLIINPIGINYELDDRLSQLRNYLDTEFEPAVIEKKVKRLAEIL SKMQRKKAENSRLVNGLIKQGVESIGRIANKSQDKRAVTKLQKMLDTEMESHAILICFNQVLTQCISSVIKELEELPQIT KVDTPQTSYQSEISLKVNDSLQQLLNHLSIPQDLDSKRGIIKTNLEHALTDEELSTIIDNLTELVVESFNVEQNRFKGFL QQLTDQLNDFEIYLRVSGDARKKASEDSRLLECGIQDNLDQIKNHLDTSKTIEELSSKVSQNIKMIGDRLKEYRHNEKIR EEEYAKQVSELQARLQESEQNAEEIKNLLAFQKYRINHDSLTGLPNRESYEEHILDSFQRWKRSSSVLSLAVCDIDHFKC INDNFGHLAGDKVLKKVAMIFKSSIRTVDFIARIGGEEFVFIFEQTSSKEAFGVLEKLRKLVEDCLFYYRDKKVDVTVSF GLTTVTEEDDIESLFMRADNAMYKAKKAGKNRVEIL
Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm. Note=Phosphorylated PleD localizes to the differentiating pole [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 response regulatory domains [H]
Homologues:
Organism=Escherichia coli, GI1787816, Length=160, Percent_Identity=35.625, Blast_Score=103, Evalue=2e-23, Organism=Escherichia coli, GI87082007, Length=175, Percent_Identity=36.5714285714286, Blast_Score=103, Evalue=3e-23, Organism=Escherichia coli, GI145693134, Length=165, Percent_Identity=32.7272727272727, Blast_Score=100, Evalue=3e-22, Organism=Escherichia coli, GI1788381, Length=177, Percent_Identity=30.5084745762712, Blast_Score=94, Evalue=2e-20, Organism=Escherichia coli, GI87081881, Length=164, Percent_Identity=36.5853658536585, Blast_Score=93, Evalue=5e-20, Organism=Escherichia coli, GI1786584, Length=158, Percent_Identity=31.6455696202532, Blast_Score=90, Evalue=3e-19, Organism=Escherichia coli, GI1787262, Length=163, Percent_Identity=34.9693251533742, Blast_Score=88, Evalue=1e-18, Organism=Escherichia coli, GI1787802, Length=130, Percent_Identity=37.6923076923077, Blast_Score=88, Evalue=1e-18, Organism=Escherichia coli, GI1787541, Length=179, Percent_Identity=31.2849162011173, Blast_Score=77, Evalue=4e-15, Organism=Escherichia coli, GI87081977, Length=207, Percent_Identity=31.8840579710145, Blast_Score=73, Evalue=6e-14, Organism=Escherichia coli, GI1787056, Length=126, Percent_Identity=37.3015873015873, Blast_Score=72, Evalue=6e-14, Organism=Escherichia coli, GI1788956, Length=248, Percent_Identity=27.4193548387097, Blast_Score=70, Evalue=3e-13, Organism=Escherichia coli, GI1788085, Length=163, Percent_Identity=34.9693251533742, Blast_Score=69, Evalue=1e-12, Organism=Escherichia coli, GI87081974, Length=154, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=4e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001054 - InterPro: IPR011006 - InterPro: IPR000160 - InterPro: IPR001789 [H]
Pfam domain/function: PF00990 GGDEF; PF00072 Response_reg [H]
EC number: =2.7.7.65 [H]
Molecular weight: Translated: 59581; Mature: 59581
Theoretical pI: Translated: 6.07; Mature: 6.07
Prosite motif: PS50887 GGDEF
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIDQELKKKIVNTISQYEHKCDKMQNQINTLRSVINQLIINPIGINYELDDRLSQLRNYL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH DTEFEPAVIEKKVKRLAEILSKMQRKKAENSRLVNGLIKQGVESIGRIANKSQDKRAVTK CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH LQKMLDTEMESHAILICFNQVLTQCISSVIKELEELPQITKVDTPQTSYQSEISLKVNDS HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEECHH LQQLLNHLSIPQDLDSKRGIIKTNLEHALTDEELSTIIDNLTELVVESFNVEQNRFKGFL HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH QQLTDQLNDFEIYLRVSGDARKKASEDSRLLECGIQDNLDQIKNHLDTSKTIEELSSKVS HHHHHCCCCEEEEEEECCCHHHHCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHH QNIKMIGDRLKEYRHNEKIREEEYAKQVSELQARLQESEQNAEEIKNLLAFQKYRINHDS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHH LTGLPNRESYEEHILDSFQRWKRSSSVLSLAVCDIDHFKCINDNFGHLAGDKVLKKVAMI CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHH FKSSIRTVDFIARIGGEEFVFIFEQTSSKEAFGVLEKLRKLVEDCLFYYRDKKVDVTVSF HHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE GLTTVTEEDDIESLFMRADNAMYKAKKAGKNRVEIL CEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC >Mature Secondary Structure MIDQELKKKIVNTISQYEHKCDKMQNQINTLRSVINQLIINPIGINYELDDRLSQLRNYL CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH DTEFEPAVIEKKVKRLAEILSKMQRKKAENSRLVNGLIKQGVESIGRIANKSQDKRAVTK CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH LQKMLDTEMESHAILICFNQVLTQCISSVIKELEELPQITKVDTPQTSYQSEISLKVNDS HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEECHH LQQLLNHLSIPQDLDSKRGIIKTNLEHALTDEELSTIIDNLTELVVESFNVEQNRFKGFL HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH QQLTDQLNDFEIYLRVSGDARKKASEDSRLLECGIQDNLDQIKNHLDTSKTIEELSSKVS HHHHHCCCCEEEEEEECCCHHHHCCCHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHH QNIKMIGDRLKEYRHNEKIREEEYAKQVSELQARLQESEQNAEEIKNLLAFQKYRINHDS HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHH LTGLPNRESYEEHILDSFQRWKRSSSVLSLAVCDIDHFKCINDNFGHLAGDKVLKKVAMI CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHH FKSSIRTVDFIARIGGEEFVFIFEQTSSKEAFGVLEKLRKLVEDCLFYYRDKKVDVTVSF HHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE GLTTVTEEDDIESLFMRADNAMYKAKKAGKNRVEIL CEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA